Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

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