Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people / Patrick SMITH in Journal of Child Psychology and Psychiatry, 66-8 (August 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1117-1128 Titre : Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people Type de document : Texte imprimé et/ou numérique Auteurs : Patrick SMITH, Auteur ; Anke EHLERS, Auteur ; Ewan CARR, Auteur ; David M. CLARK, Auteur ; Tim DALGLEISH, Auteur ; Gordon FORBES, Auteur ; Kimberley GOLDSMITH, Auteur ; Helena GRIFFITHS, Auteur ; Monica GUPTA, Auteur ; Dorothy KING, Auteur ; Sarah MILES, Auteur ; Dominic T. PLANT, Auteur ; Anne SMITH, Auteur ; Jess STEWARD, Auteur ; William YULE, Auteur ; Richard MEISER-STEDMAN, Auteur Article en page(s) : p.1117-1128 Langues : Anglais (eng) Mots-clés : Post-traumatic stress disorder  adolescence  cognitive therapy  E-health  Randomised Controlled Trial Index. décimale : PER Périodiques Résumé : Background Effective face-to-face treatments for Post-Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist-supported online Cognitive Therapy has the potential to improve accessibility of effective treatment. This early-stage trial gathered data on the feasibility, acceptability, and initial signal of clinical efficacy of a novel online Cognitive Therapy program for young people with PTSD. Methods A two-arm, parallel-groups, single-blind, early-stage feasibility RCT compared online Cognitive Therapy to a waitlList condition. Participants were N?=?31 adolescents (12?17?years-old) with a diagnosis of PTSD, randomised in a 1:1 ratio using minimisation. Thresholds for progression to a larger trial were set a priori for recruitment rate, data completeness, and the initial signal of clinical efficacy. The primary clinical outcome was PTSD diagnosis at 16?weeks post-randomisation. Secondary clinical outcomes were continuous measures of PTSD, depression, and anxiety at 16?weeks; and at 38?weeks in the online Cognitive Therapy arm. Results All pre-determined feasibility thresholds for progression to a larger trial were met. We recruited to target at a rate of 1?2 participants/month. No patient dropped out of therapy; 94% of all participants were retained at 16?weeks. At 16-weeks, the intention-to-treat (ITT) effect adjusted odds ratio was 0.20 (95% CI, 0.02, 1.42), indicating that the odds of meeting PTSD caseness after online therapy were 80% lower than after the waitlist (10/16 participants met PTSD caseness after therapy compared to 11/13 after WL). Effect-size estimates for all secondary clinical outcomes were large-moderate; improvements were sustained 38?weeks after online Cognitive Therapy. Conclusions Therapist-supported online Cognitive Therapy for PTSD is acceptable to young people and has potential for meaningful and sustained clinical effects. A larger trial appears feasible to deliver. Further work is needed to refine the intervention and its delivery and to evaluate it in a larger confirmatory trial. En ligne : https://doi.org/10.1111/jcpp.14124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Early-stage randomised controlled trial of therapist-supported online cognitive therapy for post-traumatic stress disorder in young people [Texte imprimé et/ou numérique] / Patrick SMITH, Auteur ; Anke EHLERS, Auteur ; Ewan CARR, Auteur ; David M. CLARK, Auteur ; Tim DALGLEISH, Auteur ; Gordon FORBES, Auteur ; Kimberley GOLDSMITH, Auteur ; Helena GRIFFITHS, Auteur ; Monica GUPTA, Auteur ; Dorothy KING, Auteur ; Sarah MILES, Auteur ; Dominic T. PLANT, Auteur ; Anne SMITH, Auteur ; Jess STEWARD, Auteur ; William YULE, Auteur ; Richard MEISER-STEDMAN, Auteur . - p.1117-1128. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-8 (August 2025) . - p.1117-1128 Mots-clés : Post-traumatic stress disorder  adolescence  cognitive therapy  E-health  Randomised Controlled Trial Index. décimale : PER Périodiques Résumé : Background Effective face-to-face treatments for Post-Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist-supported online Cognitive Therapy has the potential to improve accessibility of effective treatment. This early-stage trial gathered data on the feasibility, acceptability, and initial signal of clinical efficacy of a novel online Cognitive Therapy program for young people with PTSD. Methods A two-arm, parallel-groups, single-blind, early-stage feasibility RCT compared online Cognitive Therapy to a waitlList condition. Participants were N?=?31 adolescents (12?17?years-old) with a diagnosis of PTSD, randomised in a 1:1 ratio using minimisation. Thresholds for progression to a larger trial were set a priori for recruitment rate, data completeness, and the initial signal of clinical efficacy. The primary clinical outcome was PTSD diagnosis at 16?weeks post-randomisation. Secondary clinical outcomes were continuous measures of PTSD, depression, and anxiety at 16?weeks; and at 38?weeks in the online Cognitive Therapy arm. Results All pre-determined feasibility thresholds for progression to a larger trial were met. We recruited to target at a rate of 1?2 participants/month. No patient dropped out of therapy; 94% of all participants were retained at 16?weeks. At 16-weeks, the intention-to-treat (ITT) effect adjusted odds ratio was 0.20 (95% CI, 0.02, 1.42), indicating that the odds of meeting PTSD caseness after online therapy were 80% lower than after the waitlist (10/16 participants met PTSD caseness after therapy compared to 11/13 after WL). Effect-size estimates for all secondary clinical outcomes were large-moderate; improvements were sustained 38?weeks after online Cognitive Therapy. Conclusions Therapist-supported online Cognitive Therapy for PTSD is acceptable to young people and has potential for meaningful and sustained clinical effects. A larger trial appears feasible to deliver. Further work is needed to refine the intervention and its delivery and to evaluate it in a larger confirmatory trial. En ligne : https://doi.org/10.1111/jcpp.14124 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? / Teresa BENNETT ; Leann Smith DAWALT ; Maureen S. DURKIN ; Gordon FORBES ; Patricia HOWLIN ; Catherine LORD ; Anat ZAIDMAN-ZAIT ; Lonnie ZWAIGENBAUM ; Vanessa BAL ; Somer BISHOP ; Chung-Hsin CHIANG ; Adriana DIMARTINO ; Christine M. FREITAG ; Stelios GEORGIADES ; Matthew HOLLOCKS ; Meng-Chuan LAI ; Matthew J. MAENNER ; Patrick S. POWELL ; Julie Lounds TAYLOR ; Alycia HALLADAY in Autism Research, 18-4 (April 2025)  

