Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort / Quanfa HE in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort Type de document : texte imprimé Auteurs : Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort [texte imprimé] / Quanfa HE, Auteur ; Taylor J. KEDING, Auteur ; Qi ZHANG, Auteur ; Jiacheng MIAO, Auteur ; Justin D. RUSSELL, Auteur ; Ryan J. HERRINGA, Auteur ; Qiongshi LU, Auteur ; Brittany G. TRAVERS, Auteur ; James J. LI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Adolescent  Humans  Attention Deficit Disorder with Hyperactivity/genetics  Neurosciences  Brain/diagnostic imaging  Cerebral Cortex  Gray Matter/diagnostic imaging  Adhd  Brain volume  Functional annotation  Multiple mediation  Polygenic scores Index. décimale : PER Périodiques Résumé : BACKGROUND: ADHD polygenic scores (PGSs) have been previously shown to predict ADHD outcomes in several studies. However, ADHD PGSs are typically correlated with ADHD but not necessarily reflective of causal mechanisms. More research is needed to elucidate the neurobiological mechanisms underlying ADHD. We leveraged functional annotation information into an ADHD PGS to (1) improve the prediction performance over a non-annotated ADHD PGS and (2) test whether volumetric variation in brain regions putatively associated with ADHD mediate the association between PGSs and ADHD outcomes. METHODS: Data were from the Philadelphia Neurodevelopmental Cohort (N = 555). Multiple mediation models were tested to examine the indirect effects of two ADHD PGSs-one using a traditional computation involving clumping and thresholding and another using a functionally annotated approach (i.e., AnnoPred)-on ADHD inattention (IA) and hyperactivity-impulsivity (HI) symptoms, via gray matter volumes in the cingulate gyrus, angular gyrus, caudate, dorsolateral prefrontal cortex (DLPFC), and inferior temporal lobe. RESULTS: A direct effect was detected between the AnnoPred ADHD PGS and IA symptoms in adolescents. No indirect effects via brain volumes were detected for either IA or HI symptoms. However, both ADHD PGSs were negatively associated with the DLPFC. CONCLUSIONS: The AnnoPred ADHD PGS was a more developmentally specific predictor of adolescent IA symptoms compared to the traditional ADHD PGS. However, brain volumes did not mediate the effects of either a traditional or AnnoPred ADHD PGS on ADHD symptoms, suggesting that we may still be underpowered in clarifying brain-based biomarkers for ADHD using genetic measures. En ligne : https://dx.doi.org/10.1186/s11689-023-09498-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Overparenting and offspring depression, anxiety, and internalizing symptoms: A meta-analysis / Qi ZHANG in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1307-1322 Titre : Overparenting and offspring depression, anxiety, and internalizing symptoms: A meta-analysis Type de document : texte imprimé Auteurs : Qi ZHANG, Auteur ; Wongeun JI, Auteur Article en page(s) : p.1307-1322 Langues : Anglais (eng) Mots-clés : Anxiety  Depression  Internalizing symptoms  Meta-analysis  Overparenting Index. décimale : PER Périodiques Résumé : Overparenting has been considered to contribute to offspring internalizing mental disorders from theoretical perspectives, which some empirical evidence has supported. However, existing findings are inconsistent. To facilitate the understanding of the association between overparenting and depression, anxiety, and internalizing symptoms, an examination of effect sizes is required. By employing the PRISMA method, a meta-analysis was conducted. Fifty-two articles were identified, with 38 studies examining depression, 30 studies examining anxiety, and 21 studies examining internalizing symptoms. The results show that overparenting is associated with offspring depression (mean age 19.94 years) (k = 133, r = .15, p < .001), anxiety (mean age 19.57 years) (k = 101, r = .14, p < .001), and internalizing symptoms (mean age 19.76 years) (k = 58, r = .19, p < .001). Moderator analyses show that the effect sizes are largely equal across SES groups, cultures, the age of offspring, child gender, and study design but may vary depending on the parental gender and report informants. Implications for interventions and future directions are discussed. En ligne : https://dx.doi.org/10.1017/S095457942300055X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Overparenting and offspring depression, anxiety, and internalizing symptoms: A meta-analysis [texte imprimé] / Qi ZHANG, Auteur ; Wongeun JI, Auteur . - p.1307-1322. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1307-1322 Mots-clés : Anxiety  Depression  Internalizing symptoms  Meta-analysis  Overparenting Index. décimale : PER Périodiques Résumé : Overparenting has been considered to contribute to offspring internalizing mental disorders from theoretical perspectives, which some empirical evidence has supported. However, existing findings are inconsistent. To facilitate the understanding of the association between overparenting and depression, anxiety, and internalizing symptoms, an examination of effect sizes is required. By employing the PRISMA method, a meta-analysis was conducted. Fifty-two articles were identified, with 38 studies examining depression, 30 studies examining anxiety, and 21 studies examining internalizing symptoms. The results show that overparenting is associated with offspring depression (mean age 19.94 years) (k = 133, r = .15, p < .001), anxiety (mean age 19.57 years) (k = 101, r = .14, p < .001), and internalizing symptoms (mean age 19.76 years) (k = 58, r = .19, p < .001). Moderator analyses show that the effect sizes are largely equal across SES groups, cultures, the age of offspring, child gender, and study design but may vary depending on the parental gender and report informants. Implications for interventions and future directions are discussed. En ligne : https://dx.doi.org/10.1017/S095457942300055X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

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