Atypical object exploration at 12 months of age is associated with autism in a prospective sample / Sally OZONOFF in Autism, 12-5 (September 2008)  

Public ISBD [article]  inAutism > 12-5 (September 2008) . - p.457-472 Titre : Atypical object exploration at 12 months of age is associated with autism in a prospective sample Type de document : Texte imprimé et/ou numérique Auteurs : Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Stacy GOLDRING, Auteur ; Meagan THOMPSON, Auteur ; Suzanne L. MACARI, Auteur ; Sally J ROGERS, Auteur Année de publication : 2008 Article en page(s) : p.457-472 Langues : Anglais (eng) Mots-clés : autism diagnosis early-identification repetitive-behavior Index. décimale : PER Périodiques Résumé : This prospective study examined object exploration behavior in 66 12-month-old infants, of whom nine were subsequently diagnosed with an autism spectrum disorder. Previous investigations differ on when the repetitive behaviors characteristic of autism are first present in early development. A task was developed that afforded specific opportunities for a range of repetitive uses of objects and was coded blind to outcome status. The autism/ASD outcome group displayed significantly more spinning, rotating, and unusual visual exploration of objects than two comparison groups. The average unusual visual exploration score of the autism/ASD group was over four standard deviations above the mean of the group with no concerns at outcome. Repetitive behaviors at 12 months were significantly related to cognitive and symptomatic status at 36 month outcome. These results suggest that repetitive or stereotyped behaviors may be present earlier than initially thought in very young children developing the autism phenotype. En ligne : http://dx.doi.org/10.1177/1362361308096402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=601 [article] Atypical object exploration at 12 months of age is associated with autism in a prospective sample [Texte imprimé et/ou numérique] / Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Stacy GOLDRING, Auteur ; Meagan THOMPSON, Auteur ; Suzanne L. MACARI, Auteur ; Sally J ROGERS, Auteur . - 2008 . - p.457-472. Langues : Anglais (eng) in Autism > 12-5 (September 2008) . - p.457-472 Mots-clés : autism diagnosis early-identification repetitive-behavior Index. décimale : PER Périodiques Résumé : This prospective study examined object exploration behavior in 66 12-month-old infants, of whom nine were subsequently diagnosed with an autism spectrum disorder. Previous investigations differ on when the repetitive behaviors characteristic of autism are first present in early development. A task was developed that afforded specific opportunities for a range of repetitive uses of objects and was coded blind to outcome status. The autism/ASD outcome group displayed significantly more spinning, rotating, and unusual visual exploration of objects than two comparison groups. The average unusual visual exploration score of the autism/ASD group was over four standard deviations above the mean of the group with no concerns at outcome. Repetitive behaviors at 12 months were significantly related to cognitive and symptomatic status at 36 month outcome. These results suggest that repetitive or stereotyped behaviors may be present earlier than initially thought in very young children developing the autism phenotype. En ligne : http://dx.doi.org/10.1177/1362361308096402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=601

Behavior and Sleep Problems in Children With a Family History of Autism / A. J. SCHWICHTENBERG in Autism Research, 6-3 (June 2013)  

