Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood / Amy SHAKESHAFT in Journal of Child Psychology and Psychiatry, 64-11 (November 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607 Titre : Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood Type de document : texte imprimé Auteurs : Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.1596-1607 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25 years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood [texte imprimé] / Amy SHAKESHAFT, Auteur ; Jon HERON, Auteur ; Rachel BLAKEY, Auteur ; Lucy RIGLIN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.1596-1607. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-11 (November 2023) . - p.1596-1607 Index. décimale : PER Périodiques Résumé : Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or disorders, commonly co-occur. Developmental trajectories of ADHD and autistic traits both show heterogeneity in onset and course, but little is known about how symptom trajectories co-develop into adulthood. Methods Using data from a population cohort, the Avon Longitudinal Study of Parents and Children, we examined correlations between ADHD and autistic traits across development, using the Social Communication Disorders Checklist and ADHD subscale of the Strengths and Difficulties Questionnaire. We modelled joint developmental trajectories of parent-reported ADHD and autistic traits between 4 and 25 years, then characterised trajectory classes based on sociodemographic, perinatal, psychopathology, cognition and social functioning variables and tested for associations with neurodevelopmental/psychiatric polygenic scores (PGS). Results Three classes of trajectories were identified; a typically developing majority with low-stable ADHD-autistic traits (87%), a male-predominant subgroup with child/adolescent-declining traits (6%) and a subgroup with late-emerging traits (6%). ADHD-autistic trait correlations were greatest in young adulthood for the two nontypically developing classes. There were higher rates of emotional and conduct problems, low IQ, childhood seizures and poor social functioning in the declining and late-emerging classes compared to the low-stable class. Emotional, conduct and peer problems were more prevalent during childhood in the childhood/adolescent-declining class compared to other classes, but were more prevalent in young adulthood in the late-emerging class. Neurodevelopmental/psychiatric PGS also differed: both nontypically developing classes showed elevated ADHD PGS compared to the low-stable group, and the late-emerging group additionally showed elevated schizophrenia PGS and decreased executive function PGS, whereas the declining group showed elevated broad depression PGS. Conclusions Distinct patterns of ADHD-autism co-development are present across development in the general population, each with different characterising factors and genetic signatures as indexed by PGS. En ligne : https://doi.org/10.1111/jcpp.13851 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents / Alice STEPHENS in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Titre : Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents Type de document : texte imprimé Auteurs : Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur Article en page(s) : p.367-375 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents [texte imprimé] / Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur . - p.367-375. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways / Naomi WARNE in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.797-806 Titre : Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways Type de document : texte imprimé Auteurs : Naomi WARNE, Auteur ; Jon HERON, Auteur ; Becky MARS, Auteur ; Francesca SOLMI, Auteur ; Lucy BIDDLE, Auteur ; David GUNNELL, Auteur ; Gemma HAMMERTON, Auteur ; Paul MORAN, Auteur ; Marcus R. MUNAFO, Auteur ; Ian S. PENTON-VOAK, Auteur ; Andy SKINNER, Auteur ; Anne STEWART, Auteur ; Helen BOULD, Auteur Article en page(s) : p.797-806 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Emotional dysregulation may be a risk factor for disordered eating and self-harm in young people, but few prospective studies have assessed these associations long-term, or considered potential mediators. We examined prospective relationships between childhood emotional dysregulation and disordered eating and self-harm in adolescence; and social cognition, emotional recognition, and being bullied as mediators. Methods