Dépouillements

Three autism subtypes based on single-subject gray matter network revealed by semi-supervised machine learning / Guomei XU in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.1962-1973 Titre : Three autism subtypes based on single-subject gray matter network revealed by semi-supervised machine learning Type de document : Texte imprimé et/ou numérique Auteurs : Guomei XU, Auteur ; Guohong GENG, Auteur ; Ankang WANG, Auteur ; Zhangyong LI, Auteur ; Zhichao LIU, Auteur ; Yanping LIU, Auteur ; Jun HU, Auteur ; Wei WANG, Auteur ; Xinwei LI, Auteur Article en page(s) : p.1962-1973 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  graph theory  gray matter network  heterogeneity  semi-supervised machine learning Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a heterogeneous, early-onset neurodevelopmental condition characterized by persistent impairments in social interaction and communication. This study aims to delineate ASD subtypes based on individual gray matter brain networks and provide new insights from a graph theory perspective. In this study, we extracted and normalized single-subject gray matter networks and calculated each network's topological properties. The heterogeneity through discriminative analysis (HYDRA) method was utilized to subtype all patients based on network properties. Next, we explored the differences among ASD subtypes in terms of network properties and clinical measures. Our investigation identified three distinct ASD subtypes. In the case?control study, these subtypes exhibited significant differences, particularly in the precentral gyrus, lingual gyrus, and middle frontal gyrus. In the case analysis, significant differences in global and nodal properties were observed between any two subtypes. Clinically, subtype 1 showed lower VIQ and PIQ compared to subtype 3, but exhibited higher scores in ADOS-Communication and ADOS-Total compared to subtype 2. The results highlight the distinct brain network properties and behaviors among different subtypes of male patients with ASD, providing valuable insights into the neural mechanisms underlying ASD heterogeneity. En ligne : https://doi.org/10.1002/aur.3183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Three autism subtypes based on single-subject gray matter network revealed by semi-supervised machine learning [Texte imprimé et/ou numérique] / Guomei XU, Auteur ; Guohong GENG, Auteur ; Ankang WANG, Auteur ; Zhangyong LI, Auteur ; Zhichao LIU, Auteur ; Yanping LIU, Auteur ; Jun HU, Auteur ; Wei WANG, Auteur ; Xinwei LI, Auteur . - p.1962-1973. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.1962-1973 Mots-clés : autism spectrum disorders  graph theory  gray matter network  heterogeneity  semi-supervised machine learning Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a heterogeneous, early-onset neurodevelopmental condition characterized by persistent impairments in social interaction and communication. This study aims to delineate ASD subtypes based on individual gray matter brain networks and provide new insights from a graph theory perspective. In this study, we extracted and normalized single-subject gray matter networks and calculated each network's topological properties. The heterogeneity through discriminative analysis (HYDRA) method was utilized to subtype all patients based on network properties. Next, we explored the differences among ASD subtypes in terms of network properties and clinical measures. Our investigation identified three distinct ASD subtypes. In the case?control study, these subtypes exhibited significant differences, particularly in the precentral gyrus, lingual gyrus, and middle frontal gyrus. In the case analysis, significant differences in global and nodal properties were observed between any two subtypes. Clinically, subtype 1 showed lower VIQ and PIQ compared to subtype 3, but exhibited higher scores in ADOS-Communication and ADOS-Total compared to subtype 2. The results highlight the distinct brain network properties and behaviors among different subtypes of male patients with ASD, providing valuable insights into the neural mechanisms underlying ASD heterogeneity. En ligne : https://doi.org/10.1002/aur.3183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar / Samia M. LTAIEF in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.1974-1993 Titre : Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar Type de document : Texte imprimé et/ou numérique Auteurs : Samia M. LTAIEF, Auteur ; Wared NOUR-ELDINE, Auteur ; Nimshitha Pavathuparambil Abdul MANAPH, Auteur ; Ti-Myen TAN, Auteur ; Nur Diana ANUAR, Auteur ; Ilham BENSMAIL, Auteur ; Jilbin GEORGE, Auteur ; Houari B. ABDESSELEM, Auteur ; Abeer R. AL-SHAMMARI, Auteur Article en page(s) : p.1974-1993 Langues : Anglais (eng) Mots-clés : ASD  autism  autoantibodies  B cells  biomarkers  demographics  flow cytometry  logistic regression Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, as well as the occurrence of stereotyped and repetitive behaviors. Previous studies have provided solid evidence of dysregulated immune system in ASD; however, limited studies have investigated autoantibody profiles in individuals with ASD. This study aims to screen plasma autoantibodies in a well-defined cohort of young children with ASD (n?=?100) and their matched controls (n?=?60) utilizing a high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology. We identified differential protein expression of 16 autoantibodies in ASD, which were correlated with differential gene expression of these markers in independent ASD cohorts. Meanwhile, we identified a distinct list of 33 autoantibodies associated with ASD severity; several of which were correlated with maternal age and birth weight in ASD. In addition, we found dysregulated numbers of circulating B cells and activated HLADR+ B cells in ASD, which were correlated with altered levels of several autoantibodies. Further in-depth analysis of B cell subpopulations revealed an increased frequency of activated naïve B cells in ASD, as well as an association of resting naïve B cells and transitional B cells with ASD severity. Pathway enrichment analysis revealed disrupted MAPK signaling in ASD, suggesting a potential relevance of this pathway to altered autoantibodies and B cell dysfunction in ASD. Finally, we found that a combination of eight autoantibodies associated with ASD severity showed an area under the curve (ROC-AUC) of 0.937 (95% CI?=?0.890, 0.983; p? En ligne : https://doi.org/10.1002/aur.3235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Dysregulated plasma autoantibodies are associated with B cell dysfunction in young Arab children with autism spectrum disorder in Qatar [Texte imprimé et/ou numérique] / Samia M. LTAIEF, Auteur ; Wared NOUR-ELDINE, Auteur ; Nimshitha Pavathuparambil Abdul MANAPH, Auteur ; Ti-Myen TAN, Auteur ; Nur Diana ANUAR, Auteur ; Ilham BENSMAIL, Auteur ; Jilbin GEORGE, Auteur ; Houari B. ABDESSELEM, Auteur ; Abeer R. AL-SHAMMARI, Auteur . - p.1974-1993. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.1974-1993 Mots-clés : ASD  autism  autoantibodies  B cells  biomarkers  demographics  flow cytometry  logistic regression Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interaction and communication, as well as the occurrence of stereotyped and repetitive behaviors. Previous studies have provided solid evidence of dysregulated immune system in ASD; however, limited studies have investigated autoantibody profiles in individuals with ASD. This study aims to screen plasma autoantibodies in a well-defined cohort of young children with ASD (n?=?100) and their matched controls (n?=?60) utilizing a high-throughput KoRectly Expressed (KREX) i-Ome protein-array technology. We identified differential protein expression of 16 autoantibodies in ASD, which were correlated with differential gene expression of these markers in independent ASD cohorts. Meanwhile, we identified a distinct list of 33 autoantibodies associated with ASD severity; several of which were correlated with maternal age and birth weight in ASD. In addition, we found dysregulated numbers of circulating B cells and activated HLADR+ B cells in ASD, which were correlated with altered levels of several autoantibodies. Further in-depth analysis of B cell subpopulations revealed an increased frequency of activated naïve B cells in ASD, as well as an association of resting naïve B cells and transitional B cells with ASD severity. Pathway enrichment analysis revealed disrupted MAPK signaling in ASD, suggesting a potential relevance of this pathway to altered autoantibodies and B cell dysfunction in ASD. Finally, we found that a combination of eight autoantibodies associated with ASD severity showed an area under the curve (ROC-AUC) of 0.937 (95% CI?