Patterns of sensory modulation by age and sex in young people on the autism spectrum / Alison E. LANE in Autism Research, 15-10 (October 2022)  

Public ISBD [article]  inAutism Research > 15-10 (October 2022) . - p.1840-1854 Titre : Patterns of sensory modulation by age and sex in young people on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Alison E. LANE, Auteur ; Kate SIMPSON, Auteur ; Anne MASI, Auteur ; Rachel GROVE, Auteur ; Mohammad Ali MONI, Auteur ; Alicia MONTGOMERY, Auteur ; Jacqui ROBERTS, Auteur ; Natalie SILOVE, Auteur ; Olivia WHALEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Valsamma EAPEN, Auteur Article en page(s) : p.1840-1854 Langues : Anglais (eng) Mots-clés : age  autism spectrum  cluster analysis  sensory  sensory modulation  sex  subtypes  young people Index. décimale : PER Périodiques Résumé : Sensory modulation symptoms form a diagnostic criterion for autism spectrum disorder and are associated with significant daily functional limitations. Utilizing caregiver report on Short Sensory Profile-2 (SSP-2) for 919 autistic children (3-14.11 years), we examined the expression of sensory modulation symptoms by age and sex and investigated the existence of specific sensory modulation subtypes. Sensory modulation symptoms appeared to peak in frequency during middle childhood, particularly in sensory sensitivity and avoidance. Symptoms associated with sensory hypo-reactivity and seeking tended not differ between age cohorts. Males and females demonstrated similar overall sensory modulation profiles, however, females showed elevated symptoms relating to sensory sensitivity. Model-based cluster analysis revealed five interpretable sensory modulation subtypes which related to symptom severity (low, mid-range, high). Subtypes demonstrating mid-range symptom severity differed in focus on sensory hyper-reactivity or seeking symptoms. The findings of this study report for the first time that age-related differences in sensory modulation symptoms may be associated with sensory hyper-reactivity only. The subtyping results also suggest that sensory modulation symptom severity is a reliable means of classifying variance within autistic children, however, consideration of differences in the behavioral strategies employed by individuals to manage sensory modulation symptoms may inform tailored supportive strategies. LAY SUMMARY: We studied sensory symptoms such as over-responding, under-responding and sensation seeking behaviors in 919 autistic children and adolescents. We found that 6-12-year-olds and females displayed the most sensory over-responding symptoms. Autistic children could be grouped into mild, moderate, and severe levels of sensory symptoms, however, children differed in the type of strategies used to cope with their sensory symptoms meaning that they may require different intervention approaches. En ligne : http://dx.doi.org/10.1002/aur.2762 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Patterns of sensory modulation by age and sex in young people on the autism spectrum [Texte imprimé et/ou numérique] / Alison E. LANE, Auteur ; Kate SIMPSON, Auteur ; Anne MASI, Auteur ; Rachel GROVE, Auteur ; Mohammad Ali MONI, Auteur ; Alicia MONTGOMERY, Auteur ; Jacqui ROBERTS, Auteur ; Natalie SILOVE, Auteur ; Olivia WHALEN, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Valsamma EAPEN, Auteur . - p.1840-1854. Langues : Anglais (eng) in Autism Research > 15-10 (October 2022) . - p.1840-1854 Mots-clés : age  autism spectrum  cluster analysis  sensory  sensory modulation  sex  subtypes  young people Index. décimale : PER Périodiques Résumé : Sensory modulation symptoms form a diagnostic criterion for autism spectrum disorder and are associated with significant daily functional limitations. Utilizing caregiver report on Short Sensory Profile-2 (SSP-2) for 919 autistic children (3-14.11 years), we examined the expression of sensory modulation symptoms by age and sex and investigated the existence of specific sensory modulation subtypes. Sensory modulation symptoms appeared to peak in frequency during middle childhood, particularly in sensory sensitivity and avoidance. Symptoms associated with sensory hypo-reactivity and seeking tended not differ between age cohorts. Males and females demonstrated similar overall sensory modulation profiles, however, females showed elevated symptoms relating to sensory sensitivity. Model-based cluster analysis revealed five interpretable sensory modulation subtypes which related to symptom severity (low, mid-range, high). Subtypes