Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity / Margherita PROSPERI in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3574-3588 Titre : Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity Type de document : texte imprimé Auteurs : Margherita PROSPERI, Auteur ; Elisa SANTOCCHI, Auteur ; Giulia BALBONI, Auteur ; Antonio NARZISI, Auteur ; Margherita BOZZA, Auteur ; Francesca FULCERI, Auteur ; Fabio APICELLA, Auteur ; Roberta IGLIOZZI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur Article en page(s) : p.3574-3588 Langues : Anglais (eng) Mots-clés : Anxiety Problems  Child Behavior Checklist 1(1/2)-5  Externalizing Problems  Restrictive and repetitive behaviours  Sleep Problems  Young Children Index. décimale : PER Périodiques Résumé : This study investigated the prevalence and type of gastrointestinal (GI) and food selectivity (FS) symptoms in 163 preschoolers with ASD, and their possible links with core ASD features and emotional/behavioural problems. 40.5% of children with ASD had at least one severe GI symptom or FS. Preschoolers with and without GI symptoms and with and without FS were significantly different on several emotional/behavioural problems and restrictive/repetitive behaviours, whereas they did not differ significantly on performance IQ and autistic severity. The GI plus FS group presented with Sleep Problems, Self-injurious Behaviors and Anxiety Problems. Results indicated the need for early identification of GI disturbances and FS in order to design tailored intervention for these symptoms frequently associated to challenging behaviours in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3271-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 [article] Behavioral Phenotype of ASD Preschoolers with Gastrointestinal Symptoms or Food Selectivity [texte imprimé] / Margherita PROSPERI, Auteur ; Elisa SANTOCCHI, Auteur ; Giulia BALBONI, Auteur ; Antonio NARZISI, Auteur ; Margherita BOZZA, Auteur ; Francesca FULCERI, Auteur ; Fabio APICELLA, Auteur ; Roberta IGLIOZZI, Auteur ; Angela COSENZA, Auteur ; Raffaella TANCREDI, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur . - p.3574-3588. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3574-3588 Mots-clés : Anxiety Problems  Child Behavior Checklist 1(1/2)-5  Externalizing Problems  Restrictive and repetitive behaviours  Sleep Problems  Young Children Index. décimale : PER Périodiques Résumé : This study investigated the prevalence and type of gastrointestinal (GI) and food selectivity (FS) symptoms in 163 preschoolers with ASD, and their possible links with core ASD features and emotional/behavioural problems. 40.5% of children with ASD had at least one severe GI symptom or FS. Preschoolers with and without GI symptoms and with and without FS were significantly different on several emotional/behavioural problems and restrictive/repetitive behaviours, whereas they did not differ significantly on performance IQ and autistic severity. The GI plus FS group presented with Sleep Problems, Self-injurious Behaviors and Anxiety Problems. Results indicated the need for early identification of GI disturbances and FS in order to design tailored intervention for these symptoms frequently associated to challenging behaviours in ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3271-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months / Natasha CHERICONI in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842 Titre : A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months Type de document : texte imprimé Auteurs : Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; Valeria COSTANZO, Auteur ; Alice MANCINI, Auteur ; Margherita PROSPERI, Auteur ; Roberta LASALA, Auteur ; Raffaella TANCREDI, Auteur ; Maria Luisa SCATTONI, Auteur ; Filippo MURATORI, Auteur ; Fabio APICELLA, Auteur Article en page(s) : p.3829-3842 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Checklist  Child  Child Behavior  Humans  Male  Siblings  Autism spectrum disorder screening  Baby sibling paradigm  Cbcl 1½-5  Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Combined Study on the Use of the Child Behavior Checklist 1½-5 for Identifying Autism Spectrum Disorders at 18 Months [texte imprimé] / Natasha CHERICONI, Auteur ; Giulia BALBONI, Auteur ; Valeria COSTANZO, Auteur ; Alice MANCINI, Auteur ; Margherita PROSPERI, Auteur ; Roberta LASALA, Auteur ; Raffaella TANCREDI, Auteur ; Maria Luisa SCATTONI, Auteur ; Filippo MURATORI, Auteur ; Fabio APICELLA, Auteur . - p.3829-3842. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3829-3842 Mots-clés : Autism Spectrum Disorder/diagnosis  Checklist  Child  Child Behavior  Humans  Male  Siblings  Autism spectrum disorder screening  Baby sibling paradigm  Cbcl 1½-5  Familial high-risk Index. décimale : PER Périodiques Résumé : The capacity of the Child Behavior Checklist 1½-5 (CBCL 1½-5) to identify children with autism spectrum disorder (ASD) at 18 months was tested on 37 children clinically referred for ASD and 46 children at elevated likelihood of developing ASD due to having an affected brother/sister. At 30 months the clinically referred children all received a confirmatory diagnosis, and 10 out of 46 siblings received a diagnosis of ASD. CBCL 1½-5 profiles were compared with a group of matched children with typical development (effect of cognitive level controlled for). The capacity of the CBCL 1½-5 DSM Oriented-Pervasive Developmental Problems scale to differentiate correctly between children diagnosed with ASD and children with typical development appeared dependent on group ascertainment methodology. En ligne : http://dx.doi.org/10.1007/s10803-020-04838-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism / Lucia BILLECI in Autism, 27-1 (January 2023)  

Public ISBD [article]  inAutism > 27-1 (January 2023) . - p.117-132 Titre : A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism Type de document : texte imprimé Auteurs : Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur Article en page(s) : p.117-132 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  clinical trial  EEG  preschoolers  probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] A randomized controlled trial into the effects of probiotics on electroencephalography in preschoolers with autism [texte imprimé] / Lucia BILLECI, Auteur ; Alejandro Luis CALLARA, Auteur ; Letizia GUIDUCCI, Auteur ; Margherita PROSPERI, Auteur ; Maria Aurora MORALES, Auteur ; Sara CALDERONI, Auteur ; Filippo MURATORI, Auteur ; Elisa SANTOCCHI, Auteur . - p.117-132. Langues : Anglais (eng) in Autism > 27-1 (January 2023) . - p.117-132 Mots-clés : autism spectrum disorder  clinical trial  EEG  preschoolers  probiotics Index. décimale : PER Périodiques Résumé : Previous studies suggest that autism spectrum disorders are characterized by alterations in the microbiota-gut-brain axis. Probiotics may modify the composition and the functionality of the gut microbiota of autism spectrum disorder individuals, with possible cascading effects on brain function. In this study, we analyzed possible brain modifications induced by the administration of probiotics in 46 children with autism spectrum disorder using electroencephalography. A randomized 6-month controlled trial was performed. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. Lay abstract This study investigates the effects of a probiotic on preschoolers’ brain electrical activity with autism spectrum disorder. Autism is a disorder with an increasing prevalence characterized by an enormous individual, family, and social cost. Although the etiology of autism spectrum disorder is unknown, an interaction between genetic and environmental factors is implicated, converging in altered brain synaptogenesis and, therefore, connectivity. Besides deepening the knowledge on the resting brain electrical activity that characterizes this disorder, this study allows analyzing the positive central effects of a 6-month therapy with a probiotic through a randomized, double-blind placebo-controlled study and the correlations between electroencephalography activity and biochemical and clinical parameters. In subjects treated with probiotics, we observed a decrease of power in frontopolar regions in beta and gamma bands, and increased coherence in the same bands together with a shift in frontal asymmetry, which suggests a modification toward a typical brain activity. Electroencephalography measures were significantly correlated with clinical and biochemical measures. These findings support the importance of further investigations on probiotics’ benefits in autism spectrum disorder to better elucidate mechanistic links between probiotics supplementation and changes in brain activity. En ligne : http://dx.doi.org/10.1177/13623613221082710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

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