=?0.890, 0.983; p? En ligne : https://doi.org/10.1002/aur.3235 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Language growth in verbal autistic children from 5 to 11?years / Amanda BRIGNELL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.1994-2003 Titre : Language growth in verbal autistic children from 5 to 11?years Type de document : Texte imprimé et/ou numérique Auteurs : Amanda BRIGNELL, Auteur ; Katrina J. WILLIAMS, Auteur ; Sheena REILLY, Auteur ; Angela T. MORGAN, Auteur Article en page(s) : p.1994-2003 Langues : Anglais (eng) Mots-clés : autism  developmental language disorder  language  language impairment  language trajectory Index. décimale : PER Périodiques Résumé : Abstract To examine predictors and growth in language for verbal autistic and non-autistic children with/without low language from 4 to 11?years. Receptive and expressive language trajectories were compared in a community sample of 1026 children at ages 5, 7, and 11?years, across four groups: two autistic groups; one with and one without low language; and two non-autistic groups; one with and one without low language. Groups were delineated on baseline assessment at 4?years. Non-autistic and autistic children with low language had lower mean expressive language scores than the non-autistic typical language group (22.26 and 38.53?units lower, respectively, p? En ligne : https://doi.org/10.1002/aur.3171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Language growth in verbal autistic children from 5 to 11?years [Texte imprimé et/ou numérique] / Amanda BRIGNELL, Auteur ; Katrina J. WILLIAMS, Auteur ; Sheena REILLY, Auteur ; Angela T. MORGAN, Auteur . - p.1994-2003. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.1994-2003 Mots-clés : autism  developmental language disorder  language  language impairment  language trajectory Index. décimale : PER Périodiques Résumé : Abstract To examine predictors and growth in language for verbal autistic and non-autistic children with/without low language from 4 to 11?years. Receptive and expressive language trajectories were compared in a community sample of 1026 children at ages 5, 7, and 11?years, across four groups: two autistic groups; one with and one without low language; and two non-autistic groups; one with and one without low language. Groups were delineated on baseline assessment at 4?years. Non-autistic and autistic children with low language had lower mean expressive language scores than the non-autistic typical language group (22.26 and 38.53?units lower, respectively, p? En ligne : https://doi.org/10.1002/aur.3171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Loneliness in daily life: A comparison between youths with autism spectrum disorders and 22q11.2 deletion syndrome (22q11DS) / Clémence FELLER in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2004-2017 Titre : Loneliness in daily life: A comparison between youths with autism spectrum disorders and 22q11.2 deletion syndrome (22q11DS) Type de document : Texte imprimé et/ou numérique Auteurs : Clémence FELLER, Auteur ; Laura ILEN, Auteur ; Stephan ELIEZ, Auteur ; Maude SCHNEIDER, Auteur Article en page(s) : p.2004-2017 Langues : Anglais (eng) Mots-clés : attitude toward aloneness  ecological momentary assessment  emotional reactivity  mental health  neurodevelopmental disorders  state loneliness  trait loneliness Index. décimale : PER Périodiques Résumé : Abstract Loneliness is a negative emotional experience that can stem from a gap between desires and the reality of social relationships. It is also a predictor of mental health. Loneliness is therefore important to investigate in neurodevelopmental populations known for having difficulties in the social sphere. This co-registered study involved 48 youths with autism spectrum disorders (ASD), 54 youths with 22q11.2 deletion syndrome (22q11DS) and 65 typically developing youths (TD) aged 12?30. State loneliness was assessed with an ecological momentary assessment. Paper?pencil questionnaires assessing attitude toward aloneness, trait loneliness, and mental health, were completed by the youths and their caregivers. A comparable level of state loneliness between clinical groups and TD were found, with greater loneliness when alone than in a social context. Clinical groups showed a greater intra-individual variability. Both individuals with ASD and 22q11DS revealed a greater affinity toward being alone than TD, but only individuals with ASD reported greater trait loneliness. However, no significant association was found between attitude toward aloneness, trait and state loneliness. Emotional reactivity to loneliness was different between the clinical groups. Self-reported mental health only was associated with loneliness in the clinical groups. These results provide new insights into the understanding of loneliness in these clinical populations and have an impact on clinical care by highlighting the need to remain vigilant when encountering youths who report feeling lonely, and that these youths need to be supported in developing their social network, which appears to be a protective factor against loneliness. En ligne : https://doi.org/10.1002/aur.3173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Loneliness in daily life: A comparison between youths with autism spectrum disorders and 22q11.2 deletion syndrome (22q11DS) [Texte imprimé et/ou numérique] / Clémence FELLER, Auteur ; Laura ILEN, Auteur ; Stephan ELIEZ, Auteur ; Maude SCHNEIDER, Auteur . - p.2004-2017. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2004-2017 Mots-clés : attitude toward aloneness  ecological momentary assessment  emotional reactivity  mental health  neurodevelopmental disorders  state loneliness  trait loneliness Index. décimale : PER Périodiques Résumé : Abstract Loneliness is a negative emotional experience that can stem from a gap between desires and the reality of social relationships. It is also a predictor of mental health. Loneliness is therefore important to investigate in neurodevelopmental populations known for having difficulties in the social sphere. This co-registered study involved 48 youths with autism spectrum disorders (ASD), 54 youths with 22q11.2 deletion syndrome (22q11DS) and 65 typically developing youths (TD) aged 12?30. State loneliness was assessed with an ecological momentary assessment. Paper?pencil questionnaires assessing attitude toward aloneness, trait loneliness, and mental health, were completed by the youths and their caregivers. A comparable level of state loneliness between clinical groups and TD were found, with greater loneliness when alone than in a social context. Clinical groups showed a greater intra-individual variability. Both individuals with ASD and 22q11DS revealed a greater affinity toward being alone than TD, but only individuals with ASD reported greater trait loneliness. However, no significant association was found between attitude toward aloneness, trait and state loneliness. Emotional reactivity to loneliness was different between the clinical groups. Self-reported mental health only was associated with loneliness in the clinical groups. These results provide new insights into the understanding of loneliness in these clinical populations and have an impact on clinical care by highlighting the need to remain vigilant when encountering youths who report feeling lonely, and that these youths need to be supported in developing their social network, which appears to be a protective factor against loneliness. En ligne : https://doi.org/10.1002/aur.3173 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome / Eirini PAPAGEORGOPOULOU in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2018-2029 Titre : Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome Type de document : Texte imprimé et/ou numérique Auteurs : Eirini PAPAGEORGOPOULOU, Auteur ; Emily J. H. JONES, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; Basis-Staars Team THE, Auteur Article en page(s) : p.2018-2029 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  elevated likelihood of autism  infant siblings  longitudinal  mother-infant  parent-child interaction  social attention Index. décimale : PER Périodiques Résumé : Abstract Developmental antecedents of autism may affect parent?infant interactions (PII), altering the context in which core