Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills / Denis PERUZZO ; Filippo ARRIGONI ; Silvia BUSTI CECCARELLI ; Laura VILLA ; Elisa MANI ; Eleonora MAGGIONI ; Paolo BRAMBILLA ; Maria NOBILE ; Massimo MOLTENI ; Alessandro CRIPPA in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202626 Titre : Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills Type de document : Texte imprimé et/ou numérique Auteurs : Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur Article en page(s) : p.202626 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills [Texte imprimé et/ou numérique] / Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur . - p.202626. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202626 Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

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