Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways / Naomi WARNE in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.797-806 Titre : Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways Type de document : Texte imprimé et/ou numérique Auteurs : Naomi WARNE, Auteur ; Jon HERON, Auteur ; Becky MARS, Auteur ; Francesca SOLMI, Auteur ; Lucy BIDDLE, Auteur ; David GUNNELL, Auteur ; Gemma HAMMERTON, Auteur ; Paul MORAN, Auteur ; Marcus MUNAFO, Auteur ; Ian PENTON-VOAK, Auteur ; Andy SKINNER, Auteur ; Anne STEWART, Auteur ; Helen BOULD, Auteur Article en page(s) : p.797-806 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Emotional dysregulation may be a risk factor for disordered eating and self-harm in young people, but few prospective studies have assessed these associations long-term, or considered potential mediators. We examined prospective relationships between childhood emotional dysregulation and disordered eating and self-harm in adolescence; and social cognition, emotional recognition, and being bullied as mediators. Methods We analysed Avon Longitudinal Study of Parents and Children data on 3,453 males and 3,481 females. We examined associations between emotional dysregulation at 7?years and any disordered eating and any self-harm at 16?years with probit regression models. We also assessed whether social cognition (7?years), emotional recognition (8?years) and bullying victimisation (11?years) mediated these relationships. Results Emotional dysregulation at age 7?years was associated with disordered eating [fully adjusted probit B (95% CI) = 0.082 (0.029, 0.134)] and self-harm [fully adjusted probit B (95% CI) = 0.093 (0.036, 0.150)] at age 16?years. There was no evidence of sex interactions or difference in effects between self-harm and disordered eating. Mediation models found social cognition was a key pathway to disordered eating (females 51.2%; males 27.0% of total effect) and self-harm (females 15.7%; males 10.8% of total effect). Bullying victimisation was an important pathway to disordered eating (females 17.1%; males 10.0% of total effect), but only to self-harm in females (15.7% of total effect). Indirect effects were stronger for disordered eating than self-harm. Conclusions In males and females, emotional dysregulation in early childhood is associated with disordered eating and self-harm in adolescence and may be a useful target for prevention and treatment. Mediating pathways appeared to differ by sex and outcome, but social cognition was a key mediating pathway for both disordered eating and self-harm. En ligne : https://doi.org/10.1111/jcpp.13738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Emotional dysregulation in childhood and disordered eating and self-harm in adolescence: prospective associations and mediating pathways [Texte imprimé et/ou numérique] / Naomi WARNE, Auteur ; Jon HERON, Auteur ; Becky MARS, Auteur ; Francesca SOLMI, Auteur ; Lucy BIDDLE, Auteur ; David GUNNELL, Auteur ; Gemma HAMMERTON, Auteur ; Paul MORAN, Auteur ; Marcus MUNAFO, Auteur ; Ian PENTON-VOAK, Auteur ; Andy SKINNER, Auteur ; Anne STEWART, Auteur ; Helen BOULD, Auteur . - p.797-806. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-5 (May 2023) . - p.797-806 Index. décimale : PER Périodiques Résumé : Background Emotional dysregulation may be a risk factor for disordered eating and self-harm in young people, but few prospective studies have assessed these associations long-term, or considered potential mediators. We examined prospective relationships between childhood emotional dysregulation and disordered eating and self-harm in adolescence; and social cognition, emotional recognition, and being bullied as mediators. Methods We analysed Avon Longitudinal Study of Parents and Children data on 3,453 males and 3,481 females. We examined associations between emotional dysregulation at 7?years and any disordered eating and any self-harm at 16?years with probit regression models. We also assessed whether social cognition (7?years), emotional recognition (8?years) and bullying victimisation (11?years) mediated these relationships. Results Emotional dysregulation at age 7?years was associated with disordered eating [fully adjusted probit B (95% CI) = 0.082 (0.029, 0.134)] and self-harm [fully adjusted probit B (95% CI) = 0.093 (0.036, 0.150)] at age 16?years. There was no evidence of sex interactions or difference in effects between self-harm and disordered eating. Mediation models found social cognition was a key pathway to disordered eating (females 51.2%; males 27.0% of total effect) and self-harm (females 15.7%; males 10.8% of total effect). Bullying victimisation was an important pathway to disordered eating (females 17.1%; males 10.0% of total effect), but only to self-harm in females (15.7% of total effect). Indirect effects were stronger for disordered eating than self-harm. Conclusions In males and females, emotional dysregulation in early childhood is associated with disordered eating and self-harm in adolescence and may be a useful target for prevention and treatment. Mediating pathways appeared to differ by sex and outcome, but social cognition was a key mediating pathway for both disordered eating and self-harm. En