Mid-childhood autism sibling recurrence in infants with a family history of autism / Rowan ARTHUR ; Greg PASCO ; Elizabeth SHEPHARD ; Bosiljka MILOSAVLJEVIC ; Jannath Begum ALI ; Andrew PICKLES ; Mark H. JOHNSON ; Emily J.H. JONES ; Tony CHARMAN ; THE BASIS-STAARS TEAM in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1501-1514 Titre : Mid-childhood autism sibling recurrence in infants with a family history of autism Type de document : texte imprimé Auteurs : Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur ; Tony CHARMAN, Auteur ; THE BASIS-STAARS TEAM, Auteur Article en page(s) : p.1501-1514 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Mid-childhood autism sibling recurrence in infants with a family history of autism [texte imprimé] / Rowan ARTHUR, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Bosiljka MILOSAVLJEVIC, Auteur ; Jannath Begum ALI, Auteur ; Andrew PICKLES, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur ; Tony CHARMAN, Auteur ; THE BASIS-STAARS TEAM, Auteur . - p.1501-1514. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1501-1514 Index. décimale : PER Périodiques Résumé : Abstract Autism sibling recurrence in prospective infant family history studies is ~20% at 3 years but systematic follow-up to mid-childhood is rare. In population and clinical cohorts autism is not recognized in some children until school-age or later. One hundred and fifty-nine infants with an older sibling with autism underwent research diagnostic assessments at 3 years and mid-childhood (6 to 12 years (mean 9)). We report the autism sibling recurrence rate in mid-childhood and compare developmental and behavioral profiles at mid-childhood and 3 years in those with earlier versus later recognized autism, and those who had, or had not, received a community autism diagnosis. The autism recurrence rate in this sample in mid-childhood was 37.1%, 95% CI [29.9%, 44.9%] and higher in boys than girls. Around half of those diagnosed with autism in mid-childhood had not received a diagnosis at 3 years. Later, diagnosis was more common in girls than boys. While some had sub-threshold symptoms at 3, in others late diagnosis followed a largely typical early presentation. Sibling recurrence based on community clinical diagnosis was 24.5%, 95% CI [18.4%, 31.9%]. Those who also had a community diagnosis tended to be older, have lower adaptive function and higher autism and inattention symptoms. Notwithstanding limitations of a single site study, modest sample size and limits to generalisability, autism sibling recurrence in family history infants may be higher in mid-childhood than in studies reporting diagnostic outcome at 3 years. Findings have implications for families and clinical services, and for prospective family history studies. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome / Eirini PAPAGEORGOPOULOU in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2018-2029 Titre : Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome Type de document : texte imprimé Auteurs : Eirini PAPAGEORGOPOULOU, Auteur ; Emily J.H. JONES, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; THE BASIS-STAARS TEAM, Auteur Article en page(s) : p.2018-2029 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  elevated likelihood of autism  infant siblings  longitudinal  mother-infant  parent-child interaction  social attention Index. décimale : PER Périodiques Résumé : Abstract Developmental antecedents of autism may affect parent?infant interactions (PII), altering the context in which core social skills develop. While studies have identified differences in PII between infants with and without elevated likelihood (EL) for autism, samples have been small. Here, we examined whether previously reported differences are replicable. From a longitudinal study of 113 EL and 27 typical likelihood infants (TL), 6-min videotaped unstructured PII was blind rated at 8 and 14 months on eight interactional qualities. Autism outcome was assessed at 36 months. Linear mixed-effects models found higher parent sensitive responsiveness, nondirectiveness, and mutuality ratings in TL than EL infants with and without later autism. PII qualities at 8 (infant positive affect, parent directiveness) and 14 months (infant attentiveness to parent, mutuality) predicted 3-year autism. Attentiveness to parent decreased between 8 and 14 months in EL infants with later autism. This larger study supports previous findings of emerging alterations in PII in this group and extends on this by detecting earlier (8-month) predictive effects of PII for autism outcome and a more marked trajectory of decreased social attentiveness. The findings strengthen the evidence base to support the implementation of early preemptive interventions to support PII in infants with early autism signs. En ligne : https://doi.org/10.1002/aur.3190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome [texte imprimé] / Eirini PAPAGEORGOPOULOU, Auteur ; Emily J.H. JONES, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; THE BASIS-STAARS TEAM, Auteur . - p.2018-2029. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2018-2029 Mots-clés : autism spectrum disorders  elevated likelihood of autism  infant siblings  longitudinal  mother-infant  parent-child interaction  social attention Index. décimale : PER Périodiques Résumé : Abstract Developmental antecedents of autism may affect parent?infant interactions (PII), altering the context in which core social skills develop. While studies have identified differences in PII between infants with and without elevated likelihood (EL) for autism, samples have been small. Here, we examined whether previously reported differences are replicable. From a longitudinal study of 113 EL and 27 typical likelihood infants (TL), 6-min videotaped unstructured PII was blind rated at 8 and 14 months on eight interactional qualities. Autism outcome was assessed at 36 months. Linear mixed-effects models found higher parent sensitive responsiveness, nondirectiveness, and mutuality ratings in TL than EL infants with and without later autism. PII qualities at 8 (infant positive affect, parent directiveness) and 14 months (infant attentiveness to parent, mutuality) predicted 3-year autism. Attentiveness to parent decreased between 8 and 14 months in EL infants with later autism. This larger study supports previous findings of emerging alterations in PII in this group and extends on this by detecting earlier (8-month) predictive effects of PII for autism outcome and a more marked trajectory of decreased social attentiveness. The findings strengthen the evidence base to support the implementation of early preemptive interventions to support PII in infants with early autism signs. En ligne : https://doi.org/10.1002/aur.3190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

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