Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood / Einat WAIZBARD-BARTOV in Autism, 28-5 (May 2024)  

Public ISBD [article]  inAutism > 28-5 (May 2024) . - p.1216-1230 Titre : Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood Type de document : texte imprimé Auteurs : Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Brianna HEATH, Auteur ; Derek S. ANDREWS, Auteur ; Sally ROGERS, Auteur ; Connor M. KERNS, Auteur ; Christine WU NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1216-1230 Langues : Anglais (eng) Mots-clés : anxiety  attention-deficit hyperactivity disorder  autism spectrum disorders  behavioral measurement  development  psychiatric comorbidity  repetitive behaviors and interests  school-age children  social cognition and social behavior Index. décimale : PER Périodiques Résumé : Many autistic children experience changes in core symptom severity across middle childhood, when co-occurring mental health conditions emerge. We evaluated this relationship in 75 autistic children from 6 to 11 years old. Autism symptom severity change was evaluated for total autism symptoms using the autism diagnostic observation schedule calibrated severity score, as well as social-communication symptoms calibrated severity score, and restricted/repetitive behaviors calibrated severity score. Children were grouped based on their symptom severity change patterns. Mental health symptoms (attention-deficit hyperactivity disorder, anxiety, disruptive behavior problems) were assessed via parental interview and questionnaire and compared across the groups. Co-occurring mental health symptoms were more strongly associated with change in social-communication symptom or restricted/repetitive behavior severity than with total autism symptom severity. Two relevant groups were identified. The social-communication symptom-increasing-severity-group (21.3%) had elevated and increasing levels of anxiety, attention-deficit hyperactivity disorder, and disruptive behavior problems compared with children with stable social-communication symptom severity. The restricted/repetitive behavior-decreasing-severity-group (22.7%) had elevated and increasing levels of anxiety; 94% of these children met criteria for an anxiety disorder. Autism symptom severity change during middle childhood is associated with co-occurring mental health symptoms. Children that increase in social-communication symptom severity are also likely to demonstrate greater psychopathology, while decreases in restricted/repetitive behavior severity are associated with higher levels of anxiety. Lay abstract For many autistic children, the severity of their autism symptoms changes during middle childhood. We studied whether these changes are associated with the emergence of other mental health challenges such as anxiety and attention-deficit hyperactivity disorder. Children who had increased social-communication challenges had more anxiety and attention-deficit hyperactivity disorder symptoms and disruptive behavior problems than other children. Children who decreased their restricted and repetitive behaviors, on the contrary, had more anxiety. We discuss why these changes in autism symptoms may lead to increases in other mental health concerns. En ligne : https://dx.doi.org/10.1177/13623613231195108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527 [article] Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood [texte imprimé] / Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Brianna HEATH, Auteur ; Derek S. ANDREWS, Auteur ; Sally ROGERS, Auteur ; Connor M. KERNS, Auteur ; Christine WU NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur . - p.1216-1230. Langues : Anglais (eng) in Autism > 28-5 (May 2024) . - p.1216-1230 Mots-clés : anxiety  attention-deficit hyperactivity disorder  autism spectrum disorders  behavioral measurement  development  psychiatric comorbidity  repetitive behaviors and interests  school-age children  social cognition and social behavior Index. décimale : PER Périodiques Résumé : Many autistic children experience changes in core symptom severity across middle childhood, when co-occurring mental health conditions emerge. We evaluated this relationship in 75 autistic children from 6 to 11 years old. Autism symptom severity change was evaluated for total autism symptoms using the autism diagnostic observation schedule calibrated severity score, as well as social-communication symptoms calibrated severity score, and restricted/repetitive behaviors calibrated severity score. Children were grouped based on their symptom severity change patterns. Mental health symptoms (attention-deficit hyperactivity disorder, anxiety, disruptive behavior problems) were assessed via parental interview and questionnaire and compared across the groups. Co-occurring mental health symptoms were more strongly associated with change in social-communication symptom or restricted/repetitive behavior severity than with total autism symptom severity. Two relevant groups were identified. The social-communication symptom-increasing-severity-group (21.3%) had elevated and increasing levels of anxiety, attention-deficit hyperactivity disorder, and disruptive behavior problems compared with children with stable social-communication symptom severity. The restricted/repetitive behavior-decreasing-severity-group (22.7%) had elevated and increasing levels of anxiety; 94% of these children