ligne : https://doi.org/10.1111/jcpp.13738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Maternal depression and co-occurring antisocial behaviour: testing maternal hostility and warmth as mediators of risk for offspring psychopathology / Ruth SELLERS in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.112-120 Titre : Maternal depression and co-occurring antisocial behaviour: testing maternal hostility and warmth as mediators of risk for offspring psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Ruth SELLERS, Auteur ; Gordon T. HAROLD, Auteur ; Kit ELAM, Auteur ; Kimberly A. RHOADES, Auteur ; Robert POTTER, Auteur ; Becky MARS, Auteur ; Nick CRADDOCK, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur Article en page(s) : p.112-120 Langues : Anglais (eng) Mots-clés : Hostility  warmth  mediation  depression  antisocial behaviour  disruptive behaviour Index. décimale : PER Périodiques Résumé : Background Disruption in the parent–child relationship is a commonly hypothesized risk factor through which maternal depression may increase risk for offspring psychopathology. However, maternal depression is commonly accompanied by other psychopathology, including antisocial behaviour. Few studies have examined the role of co-occurring psychopathology in depressed mothers. Using a longitudinal study of offspring of mothers with recurrent depression, we aimed to test whether maternal warmth/hostility mediated links between maternal depression severity and child outcomes, and how far direct and indirect pathways were robust to controls for co-occurring maternal antisocial behaviour. Methods Mothers with a history of recurrent major depressive disorder and their adolescent offspring (9–17 years at baseline) were assessed three times between 2007 and 2010. Mothers completed questionnaires assessing their own depression severity and antisocial behaviour at Time 1 (T1). The parent–child relationship was assessed using parent-rated questionnaire and interviewer-rated 5-min speech sample at Time 2 (T2). Offspring symptoms of depression and disruptive behaviours were assessed using the Child and Adolescent Psychiatric Assessment at Time 3 (T3). Results Maternal hostility and warmth, respectively, mediated the association between maternal depression severity and risk for offspring psychopathology. However, the effects were attenuated when maternal antisocial behaviour was included in the analysis. In tests of the full theoretical model, maternal antisocial behaviour predicted both maternal hostility and low warmth, maternal hostility predicted offspring disruptive behaviour disorder symptoms, but not depression, and maternal warmth was not associated with either child outcome. Conclusions Parenting interventions aimed at reducing hostility may be beneficial for preventing or reducing adolescent disruptive behaviours in offspring of depressed mothers, especially when depressed mothers report co-occurring antisocial behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Maternal depression and co-occurring antisocial behaviour: testing maternal hostility and warmth as mediators of risk for offspring psychopathology [Texte imprimé et/ou numérique] / Ruth SELLERS, Auteur ; Gordon T. HAROLD, Auteur ; Kit ELAM, Auteur ; Kimberly A. RHOADES, Auteur ; Robert POTTER, Auteur ; Becky MARS, Auteur ; Nick CRADDOCK, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur . - p.112-120. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.112-120 Mots-clés : Hostility  warmth  mediation  depression  antisocial behaviour  disruptive behaviour Index. décimale : PER Périodiques Résumé : Background Disruption in the parent–child relationship is a commonly hypothesized risk factor through which maternal depression may increase risk for offspring psychopathology. However, maternal depression is commonly accompanied by other psychopathology, including antisocial behaviour. Few studies have examined the role of co-occurring psychopathology in depressed mothers. Using a longitudinal study of offspring of mothers with recurrent depression, we aimed to test whether maternal warmth/hostility mediated links between maternal depression severity and child outcomes, and how far direct and indirect pathways were robust to controls for co-occurring maternal antisocial behaviour. Methods Mothers with a history of recurrent major depressive disorder and their adolescent offspring (9–17 years at baseline) were assessed three times between 2007 and 2010. Mothers completed questionnaires assessing their own depression severity and antisocial behaviour at Time 1 (T1). The parent–child relationship was assessed using parent-rated questionnaire and interviewer-rated 5-min speech sample at Time 2 (T2). Offspring symptoms of depression and disruptive behaviours were assessed using the Child and Adolescent Psychiatric Assessment at Time 3 (T3). Results Maternal hostility and warmth, respectively, mediated the association between maternal depression severity and risk for offspring psychopathology. However, the effects were attenuated when maternal antisocial behaviour was included in the analysis. In tests of the full theoretical model, maternal antisocial behaviour predicted both maternal