social skills develop. While studies have identified differences in PII between infants with and without elevated likelihood (EL) for autism, samples have been small. Here, we examined whether previously reported differences are replicable. From a longitudinal study of 113 EL and 27 typical likelihood infants (TL), 6-min videotaped unstructured PII was blind rated at 8 and 14?months on eight interactional qualities. Autism outcome was assessed at 36?months. Linear mixed-effects models found higher parent sensitive responsiveness, nondirectiveness, and mutuality ratings in TL than EL infants with and without later autism. PII qualities at 8 (infant positive affect, parent directiveness) and 14?months (infant attentiveness to parent, mutuality) predicted 3-year autism. Attentiveness to parent decreased between 8 and 14?months in EL infants with later autism. This larger study supports previous findings of emerging alterations in PII in this group and extends on this by detecting earlier (8-month) predictive effects of PII for autism outcome and a more marked trajectory of decreased social attentiveness. The findings strengthen the evidence base to support the implementation of early preemptive interventions to support PII in infants with early autism signs. En ligne : https://doi.org/10.1002/aur.3190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Parent-infant interaction trajectories in infants with an elevated likelihood for autism in relation to 3-year clinical outcome [Texte imprimé et/ou numérique] / Eirini PAPAGEORGOPOULOU, Auteur ; Emily J. H. JONES, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Jonathan GREEN, Auteur ; Ming Wai WAN, Auteur ; Basis-Staars Team THE, Auteur . - p.2018-2029. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2018-2029 Mots-clés : autism spectrum disorders  elevated likelihood of autism  infant siblings  longitudinal  mother-infant  parent-child interaction  social attention Index. décimale : PER Périodiques Résumé : Abstract Developmental antecedents of autism may affect parent?infant interactions (PII), altering the context in which core social skills develop. While studies have identified differences in PII between infants with and without elevated likelihood (EL) for autism, samples have been small. Here, we examined whether previously reported differences are replicable. From a longitudinal study of 113 EL and 27 typical likelihood infants (TL), 6-min videotaped unstructured PII was blind rated at 8 and 14?months on eight interactional qualities. Autism outcome was assessed at 36?months. Linear mixed-effects models found higher parent sensitive responsiveness, nondirectiveness, and mutuality ratings in TL than EL infants with and without later autism. PII qualities at 8 (infant positive affect, parent directiveness) and 14?months (infant attentiveness to parent, mutuality) predicted 3-year autism. Attentiveness to parent decreased between 8 and 14?months in EL infants with later autism. This larger study supports previous findings of emerging alterations in PII in this group and extends on this by detecting earlier (8-month) predictive effects of PII for autism outcome and a more marked trajectory of decreased social attentiveness. The findings strengthen the evidence base to support the implementation of early preemptive interventions to support PII in infants with early autism signs. En ligne : https://doi.org/10.1002/aur.3190 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development / Fiona JOURNAL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2030-2044 Titre : Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development Type de document : Texte imprimé et/ou numérique Auteurs : Fiona JOURNAL, Auteur ; Martina FRANCHINI, Auteur ; Michel GODEL, Auteur ; Nada KOJOVIC, Auteur ; Kenza LATRÈCHE, Auteur ; Stefania SOLAZZO, Auteur ; Maude SCHNEIDER, Auteur ; Marie SCHAER, Auteur Article en page(s) : p.2030-2044 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  cluster analysis  deep phenotyping  joint attention  nonverbal communication  phenotype  trajectories Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18?60?months, comparing them to age-matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects-directed behaviors and social interaction-directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low-level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies. En ligne : https://doi.org/10.1002/aur.3188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Phenotyping variability in early socio-communicative skills in young children with autism and its influence on later development [Texte imprimé et/ou numérique] / Fiona JOURNAL, Auteur ; Martina FRANCHINI, Auteur ; Michel GODEL, Auteur ; Nada KOJOVIC, Auteur ; Kenza LATRÈCHE, Auteur ; Stefania SOLAZZO, Auteur ; Maude SCHNEIDER, Auteur ; Marie SCHAER, Auteur . - p.2030-2044. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2030-2044 Mots-clés : autism spectrum disorders  cluster analysis  deep phenotyping  joint attention  nonverbal communication  phenotype  trajectories Index. décimale : PER Périodiques Résumé : Abstract Children with autism spectrum disorder (ASD) often face challenges in early social communication skills, prompting the need for a detailed exploration of specific behaviors and their impact on cognitive and adaptive functioning. This study aims to address this gap by examining the developmental trajectories of early social communication skills in preschoolers with ASD aged 18?60?months, comparing them to age-matched typically developing (TD) children. Utilizing the early social communication scales (ESCS), the research employs a longitudinal design to capture changes over time. We apply a principal component analysis (PCA) to ESCS variables to identify underlying components, and cluster analysis to identify subgroups based on preverbal communication profiles. The results reveal consistent differences in early social communication skills between ASD and TD children, with ASD children exhibiting reduced skills. PCA identifies two components, distinguishing objects-directed behaviors and social interaction-directed behaviors. Cluster analysis identifies three subgroups of autistic children, each displaying specific communication profiles associated with distinct cognitive and adaptive functioning trajectories. In conclusion, this study provides a nuanced understanding of early social communication development in ASD, emphasizing the importance of low-level behaviors. The identification of subgroups and their unique trajectories contributes to a more comprehensive understanding of ASD heterogeneity. These findings underscore the significance of early diagnosis, focusing on specific behaviors predicting cognitive and adaptive functioning outcomes. The study encourages further research to explore the sequential development of these skills, offering valuable insights for interventions and support strategies. En ligne : https://doi.org/10.1002/aur.3188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses / Michael K. YEUNG in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2045-2063 Titre : Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses Type de document : Texte imprimé et/ou numérique Auteurs : Michael K. YEUNG, Auteur ; Jieru BAI, Auteur ; Kwai-Lai MAK, Auteur Article en page(s) : p.2045-2063 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  development  executive function  longitudinal study  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Abstract Individuals with an autism spectrum disorder (ASD) diagnosis show impairment in executive function (EF). However, findings are mixed regarding differences in the age effect on EF between autistic individuals and persons with typical development (TD). Questions remain regarding whether the age-related trajectories of EF in ASD are the same as or different from those in TD. To bridge this knowledge gap, we conducted a systematic review and meta-analyses of longitudinal studies that compared age-related changes in EF between ASD and TD groups (preregistration: osf.io/j5764). A literature search was conducted using PubMed, PsycINFO, and Web of Science on January 29, 2024. After screening by two independent reviewers, 14 longitudinal studies were included. Random-effects meta-analyses of studies involving a maximum total of 518 autistic and 3558 TD children and adolescents (mean baseline ages: 5.7?12.0?years) showed that ASD had significantly poorer EF than TD at both baseline and follow-up. However, there was no significant group difference in the age-related change in EF across domains, including working memory, inhibition, shifting, and planning. Robust Bayesian meta-analyses also provided substantial evidence in favor of the null hypothesis that ASD and TD groups showed similar changes over time for most EF processes. Limitations of the literature included the limited number of longitudinal studies and a narrow range of developmental stages and EF constructs analyzed across studies. Altogether, these findings suggest that autistic children and adolescents generally can improve in EF over time similarly to their neurotypical peers. This has important implications for parents and educators, encouraging appropriate EF training and intervention for autistic children and adolescents at an early stage. En ligne : https://doi.org/10.1002/aur.3196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Longitudinal changes in executive function in autism spectrum disorder: A systematic review and meta-analyses [Texte imprimé et/ou numérique] / Michael K. YEUNG, Auteur ; Jieru BAI, Auteur ; Kwai-Lai MAK, Auteur . - p.2045-2063. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2045-2063 Mots-clés : autism spectrum disorder  development  executive function  longitudinal study  meta-analysis  systematic review Index. décimale : PER Périodiques Résumé : Abstract Individuals with an autism spectrum disorder (ASD) diagnosis show impairment in executive function (EF). However, findings are mixed regarding differences in the age effect on EF between autistic individuals and persons with typical development (TD). Questions remain regarding whether the age-related trajectories of EF in ASD are the same as or different from those in TD. To bridge this knowledge gap, we conducted a systematic review and meta-analyses of longitudinal studies that compared age-related changes in EF between ASD and TD groups (preregistration: osf.io/j5764). A literature search was conducted using PubMed, PsycINFO, and Web of Science on January 29, 2024. After screening by two independent reviewers, 14 longitudinal studies were included. Random-effects meta-analyses of studies involving a maximum total of 518 autistic and 3558 TD children and adolescents (mean baseline ages: 5.7?12.0?years) showed that ASD had significantly poorer EF than TD at both baseline and follow-up. However, there was no significant group difference in the age-related change in EF across domains, including working memory, inhibition, shifting, and planning. Robust Bayesian meta-analyses also provided substantial evidence in favor of the null hypothesis that ASD and TD groups showed similar changes over time for most EF processes. Limitations of the literature included the limited number of longitudinal studies and a narrow range of developmental stages and EF constructs analyzed across studies. Altogether, these findings suggest that autistic children and adolescents generally can improve in EF over time similarly to their neurotypical peers. This has important implications for parents and educators, encouraging appropriate EF training and intervention for autistic children and adolescents at an early stage. En ligne : https://doi.org/10.1002/aur.3196 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Visual mental imagery abilities in autism / Clara BLED in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2064-2078 Titre : Visual mental imagery abilities in autism Type de document : Texte imprimé et/ou numérique Auteurs : Clara BLED, Auteur ; Quentin GUILLON, Auteur ; Laurent MOTTRON, Auteur ; Isabelle SOULIERES, Auteur ; Lucie BOUVET, Auteur Article en page(s) : p.2064-2078 Langues : Anglais (eng) Mots-clés : autism  cognitive style  generation  maintenance  manipulation  mental imagery  scanning Index. décimale : PER Périodiques Résumé : Abstract In autistic individuals, the role, performance, and autonomy of perceptual functioning are atypical. Overlapping underlying mechanisms of perception and mental imagery predict that the mental imagery abilities of autistic individuals should differ from those of non-autistic individuals. While enhanced abilities to manipulate mental images have been demonstrated in autism, the other stages of mental imagery (generation, maintenance, inspection) remain to be explored. Forty-four autistic adults and 42 typical participants performed four tasks to assess different stages of mental imagery: the Image generation task (mentally generating a letter on a grid and indicating whether it passes over a probe located in the grid), the Visual pattern test (maintaining visual patterns in memory), the Image scanning test (inspecting mental images) and the Mental rotation test (mentally manipulating representations of geometric figures). In the image generation task and the mental rotation test, autistic and typical individuals performed equivalently, both in accuracy and response time. The span observed in the visual pattern test was significantly higher in the autistic group, indicating better maintenance of mental images. In the image scanning test, response times were influenced by the distance to mentally inspect in the typical group but not in the autistic group. Autistic participants were equally fast regardless of distance to inspect. Preserved, greater or differently influenced visual mental imagery abilities are in line with an atypical perceptual functioning in autism, possibly reflecting an increased weight of perception-based information relatively to the top-down effect of knowledge and language-based influence. En ligne : https://doi.org/10.1002/aur.3192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Visual mental imagery abilities in autism [Texte imprimé et/ou numérique] / Clara BLED, Auteur ; Quentin GUILLON, Auteur ; Laurent MOTTRON, Auteur ; Isabelle SOULIERES, Auteur ; Lucie BOUVET, Auteur . - p.2064-2078. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2064-2078 Mots-clés : autism  cognitive style  generation  maintenance  manipulation  mental imagery  scanning Index. décimale : PER Périodiques Résumé : Abstract In autistic individuals, the role, performance, and autonomy of perceptual functioning are atypical. Overlapping underlying mechanisms of perception and mental imagery predict that the mental imagery abilities of autistic individuals should differ from those of non-autistic individuals. While enhanced abilities to manipulate mental images have been demonstrated in autism, the other stages of mental imagery (generation, maintenance, inspection) remain to be explored. Forty-four autistic adults and 42 typical participants performed four tasks to assess different stages of mental imagery: the Image generation task (mentally generating a letter on a grid and indicating whether it passes over a probe located in the grid), the Visual pattern test (maintaining visual patterns in memory), the Image scanning test (inspecting mental images) and the Mental rotation test (mentally manipulating representations of geometric figures). In the image generation task and the mental rotation test, autistic and typical individuals performed equivalently, both in accuracy and response time. The span observed in the visual pattern test was significantly higher in the autistic group, indicating better maintenance of mental images. In the image scanning test, response times were influenced by the distance to mentally inspect in the typical group but not in the autistic group. Autistic participants were equally fast regardless of distance to inspect. Preserved, greater or differently influenced visual mental imagery abilities are in line with an atypical perceptual functioning in autism, possibly reflecting an increased weight of perception-based information relatively to the top-down effect of knowledge and language-based influence. En ligne : https://doi.org/10.1002/aur.3192 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Validating motor delays across the developmental coordination disorder-questionnaire and the Vineland adaptive behavior scales (VABS) in children with autism spectrum disorderASD: A SPARK dataset analysis / A. N. BHAT in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2079-2091 Titre : Validating motor delays across the developmental coordination disorder-questionnaire and the Vineland adaptive behavior scales (VABS) in children with autism spectrum disorderASD: A SPARK dataset analysis Type de document : Texte imprimé et/ou numérique Auteurs : A. N. BHAT, Auteur Article en page(s) : p.2079-2091 Langues : Anglais (eng) Mots-clés : autism  DCD-Q  motor delay  motor impairment  VABS  Vineland Index. décimale : PER Périodiques Résumé : Abstract Motor delays in children with autism spectrum disorder (ASD) are being increasingly recognized using a brief screening tool, called the Developmental Coordination Disorder-Questionnaire (DCD-Q). Further validation of these motor delays using a more robust normed, developmental measure is clearly warranted. In this analysis, a nationally representative sample from the SPARK study was used wherein parents completed the DCD-Q and a more widely used developmental/adaptive functioning measure, called the Vineland Adaptive Behavior Scales (VABS); which comprises of various developmental domains including the motor domain (N?