Public ISBD [article]  inAutism Research > 6-3 (June 2013) . - p.169-176 Titre : Behavior and Sleep Problems in Children With a Family History of Autism Type de document : Texte imprimé et/ou numérique Auteurs : A. J. SCHWICHTENBERG, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Ana-Maria IOSIF, Auteur ; Marian SIGMAN, Auteur ; Sally J ROGERS, Auteur ; Sally OZONOFF, Auteur Année de publication : 2013 Article en page(s) : p.169-176 Langues : Anglais (eng) Mots-clés : autism  siblings  behavior problems  sleep Index. décimale : PER Périodiques Résumé : The present study explores behavioral and sleep outcomes in preschool-age siblings of children with autism spectrum disorders (ASD). This study focuses on behavior problems that are common in children with ASD, such as emotional reactivity, anxiety, inattention, aggression, and sleep problems. Infant siblings were recruited from families with at least one older child with ASD (high-risk group, n?=?104) or families with no history of ASD (low-risk group, n?=?76). As part of a longitudinal prospective study, children completed the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, and parents completed the Child Behavior Checklist (CBCL) and the Social Communication Questionnaire at 36 months of age. This study focuses on developmental concerns outside of ASD; therefore, only siblings who did not develop an ASD were included in analyses. Negative binomial regression analyses revealed that children in the high-risk group were more likely to have elevated behavior problems on the CBCL Anxious/Depressed and Aggression subscales. To explore sleep problems as a correlate of these behavior problems, a second series of models was specified. For both groups of children, sleep problems were associated with elevated behavior problems in each of the areas assessed (reactivity, anxiety, somatic complaints, withdrawal, attention, and aggression). These findings support close monitoring of children with a family history of ASD for both behavioral and sleep issues. En ligne : http://dx.doi.org/10.1002/aur.1278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Behavior and Sleep Problems in Children With a Family History of Autism [Texte imprimé et/ou numérique] / A. J. SCHWICHTENBERG, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur ; Ana-Maria IOSIF, Auteur ; Marian SIGMAN, Auteur ; Sally J ROGERS, Auteur ; Sally OZONOFF, Auteur . - 2013 . - p.169-176. Langues : Anglais (eng) in Autism Research > 6-3 (June 2013) . - p.169-176 Mots-clés : autism  siblings  behavior problems  sleep Index. décimale : PER Périodiques Résumé : The present study explores behavioral and sleep outcomes in preschool-age siblings of children with autism spectrum disorders (ASD). This study focuses on behavior problems that are common in children with ASD, such as emotional reactivity, anxiety, inattention, aggression, and sleep problems. Infant siblings were recruited from families with at least one older child with ASD (high-risk group, n?=?104) or families with no history of ASD (low-risk group, n?