demonstrating mid-range symptom severity differed in focus on sensory hyper-reactivity or seeking symptoms. The findings of this study report for the first time that age-related differences in sensory modulation symptoms may be associated with sensory hyper-reactivity only. The subtyping results also suggest that sensory modulation symptom severity is a reliable means of classifying variance within autistic children, however, consideration of differences in the behavioral strategies employed by individuals to manage sensory modulation symptoms may inform tailored supportive strategies. LAY SUMMARY: We studied sensory symptoms such as over-responding, under-responding and sensation seeking behaviors in 919 autistic children and adolescents. We found that 6-12-year-olds and females displayed the most sensory over-responding symptoms. Autistic children could be grouped into mild, moderate, and severe levels of sensory symptoms, however, children differed in the type of strategies used to cope with their sensory symptoms meaning that they may require different intervention approaches. En ligne : http://dx.doi.org/10.1002/aur.2762 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis / Renee VAN DER SCHAAF in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1630-1650 Titre : The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Renee VAN DER SCHAAF, Auteur ; Vanessa E. MURPHY, Auteur ; Soriah HARVEY, Auteur ; Paige DENT, Auteur ; Alison LANE, Auteur ; Olivia WHALEN, Auteur Article en page(s) : p.1630-1650 Langues : Anglais (eng) Mots-clés : asthma  asthma medication  autism  child  infant  maternal  pregnancy Index. décimale : PER Périodiques Résumé : ABSTRACT Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle?Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel?Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR?=?1.32; 95% CI?=?1.21, 1.44; I2?=?61%, n?=?14), with current asthma during pregnancy (OR?=?1.23; 95% CI?=?1.12, 1.35; I2?=?35%, n?=?10) and with medication use during pregnancy (OR?=?1.48; 95% CI?=?1.30, 1.68; I2?=?0%, n?=?3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR?=?1.07; 95% CI?=?0.89, 1.27; I2?=?34%, n?=?2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association. Trial Registration: PROSPERO registration: CRD42021265060 En ligne : https://doi.org/10.1002/aur.70071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] The Association Between Maternal Asthma and Child Autism: A Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / Renee VAN DER SCHAAF, Auteur ; Vanessa E. MURPHY, Auteur ; Soriah HARVEY, Auteur ; Paige DENT, Auteur ; Alison LANE, Auteur ; Olivia WHALEN, Auteur . - p.1630-1650. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1630-1650 Mots-clés : asthma  asthma medication  autism  child  infant  maternal  pregnancy Index. décimale : PER Périodiques Résumé : ABSTRACT Maternal asthma has been linked to child autism. In this study, we systematically reviewed observational studies published between July 2001 and February 2024 that assessed maternal asthma during pregnancy (exposure) and child autism (outcome). Databases searched included MEDLINE, CINAHL, EMBASE, and PsycINFO. Of the 350 potential studies, 19 met the inclusion criteria (2,530,716 participants; 73,065 autistic participants). Quality was assessed with the Newcastle?Ottawa Scale. Meta-analyses using proportions and odds ratios were conducted using the Mantel?Haenszel method with a random-effects model. Compared to women without asthma, there was an increased odds of child autism with any history of maternal asthma (OR?=?1.32; 95% CI?=?1.21, 1.44; I2?=?61%, n?=?14), with current asthma during pregnancy (OR?=?1.23; 95% CI?=?1.12, 1.35; I2?=?35%, n?=?10) and with medication use during pregnancy (OR?=?1.48; 95% CI?=?1.30, 1.68; I2?=?0%, n?=?3). However, when women with asthma who used asthma medication were compared to those with asthma who did not use medication, there were no increased odds for child autism (OR?=?1.07; 95% CI?=?0.89, 1.27; I2?=?34%, n?=?2). Maternal asthma is associated with an increased odds of child autism. Future studies should consider neurodivergence in the parents, the severity of asthma, and the effectiveness of prescribed medication in managing the mother's asthma to improve our understanding of this association. Trial Registration: PROSPERO registration: CRD42021265060 En ligne : https://doi.org/10.1002/aur.70071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

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