=?2,644 completed the DCD-Q and VABS). Eighty two percent children with ASD had a motor delay based on their DCD-Q scores whereas 77% children with ASD had a motor delay based on their VABS motor domain scores. Approximately 70% children with ASD had concurrent motor delay on the DCD-Q and the VABS (i.e., positive predictive value of DCD-Q). Furthermore, there was 81.2% accuracy in reporting a risk/no risk of motor delay across both measures. Overall, these statistics align with the recent reports on proportions of children with ASD having motor delays. Parents of ~70% children with ASD are reporting motor delays that are corroborated across two different motor measures. This not only validates the motor delays reported based on the DCD-Q but also indicates the need for concurrent motor screening using both DCD-Q and VABS for better detection of motor delays in children with ASD. Only 10%?32% of the current SPARK sample received any physical or recreational therapies. This mismatch between presence of motor delays and the lack of access to motor services highlights the need for more motor intervention referrals for children with ASD. En ligne : https://doi.org/10.1002/aur.3189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Validating motor delays across the developmental coordination disorder-questionnaire and the Vineland adaptive behavior scales (VABS) in children with autism spectrum disorderASD: A SPARK dataset analysis [Texte imprimé et/ou numérique] / A. N. BHAT, Auteur . - p.2079-2091. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2079-2091 Mots-clés : autism  DCD-Q  motor delay  motor impairment  VABS  Vineland Index. décimale : PER Périodiques Résumé : Abstract Motor delays in children with autism spectrum disorder (ASD) are being increasingly recognized using a brief screening tool, called the Developmental Coordination Disorder-Questionnaire (DCD-Q). Further validation of these motor delays using a more robust normed, developmental measure is clearly warranted. In this analysis, a nationally representative sample from the SPARK study was used wherein parents completed the DCD-Q and a more widely used developmental/adaptive functioning measure, called the Vineland Adaptive Behavior Scales (VABS); which comprises of various developmental domains including the motor domain (N?=?2,644 completed the DCD-Q and VABS). Eighty two percent children with ASD had a motor delay based on their DCD-Q scores whereas 77% children with ASD had a motor delay based on their VABS motor domain scores. Approximately 70% children with ASD had concurrent motor delay on the DCD-Q and the VABS (i.e., positive predictive value of DCD-Q). Furthermore, there was 81.2% accuracy in reporting a risk/no risk of motor delay across both measures. Overall, these statistics align with the recent reports on proportions of children with ASD having motor delays. Parents of ~70% children with ASD are reporting motor delays that are corroborated across two different motor measures. This not only validates the motor delays reported based on the DCD-Q but also indicates the need for concurrent motor screening using both DCD-Q and VABS for better detection of motor delays in children with ASD. Only 10%?32% of the current SPARK sample received any physical or recreational therapies. This mismatch between presence of motor delays and the lack of access to motor services highlights the need for more motor intervention referrals for children with ASD. En ligne : https://doi.org/10.1002/aur.3189 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Memory strategies in autistic and older adults / C. TORENVLIET in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2092-2104 Titre : Memory strategies in autistic and older adults Type de document : Texte imprimé et/ou numérique Auteurs : C. TORENVLIET, Auteur ; A. P. GROENMAN, Auteur ; E. VAN DER BURG, Auteur ; R. C. CHARLTON, Auteur ; C. J. HAMILTON, Auteur ; H. M. GEURTS, Auteur Article en page(s) : p.2092-2104 Langues : Anglais (eng) Mots-clés : aging  autism  memory strategies  visual memory Index. décimale : PER Périodiques Résumé : Abstract Memory strategies in autistic adults seem to mimic strategies at older age, as both younger autistic and older non-autistic individuals use fewer semantic features in visual memory tasks. Therefore, the current study aims to investigate whether early differences in memory strategies lead to altered age-related effects in autism, particularly whether initial difficulties in strategy use become advantageous at older age (i.e., ?protective aging?). A total of 147 participants across four groups (autistic younger/older, non-autistic younger/older) completed an online assessment. This assessment included a recognition version of the Visual Patterns Test (VPT) to evaluate semantic strategy use in visual memory, the Just Noticeable Difference (JND) size task for assessing visual processing, and the Multifactorial Memory Questionnaire to evaluate subjective memory functioning and strategy use (MMQ). Unexpectedly, all groups benefited from semantic features on the VPT, although the older groups performed less accurately and slower than the younger groups. The JND Size task showed no group differences. Autistic adults rated their MMQ memory as worse than non-autistic adults, despite reporting greater strategy use. These results indicate that cognitive strategies might be more similar between younger/older and autistic/non-autistic people than previously expected, although notable discrepancies between objective and subjective measures were present. They also substantiate previously reported parallel (i.e., similar) age-related effects between autistic and non-autistic people. En ligne : https://doi.org/10.1002/aur.3195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Memory strategies in autistic and older adults [Texte imprimé et/ou numérique] / C. TORENVLIET, Auteur ; A. P. GROENMAN, Auteur ; E. VAN DER BURG, Auteur ; R. C. CHARLTON, Auteur ; C. J. HAMILTON, Auteur ; H. M. GEURTS, Auteur . - p.2092-2104. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2092-2104 Mots-clés : aging  autism  memory strategies  visual memory Index. décimale : PER Périodiques Résumé : Abstract Memory strategies in autistic adults seem to mimic strategies at older age, as both younger autistic and older non-autistic individuals use fewer semantic features in visual memory tasks. Therefore, the current study aims to investigate whether early differences in memory strategies lead to altered age-related effects in autism, particularly whether initial difficulties in strategy use become advantageous at older age (i.e., ?protective aging?). A total of 147 participants across four groups (autistic younger/older, non-autistic younger/older) completed an online assessment. This assessment included a recognition version of the Visual Patterns Test (VPT) to evaluate semantic strategy use in visual memory, the Just Noticeable Difference (JND) size task for assessing visual processing, and the Multifactorial Memory Questionnaire to evaluate subjective memory functioning and strategy use (MMQ). Unexpectedly, all groups benefited from semantic features on the VPT, although the older groups performed less accurately and slower than the younger groups. The JND Size task showed no group differences. Autistic adults rated their MMQ memory as worse than non-autistic adults, despite reporting greater strategy use. These results indicate that cognitive strategies might be more similar between younger/older and autistic/non-autistic people than previously expected, although notable discrepancies between objective and subjective measures were present. They also substantiate previously reported parallel (i.e., similar) age-related effects between autistic and non-autistic people. En ligne : https://doi.org/10.1002/aur.3195 