Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes / Daniela Jardim PEREIRA in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes Type de document : texte imprimé Auteurs : Daniela Jardim PEREIRA, Auteur ; Sofia MORAIS, Auteur ; Alexandre SAYAL, Auteur ; João PEREIRA, Auteur ; Sofia MENESES, Auteur ; Graça AREIAS, Auteur ; Bruno DIREITO, Auteur ; António MACEDO, Auteur ; Miguel CASTELO-BRANCO, Auteur Langues : Anglais (eng) Mots-clés : Humans  Executive Function  Neurofeedback  Autism Spectrum Disorder/therapy  Brain/diagnostic imaging  Brain Mapping  Autism spectrum disorders  Dorsolateral prefrontal cortex  Rt-fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in executive function (EF) are consistently reported in autism spectrum disorders (ASD). Tailored cognitive training tools, such as neurofeedback, focused on executive function enhancement might have a significant impact on the daily life functioning of individuals with ASD. We report the first real-time fMRI neurofeedback (rt-fMRI NF) study targeting the left dorsolateral prefrontal cortex (DLPFC) in ASD. METHODS: Thirteen individuals with autism without intellectual disability and seventeen neurotypical individuals completed a rt-fMRI working memory NF paradigm, consisting of subvocal backward recitation of self-generated numeric sequences. We performed a region-of-interest analysis of the DLPFC, whole-brain comparisons between groups and, DLPFC-based functional connectivity. RESULTS: The ASD and control groups were able to modulate DLPFC activity in 84% and 98% of the runs. Activity in the target region was persistently lower in the ASD group, particularly in runs without neurofeedback. Moreover, the ASD group showed lower activity in premotor/motor areas during pre-neurofeedback run than controls, but not in transfer runs, where it was seemingly balanced by higher connectivity between the DLPFC and the motor cortex. Group comparison in the transfer run also showed significant differences in DLPFC-based connectivity between groups, including higher connectivity with areas integrated into the multidemand network (MDN) and the visual cortex. CONCLUSIONS: Neurofeedback seems to induce a higher between-group similarity of the whole-brain activity levels (including the target ROI) which might be promoted by changes in connectivity between the DLPFC and both high and low-level areas, including motor, visual and MDN regions. En ligne : https://dx.doi.org/10.1186/s11689-024-09531-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes [texte imprimé] / Daniela Jardim PEREIRA, Auteur ; Sofia MORAIS, Auteur ; Alexandre SAYAL, Auteur ; João PEREIRA, Auteur ; Sofia MENESES, Auteur ; Graça AREIAS, Auteur ; Bruno DIREITO, Auteur ; António MACEDO, Auteur ; Miguel CASTELO-BRANCO, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Executive Function  Neurofeedback  Autism Spectrum Disorder/therapy  Brain/diagnostic imaging  Brain Mapping  Autism spectrum disorders  Dorsolateral prefrontal cortex  Rt-fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Deficits in executive function (EF) are consistently reported in autism spectrum disorders (ASD). Tailored cognitive training tools, such as neurofeedback, focused on executive function enhancement might have a significant impact on the daily life functioning of individuals with ASD. We report the first real-time fMRI neurofeedback (rt-fMRI NF) study targeting the left dorsolateral prefrontal cortex (DLPFC) in ASD. METHODS: Thirteen individuals with autism without intellectual disability and seventeen neurotypical individuals completed a rt-fMRI working memory NF paradigm, consisting of subvocal backward recitation of self-generated numeric sequences. We performed a region-of-interest analysis of the DLPFC, whole-brain comparisons between groups and, DLPFC-based functional connectivity. RESULTS: The ASD and control groups were able to modulate DLPFC activity in 84% and 98% of the runs. Activity in the target region was persistently lower in the ASD group, particularly in runs without neurofeedback. Moreover, the ASD group showed lower activity in premotor/motor areas during pre-neurofeedback run than controls, but not in transfer runs, where it was seemingly balanced by higher connectivity between the DLPFC and the motor cortex. Group comparison in the transfer run also showed significant differences in DLPFC-based connectivity between groups, including higher connectivity with areas integrated into the multidemand network (MDN) and the visual cortex. CONCLUSIONS: Neurofeedback seems to induce a higher between-group similarity of the whole-brain activity levels (including the target ROI) which might be promoted by changes in connectivity between the DLPFC and both high and low-level areas, including motor, visual and MDN regions. En ligne : https://dx.doi.org/10.1186/s11689-024-09531-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 25-6 (August 2021)  

Public ISBD [article]  inAutism > 25-6 (August 2021) . - p.1746-1760 Titre : Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism Type de document : texte imprimé Auteurs : Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1746-1760 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism [texte imprimé] / Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1746-1760. Langues : Anglais (eng) in Autism > 25-6 (August 2021) . - p.1746-1760 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism / Bruno DIREITO in Autism, 26-6 (August 2022)  

Public ISBD [article]  inAutism > 26-6 (August 2022) . - p.1746-1760 Titre : Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism Type de document : texte imprimé Auteurs : Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur Article en page(s) : p.1746-1760 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurofeedback  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Training the social brain: Clinical and neural effects of an 8-week real-time functional magnetic resonance imaging neurofeedback Phase IIa Clinical Trial in Autism [texte imprimé] / Bruno DIREITO, Auteur ; Susana MOUGA, Auteur ; Alexandre SAYAL, Auteur ; Marco SIMÕES, Auteur ; Hugo QUENTAL, Auteur ; Inês BERNARDINO, Auteur ; Rebecca PLAYLE, Auteur ; Rachel MCNAMARA, Auteur ; David E.J. LINDEN, Auteur ; Guiomar OLIVEIRA, Auteur ; Miguel CASTELO-BRANCO, Auteur . - p.1746-1760. Langues : Anglais (eng) in Autism > 26-6 (August 2022) . - p.1746-1760 Mots-clés : Autism Spectrum Disorder/diagnostic imaging/therapy  Autistic Disorder/diagnostic imaging/therapy  Brain/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neurofeedback  autism spectrum disorder  neurofeedback  neurorehabilitation  posterior superior temporal sulcus  real-time functional magnetic resonance imaging  social cognition Index. décimale : PER Périodiques Résumé : Neurofeedback is an emerging therapeutic approach in neuropsychiatric disorders. Its potential application in autism spectrum disorder remains to be tested. Here, we demonstrate the feasibility of real-time functional magnetic resonance imaging volitional neurofeedback in targeting social brain regions in autism spectrum disorder. In this clinical trial, autism spectrum disorder patients were enrolled in a program with five training sessions of neurofeedback. Participants were able to control their own brain activity in this social brain region, with positive clinical and neural effects. Larger, controlled, and blinded clinical studies will be required to confirm the benefits. En ligne : http://dx.doi.org/10.1177/13623613211002052 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

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