Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder / Jeffrey R. WOZNIAK in Journal of Neurodevelopmental Disorders, 12 (2020)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 12 (2020) Titre : Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder Type de document : texte imprimé Auteurs : Jeffrey R. WOZNIAK, Auteur ; Birgit A. FINK, Auteur ; Anita J. FUGLESTAD, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Kristin E. SANDNESS, Auteur ; Joshua P. RADKE, Auteur ; Neely C. MILLER, Auteur ; Christopher LINDGREN, Auteur ; Ann M. BREARLEY, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur Langues : Anglais (eng) Mots-clés : Child, Preschool  Choline/therapeutic use  Cognition/drug effects  Double-Blind Method  Female  Fetal Alcohol Spectrum Disorders/drug therapy  Follow-Up Studies  Humans  Intelligence/drug effects  Male  Memory, Short-Term/drug effects  Nootropic Agents/therapeutic use  Pregnancy  Prenatal Exposure Delayed Effects/drug therapy  Choline  Cognition  Fetal alcohol spectrum disorders  Longitudinal studies  Randomized controlled trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging. We present a long-term follow-up study evaluating the neurodevelopmental effects of choline supplementation in children with FASD 4 years after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2-5-year-olds with FASD. Participants include 31 children (16 placebo; 15 choline) seen 4 years after trial completion. The mean age at follow-up was 8.6 years. Diagnoses were 12.9% fetal alcohol syndrome (FAS), 41.9% partial FAS, and 45.1% alcohol-related neurodevelopmental disorder. The follow-up included measures of intelligence, memory, executive functioning, and behavior. RESULTS: Children who received choline had higher non-verbal intelligence, higher visual-spatial skill, higher working memory ability, better verbal memory, and fewer behavioral symptoms of attention deficit hyperactivity disorder than the placebo group. No differences were seen for verbal intelligence, visual memory, or other executive functions. CONCLUSIONS: These data support choline as a potential neurodevelopmental intervention for FASD and highlight the need for long-term follow-up to capture treatment effects on neurodevelopmental trajectories. TRIAL REGISTRATION: ClinicalTrials.Gov #NCT01149538; Registered: June 23, 2010; first enrollment July 2, 2010. En ligne : https://dx.doi.org/10.1186/s11689-020-09312-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder [texte imprimé] / Jeffrey R. WOZNIAK, Auteur ; Birgit A. FINK, Auteur ; Anita J. FUGLESTAD, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Kristin E. SANDNESS, Auteur ; Joshua P. RADKE, Auteur ; Neely C. MILLER, Auteur ; Christopher LINDGREN, Auteur ; Ann M. BREARLEY, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 12 (2020) Mots-clés : Child, Preschool  Choline/therapeutic use  Cognition/drug effects  Double-Blind Method  Female  Fetal Alcohol Spectrum Disorders/drug therapy  Follow-Up Studies  Humans  Intelligence/drug effects  Male  Memory, Short-Term/drug effects  Nootropic Agents/therapeutic use  Pregnancy  Prenatal Exposure Delayed Effects/drug therapy  Choline  Cognition  Fetal alcohol spectrum disorders  Longitudinal studies  Randomized controlled trials Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite the high prevalence of fetal alcohol spectrum disorder (FASD), there are few interventions targeting its core neurocognitive and behavioral deficits. FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging. We present a long-term follow-up study evaluating the neurodevelopmental effects of choline supplementation in children with FASD 4 years after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2-5-year-olds with FASD. Participants include 31 children (16 placebo; 15 choline) seen 4 years after trial completion. The mean age at follow-up was 8.6 years. Diagnoses were 12.9% fetal alcohol syndrome (FAS), 41.9% partial FAS, and 45.1% alcohol-related neurodevelopmental disorder. The follow-up included measures of intelligence, memory, executive functioning, and behavior. RESULTS: Children who received choline had higher non-verbal intelligence, higher visual-spatial skill, higher working memory ability, better verbal memory, and fewer behavioral symptoms of