Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention / Kit K. ELAM in Development and Psychopathology, 38-2 (May 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-2 (May 2026) . - p.732-742 Titre : Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention Type de document : texte imprimé Auteurs : Kit K. ELAM, Auteur ; Daniel SHAW, Auteur ; Erika WESTLING, Auteur ; Jazmin BROWN-IANNUZZI, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.732-742 Langues : Anglais (eng) Mots-clés : Adolescence  depressive symptoms  polygenic  substance use  trajectories Index. décimale : PER Périodiques Résumé : Research finds genetic predisposition for depression is associated with increases in depression across adolescence and adulthood. In turn, depressive symptoms in adolescence are associated with substance use. However, there has been modest examination of genetic predisposition for depression, growth in depressive symptoms, and substance use from late childhood through adolescence, and mostly in White samples. Also, psychosocial interventions can attenuate associations between genetic predisposition and psychopathology, a genotype by intervention (GxI) effect. We examined associations among polygenic risk for depression, growth in depressive symptoms from age 7 to 16, and substance use at age 16, as well as moderation by a family-based preventive intervention. Participants were African-ancestry (n = 154) and European-ancestry (n = 219) youth from the Early Steps Multisite Study, half of whom participated in the Family Check-Up intervention. A small polygenic by intervention effect was found on reductions in depressive symptoms for African-ancestry youth, and growth in depressive symptoms was positively associated with substance use at age 16. In sensitivity analyses, a small GxI effect was detected in European-ancestry youth on reductions in depressive symptom slopes from age 10 to 16. These findings highlight how early intervention can buffer genetic effects on depressive symptoms over time. En ligne : https://dx.doi.org/10.1017/S0954579425100709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586 [article] Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention [texte imprimé] / Kit K. ELAM, Auteur ; Daniel SHAW, Auteur ; Erika WESTLING, Auteur ; Jazmin BROWN-IANNUZZI, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.732-742. Langues : Anglais (eng) in Development and Psychopathology > 38-2 (May 2026) . - p.732-742 Mots-clés : Adolescence  depressive symptoms  polygenic  substance use  trajectories Index. décimale : PER Périodiques Résumé : Research finds genetic predisposition for depression is associated with increases in depression across adolescence and adulthood. In turn, depressive symptoms in adolescence are associated with substance use. However, there has been modest examination of genetic predisposition for depression, growth in depressive symptoms, and substance use from late childhood through adolescence, and mostly in White samples. Also, psychosocial interventions can attenuate associations between genetic predisposition and psychopathology, a genotype by intervention (GxI) effect. We examined associations among polygenic risk for depression, growth in depressive symptoms from age 7 to 16, and substance use at age 16, as well as moderation by a family-based preventive intervention. Participants were African-ancestry (n = 154) and European-ancestry (n = 219) youth from the Early Steps Multisite Study, half of whom participated in the Family Check-Up intervention. A small polygenic by intervention effect was found on reductions in depressive symptoms for African-ancestry youth, and growth in depressive symptoms was positively associated with substance use at age 16. In sensitivity analyses, a small GxI effect was detected in European-ancestry youth on reductions in depressive symptom slopes from age 10 to 16. These findings highlight how early intervention can buffer genetic effects on depressive symptoms over time. En ligne : https://dx.doi.org/10.1017/S0954579425100709 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=586

How pubertal timing and self-regulation predict adolescent sexual activity in resource-poor environments / Roy OTTEN in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1941-1947 Titre : How pubertal timing and self-regulation predict adolescent sexual activity in resource-poor environments Type de document : texte imprimé Auteurs : Roy OTTEN, Auteur ; Thao HA, Auteur ; Erika WESTLING, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Melvin N. WILSON, Auteur ; Daniel S. SHAW, Auteur Article en page(s) : p.1941-1947 Langues : Anglais (eng) Mots-clés : adolescence  puberty  self-regulation  sexual activity Index. décimale : PER Périodiques Résumé : Studies found support for a link between pubertal timing and self-regulation in low-resource environments. This link could potentially explain a link between pubertal timing and early risk behavior. This study builds on this body of research by examining the mediated effect of pubertal timing on sexual activity through self-regulation in 728 adolescents and their families in a group with poor resources and a group with adequate resources. Income-to-Needs (ITN) was measured at age 7.5 to establish two groups (low-ITN and Medium/High-ITN). Pubertal timing was measured at age 10.5, self-regulation was assessed at age 14 and operationalized with effortful control, and sexual activity was assessed at age 16. Structural equation modeling was employed to test the hypothesized model in both groups. The link between pubertal timing and sexual activity mediated by effortful control was only significant in the low-ITN group. Specifically, more advanced pubertal maturity was associated with lower levels of adolescents' effortful control, which in turn was associated with more sexual activity at age 16. Findings were partially replicated with a drug use index replacing sexual activity. This study shows a different operating link from pubertal timing to effortful control and subsequent risk behavior in resource-poor environments. Implications are discussed. En ligne : https://dx.doi.org/10.1017/S095457942300127X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] How pubertal timing and self-regulation predict adolescent sexual activity in resource-poor environments [texte imprimé] / Roy OTTEN, Auteur ; Thao HA, Auteur ; Erika WESTLING, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Melvin N. WILSON, Auteur ; Daniel S. SHAW, Auteur . - p.1941-1947. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1941-1947 Mots-clés : adolescence  puberty  self-regulation  sexual activity Index. décimale : PER Périodiques Résumé : Studies found support for a link between pubertal timing and self-regulation in low-resource environments. This link could potentially explain a link between pubertal timing and early risk behavior. This study builds on this body of research by examining the mediated effect of pubertal timing on sexual activity through self-regulation in 728 adolescents and their families in a group with poor resources and a group with adequate resources. Income-to-Needs (ITN) was measured at age 7.5 to establish two groups (low-ITN and Medium/High-ITN). Pubertal timing was measured at age 10.5, self-regulation was assessed at age 14 and operationalized with effortful control, and sexual activity was assessed at age 16. Structural equation modeling was employed to test the hypothesized model in both groups. The link between pubertal timing and sexual activity mediated by effortful control was only significant in the low-ITN group. Specifically, more advanced pubertal maturity was associated with lower levels of adolescents' effortful control, which in turn was associated with more sexual activity at age 16. Findings were partially replicated with a drug use index replacing sexual activity. This study shows a different operating link from pubertal timing to effortful control and subsequent risk behavior in resource-poor environments. Implications are discussed. En ligne : https://dx.doi.org/10.1017/S095457942300127X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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