met criteria for an anxiety disorder. Autism symptom severity change during middle childhood is associated with co-occurring mental health symptoms. Children that increase in social-communication symptom severity are also likely to demonstrate greater psychopathology, while decreases in restricted/repetitive behavior severity are associated with higher levels of anxiety. Lay abstract For many autistic children, the severity of their autism symptoms changes during middle childhood. We studied whether these changes are associated with the emergence of other mental health challenges such as anxiety and attention-deficit hyperactivity disorder. Children who had increased social-communication challenges had more anxiety and attention-deficit hyperactivity disorder symptoms and disruptive behavior problems than other children. Children who decreased their restricted and repetitive behaviors, on the contrary, had more anxiety. We discuss why these changes in autism symptoms may lead to increases in other mental health concerns. En ligne : https://dx.doi.org/10.1177/13623613231195108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527

Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability / Derek S. ANDREWS in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.486-497 Titre : Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability Type de document : texte imprimé Auteurs : Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur Article en page(s) : p.486-497 Langues : Anglais (eng) Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n 88, mean age 5.37 years) with a large range of intellectual ability (IQ 19 133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n 53, mean age 5.29 years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ?? 70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability [texte imprimé] / Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur . - p.486-497. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.486-497 Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n 88, mean age 5.37 years) with a large range of intellectual ability (IQ 19 133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n 53, mean age 5.29 years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ?? 70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children / Burt HATCH in Autism, 29-11 (November 2025)  

Public ISBD [article]  inAutism > 29-11 (November 2025) . - p.2885-2897 Titre : Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children Type de document : texte imprimé Auteurs : Burt HATCH, Auteur ; Derek S. ANDREWS, Auteur ; Brett D. DUFOUR, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Joshua K LEE, Auteur ; Sally ROGERS, Auteur ; Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Christine WU NORDAHL, Auteur Article en page(s) : p.2885-2897 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  externalizing  hypothalamus  internalizing  MRI  sleep Index. décimale : PER Périodiques Résumé : Difficulty initiating or maintaining sleep is common among autistic individuals and co-occurs with internalizing and externalizing symptoms. This study tested associations between subcortical regions implicated in sleep processes and measures of dysregulated sleep initiation/maintenance in autistic and non-autistic 2- to 4-year-olds. The role of co-occurring externalizing and internalizing symptoms in these associations was also evaluated. Participants included 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds who completed magnetic resonance imaging. A subscale of items from the Children’s Sleep Habits Questionnaire, previously shown to be reliable across both autistic and non-autistic children, was used to measure dysregulated sleep initiation/maintenance. Externalizing and internalizing symptoms were evaluated using the Child Behavior Checklist–Preschool. Associations between volumes for nine subcortical structures known to be implicated in sleep were separately modeled. Mediation analyses explored whether such associations could be accounted for by externalizing or internalizing symptoms. Smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. Externalizing (but not internalizing) problems partially mediated this association. Findings implicate the right hypothalamus in sleep initiation and maintenance issues for both autistic and non-autistic young children, supporting prior evidence of its central role in sleep regulation.Lay Abstract Difficulty initiating or maintaining sleep is common among autistic individuals and often goes alongside difficulties regulating emotions and behavior during the day. Although there is a body of research suggesting that subcortical brain regions, including a brain region known as the hypothalamus, play important roles regulating sleep, few studies have examined whether this extends to young autistic children. Using data from a sample of 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds, we examined whether size of subcortical brain regions implicated in sleep processes is associated with difficulties initiating and/or maintaining sleep. In addition, we examined whether daytime behaviors and emotions were also implicated in these associations. We found that smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. This relationship remained evident even after accounting for externalizing behaviors and emotions like anger that were also associated with both the