We analysed Avon Longitudinal Study of Parents and Children data on 3,453 males and 3,481 females. We examined associations between emotional dysregulation at 7 years and any disordered eating and any self-harm at 16 years with probit regression models. We also assessed whether social cognition (7 years), emotional recognition (8 years) and bullying victimisation (11 years) mediated these relationships. Results Emotional dysregulation at age 7 years was associated with disordered eating [fully adjusted probit B (95% CI) = 0.082 (0.029, 0.134)] and self-harm [fully adjusted probit B (95% CI) = 0.093 (0.036, 0.150)] at age 16 years. There was no evidence of sex interactions or difference in effects between self-harm and disordered eating. Mediation models found social cognition was a key pathway to disordered eating (females 51.2%; males 27.0% of total effect) and self-harm (females 15.7%; males 10.8% of total effect). Bullying victimisation was an important pathway to disordered eating (females 17.1%; males 10.0% of total effect), but only to self-harm in females (15.7% of total effect). Indirect effects were stronger for disordered eating than self-harm. Conclusions In males and females, emotional dysregulation in early childhood is associated with disordered eating and self-harm in adolescence and may be a useful target for prevention and treatment. Mediating pathways appeared to differ by sex and outcome, but social cognition was a key mediating pathway for both disordered eating and self-harm. En ligne : https://doi.org/10.1111/jcpp.13738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways [texte imprimé] / Naomi WARNE, Auteur ; Jon HERON, Auteur ; Becky MARS, Auteur ; Francesca SOLMI, Auteur ; Lucy BIDDLE, Auteur ; David GUNNELL, Auteur ; Gemma HAMMERTON, Auteur ; Paul MORAN, Auteur ; Marcus R. MUNAFO, Auteur ; Ian S. PENTON-VOAK, Auteur ; Andy SKINNER, Auteur ; Anne STEWART, Auteur ; Helen BOULD, Auteur . - p.797-806. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.797-806 Index. décimale : PER Périodiques Résumé : Background Emotional dysregulation may be a risk factor for disordered eating and self-harm in young people, but few prospective studies have assessed these associations long-term, or considered potential mediators. We examined prospective relationships between childhood emotional dysregulation and disordered eating and self-harm in adolescence; and social cognition, emotional recognition, and being bullied as mediators. Methods We analysed Avon Longitudinal Study of Parents and Children data on 3,453 males and 3,481 females. We examined associations between emotional dysregulation at 7 years and any disordered eating and any self-harm at 16 years with probit regression models. We also assessed whether social cognition (7 years), emotional recognition (8 years) and bullying victimisation (11 years) mediated these relationships. Results Emotional dysregulation at age 7 years was associated with disordered eating [fully adjusted probit B (95% CI) = 0.082 (0.029, 0.134)] and self-harm [fully adjusted probit B (95% CI) = 0.093 (0.036, 0.150)] at age 16 years. There was no evidence of sex interactions or difference in effects between self-harm and disordered eating. Mediation models found social cognition was a key pathway to disordered eating (females 51.2%; males 27.0% of total effect) and self-harm (females 15.7%; males 10.8% of total effect). Bullying victimisation was an important pathway to disordered eating (females 17.1%; males 10.0% of total effect), but only to self-harm in females (15.7% of total effect). Indirect effects were stronger for disordered eating than self-harm. Conclusions In males and females, emotional dysregulation in early childhood is associated with disordered eating and self-harm in adolescence and may be a useful target for prevention and treatment. Mediating pathways appeared to differ by sex and outcome, but social cognition was a key mediating pathway for both disordered eating and self-harm. En ligne : https://doi.org/10.1111/jcpp.13738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Externalising pathways to alcohol-related problems in emerging adulthood / Gemma HAMMERTON in Journal of Child Psychology and Psychiatry, 61-6 (June 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.721-731 Titre : Externalising pathways to alcohol-related problems in emerging adulthood Type de document : texte imprimé Auteurs : Gemma HAMMERTON, Auteur ; Alexis C. EDWARDS, Auteur ; Liam MAHEDY, Auteur ; Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Kenneth S. KENDLER, Auteur ; Matthew HICKMAN, Auteur ; Jon HERON, Auteur Article en page(s) : p.721-731 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  alcohol-related problems  conduct problems  criminal behaviour  mediation Index. décimale : PER Périodiques Résumé : BACKGROUND: Both 'early-onset persistent' and 'adolescent-onset' conduct problems (CPs) are associated with alcohol-related problems in emerging adulthood. The escalation of early CPs into criminal behaviour and heavy alcohol consumption prior to emerging adulthood are both likely to be important pathways. METHODS: Data were analysed from 3,038 young people in a UK birth cohort, the Avon Longitudinal Study of Parents and Children. The exposure was developmental trajectories of CPs ('low', 'childhood-limited', 'adolescent-onset' and 'early-onset persistent') between ages 4 and 13 years. The mediator was latent classes representing heavy alcohol consumption and/ or criminal behaviour at age 15 years. For the outcome, a quadratic latent growth curve was estimated to capture nonlinear change in alcohol-related problems between ages 18 and 23 years. RESULTS: Those with 'early-onset persistent' [b(95% CI) = 1.16 (0.17, 2.14)] and 'adolescent-onset' CPs [b(95% CI) = 1.31 (0.17, 2.45)] had higher levels of alcohol-related problems at age 18 years compared to those with 'low' CPs', but there was little evidence of an association with alcohol-related problems after age 19 years. There was evidence for an indirect effect of 'early-onset persistent' CPs [b(95% CI) = 1.12 (0.52, 1.72)] on alcohol-related problems at age 18 years via the latent classes of alcohol and criminal behaviour in adolescence. This was not found for 'adolescent-onset' CPs [b(95% CI) = 0.35 (-0.36, 1.07)]. CONCLUSIONS: Strong associations exist between early CPs, adolescent alcohol consumption and criminal behaviour and alcohol-related problems at age 18 years. Associations between early CPs and alcohol-related problems weakened considerably across emerging adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Externalising pathways to alcohol-related problems in emerging adulthood [texte imprimé] / Gemma HAMMERTON, Auteur ; Alexis C. EDWARDS, Auteur ; Liam MAHEDY, Auteur ; Joseph MURRAY, Auteur ; Barbara MAUGHAN, Auteur ; Kenneth S. KENDLER, Auteur ; Matthew HICKMAN, Auteur ; Jon HERON, Auteur . - p.721-731. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-6 (June 2020) . - p.721-731 Mots-clés : Avon Longitudinal Study of Parents and Children  alcohol-related problems  conduct problems  criminal behaviour  mediation Index. décimale : PER Périodiques Résumé : BACKGROUND: Both 'early-onset persistent' and 'adolescent-onset' conduct problems (CPs) are associated with alcohol-related problems in emerging adulthood. The escalation of early CPs into criminal behaviour and heavy alcohol consumption prior to emerging adulthood are both likely to be important pathways. METHODS: Data were analysed from 3,038 young people in a UK birth cohort, the Avon Longitudinal Study of Parents and Children. The exposure was developmental trajectories of CPs ('low', 'childhood-limited', 'adolescent-onset' and 'early-onset persistent') between ages 4 and 13 years. The mediator was latent classes representing heavy alcohol consumption and/ or criminal behaviour at age 15 years. For the outcome, a quadratic latent growth curve was estimated to capture nonlinear change in alcohol-related problems between ages 18 and 23 years. RESULTS: Those with 'early-onset persistent' [b(95% CI) = 1.16 (0.17, 2.14)] and 'adolescent-onset' CPs [b(95% CI) = 1.31 (0.17, 2.45)] had higher levels of alcohol-related problems at age 18 years compared to those with 'low' CPs', but there was little evidence of an association with alcohol-related problems after age 19 years. There was evidence for an indirect effect of 'early-onset persistent' CPs [b(95% CI) = 1.12 (0.52, 1.72)] on alcohol-related problems at age 18 years via the latent classes of alcohol and criminal behaviour in adolescence. This was not found for 'adolescent-onset' CPs [b(95% CI) = 0.35 (-0.36, 1.07)]. CONCLUSIONS: Strong associations exist between early CPs, adolescent alcohol consumption and criminal behaviour and alcohol-related problems at age 18 years. Associations between early CPs and alcohol-related problems weakened considerably across emerging adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13167 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children / Abigail E. RUSSELL in Journal of Child Psychology and Psychiatry, 60-10 (October 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103 Titre : Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children Type de document : texte imprimé Auteurs : Abigail E. RUSSELL, Auteur ; Jon HERON, Auteur ; David GUNNELL, Auteur ; Tamsin FORD, Auteur ; Gibran HEMANI, Auteur ; C. JOINSON, Auteur ; Paul MORAN, Auteur ; Caroline L. RELTON, Auteur ; Matthew SUDERMAN, Auteur ; Becky MARS, Auteur Article en page(s) : p.1094-1103 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  C-reactive protein  Inflammation  Self-harm  adverse childhood experiences  interleukin-6  mediation  suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Pathways between early-life adversity and adolescent self-harm: the mediating role of inflammation in the Avon Longitudinal Study of Parents and Children [texte imprimé] / Abigail E. RUSSELL, Auteur ; Jon HERON, Auteur ; David GUNNELL, Auteur ; Tamsin FORD, Auteur ; Gibran HEMANI, Auteur ; C. JOINSON, Auteur ; Paul MORAN, Auteur ; Caroline L. RELTON, Auteur ; Matthew SUDERMAN, Auteur ; Becky MARS, Auteur . - p.1094-1103. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-10 (October 2019) . - p.1094-1103 Mots-clés : Avon Longitudinal Study of Parents and Children  C-reactive protein  Inflammation  Self-harm  adverse childhood experiences  interleukin-6  mediation  suicide Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experiences (ACEs) such as physical and emotional abuse are strongly associated with self-harm, but mechanisms underlying this relationship are unclear. Inflammation has been linked to both the experience of ACEs and self-harm or suicide in prior research. This is the first study to examine whether inflammatory markers mediate the association between exposure to ACEs and self-harm. METHODS: Participants were 4,308 young people from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based birth cohort in the United Kingdom. A structural equation modelling approach was used to fit a mediation model with the number of ACEs experienced between ages 0 and 9 years old (yo), levels of the inflammatory markers interleukin-6 and C-reactive protein measured at 9.5 yo, and self-harm reported at 16 yo. RESULTS: The mean number of ACEs young people experienced was 1.41 (SE 0.03). Higher ACE scores were associated with an increased risk of self-harm at 16 yo (direct effect relative risk (RR) per additional ACE 1.11, 95% CI 1.05, 1.18, p < 0.001). We did not find evidence of an indirect effect of ACEs on self-harm via inflammation (RR 1.00, 95% CI 1.00, 1.01, p = 0.38). CONCLUSIONS: Young people who have been exposed to ACEs are a group at high risk of self-harm. The association between ACEs and self-harm does not appear to be mediated by an inflammatory process in childhood, as indexed by peripheral levels of circulating inflammatory markers measured in childhood. Further research is needed to identify alternative psychological and biological mechanisms underlying this relationship. En ligne : http://dx.doi.org/10.1111/jcpp.13100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year / Séverine LANNOY in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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The development of autistic social traits across childhood and adolescence in males and females / William MANDY in Journal of Child Psychology and Psychiatry, 59-11 (November 2018)  

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The effects of pre- and postnatal depression in fathers: a natural experiment comparing the effects of exposure to depression on offspring / Paul G. RAMCHANDANI in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

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The longitudinal heterogeneity of autistic traits: A systematic review / Richard PENDER in Research in Autism Spectrum Disorders, 79 (November 2020)  

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The timing of maternal depressive symptoms and child cognitive development: a longitudinal study / Jonathan P. EVANS in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)  

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What distinguishes adolescents with suicidal thoughts from those who have attempted suicide? A population-based birth cohort study / Becky MARS in Journal of Child Psychology and Psychiatry, 60-1 (January 2019)  

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