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Toward a functional classification for autism in adulthood / Kyle STERRETT in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2105-2119 Titre : Toward a functional classification for autism in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Kyle STERRETT, Auteur ; Elaine CLARKE, Auteur ; Jane NOFER, Auteur ; Joseph PIVEN, Auteur ; Catherine LORD, Auteur Article en page(s) : p.2105-2119 Langues : Anglais (eng) Mots-clés : adaptive functioning  autism  profound autism  support needs Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a heterogeneous condition that affects development and functioning from infancy through adulthood. Efforts to parse the heterogeneity of the autism spectrum through subgroups such as Asperger's and Profound Autism have been controversial, and have consistently struggled with issues of reliability, validity, and interpretability. Nonetheless, methods for successfully identifying clinically meaningful subgroups within autism are needed to ensure that research, interventions, and services address the range of needs experienced by autistic individuals. The purpose of this study was to generate and test whether a simple set of questions, organized in a flowchart, could be used in clinical practice and research to differentiate meaningful subgroups based on individuals' level of functioning. Once generated, subgroups could also be compared to the recently proposed administrative category of Profound Autism and to groupings based on standardized adaptive measures. Ninety-seven adults with autism or related neurodevelopmental disorders participating in a longstanding longitudinal study, or their caregivers if they could not answer for themselves, completed phone interviews when the participants were ~30?years old. Information from these phone interviews was used to generate vignettes summarizing characteristics and aspects of the daily lives of each participant (e.g., language level, vocational activities, and social relationships). Three expert clinicians then used these vignettes to classify each participant based on their level of support needs. Meaningfully distinct subgroups within the sample were identified which could be reliably distinguished from one another. Implications of such categorizations and future directions are discussed. En ligne : https://doi.org/10.1002/aur.3201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Toward a functional classification for autism in adulthood [Texte imprimé et/ou numérique] / Kyle STERRETT, Auteur ; Elaine CLARKE, Auteur ; Jane NOFER, Auteur ; Joseph PIVEN, Auteur ; Catherine LORD, Auteur . - p.2105-2119. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2105-2119 Mots-clés : adaptive functioning  autism  profound autism  support needs Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a heterogeneous condition that affects development and functioning from infancy through adulthood. Efforts to parse the heterogeneity of the autism spectrum through subgroups such as Asperger's and Profound Autism have been controversial, and have consistently struggled with issues of reliability, validity, and interpretability. Nonetheless, methods for successfully identifying clinically meaningful subgroups within autism are needed to ensure that research, interventions, and services address the range of needs experienced by autistic individuals. The purpose of this study was to generate and test whether a simple set of questions, organized in a flowchart, could be used in clinical practice and research to differentiate meaningful subgroups based on individuals' level of functioning. Once generated, subgroups could also be compared to the recently proposed administrative category of Profound Autism and to groupings based on standardized adaptive measures. Ninety-seven adults with autism or related neurodevelopmental disorders participating in a longstanding longitudinal study, or their caregivers if they could not answer for themselves, completed phone interviews when the participants were ~30?years old. Information from these phone interviews was used to generate vignettes summarizing characteristics and aspects of the daily lives of each participant (e.g., language level, vocational activities, and social relationships). Three expert clinicians then used these vignettes to classify each participant based on their level of support needs. Meaningfully distinct subgroups within the sample were identified which could be reliably distinguished from one another. Implications of such categorizations and future directions are discussed. En ligne : https://doi.org/10.1002/aur.3201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Pupillary response during social emotion tasks in autism spectrum disorder / Juei-Po LEE in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2120-2132 Titre : Pupillary response during social emotion tasks in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Juei-Po LEE, Auteur ; Yi-Hsuan CHANG, Auteur ; Yi-Li TSENG, Auteur ; Tai-Li CHOU, Auteur ; Yi-Ling CHIEN, Auteur Article en page(s) : p.2120-2132 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  pupillary response  socio-affective task Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals encounter challenges in recognizing emotional expressions of others. Pupillary response has been proposed as an indicator of arousal dysregulation or cognitive load. The pupillary response of autistic individuals during socio-affective tasks remains unclear. This study investigated pupillary response in autistic adults when viewing emotional faces/eyes and recognizing emotions during the Reading the Mind in the Eyes Test (RMET) and watching interpersonal touch scenes in the social touch task. The study included 98 participants diagnosed with autism spectrum disorder and 37 typically developing controls (TD). Pupil size was measured using the Tobii X2-30 Eye Tracker. The results showed that autistic adults had larger maximal pupil sizes, smaller minimal pupil sizes, and greater change rates of pupil size, particularly during the RMET Eyes task. Clinical correlations revealed that attention switching difficulty positively correlated with mean pupil size in TD participants, while social communication deficits positively correlated with mean pupil size in autistic participants. In conclusion, our findings suggest atypical pupillary responses in autistic adults during socio-affective tasks, indicating heightened cognitive demand. Further investigation is necessary to understand the underlying mechanisms and their association with autistic traits. En ligne : https://doi.org/10.1002/aur.3206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Pupillary response during social emotion tasks in autism spectrum disorder [Texte imprimé et/ou numérique] / Juei-Po LEE, Auteur ; Yi-Hsuan CHANG, Auteur ; Yi-Li TSENG, Auteur ; Tai-Li CHOU, Auteur ; Yi-Ling CHIEN, Auteur . - p.2120-2132. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2120-2132 Mots-clés : autism spectrum disorder  pupillary response  socio-affective task Index. décimale : PER Périodiques Résumé : Abstract Autistic individuals encounter challenges in recognizing emotional expressions of others. Pupillary response has been proposed as an indicator of arousal dysregulation or cognitive load. The pupillary response of autistic individuals during socio-affective tasks remains unclear. This study investigated pupillary response in autistic adults when viewing emotional faces/eyes and recognizing emotions during the Reading the Mind in the Eyes Test (RMET) and watching interpersonal touch scenes in the social touch task. The study included 98 participants diagnosed with autism spectrum disorder and 37 typically developing controls (TD). Pupil size was measured using the Tobii X2-30 Eye Tracker. The results showed that autistic adults had larger maximal pupil sizes, smaller minimal pupil sizes, and greater change rates of pupil size, particularly during the RMET Eyes task. Clinical correlations revealed that attention switching difficulty positively correlated with mean pupil size in TD participants, while social communication deficits positively correlated with mean pupil size in autistic participants. In conclusion, our findings suggest atypical pupillary responses in autistic adults during socio-affective tasks, indicating heightened cognitive demand. Further investigation is necessary to understand the underlying mechanisms and their association with autistic traits. En ligne : https://doi.org/10.1002/aur.3206 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