=?76). As part of a longitudinal prospective study, children completed the Mullen Scales of Early Learning and the Autism Diagnostic Observation Schedule, and parents completed the Child Behavior Checklist (CBCL) and the Social Communication Questionnaire at 36 months of age. This study focuses on developmental concerns outside of ASD; therefore, only siblings who did not develop an ASD were included in analyses. Negative binomial regression analyses revealed that children in the high-risk group were more likely to have elevated behavior problems on the CBCL Anxious/Depressed and Aggression subscales. To explore sleep problems as a correlate of these behavior problems, a second series of models was specified. For both groups of children, sleep problems were associated with elevated behavior problems in each of the areas assessed (reactivity, anxiety, somatic complaints, withdrawal, attention, and aggression). These findings support close monitoring of children with a family history of ASD for both behavioral and sleep issues. En ligne : http://dx.doi.org/10.1002/aur.1278 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication / Agata ROZGA in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.287-301 Titre : Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication Type de document : Texte imprimé et/ou numérique Auteurs : Agata ROZGA, Auteur ; Ted HUTMAN, Auteur ; Gregory S. YOUNG, Auteur ; Sally J ROGERS, Auteur ; Sally OZONOFF, Auteur ; Mirella DAPRETTO, Auteur ; Marian SIGMAN, Auteur Année de publication : 2011 Article en page(s) : p.287-301 Langues : Anglais (eng) Mots-clés : Autism  Broader autism phenotype  Early identification  Mother–infant interaction  Still face procedure  Nonverbal communication Index. décimale : PER Périodiques Résumé : We investigated whether deficits in social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (NoASD-sib) compared to low-risk controls. The ASD group did not differ from the other two groups at 6 months of age in the frequency of gaze, smiles, and vocalizations directed toward the caregiver, nor in their sensitivity to her withdrawal from interaction. However, by 12 months, infants in the ASD group exhibited lower rates of joint attention and requesting behaviors. In contrast, NoASD-sibs did not differ from comparison infants on any variables of interest at 6 and 12 months. En ligne : http://dx.doi.org/10.1007/s10803-010-1051-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication [Texte imprimé et/ou numérique] / Agata ROZGA, Auteur ; Ted HUTMAN, Auteur ; Gregory S. YOUNG, Auteur ; Sally J ROGERS, Auteur ; Sally OZONOFF, Auteur ; Mirella DAPRETTO, Auteur ; Marian SIGMAN, Auteur . - 2011 . - p.287-301. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.287-301 Mots-clés : Autism  Broader autism phenotype  Early identification  Mother–infant interaction  Still face procedure  Nonverbal communication Index. décimale : PER Périodiques Résumé : We investigated whether deficits in social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (NoASD-sib) compared to low-risk controls. The ASD group did not differ from the other two groups at 6 months of age in the frequency of gaze, smiles, and vocalizations directed toward the caregiver, nor in their sensitivity to her withdrawal from interaction. However, by 12 months, infants in the ASD group exhibited lower rates of joint attention and requesting behaviors. In contrast, NoASD-sibs did not differ from comparison infants on any variables of interest at 6 and 12 months. En ligne : http://dx.doi.org/10.1007/s10803-010-1051-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? / Meagan R. TALBOTT ; Gregory S. YOUNG ; Sally OZONOFF in Autism, 29-2 (February 2025)  

