Cross-Disorder Analysis of De Novo Mutations in Neuropsychiatric Disorders / Kaiqin LI in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1299-1313 Titre : Cross-Disorder Analysis of De Novo Mutations in Neuropsychiatric Disorders Type de document : texte imprimé Auteurs : Kaiqin LI, Auteur ; Zhenghuan FANG, Auteur ; Guifang ZHAO, Auteur ; Bingshan LI, Auteur ; Chao CHEN, Auteur ; Lu XIA, Auteur ; Lifang WANG, Auteur ; Tengfei LUO, Auteur ; Xiaoming WANG, Auteur ; Ziqi WANG, Auteur ; Yi ZHANG, Auteur ; Yi JIANG, Auteur ; Qian PAN, Auteur ; Zhengmao HU, Auteur ; Hui GUO, Auteur ; Beisha TANG, Auteur ; Chaoyu LIU, Auteur ; Zhongsheng SUN, Auteur ; Kun XIA, Auteur ; Jun LI, Auteur Année de publication : 2022 Article en page(s) : p.1299-1313 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/genetics  Genetic Predisposition to Disease  Humans  Intellectual Disability/genetics  Mutation  Phenotype  Schizophrenia  Candidate gene  De novo mutation  Expression pattern  Functional network  Neuropsychiatric disorder Index. décimale : PER Périodiques Résumé : The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations (DNMs) from 6511 patients with autism spectrum disorder (ASD), 4,293 undiagnosed developmental disorder (UDD), 933 epileptic encephalopathy (EE), 1022 intellectual disability (ID), 1094 schizophrenia (SCZ), and 3391 controls. We evaluated that putative functional DNMs contribute to 38.11%, 34.40%, 33.31%, 10.98% and 6.91% of patients with ID, EE, UDD, ASD and SCZ, respectively. Consistent with phenotype similarity and heterogeneity in different NPDs, they show different degree of genetic association. Cross-disorder analysis of DNMs prioritized 321 candidate genes (FDR < 0.05) and showed that genes shared in more disorders were more likely to exhibited specific expression pattern, functional pathway, genetic convergence, and genetic intolerance. En ligne : http://dx.doi.org/10.1007/s10803-021-05031-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Cross-Disorder Analysis of De Novo Mutations in Neuropsychiatric Disorders [texte imprimé] / Kaiqin LI, Auteur ; Zhenghuan FANG, Auteur ; Guifang ZHAO, Auteur ; Bingshan LI, Auteur ; Chao CHEN, Auteur ; Lu XIA, Auteur ; Lifang WANG, Auteur ; Tengfei LUO, Auteur ; Xiaoming WANG, Auteur ; Ziqi WANG, Auteur ; Yi ZHANG, Auteur ; Yi JIANG, Auteur ; Qian PAN, Auteur ; Zhengmao HU, Auteur ; Hui GUO, Auteur ; Beisha TANG, Auteur ; Chaoyu LIU, Auteur ; Zhongsheng SUN, Auteur ; Kun XIA, Auteur ; Jun LI, Auteur . - 2022 . - p.1299-1313. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1299-1313 Mots-clés : Autism Spectrum Disorder/genetics  Genetic Predisposition to Disease  Humans  Intellectual Disability/genetics  Mutation  Phenotype  Schizophrenia  Candidate gene  De novo mutation  Expression pattern  Functional network  Neuropsychiatric disorder Index. décimale : PER Périodiques Résumé : The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations (DNMs) from 6511 patients with autism spectrum disorder (ASD), 4,293 undiagnosed developmental disorder (UDD), 933 epileptic encephalopathy (EE), 1022 intellectual disability (ID), 1094 schizophrenia (SCZ), and 3391 controls. We evaluated that putative functional DNMs contribute to 38.11%, 34.40%, 33.31%, 10.98% and 6.91% of patients with ID, EE, UDD, ASD and SCZ, respectively. Consistent with phenotype similarity and heterogeneity in different NPDs, they show different degree of genetic association. Cross-disorder analysis of DNMs prioritized 321 candidate genes (FDR < 0.05) and showed that genes shared in more disorders were more likely to exhibited specific expression pattern, functional pathway, genetic convergence, and genetic intolerance. En ligne : http://dx.doi.org/10.1007/s10803-021-05031-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Visuospatial Bias in Children with Autism Spectrum Disorder: Evidence from Line Bisection Tasks / Chunyan LIU in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4861-4871 Titre : Visuospatial Bias in Children with Autism Spectrum Disorder: Evidence from Line Bisection Tasks Type de document : texte imprimé Auteurs : Chunyan LIU, Auteur ; Huajie ZHAI, Auteur ; Shuhua SU, Auteur ; Sutao SONG, Auteur ; Gongxiang CHEN, Auteur ; Yi JIANG, Auteur Article en page(s) : p.4861-4871 Langues : Anglais (eng) Mots-clés : Attention  Autism Spectrum Disorder  Child  Cues  Humans  Space Perception  Visual Perception  Autism spectrum disorder  Line bisection task  Visual processing  Visuospatial bias Index. décimale : PER Périodiques Résumé : Previous studies have found reduced leftward bias of facial processing in individuals with Autism Spectrum Disorder (ASD). However, it is not clear whether they manifest a leftward bias in general visual processing. To shed light on this issue, the current study used the manual line bisection task to assess children 5 to 15 years of age with ASD as well as typically developing (TD) children. Results showed that children with ASD, similar to TD children, demonstrate a leftward bias in general visual processing, especially for bisecting long lines (â§Â 80 mm). In both groups, participant performance in line bisection was affected by the hand used, the length of the line, the cueing symbol, and the location of the symbol. The ASD group showed a rightward bias when bisecting short lines (30 mm) with their left hands, which slightly differed from the TD group. These results indicate that while ASD individuals and TD individuals share a similar leftward bias in general visual processing, when using their left hands to bisect short lines, ASD individuals may show an atypical bias pattern. En ligne : http://dx.doi.org/10.1007/s10803-021-05350-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Visuospatial Bias in Children with Autism Spectrum Disorder: Evidence from Line Bisection Tasks [texte imprimé] / Chunyan LIU, Auteur ; Huajie ZHAI, Auteur ; Shuhua SU, Auteur ; Sutao SONG, Auteur ; Gongxiang CHEN, Auteur ; Yi JIANG, Auteur . - p.4861-4871. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4861-4871 Mots-clés : Attention  Autism Spectrum Disorder  Child  Cues  Humans  Space Perception  Visual Perception  Autism spectrum disorder  Line bisection task  Visual processing  Visuospatial bias Index. décimale : PER Périodiques Résumé : Previous studies have found reduced leftward bias of facial processing in individuals with Autism Spectrum Disorder (ASD). However, it is not clear whether they manifest a leftward bias in general visual processing. To shed light on this issue, the current study used the manual line bisection task to assess children 5 to 15 years of age with ASD as well as typically developing (TD) children. Results showed that children with ASD, similar to TD children, demonstrate a leftward bias in general visual processing, especially for bisecting long lines (â§Â 80 mm). In both groups, participant performance in line bisection was affected by the hand used, the length of the line, the cueing symbol, and the location of the symbol. The ASD group showed a rightward bias when bisecting short lines (30 mm) with their left hands, which slightly differed from the TD group. These results indicate that while ASD individuals and TD individuals share a similar leftward bias in general visual processing, when using their left hands to bisect short lines, ASD individuals may show an atypical bias pattern. En ligne : http://dx.doi.org/10.1007/s10803-021-05350-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

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