hostility and low warmth, maternal hostility predicted offspring disruptive behaviour disorder symptoms, but not depression, and maternal warmth was not associated with either child outcome. Conclusions Parenting interventions aimed at reducing hostility may be beneficial for preventing or reducing adolescent disruptive behaviours in offspring of depressed mothers, especially when depressed mothers report co-occurring antisocial behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year / Séverine LANNOY in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1164-1173 Titre : Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year Type de document : Texte imprimé et/ou numérique Auteurs : Séverine LANNOY, Auteur ; Becky MARS, Auteur ; Jon HERON, Auteur ; Alexis C. EDWARDS, Auteur Année de publication : 2022 Article en page(s) : p.1164-1173 Langues : Anglais (eng) Mots-clés : Adolescent  Bullying  Female  Humans  Male  Risk Factors  Schools  Substance-Related Disorders  Suicidal Ideation  Suicide, Attempted  Alspac  environment  genes  polygenic  suicidality Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggregate genetic liability and its possible interaction with negative life events. Moreover, information is needed to understand how these factors differently affect STB in boys and girls. METHODS: We evaluated suicidal ideation at 17years old and examined the role of aggregate genetic liability, negative life events, and their interaction in a sample of 2,571 adolescents. Aggregate genetic liability was measured using a polygenic score (PGS) for suicide attempts. Negative life events were assessed in the past year and included parental divorce and hospitalizations, death of friends and relatives, bullying, failure-related events, and involvement with drugs. We conducted univariable and multivariable general linear models stratified by sex and evaluated the interactions between PGS and negative life events in subsequent models. RESULTS: Analyses showed that suicidal ideation in boys is associated with failure to achieve something important (estimate=0.198), bullying (estimate=0.285), drug use (estimate=0.325), and parental death (estimate=0.923). In girls, both aggregate genetic liability (estimate=0.041) and negative life events (failure at school [estimate=0.120], failure to achieve something important [estimate=0.279], drug use [estimate=0.395], and bullying [estimate=0.472]) were associated with suicidal ideation. Interaction analyses suggested that PGS interacted with drug use and failures at school, though this would need additional support. CONCLUSIONS: These findings represent significant contributions to the fundamental understanding of STB in adolescence, suggesting to monitor the impact of negative life events during adolescence to better prevent suicide risk. Genetic liability is also of importance in girls and might influence the way they respond to environmental threats. En ligne : http://dx.doi.org/10.1111/jcpp.13653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Suicidal ideation during adolescence: The roles of aggregate genetic liability for suicide attempts and negative life events in the past year [Texte imprimé et/ou numérique] / Séverine LANNOY, Auteur ; Becky MARS, Auteur ; Jon HERON, Auteur ; Alexis C. EDWARDS, Auteur . - 2022 . - p.1164-1173. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1164-1173 Mots-clés : Adolescent  Bullying  Female  Humans  Male  Risk Factors  Schools  Substance-Related Disorders  Suicidal Ideation  Suicide, Attempted  Alspac  environment  genes  polygenic  suicidality Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggregate genetic liability and its possible interaction with negative life events. Moreover, information is needed to understand how these factors differently affect STB in boys and girls. METHODS: We evaluated suicidal ideation at 17years old and examined the role of aggregate genetic liability, negative life events, and their interaction in a sample of 2,571 adolescents. Aggregate genetic liability was measured using a polygenic score (PGS) for suicide attempts. Negative life events were assessed in the past year and included parental divorce and hospitalizations, death of friends and relatives, bullying, failure-related events, and involvement with drugs. We conducted univariable and multivariable general linear models stratified by sex and evaluated the interactions between PGS and negative life events in subsequent models. RESULTS: Analyses showed that suicidal ideation in boys is associated with failure to achieve something important (estimate=0.198), bullying (estimate=0.285), drug use (estimate=0.325), and parental death (estimate=0.923). In girls, both aggregate genetic liability (estimate=0.041) and negative life events (failure at school [estimate=0.120], failure to achieve something important [estimate=0.279], drug use [estimate=0.395], and bullying [estimate=0.472]) were associated with suicidal ideation. Interaction analyses suggested that PGS interacted with drug use and failures at school, though this would need additional support. CONCLUSIONS: These findings represent significant contributions to the fundamental understanding of STB in adolescence, suggesting