Public ISBD [article]  inAutism > 29-2 (February 2025) . - p.462-475 Titre : Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? : Autism Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.462-475 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  early detection  infant sibling  screening Index. décimale : PER Périodiques Résumé : Identifying infants at elevated likelihood for autism and other developmental differences in the first year of life remains a significant challenge. This study explored associations between behavioral differences in infancy and developmental outcomes in toddlerhood. We conducted a secondary data analysis of 256 infants with an older autistic sibling followed from 6 to 36?months of age. We defined conceptually driven cutoffs for three behavioral measures collected at 6, 9, and 12?months and examined the utility of these measures, individually and in combination, in predicting 36-month outcome classification (typical development or developmental concerns, including autism). Overall, relatively few infants met multiple measure definitions (range: 5 to 43 infants across ages). However, infants meeting multiple definitions had a higher likelihood of developmental concerns outcomes at all ages. Positive predictive values for meeting all three measure definitions combined ranged from 0.67 [0.22, 0.96] at 6?months to 0.95 [0.75, 1.0] at 12?months. These findings suggest that while majority of infants ultimately classified with developmental concerns do not show significant behavioral differences in the first year, when early differences are present, they have predictive value. Combining behavioral tools may help to improve identification of infants most in need of early supports. Lay abstract Many families have concerns about their infants' development in the first year of life. Current screeners cannot tell whether these differences might be related to autism, developmental delays, or likely to resolve on their own. As a result, many families are told to "wait and see." In this study, we looked at whether combining multiple behavior measures can improve prediction of outcomes in toddlerhood. This could help to provide families with more information about the significance of early behavioral differences. We assessed 256 infants with an older autistic sibling at 6, 9, and 12?months. We created three markers of behavioral differences at these ages. We looked at whether infants who had two or more markers were more likely to be on the autism spectrum or have other developmental differences than to have typically developing outcomes at 36?months. We found that very few infants had more than one marker at any age. However, infants who showed two or more markers were more likely to be on the spectrum or have other developmental differences at 36?months than infants who showed only one marker. These findings suggest that when behavioral differences are present on multiple measures, there is no need to wait and see before referring for services. En ligne : https://dx.doi.org/10.1177/13623613241275455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547 [article] Can combining existing behavioral tools improve identification of infants at elevated likelihood of autism in the first year of life? : Autism [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Gregory S. YOUNG, Auteur ; Sally OZONOFF, Auteur . - p.462-475. Langues : Anglais (eng) in Autism > 29-2 (February 2025) . - p.462-475 Mots-clés : Autism spectrum disorders  early detection  infant sibling  screening Index. décimale : PER Périodiques Résumé : Identifying infants at elevated likelihood for autism and other developmental differences in the first year of life remains a significant challenge. This study explored associations between behavioral differences in infancy and developmental outcomes in toddlerhood. We conducted a secondary data analysis of 256 infants with an older autistic sibling followed from 6 to 36?months of age. We defined conceptually driven cutoffs for three behavioral measures collected at 6, 9, and 12?months and examined the utility of these measures, individually and in combination, in predicting 36-month outcome classification (typical development or developmental concerns, including autism). Overall, relatively few infants met multiple measure definitions (range: 5 to 43 infants across ages). However, infants meeting multiple definitions had a higher likelihood of developmental concerns outcomes at all ages. Positive predictive values for meeting all three measure definitions combined ranged from 0.67 [0.22, 0.96] at 6?months to 0.95 [0.75, 1.0] at 12?months. These findings suggest that while majority of infants ultimately classified with developmental concerns do not show significant behavioral differences in the first year, when early differences are present, they have predictive value. Combining behavioral tools may help to improve identification of infants most in need of early supports. Lay abstract Many families have concerns about their infants' development in the first year of life. Current screeners cannot tell whether these differences might be related to autism, developmental delays, or likely to resolve on their own. As a result, many families are told to "wait and see." In this study, we looked at whether combining multiple behavior measures can improve prediction of outcomes in toddlerhood. This could help to provide families with more information about the significance of early behavioral differences. We assessed 256 infants with an older autistic sibling at 6, 9, and 12?months. We created three markers of behavioral differences at these ages. We looked at whether infants who had two or more markers were more likely to be on the autism spectrum or have other developmental differences than to have typically developing outcomes at 36?months. We found that very few infants had more than one marker at any age. However, infants who showed two or more markers were more likely to be on the spectrum or have other developmental differences at 36?months than infants who showed only one marker. These findings suggest that when behavioral differences are present on multiple measures, there is no need to wait and see before referring for services. En ligne : https://dx.doi.org/10.1177/13623613241275455 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=547

