Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : S. CASEY, Auteur ; Mark CARTER, Auteur ; A.M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G.W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; Louise C. KENNY, Auteur ; Fergus P. MCCARTHY, Auteur ; L.M.E. MCCOWAN, Auteur ; J.M.D. THOMPSON, Auteur ; D.M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [texte imprimé] / S. CASEY, Auteur ; Mark CARTER, Auteur ; A.M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G.W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; Louise C. KENNY, Auteur ; Fergus P. MCCARTHY, Auteur ; L.M.E. MCCOWAN, Auteur ; J.M.D. THOMPSON, Auteur ; D.M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932 Mots-clés : Autism Spectrum Disorder  Child  Cytokines  Female  Humans  Mothers  Pregnancy  Autism spectrum disorder  Cytokine  Il-17a  Inflammation  Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

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