Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission / Kristine MARCEAU in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1125-1138 Titre : Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission Type de document : texte imprimé Auteurs : Kristine MARCEAU, Auteur ; Sohee LEE, Auteur ; Muskan DATTA, Auteur ; Olivia C. ROBERTSON, Auteur ; Daniel S. SHAW, Auteur ; Misaki N. NATSUAKI, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur Article en page(s) : p.1125-1138 Langues : Anglais (eng) Mots-clés : adoption design  comorbidity  intergenerational transmission  internalizing and externalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Psychopathology is intergenerationally transmitted through both genetic and environmental mechanisms via heterotypic (cross-domain), homotypic (domain-specific), and general (e.g., "p-factor") pathways. The current study leveraged an adopted-at-birth design, the Early Growth and Development Study (57% male; 55.6% White, 19.3% Multiracial, 13% Black/African American, 10.9% Hispanic/Latine) to explore the relative influence of these pathways via associations between adoptive caregiver psychopathology (indexing potential environmental transmission) and birth parent psychopathology (indexing genetic transmission) with adolescent internalizing and externalizing symptoms. We included composite measures of adoptive and birth parent internalizing, externalizing, and substance use domains, and a general "p-factor." Age 11 adolescent internalizing and externalizing symptom scores were the average of adoptive parent reports on the Child Behavior Checklist (n = 407). Examining domains independently without addressing comorbidity can lead to incorrect interpretations of transmission mode. Therefore, we also examined symptom severity (like the "p-factor") and an orthogonal symptom directionality score to more cleanly disentangle transmission modes. The pattern of correlations was consistent with mostly general transmission in families with youth showing comorbid internalizing and externalizing symptoms, rather than homotypic transmission. Findings more strongly supported potential environmental or evocative mechanisms of intergenerational transmission than genetic transmission mechanisms (though see limitations). Parent-specific effects are discussed. En ligne : https://www.cambridge.org/core/product/E7250A64CD2FFA843076B81FAA9109BA Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Intergenerational transmission of comorbid internalizing and externalizing psychopathology at age 11: Evidence from an adoption design for general transmission of comorbidity rather than homotypic transmission [texte imprimé] / Kristine MARCEAU, Auteur ; Sohee LEE, Auteur ; Muskan DATTA, Auteur ; Olivia C. ROBERTSON, Auteur ; Daniel S. SHAW, Auteur ; Misaki N. NATSUAKI, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur . - p.1125-1138. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1125-1138 Mots-clés : adoption design  comorbidity  intergenerational transmission  internalizing and externalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Psychopathology is intergenerationally transmitted through both genetic and environmental mechanisms via heterotypic (cross-domain), homotypic (domain-specific), and general (e.g., "p-factor") pathways. The current study leveraged an adopted-at-birth design, the Early Growth and Development Study (57% male; 55.6% White, 19.3% Multiracial, 13% Black/African American, 10.9% Hispanic/Latine) to explore the relative influence of these pathways via associations between adoptive caregiver psychopathology (indexing potential environmental transmission) and birth parent psychopathology (indexing genetic transmission) with adolescent internalizing and externalizing symptoms. We included composite measures of adoptive and birth parent internalizing, externalizing, and substance use domains, and a general "p-factor." Age 11 adolescent internalizing and externalizing symptom scores were the average of adoptive parent reports on the Child Behavior Checklist (n = 407). Examining domains independently without addressing comorbidity can lead to incorrect interpretations of transmission mode. Therefore, we also examined symptom severity (like the "p-factor") and an orthogonal symptom directionality score to more cleanly disentangle transmission modes. The pattern of correlations was consistent with mostly general transmission in families with youth showing comorbid internalizing and externalizing symptoms, rather than homotypic transmission. Findings more strongly supported potential environmental or evocative mechanisms of intergenerational transmission than genetic transmission mechanisms (though see limitations). Parent-specific effects are discussed. En ligne : https://www.cambridge.org/core/product/E7250A64CD2FFA843076B81FAA9109BA Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort / Kristine MARCEAU in Development and Psychopathology, 38-3 (August 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-3 (August 2026) . - p.1551-1563 Titre : Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort Type de document : texte imprimé Auteurs : Kristine MARCEAU, Auteur ; Andrew LAW, Auteur ; Karen J. DEREFINKO, Auteur ; Olivia C. ROBERTSON, Auteur ; Sara S. NOZADI, Auteur ; Lijun LI, Auteur ; Chang LIU, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Nicole BUSH, Auteur ; Cathi PROPPER, Auteur ; Briana MOORE, Auteur ; Amy J. ELLIOTT, Auteur ; Catrina A. CALUB, Auteur ; Theresa M. BASTAIN, Auteur ; Donghai LIANG, Auteur ; Julie B. SCHWEITZER, Auteur ; Ban AL-SAHAB, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Jenae M. NEIDERHISER, Auteur Article en page(s) : p.1551-1563 Langues : Anglais (eng) Mots-clés : Environmental Influences on Child Health Outcomes (ECHO)  Smoking during pregnancy  externalizing  internalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Maternal tobacco smoking during pregnancy (MSDP) is associated with an increased risk of child externalizing problems. It remains unclear whether these associations are externalizing-specific, or better explained by comorbidity between externalizing and internalizing domains, or vary by age and sex. To address comorbidity and differentiation between domains, we leveraged the severity-directional model of psychopathology. Severity reflects the overall level of psychopathology symptoms across both domains (high levels of severity can only be reached by having symptoms of both types simultaneously), whereas directionality captures the balance/differentiation of internalizing vs. externalizing symptoms regardless of number of total symptoms. Participants included 16,335 children aged 1–19 years old (47.78% female, 58.17% White, 75.46% non-Hispanic) from 55 U.S.-based cohorts within the Environmental Influences on Child Health Outcomes (ECHO) consortium. MSDP predicted differentiation toward externalizing problems in 2-year age bins 1–2 through 7–8 and 13–14 years; remaining (non-significant) age bins had similar magnitudes. MSDP predicted higher symptom severity in all age bins. Findings likely reflect a combination of MSDP associations with comorbid symptom severity and specificity toward externalizing problems, with little evidence of age or sex differences. Additional analyses explored e-cigarette use, other prenatal substance use, and postnatal smoke exposure; associations were sparse and unsystematic. En ligne : https://dx.doi.org/10.1017/S095457942610128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590 [article] Prenatal smoking and child psychopathology associations by age and sex in the ECHO cohort [texte imprimé] / Kristine MARCEAU, Auteur ; Andrew LAW, Auteur ; Karen J. DEREFINKO, Auteur ; Olivia C. ROBERTSON, Auteur ; Sara S. NOZADI, Auteur ; Lijun LI, Auteur ; Chang LIU, Auteur ; Leslie D. LEVE, Auteur ; Jody M. GANIBAN, Auteur ; Nicole BUSH, Auteur ; Cathi PROPPER, Auteur ; Briana MOORE, Auteur ; Amy J. ELLIOTT, Auteur ; Catrina A. CALUB, Auteur ; Theresa M. BASTAIN, Auteur ; Donghai LIANG, Auteur ; Julie B. SCHWEITZER, Auteur ; Ban AL-SAHAB, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Jenae M. NEIDERHISER, Auteur . - p.1551-1563. Langues : Anglais (eng) in Development and Psychopathology > 38-3 (August 2026) . - p.1551-1563 Mots-clés : Environmental Influences on Child Health Outcomes (ECHO)  Smoking during pregnancy  externalizing  internalizing  severity and directionality Index. décimale : PER Périodiques Résumé : Maternal tobacco smoking during pregnancy (MSDP) is associated with an increased risk of child externalizing problems. It remains unclear whether these associations are externalizing-specific, or better explained by comorbidity between externalizing and internalizing domains, or vary by age and sex. To address comorbidity and differentiation between domains, we leveraged the severity-directional model of psychopathology. Severity reflects the overall level of psychopathology symptoms across both domains (high levels of severity can only be reached by having symptoms of both types simultaneously), whereas directionality captures the balance/differentiation of internalizing vs. externalizing symptoms regardless of number of total symptoms. Participants included 16,335 children aged 1–19 years old (47.78% female, 58.17% White, 75.46% non-Hispanic) from 55 U.S.-based cohorts within the Environmental Influences on Child Health Outcomes (ECHO) consortium. MSDP predicted differentiation toward externalizing problems in 2-year age bins 1–2 through 7–8 and 13–14 years; remaining (non-significant) age bins had similar magnitudes. MSDP predicted higher symptom severity in all age bins. Findings likely reflect a combination of MSDP associations with comorbid symptom severity and specificity toward externalizing problems, with little evidence of age or sex differences. Additional analyses explored e-cigarette use, other prenatal substance use, and postnatal smoke exposure; associations were sparse and unsystematic. En ligne : https://dx.doi.org/10.1017/S095457942610128X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=590

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