hypothalamus and dysregulated sleep initiation/maintenance. The strength of association between right hypothalamus volumes and dysregulated sleep initiation/maintenance was similar for autistic and non-autistic children. These findings suggest that for both young autistic and non-autistic children, the hypothalamus plays unique roles in regulating both sleep and externalizing behaviors. For managing sleep initiation and maintenance difficulties in clinical practice, the findings underscore the importance of considering environmental (e.g. not having a regular bedtime routine) and neurobiological factors, for both autistic and non-autistic young children. En ligne : https://dx.doi.org/10.1177/13623613251352249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children [texte imprimé] / Burt HATCH, Auteur ; Derek S. ANDREWS, Auteur ; Brett D. DUFOUR, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Joshua K LEE, Auteur ; Sally ROGERS, Auteur ; Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Christine WU NORDAHL, Auteur . - p.2885-2897. Langues : Anglais (eng) in Autism > 29-11 (November 2025) . - p.2885-2897 Mots-clés : autism spectrum disorder  externalizing  hypothalamus  internalizing  MRI  sleep Index. décimale : PER Périodiques Résumé : Difficulty initiating or maintaining sleep is common among autistic individuals and co-occurs with internalizing and externalizing symptoms. This study tested associations between subcortical regions implicated in sleep processes and measures of dysregulated sleep initiation/maintenance in autistic and non-autistic 2- to 4-year-olds. The role of co-occurring externalizing and internalizing symptoms in these associations was also evaluated. Participants included 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds who completed magnetic resonance imaging. A subscale of items from the Children’s Sleep Habits Questionnaire, previously shown to be reliable across both autistic and non-autistic children, was used to measure dysregulated sleep initiation/maintenance. Externalizing and internalizing symptoms were evaluated using the Child Behavior Checklist–Preschool. Associations between volumes for nine subcortical structures known to be implicated in sleep were separately modeled. Mediation analyses explored whether such associations could be accounted for by externalizing or internalizing symptoms. Smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. Externalizing (but not internalizing) problems partially mediated this association. Findings implicate the right hypothalamus in sleep initiation and maintenance issues for both autistic and non-autistic young children, supporting prior evidence of its central role in sleep regulation.Lay Abstract Difficulty initiating or maintaining sleep is common among autistic individuals and often goes alongside difficulties regulating emotions and behavior during the day. Although there is a body of research suggesting that subcortical brain regions, including a brain region known as the hypothalamus, play important roles regulating sleep, few studies have examined whether this extends to young autistic children. Using data from a sample of 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds, we examined whether size of subcortical brain regions implicated in sleep processes is associated with difficulties initiating and/or maintaining sleep. In addition, we examined whether daytime behaviors and emotions were also implicated in these associations. We found that smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. This relationship remained evident even after accounting for externalizing behaviors and emotions like anger that were also associated with both the hypothalamus and dysregulated sleep initiation/maintenance. The strength of association between right hypothalamus volumes and dysregulated sleep initiation/maintenance was similar for autistic and non-autistic children. These findings suggest that for both young autistic and non-autistic children, the hypothalamus plays unique roles in regulating both sleep and externalizing behaviors. For managing sleep initiation and maintenance difficulties in clinical practice, the findings underscore the importance of considering environmental (e.g. not having a regular bedtime routine) and neurobiological factors, for both autistic and non-autistic young children. En ligne : https://dx.doi.org/10.1177/13623613251352249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly / Nicholas K. HAGHANI ; Gabriana N. LA ; Natasha Ann F. MARIANO ; José M. URIBE-SALAZAR ; Gulhan KAYA ; Melissa REGESTER ; Derek S. ANDREWS ; Christine Wu NORDAHL ; David G. AMARAL ; Megan Y. DENNIS in Autism Research, 18-5 (May 2025)  