Can family affectedness inform infant sibling outcomes of autism spectrum disorders? / A. J. SCHWICHTENBERG in Journal of Child Psychology and Psychiatry, 51-9 (September 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1021-1030 Titre : Can family affectedness inform infant sibling outcomes of autism spectrum disorders? Type de document : Texte imprimé et/ou numérique Auteurs : A. J. SCHWICHTENBERG, Auteur ; Marian SIGMAN, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur Année de publication : 2010 Article en page(s) : p.1021-1030 Langues : Anglais (eng) Mots-clés : Autistic-disorder pervasive-developmental-disorder family-factors siblings structural-equation-modeling Index. décimale : PER Périodiques Résumé : Background:  Difficulties in communication and reciprocal social behavior are core features of autism spectrum disorders (ASD) and are often present, to varying degrees, in other family members. This prospective longitudinal infant sibling study examines whether social-communicative features of family members may inform which infants are at increased risk for ASD and other developmental concerns. Method:  Two hundred and seventeen families participated in this study. Infant siblings were recruited from families with at least one older child diagnosed with an ASD (n = 135) or at least one typically developing older child (n = 82). Families completed the Social Responsiveness Scale to assess social and communication features of the broader autism phenotype (BAP), sometimes called quantitative autistic traits (QAT). Family affectedness was assessed in two ways: categorically, based on number of affected older siblings (i.e., typical, simplex, multiplex risk groups) and dimensionally, by assessing varying degrees of QAT in all family members. Infant siblings were assessed at 36 months of age and completed the Autism Diagnostic Observation Schedule and the Mullen Scales of Early Learning. Results:  In structural equation models, comparisons between multiplex, simplex and typical groups revealed the highest rates of QAT in the multiplex group followed by the simplex and typical groups. Infant sibling outcomes were predicted by gender, family risk group, proband QAT, and additional sibling QAT. Conclusions:  Replicating previous cross-sectional and family history findings, the present study found elevated social and communication features of the BAP in siblings and fathers of ASD families, but not in mothers. While social and communication features of the BAP in mothers, fathers, and undiagnosed siblings did not predict infant sibling outcomes, having more than one affected older sibling did. Infant siblings from multiplex families were at significantly higher risk for ASD than infant siblings from simplex families in this sample. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02267.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Can family affectedness inform infant sibling outcomes of autism spectrum disorders? [Texte imprimé et/ou numérique] / A. J. SCHWICHTENBERG, Auteur ; Marian SIGMAN, Auteur ; Sally OZONOFF, Auteur ; Gregory S. YOUNG, Auteur ; Ted HUTMAN, Auteur . - 2010 . - p.1021-1030. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-9 (September 2010) . - p.1021-1030 Mots-clés : Autistic-disorder pervasive-developmental-disorder family-factors siblings structural-equation-modeling Index. décimale : PER Périodiques Résumé : Background:  Difficulties in communication and reciprocal social behavior are core features of autism spectrum disorders (ASD) and are often present, to varying degrees, in other family members. This prospective longitudinal infant sibling study examines whether social-communicative features of family members may inform which infants are at increased risk for ASD and other developmental concerns. Method:  Two hundred and seventeen families participated in this study. Infant siblings were recruited from families with at least one older child diagnosed with an ASD (n = 135) or at least one typically developing older child (n = 82). Families completed the Social Responsiveness Scale to assess social and communication features of the broader autism phenotype (BAP), sometimes called quantitative autistic traits (QAT). Family affectedness was assessed in two ways: categorically, based on number of affected older siblings (i.e., typical, simplex, multiplex risk groups) and dimensionally, by assessing varying degrees of QAT in all family members. Infant siblings were assessed at 36 months of age and completed the Autism Diagnostic Observation Schedule and the Mullen Scales of Early Learning. Results:  In structural equation models, comparisons between multiplex, simplex and typical groups revealed the highest rates of QAT in the multiplex group followed by the simplex and typical groups. Infant sibling outcomes were predicted by gender, family risk group, proband QAT, and additional sibling QAT. Conclusions:  Replicating previous cross-sectional and family history findings, the present study found elevated social and communication features of the BAP in siblings and fathers of ASD families, but not in mothers. While social and communication features of the BAP in mothers, fathers, and undiagnosed siblings did not predict infant sibling outcomes, having more than one affected older sibling did. Infant siblings from multiplex families were at significantly higher risk for ASD than infant siblings from simplex families in this sample. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02267.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

A Case Study of Childhood Disintegrative Disorder Using Systematic Analysis of Family Home Movies / Ruben PALOMO in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

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Commentary: sex difference differences? A reply to Constantino / D. S. MESSINGER in Molecular Autism, 7 (2016)  

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Deferred and immediate imitation in regressive and early onset autism / Sally J ROGERS in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)  

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Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study / Sally OZONOFF in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

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Dissemination of Evidence-Based Practice: Can We Train Therapists from a Distance? / Laurie A. VISMARA in Journal of Autism and Developmental Disorders, 39-12 (December 2009)  

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Dyadic Synchrony and Responsiveness in the First Year: Associations with Autism Risk / Ashleigh M. KELLERMAN in Autism Research, 13-12 (December 2020)  

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Early pragmatic language difficulties in siblings of children with autism: implications for DSM-5 social communication disorder? / Meghan MILLER in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

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Early predictors of language skills at 3?years of age vary based on diagnostic outcome: A baby siblings research consortium study / Meredith PECUKONIS in Autism Research, 15-7 (July 2022)  

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Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study / Daniel S. MESSINGER in Molecular Autism, (June 2015)  

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Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (June 2015)  

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