Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood / Einat WAIZBARD-BARTOV in Autism, 28-5 (May 2024)  

Public ISBD [article]  inAutism > 28-5 (May 2024) . - p.1216-1230 Titre : Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood Type de document : Texte imprimé et/ou numérique Auteurs : Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Brianna HEATH, Auteur ; Derek S. ANDREWS, Auteur ; Sally ROGERS, Auteur ; Connor M. KERNS, Auteur ; Christine WU NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1216-1230 Langues : Anglais (eng) Mots-clés : anxiety  attention-deficit hyperactivity disorder  autism spectrum disorders  behavioral measurement  development  psychiatric comorbidity  repetitive behaviors and interests  school-age children  social cognition and social behavior Index. décimale : PER Périodiques Résumé : Many autistic children experience changes in core symptom severity across middle childhood, when co-occurring mental health conditions emerge. We evaluated this relationship in 75 autistic children from 6 to 11?years old. Autism symptom severity change was evaluated for total autism symptoms using the autism diagnostic observation schedule calibrated severity score, as well as social-communication symptoms calibrated severity score, and restricted/repetitive behaviors calibrated severity score. Children were grouped based on their symptom severity change patterns. Mental health symptoms (attention-deficit hyperactivity disorder, anxiety, disruptive behavior problems) were assessed via parental interview and questionnaire and compared across the groups. Co-occurring mental health symptoms were more strongly associated with change in social-communication symptom or restricted/repetitive behavior severity than with total autism symptom severity. Two relevant groups were identified. The social-communication symptom-increasing-severity-group (21.3%) had elevated and increasing levels of anxiety, attention-deficit hyperactivity disorder, and disruptive behavior problems compared with children with stable social-communication symptom severity. The restricted/repetitive behavior-decreasing-severity-group (22.7%) had elevated and increasing levels of anxiety; 94% of these children met criteria for an anxiety disorder. Autism symptom severity change during middle childhood is associated with co-occurring mental health symptoms. Children that increase in social-communication symptom severity are also likely to demonstrate greater psychopathology, while decreases in restricted/repetitive behavior severity are associated with higher levels of anxiety. Lay abstract For many autistic children, the severity of their autism symptoms changes during middle childhood. We studied whether these changes are associated with the emergence of other mental health challenges such as anxiety and attention-deficit hyperactivity disorder. Children who had increased social-communication challenges had more anxiety and attention-deficit hyperactivity disorder symptoms and disruptive behavior problems than other children. Children who decreased their restricted and repetitive behaviors, on the contrary, had more anxiety. We discuss why these changes in autism symptoms may lead to increases in other mental health concerns. En ligne : https://dx.doi.org/10.1177/13623613231195108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527 [article] Changes in the severity of autism symptom domains are related to mental health challenges during middle childhood [Texte imprimé et/ou numérique] / Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Brianna HEATH, Auteur ; Derek S. ANDREWS, Auteur ; Sally ROGERS, Auteur ; Connor M. KERNS, Auteur ; Christine WU NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur . - p.1216-1230. Langues : Anglais (eng) in Autism > 28-5 (May 2024) . - p.1216-1230 Mots-clés : anxiety  attention-deficit hyperactivity disorder  autism spectrum disorders  behavioral measurement  development  psychiatric comorbidity  repetitive behaviors and interests  school-age children  social cognition and social behavior Index. décimale : PER Périodiques Résumé : Many autistic children experience changes in core symptom severity across middle childhood, when co-occurring mental health conditions emerge. We evaluated this relationship in 75 autistic children from 6 to 11?years old. Autism symptom severity change was evaluated for total autism symptoms using the autism diagnostic observation schedule calibrated severity score, as well as social-communication symptoms calibrated severity score, and restricted/repetitive behaviors calibrated severity score. Children were grouped based on their symptom severity change patterns. Mental health symptoms (attention-deficit hyperactivity disorder, anxiety, disruptive behavior problems) were assessed via parental interview and questionnaire and compared across the groups. Co-occurring mental health symptoms were more strongly associated with change in social-communication symptom or restricted/repetitive behavior severity than with total autism symptom severity. Two relevant groups were identified. The social-communication symptom-increasing-severity-group (21.3%) had elevated and increasing levels of anxiety, attention-deficit hyperactivity disorder, and disruptive behavior problems compared with children with stable social-communication symptom severity. The restricted/repetitive behavior-decreasing-severity-group (22.7%) had elevated and increasing levels of anxiety; 94% of these children met criteria for an anxiety disorder. Autism symptom severity change during middle childhood is associated with co-occurring mental health symptoms. Children that increase in social-communication symptom severity are also likely to demonstrate greater psychopathology, while decreases in restricted/repetitive behavior severity are associated with higher levels of anxiety. Lay abstract For many autistic children, the severity of their autism symptoms changes during middle childhood. We studied whether these changes are associated with the emergence of other mental health challenges such as anxiety and attention-deficit hyperactivity disorder. Children who had increased social-communication challenges had more anxiety and attention-deficit hyperactivity disorder symptoms and disruptive behavior problems than other children. Children who decreased their restricted and repetitive behaviors, on the contrary, had more anxiety. We discuss why these changes in autism symptoms may lead to increases in other mental health concerns. En ligne : https://dx.doi.org/10.1177/13623613231195108 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=527

Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability / Derek S. ANDREWS in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.486-497 Titre : Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur Article en page(s) : p.486-497 Langues : Anglais (eng) Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n?=?88, mean age 5.37?years) with a large range of intellectual ability (IQ 19?133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n?=?53, mean age 5.29?years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ???70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability [Texte imprimé et/ou numérique] / Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur . - p.486-497. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.486-497 Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n?=?88, mean age 5.37?years) with a large range of intellectual ability (IQ 19?133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n?=?53, mean age 5.29?years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ???70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

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