Public ISBD [article]  inAutism Research > 18-4 (April 2025) . - p.710-716 Titre : Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? Type de document : Texte imprimé et/ou numérique Auteurs : Teresa BENNETT, Auteur ; Leann Smith DAWALT, Auteur ; Maureen S. DURKIN, Auteur ; Gordon FORBES, Auteur ; Patricia HOWLIN, Auteur ; Catherine LORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Vanessa BAL, Auteur ; Somer BISHOP, Auteur ; Chung-Hsin CHIANG, Auteur ; Adriana DIMARTINO, Auteur ; Christine M. FREITAG, Auteur ; Stelios GEORGIADES, Auteur ; Matthew HOLLOCKS, Auteur ; Meng-Chuan LAI, Auteur ; Matthew J. MAENNER, Auteur ; Patrick S. POWELL, Auteur ; Julie Lounds TAYLOR, Auteur ; Alycia HALLADAY, Auteur Article en page(s) : p.710-716 Langues : Anglais (eng) Mots-clés : autism  behavior  contextual  longitudinal  outcomes  research Index. décimale : PER Périodiques Résumé : ABSTRACT Although autism is a childhood-onset neurodevelopmental disorder, its features change across the life course due to a combination of individual and contextual influences. However, the influence of contextual factors on development during childhood and beyond is less frequently studied than individual factors such as genetic variants that increase autism risk, IQ, language, and autistic features. Potentially important contexts include the family environment and socioeconomic status, social networks, school, work, services, neighborhood characteristics, environmental events, and sociocultural factors. Here, we articulate the benefit of studying contextual factors, and we offer selected examples of published longitudinal autism studies that have focused on how individuals develop within context. Expanding the autism research agenda to include the broader context in which autism emerges and changes across the life course can enhance understanding of how contexts influence the heterogeneity of autism, support strengths and resilience, or amplify disabilities. We describe challenges and opportunities for future research on contextual influences and provide a list of digital resources that can be integrated into autism data sets. It is important to conceptualize contextual influences on autism development as main exposures, not only as descriptive variables or factors needing statistical control. En ligne : https://doi.org/10.1002/aur.3312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Expanding Research on Contextual Factors in Autism Research: What Took Us So Long? [Texte imprimé et/ou numérique] / Teresa BENNETT, Auteur ; Leann Smith DAWALT, Auteur ; Maureen S. DURKIN, Auteur ; Gordon FORBES, Auteur ; Patricia HOWLIN, Auteur ; Catherine LORD, Auteur ; Anat ZAIDMAN-ZAIT, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Vanessa BAL, Auteur ; Somer BISHOP, Auteur ; Chung-Hsin CHIANG, Auteur ; Adriana DIMARTINO, Auteur ; Christine M. FREITAG, Auteur ; Stelios GEORGIADES, Auteur ; Matthew HOLLOCKS, Auteur ; Meng-Chuan LAI, Auteur ; Matthew J. MAENNER, Auteur ; Patrick S. POWELL, Auteur ; Julie Lounds TAYLOR, Auteur ; Alycia HALLADAY, Auteur . - p.710-716. Langues : Anglais (eng) in Autism Research > 18-4 (April 2025) . - p.710-716 Mots-clés : autism  behavior  contextual  longitudinal  outcomes  research Index. décimale : PER Périodiques Résumé : ABSTRACT Although autism is a childhood-onset neurodevelopmental disorder, its features change across the life course due to a combination of individual and contextual influences. However, the influence of contextual factors on development during childhood and beyond is less frequently studied than individual factors such as genetic variants that increase autism risk, IQ, language, and autistic features. Potentially important contexts include the family environment and socioeconomic status, social networks, school, work, services, neighborhood characteristics, environmental events, and sociocultural factors. Here, we articulate the benefit of studying contextual factors, and we offer selected examples of published longitudinal autism studies that have focused on how individuals develop within context. Expanding the autism research agenda to include the broader context in which autism emerges and changes across the life course can enhance understanding of how contexts influence the heterogeneity of autism, support strengths and resilience, or amplify disabilities. We describe challenges and opportunities for future research on contextual influences and provide a list of digital resources that can be integrated into autism data sets. It is important to conceptualize contextual influences on autism development as main exposures, not only as descriptive variables or factors needing statistical control. En ligne : https://doi.org/10.1002/aur.3312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

---

1 (1 - 2 / 2)