to monitor the impact of negative life events during adolescence to better prevent suicide risk. Genetic liability is also of importance in girls and might influence the way they respond to environmental threats. En ligne : http://dx.doi.org/10.1111/jcpp.13653 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts / Abigail E. RUSSELL ; Laura D. HOWE ; Annie HERBERT ; Andrew D. A. C. SMITH ; Helen L. FISHER ; Jessie R. BALDWIN ; Louise ARSENEAULT ; Andrea DANESE ; Becky MARS in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1369-1387 Titre : The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Abigail E. RUSSELL, Auteur ; Laura D. HOWE, Auteur ; Annie HERBERT, Auteur ; Andrew D. A. C. SMITH, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur ; Louise ARSENEAULT, Auteur ; Andrea DANESE, Auteur ; Becky MARS, Auteur Article en page(s) : p.1369-1387 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  self-harm  depression  ALSPAC  E-Risk  MCS  cohort  developmental timing  accumulation of risk Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure to ACEs on co-occurring self-harm and depression. Methods Data were utilised from over 22,000 children and adolescents participating in three UK cohorts, followed up longitudinally for 14?18?years: the Avon Longitudinal Study of Parents and Children (ALSPAC), the Millennium Cohort Study (MCS) and the Environmental Risk (E-Risk) Longitudinal Twin Study. Multinomial logistic regression models estimated associations between each ACE type and a four-category outcome: no self-harm or depression, self-harm alone, depression alone and self-harm with co-occurring depression. A structured life course modelling approach was used to examine whether the accumulation (duration) of exposure to each ACE, or a critical period (timing of ACEs) had the strongest effects on self-harm and depression in adolescence. Results The majority of ACEs were associated with co-occurring self-harm and depression, with consistent findings across cohorts. The importance of timing and duration of ACEs differed across ACEs and across cohorts. For parental mental health problems, longer duration of exposure was strongly associated with co-occurring self-harm and depression in both ALSPAC (adjusted OR: 1.18, 95% CI: 1.10?1.25) and MCS (1.18, 1.11?1.26) cohorts. For other ACEs in ALSPAC, exposure in middle childhood was most strongly associated with co-occurring self-harm and depression, and ACE occurrence in early childhood and adolescence was more important in the MCS. Conclusions Efforts to mitigate the impact of ACEs should start in early life with continued support throughout childhood, to prevent long-term exposure to ACEs contributing to risk of self-harm and depression in adolescence. En ligne : https://doi.org/10.1111/jcpp.13986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts [Texte imprimé et/ou numérique] / Abigail E. RUSSELL, Auteur ; Laura D. HOWE, Auteur ; Annie HERBERT, Auteur ; Andrew D. A. C. SMITH, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur ; Louise ARSENEAULT, Auteur ; Andrea DANESE, Auteur ; Becky MARS, Auteur . - p.1369-1387. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1369-1387 Mots-clés : Adverse childhood experiences  self-harm  depression  ALSPAC  E-Risk  MCS  cohort  developmental timing  accumulation of risk Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure to ACEs on co-occurring self-harm and depression. Methods Data were utilised from over 22,000 children and adolescents participating in three UK cohorts, followed up longitudinally for 14?18?years: the Avon Longitudinal Study of Parents and Children (ALSPAC), the Millennium Cohort Study (MCS) and the Environmental Risk (E-Risk) Longitudinal Twin Study. Multinomial logistic regression models estimated associations between each ACE type and a four-category outcome: no self-harm or depression, self-harm alone, depression alone and self-harm with co-occurring depression. A structured life course modelling approach was used to examine whether the accumulation (duration) of exposure to each ACE, or a critical period (timing of ACEs) had the strongest effects on self-harm and depression in adolescence. Results The majority of ACEs were associated with co-occurring self-harm and depression, with consistent findings across cohorts. The importance of timing and duration of ACEs differed across ACEs and across cohorts. For parental mental health problems, longer duration of exposure was strongly associated with co-occurring self-harm and depression in both ALSPAC (adjusted OR: 1.18, 95% CI: 1.10?1.25) and MCS (1.18, 1.11?1.26) cohorts. For other ACEs in ALSPAC, exposure in middle childhood was most strongly associated with co-occurring self-harm and depression, and ACE occurrence in early childhood and adolescence was more important in the MCS. Conclusions Efforts to mitigate the impact of ACEs should start in early life with continued support throughout childhood, to prevent long-term exposure to ACEs contributing to risk of self-harm and depression in adolescence. En ligne : https://doi.org/10.1111/jcpp.13986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

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