What do we know about autism and policing globally? Preliminary findings from an international effort to examine autism and the criminal justice system / Dylan COOPER in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2133-2143 Titre : What do we know about autism and policing globally? Preliminary findings from an international effort to examine autism and the criminal justice system Type de document : Texte imprimé et/ou numérique Auteurs : Dylan COOPER, Auteur ; Shelby FRISBIE, Auteur ; Shufang WANG, Auteur ; Jonas VENTIMIGLIA, Auteur ; Vicki GIBBS, Auteur ; Abigail M. A. LOVE, Auteur ; Melanie MOGAVERO, Auteur ; Teal W. BENEVIDES, Auteur ; Jordan M. HYATT, Auteur ; Kate HOOVEN, Auteur ; Icylee BASKETBILL, Auteur ; Lindsay SHEA, Auteur Article en page(s) : p.2133-2143 Langues : Anglais (eng) Mots-clés : autism  criminal justice  international  police  survey Index. décimale : PER Périodiques Résumé : Abstract Research has demonstrated that autistic individuals have higher rates of police contact, however, research has seldom explored the fundamental reasons for these interactions and how this might vary across international contexts. To remedy this, the Global Autism and Criminal Justice Consortium created and disseminated the Global Criminal Justice Survey. Descriptive statistics of survey respondents with and without police contact were compared to glean differential characteristics. Frequency and type of recent police interactions (within the last 5?years) among autistic individuals were also examined to better contextualize the reasons that autistic individuals encounter police. Study findings indicated that across a global sample (i.e., North America, Scandinavia, Europe, and Oceania) nearly half of all autistic individuals had an interaction with police and that those with a history of police contact were usually older, had higher educational qualifications, and were more likely to have a co-occurring mental health or developmental disorder. Among types of interactions, noncriminal encounters, such as welfare checks, traffic incidents, wandering, and behaviors associated with autism, were most common, followed by autistic individuals alleging a crime was committed against them. These findings offer important directions for future research and for targeted policy responses that can address the unique needs of autistic individuals within the justice system. En ligne : https://doi.org/10.1002/aur.3203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] What do we know about autism and policing globally? Preliminary findings from an international effort to examine autism and the criminal justice system [Texte imprimé et/ou numérique] / Dylan COOPER, Auteur ; Shelby FRISBIE, Auteur ; Shufang WANG, Auteur ; Jonas VENTIMIGLIA, Auteur ; Vicki GIBBS, Auteur ; Abigail M. A. LOVE, Auteur ; Melanie MOGAVERO, Auteur ; Teal W. BENEVIDES, Auteur ; Jordan M. HYATT, Auteur ; Kate HOOVEN, Auteur ; Icylee BASKETBILL, Auteur ; Lindsay SHEA, Auteur . - p.2133-2143. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2133-2143 Mots-clés : autism  criminal justice  international  police  survey Index. décimale : PER Périodiques Résumé : Abstract Research has demonstrated that autistic individuals have higher rates of police contact, however, research has seldom explored the fundamental reasons for these interactions and how this might vary across international contexts. To remedy this, the Global Autism and Criminal Justice Consortium created and disseminated the Global Criminal Justice Survey. Descriptive statistics of survey respondents with and without police contact were compared to glean differential characteristics. Frequency and type of recent police interactions (within the last 5?years) among autistic individuals were also examined to better contextualize the reasons that autistic individuals encounter police. Study findings indicated that across a global sample (i.e., North America, Scandinavia, Europe, and Oceania) nearly half of all autistic individuals had an interaction with police and that those with a history of police contact were usually older, had higher educational qualifications, and were more likely to have a co-occurring mental health or developmental disorder. Among types of interactions, noncriminal encounters, such as welfare checks, traffic incidents, wandering, and behaviors associated with autism, were most common, followed by autistic individuals alleging a crime was committed against them. These findings offer important directions for future research and for targeted policy responses that can address the unique needs of autistic individuals within the justice system. En ligne : https://doi.org/10.1002/aur.3203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings / Diana SCHENDEL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2144-2155 Titre : 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings Type de document : Texte imprimé et/ou numérique Auteurs : Diana SCHENDEL, Auteur ; Linda EJLSKOV, Auteur ; Morten OVERGAARD, Auteur ; Zeal JINWALA, Auteur ; Viktor KIM, Auteur ; Erik PARNER, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine LADD ACOSTA, Auteur ; M. Danielle FALLIN, Auteur ; Sherlly XIE, Auteur ; Preben Bo MORTENSEN, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.2144-2155 Langues : Anglais (eng) Mots-clés : allergy  asthma  autism  autoimmune  birth defect  cardiometabolic  family history  mental disorder  neurologic Index. décimale : PER Périodiques Résumé : Abstract The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis-generation, we produced an open-source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980?2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are cataloged in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity. En ligne : https://doi.org/10.1002/aur.3232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] 3-generation family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions associated with autism: An open-source catalog of findings [Texte imprimé et/ou numérique] / Diana SCHENDEL, Auteur ; Linda EJLSKOV, Auteur ; Morten OVERGAARD, Auteur ; Zeal JINWALA, Auteur ; Viktor KIM, Auteur ; Erik PARNER, Auteur ; Amy E. KALKBRENNER, Auteur ; Christine LADD ACOSTA, Auteur ; M. Danielle FALLIN, Auteur ; Sherlly XIE, Auteur ; Preben Bo MORTENSEN, Auteur ; Brian K. LEE, Auteur . - p.2144-2155. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2144-2155 Mots-clés : allergy  asthma  autism  autoimmune  birth defect  cardiometabolic  family history  mental disorder  neurologic Index. décimale : PER Périodiques Résumé : Abstract The relatively few conditions and family member types (e.g., sibling, parent) considered in investigations of family health history in autism spectrum disorder (ASD, or autism) limits understanding of the role of family history in autism etiology. For more comprehensive understanding and hypothesis-generation, we produced an open-source catalog of autism associations with family histories of mental, neurologic, cardiometabolic, birth defect, asthma, allergy, and autoimmune conditions. All live births in Denmark, 1980?2012, of Denmark-born parents (1,697,231 births), and their 3-generation family members were followed through April 10, 2017 for each of 90 diagnoses (including autism), emigration or death. Adjusted hazard ratios (aHR) were estimated via Cox regression for each diagnosis-family member type combination, adjusting for birth year, sex, birth weight, gestational age, parental ages at birth, and number of family member types of index person; aHRs also calculated for sex-specific co-occurrence of each disorder. We obtained 6462 individual family history aHRS across autism overall (26,840 autistic persons; 1.6% of births), by sex, and considering intellectual disability (ID); and 350 individual co-occurrence aHRS. Results are cataloged in interactive heat maps and down-loadable data files: https://ncrr-au.shinyapps.io/asd-riskatlas/ and interactive graphic summaries: https://public.tableau.com/app/profile/diana.schendel/viz/ASDPlots_16918786403110/e-Figure5. While primarily for reference material or use in other studies (e.g., meta-analyses), results revealed considerable breadth and variation in magnitude of familial health history associations with autism by type of condition, family member type, sex of the family member, side of the family, sex of the index person, and ID status, indicative of diverse genetic, familial, and nongenetic autism etiologic pathways. Careful attention to sources of autism likelihood in family health history, aided by our open data resource, may accelerate understanding of factors underlying neurodiversity. En ligne : https://doi.org/10.1002/aur.3232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