Public ISBD [article]  inAutism Research > 18-5 (May 2025) . - p.966-982 Titre : m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly Type de document : texte imprimé Auteurs : Nicholas K. HAGHANI, Auteur ; Gabriana N. LA, Auteur ; Natasha Ann F. MARIANO, Auteur ; José M. URIBE-SALAZAR, Auteur ; Gulhan KAYA, Auteur ; Melissa REGESTER, Auteur ; Derek S. ANDREWS, Auteur ; Christine Wu NORDAHL, Auteur ; David G. AMARAL, Auteur ; Megan Y. DENNIS, Auteur Article en page(s) : p.966-982 Langues : Anglais (eng) Mots-clés : autism  disproportionate megalencephaly  genetics  m6A-RNA modification  YTHDF2  zebrafish Index. décimale : PER Périodiques Résumé : ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this subphenotype of autism. We expanded the previously studied sample size of ASD-DM individuals ten fold by including probands from the Autism Phenome Project and Simons Simplex Collection, totaling 766 autistic individuals meeting the criteria for megalencephaly or macrocephaly and revealing 154 candidate ASD-DM genes harboring de novo protein-impacting variants. Our findings include 14 high confidence autism genes and seven genes previously associated with DM. Five impacted genes have previously been associated with both autism and DM, including CHD8 and PTEN. By performing functional network analysis, we expanded to additional candidate genes, including one previously implicated in ASD-DM (PIK3CA) as well as 184 additional genes connected with ASD or DM alone. Using zebrafish, we modeled a de novo tandem duplication impacting YTHDF2, encoding an N6-methyladenosine (m6A)-mRNA reader, in an ASD-DM proband. Testing zebrafish CRISPR knockdown led to reduced head/brain size, while overexpressing YTHDF2 resulted in increased head/brain size matching that of the proband. Single-cell transcriptomes of YTHDF2 gain-of-function larvae point to reduced expression of Fragile-X-syndrome-associated FMRP-target genes globally and in the developing brain, providing insight into the mechanism underlying autistic phenotypes. We additionally discovered a variant impacting a different gene encoding an m6A reader, YTHDC1, in our ASD-DM cohort. Though we highlight only two cases to date, our study provides support for the m6A-RNA modification pathway as potentially contributing to this severe form of autism. En ligne : https://doi.org/10.1002/aur.3314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly [texte imprimé] / Nicholas K. HAGHANI, Auteur ; Gabriana N. LA, Auteur ; Natasha Ann F. MARIANO, Auteur ; José M. URIBE-SALAZAR, Auteur ; Gulhan KAYA, Auteur ; Melissa REGESTER, Auteur ; Derek S. ANDREWS, Auteur ; Christine Wu NORDAHL, Auteur ; David G. AMARAL, Auteur ; Megan Y. DENNIS, Auteur . - p.966-982. Langues : Anglais (eng) in Autism Research > 18-5 (May 2025) . - p.966-982 Mots-clés : autism  disproportionate megalencephaly  genetics  m6A-RNA modification  YTHDF2  zebrafish Index. décimale : PER Périodiques Résumé : ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this subphenotype of autism. We expanded the previously studied sample size of ASD-DM individuals ten fold by including probands from the Autism Phenome Project and Simons Simplex Collection, totaling 766 autistic individuals meeting the criteria for megalencephaly or macrocephaly and revealing 154 candidate ASD-DM genes harboring de novo protein-impacting variants. Our findings include 14 high confidence autism genes and seven genes previously associated with DM. Five impacted genes have previously been associated with both autism and DM, including CHD8 and PTEN. By performing functional network analysis, we expanded to additional candidate genes, including one previously implicated in ASD-DM (PIK3CA) as well as 184 additional genes connected with ASD or DM alone. Using zebrafish, we modeled a de novo tandem duplication impacting YTHDF2, encoding an N6-methyladenosine (m6A)-mRNA reader, in an ASD-DM proband. Testing zebrafish CRISPR knockdown led to reduced head/brain size, while overexpressing YTHDF2 resulted in increased head/brain size matching that of the proband. Single-cell transcriptomes of YTHDF2 gain-of-function larvae point to reduced expression of Fragile-X-syndrome-associated FMRP-target genes globally and in the developing brain, providing insight into the mechanism underlying autistic phenotypes. We additionally discovered a variant impacting a different gene encoding an m6A reader, YTHDC1, in our ASD-DM cohort. Though we highlight only two cases to date, our study provides support for the m6A-RNA modification pathway as potentially contributing to this severe form of autism. En ligne : https://doi.org/10.1002/aur.3314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder / C. MANN in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 49p. Titre : The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder Type de document : texte imprimé Auteurs : C. MANN, Auteur ; Anke BLETSCH, Auteur ; Derek S. ANDREWS, Auteur ; Eileen DALY, Auteur ; C. MURPHY, Auteur ; D. MURPHY, Auteur ; C. ECKER, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Brain anatomy  Neurodevelopment  Neuroimaging  Structural MRI  Psychosomatics and Psychotherapy, University Hospital, Goethe-University  Frankfurt am Main, Deutschordenstrasse 50, 60528 Frankfurt, Germany  DA, PhD, The  Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and  Department of Psychiatry and Behavioural Sciences, UC Davis School of Medicine,  University of California Davis, Sacramento, CA, USA  ED, PhD and CM, PhD,  Department of Forensic and Neurodevelopmental Sciences, and the Sackler Institute  for Translational Neurodevelopmental Sciences, Institute of Psychiatry,  Psychology & Neuroscience (IoPPN), King's College London, London SE5 8AF, United  Kingdom  DM, Professor, Head of Department of Forensic and Neurodevelopmental  Sciences, and the Sackler Institute for Translational Neurodevelopmental  Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's  College London, London SE5 8AF, United Kingdom  CE, Professor, Department of  Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University  Hospital, Goethe-University Frankfurt am Main, Deutschordenstrasse 50, 60528  Frankfurt, Germany and Department of Forensic and Neurodevelopmental Sciences,  and the Sackler Institute for Translational Neurodevelopmental Sciences,  Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College  London, London SE5 8AF, United Kingdom.All participants gave informed written  consent in accordance with the ethics approval by the National Research Ethics  Committee, Suffolk, England.Not applicable.