A longitudinal health promotion program for autistic children and their caregivers: Impact of an urban community-based program / Leah R. KETCHESON in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2156-2176 Titre : A longitudinal health promotion program for autistic children and their caregivers: Impact of an urban community-based program Type de document : Texte imprimé et/ou numérique Auteurs : Leah R. KETCHESON, Auteur ; Franziska LOETZNER, Auteur ; Chandler F. WENTZ, Auteur ; Samantha MILLER, Auteur ; E. Andrew PITCHFORD, Auteur Article en page(s) : p.2156-2176 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child  exercise  health promotion  motor skills  parents  physical fitness Index. décimale : PER Périodiques Résumé : Abstract Autistic children, as well as their primary caregivers (e.g., parents), experience greater health disparities when compared with the general population. Despite this reality, there has been relatively little priority placed on promoting positive trajectories of health in either of these underserved populations. The primary purpose of this study was to examine the impact of participation in a 12-month, longitudinal health promotion program designed for both autistic children and their parent. A total of 27 families participated in the intervention, including 29 autistic children (83% male, M?=?8.28?+?3.60?years) and 27 parents (93% female, M?=?40.04?+?7.95). Families attended in-person health promotion programming for 90?min per week. Children and parents were evaluated at four time points across the program, including baseline (0-months), 4-months, 8-months, and 12-months. Children were measured on fundamental motor competence, physical fitness, body composition, and proxy-reported physical activity. Parents were measured on body composition, physical fitness, and self-reported physical activity. Significant improvements were observed for autistic children in motor competence (p? En ligne : https://doi.org/10.1002/aur.3231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] A longitudinal health promotion program for autistic children and their caregivers: Impact of an urban community-based program [Texte imprimé et/ou numérique] / Leah R. KETCHESON, Auteur ; Franziska LOETZNER, Auteur ; Chandler F. WENTZ, Auteur ; Samantha MILLER, Auteur ; E. Andrew PITCHFORD, Auteur . - p.2156-2176. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2156-2176 Mots-clés : autism spectrum disorder  child  exercise  health promotion  motor skills  parents  physical fitness Index. décimale : PER Périodiques Résumé : Abstract Autistic children, as well as their primary caregivers (e.g., parents), experience greater health disparities when compared with the general population. Despite this reality, there has been relatively little priority placed on promoting positive trajectories of health in either of these underserved populations. The primary purpose of this study was to examine the impact of participation in a 12-month, longitudinal health promotion program designed for both autistic children and their parent. A total of 27 families participated in the intervention, including 29 autistic children (83% male, M?=?8.28?+?3.60?years) and 27 parents (93% female, M?=?40.04?+?7.95). Families attended in-person health promotion programming for 90?min per week. Children and parents were evaluated at four time points across the program, including baseline (0-months), 4-months, 8-months, and 12-months. Children were measured on fundamental motor competence, physical fitness, body composition, and proxy-reported physical activity. Parents were measured on body composition, physical fitness, and self-reported physical activity. Significant improvements were observed for autistic children in motor competence (p? En ligne : https://doi.org/10.1002/aur.3231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536

Telehealth coaching in Project ImPACT indirectly affects children's expressive language ability through parent intervention strategy use and child intentional communication: An RCT / Brooke INGERSOLL in Autism Research, 17-10 (October 2024)  

Public ISBD [article]  inAutism Research > 17-10 (October 2024) . - p.2177-2187 Titre : Telehealth coaching in Project ImPACT indirectly affects children's expressive language ability through parent intervention strategy use and child intentional communication: An RCT Type de document : Texte imprimé et/ou numérique Auteurs : Brooke INGERSOLL, Auteur ; Kyle M. FROST, Auteur ; Diondra STRAITON, Auteur ; Anamiguel Pomales RAMOS, Auteur ; Karís CASAGRANDE, Auteur Article en page(s) : p.2177-2187 Langues : Anglais (eng) Mots-clés : autism  NDBI  parent-mediated intervention  social communication  telehealth Index. décimale : PER Périodiques Résumé : Abstract Parent-mediated, naturalistic developmental behavioral interventions (NDBIs) are a promising approach for supporting social communication development in young autistic children. This study examined the effect of telehealth delivery of a parent-mediated NDBI, Project ImPACT, on children's expressive language ability using a randomized control trial with intent-to-treat analysis. Sixty-four young autistic children and their primary caregiver were matched on age and developmental quotient and randomly assigned to receive 6?months of therapist-assisted Project ImPACT (i.e., telehealth coaching), self-directed Project ImPACT, or an active control. Parent?child interactions were recorded at intake and immediately post-treatment, and the children's expressive language skills were assessed at intake and a 9-month follow-up using standardized measures. Although there was no total effect of treatment group assignment on child outcomes, a serial mediation analysis revealed that therapist-assisted ImPACT had an indirect effect on children's expressive language ability at follow-up through their parents' use of the intervention strategies and their intentional communication immediately post-treatment. Findings support Project ImPACT's program theory and highlight the importance of coaching in achieving positive outcomes when delivered via telehealth. En ligne : https://doi.org/10.1002/aur.3230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536 [article] Telehealth coaching in Project ImPACT indirectly affects children's expressive language ability through parent intervention strategy use and child intentional communication: An RCT [Texte imprimé et/ou numérique] / Brooke INGERSOLL, Auteur ; Kyle M. FROST, Auteur ; Diondra STRAITON, Auteur ; Anamiguel Pomales RAMOS, Auteur ; Karís CASAGRANDE, Auteur . - p.2177-2187. Langues : Anglais (eng) in Autism Research > 17-10 (October 2024) . - p.2177-2187 Mots-clés : autism  NDBI  parent-mediated intervention  social communication  telehealth Index. décimale : PER Périodiques Résumé : Abstract Parent-mediated, naturalistic developmental behavioral interventions (NDBIs) are a promising approach for supporting social communication development in young autistic children. This study examined the effect of telehealth delivery of a parent-mediated NDBI, Project ImPACT, on children's expressive language ability using a randomized control trial with intent-to-treat analysis. Sixty-four young autistic children and their primary caregiver were matched on age and developmental quotient and randomly assigned to receive 6?months of therapist-assisted Project ImPACT (i.e., telehealth coaching), self-directed Project ImPACT, or an active control. Parent?child interactions were recorded at intake and immediately post-treatment, and the children's expressive language skills were assessed at intake and a 9-month follow-up using standardized measures. Although there was no total effect of treatment group assignment on child outcomes, a serial mediation analysis revealed that therapist-assisted ImPACT had an indirect effect on children's expressive language ability at follow-up through their parents' use of the intervention strategies and their intentional communication immediately post-treatment. Findings support Project ImPACT's program theory and highlight the importance of coaching in achieving positive outcomes when delivered via telehealth. En ligne : https://doi.org/10.1002/aur.3230 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=536