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo reporting significantly reduced grey-white matter tissue contrast (GWC) in adult individuals (18-42 years of age) with ASD relative to typically developing (TD) controls. However, it remains unknown whether the neuroanatomical differences in ASD at the grey-white matter boundary are stable across development or are age-dependent. Methods: Here, we examined differences in the neurodevelopmental trajectories of GWC in a cross-sectional sample of 77 male ASD individuals and 76 typically developing (TD) controls across childhood and early adulthood (from 7 to 25 years). Results: Using nested model comparisons, we first established that the developmental trajectory of GWC is complex in many regions across the cortex and includes linear and non-linear effects of age. Second, while ASD individuals have significantly reduced GWC overall, these differences are age-dependent and are most prominent during childhood (< 15 years). Conclusions: Taken together, our findings suggest that differences in GWC in ASD are unlikely to reflect atypical grey matter cytoarchitecture alone, but may also represent other aspects of the cortical architecture such as age-dependent variability in myelin integrity. En ligne : https://dx.doi.org/10.1186/s13229-018-0232-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder [texte imprimé] / C. MANN, Auteur ; Anke BLETSCH, Auteur ; Derek S. ANDREWS, Auteur ; Eileen DALY, Auteur ; C. MURPHY, Auteur ; D. MURPHY, Auteur ; C. ECKER, Auteur . - 49p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 49p. Mots-clés : Autism spectrum disorder  Brain anatomy  Neurodevelopment  Neuroimaging  Structural MRI  Psychosomatics and Psychotherapy, University Hospital, Goethe-University  Frankfurt am Main, Deutschordenstrasse 50, 60528 Frankfurt, Germany  DA, PhD, The  Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and  Department of Psychiatry and Behavioural Sciences, UC Davis School of Medicine,  University of California Davis, Sacramento, CA, USA  ED, PhD and CM, PhD,  Department of Forensic and Neurodevelopmental Sciences, and the Sackler Institute  for Translational Neurodevelopmental Sciences, Institute of Psychiatry,  Psychology & Neuroscience (IoPPN), King's College London, London SE5 8AF, United  Kingdom  DM, Professor, Head of Department of Forensic and Neurodevelopmental  Sciences, and the Sackler Institute for Translational Neurodevelopmental  Sciences, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's  College London, London SE5 8AF, United Kingdom  CE, Professor, Department of  Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University  Hospital, Goethe-University Frankfurt am Main, Deutschordenstrasse 50, 60528  Frankfurt, Germany and Department of Forensic and Neurodevelopmental Sciences,  and the Sackler Institute for Translational Neurodevelopmental Sciences,  Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King's College  London, London SE5 8AF, United Kingdom.All participants gave informed written  consent in accordance with the ethics approval by the National Research Ethics  Committee, Suffolk, England.Not applicable.The authors declare that they have no  competing interests.Springer Nature remains neutral with regard to jurisdictional  claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo reporting significantly reduced grey-white matter tissue contrast (GWC) in adult individuals (18-42 years of age) with ASD relative to typically developing (TD) controls. However, it remains unknown whether the neuroanatomical differences in ASD at the grey-white matter boundary are stable across development or are age-dependent. Methods: Here, we examined differences in the neurodevelopmental trajectories of GWC in a cross-sectional sample of 77 male ASD individuals and 76 typically developing (TD) controls across childhood and early adulthood (from 7 to 25 years). Results: Using nested model comparisons, we first established that the developmental trajectory of GWC is complex in many regions across the cortex and includes linear and non-linear effects of age. Second, while ASD individuals have significantly reduced GWC overall, these differences are age-dependent and are most prominent during childhood (< 15 years). Conclusions: Taken together, our findings suggest that differences in GWC in ASD are unlikely to reflect atypical grey matter cytoarchitecture alone, but may also represent other aspects of the cortical architecture such as age-dependent variability in myelin integrity. En ligne : https://dx.doi.org/10.1186/s13229-018-0232-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Trajectories of autism symptom severity for boys and girls across childhood / Emilio FERRER ; Meghan MILLER ; Brianna HEATH ; Derek S. ANDREWS ; Sally J ROGERS ; Christine Wu NORDAHL ; Marjorie SOLOMON ; David G. AMARAL in Autism, 29-7 (July 2025)  

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