attention deficit hyperactivity disorder than the placebo group. No differences were seen for verbal intelligence, visual memory, or other executive functions. CONCLUSIONS: These data support choline as a potential neurodevelopmental intervention for FASD and highlight the need for long-term follow-up to capture treatment effects on neurodevelopmental trajectories. TRIAL REGISTRATION: ClinicalTrials.Gov #NCT01149538; Registered: June 23, 2010; first enrollment July 2, 2010. En ligne : https://dx.doi.org/10.1186/s11689-020-09312-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes / Blake A. GIMBEL in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes Type de document : texte imprimé Auteurs : Blake A. GIMBEL, Auteur ; Mary E. ANTHONY, Auteur ; Abigail M. ERNST, Auteur ; Donovan J. ROEDIGER, Auteur ; Erik DE WATER, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Joshua P. RADKE, Auteur ; Bryon A. MUELLER, Auteur ; Anita J. FUGLESTAD, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur ; Jeffrey R. WOZNIAK, Auteur Langues : Anglais (eng) Mots-clés : Child  Pregnancy  Female  Humans  Child, Preschool  Fetal Alcohol Spectrum Disorders/drug therapy  Choline/therapeutic use  Corpus Callosum/diagnostic imaging  Follow-Up Studies  White Matter/diagnostic imaging  Choline  Cognition  Diffusion MRI  Fetal alcohol spectrum disorders  Longitudinal studies  Neurite orientation dispersion and density imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2.5 to 5 year olds with FASD. Participants in this long-term follow-up study include 18 children (9 placebo; 9 choline) seen 7 years on average following initial trial completion. The mean age at follow-up was 11.0 years old. Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder. The follow-up included measures of executive functioning and an MRI scan. RESULTS: Children who received choline had better performance on several tasks of lower-order executive function (e.g., processing speed) and showed higher white matter microstructure organization (i.e., greater axon coherence) in the splenium of the corpus callosum compared to the placebo group. CONCLUSIONS: These preliminary findings, although exploratory at this stage, highlight potential long-term benefits of choline as a neurodevelopmental intervention for FASD and suggest that choline may affect white matter development, representing a potential target of choline in this population. TRIAL REGISTRATION: Prior to enrollment, this trial was registered with clinicaltrials.gov ( NCT01149538 ) on June 23, 2010. En ligne : https://dx.doi.org/10.1186/s11689-022-09470-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes [texte imprimé] / Blake A. GIMBEL, Auteur ; Mary E. ANTHONY, Auteur ; Abigail M. ERNST, Auteur ; Donovan J. ROEDIGER, Auteur ; Erik DE WATER, Auteur ; Judith K. ECKERLE, Auteur ; Christopher J. BOYS, Auteur ; Joshua P. RADKE, Auteur ; Bryon A. MUELLER, Auteur ; Anita J. FUGLESTAD, Auteur ; Steven H. ZEISEL, Auteur ; Michael K. GEORGIEFF, Auteur ; Jeffrey R. WOZNIAK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Child  Pregnancy  Female  Humans  Child, Preschool  Fetal Alcohol Spectrum Disorders/drug therapy  Choline/therapeutic use  Corpus Callosum/diagnostic imaging  Follow-Up Studies  White Matter/diagnostic imaging  Choline  Cognition  Diffusion MRI  Fetal alcohol spectrum disorders  Longitudinal studies  Neurite orientation dispersion and density imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial. METHODS: The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2.5 to 5 year olds with FASD. Participants in this long-term follow-up study include 18 children (9 placebo; 9 choline) seen 7 years on average following initial trial completion. The mean age at follow-up was 11.0 years old. Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder. The follow-up included measures of executive functioning and an MRI scan. RESULTS: Children who received choline had better performance on several tasks of lower-order executive function (e.g., processing speed) and showed higher white matter microstructure organization (i.e., greater axon coherence) in the splenium of the corpus callosum compared to the placebo group. CONCLUSIONS: These preliminary findings, although exploratory at this stage, highlight potential long-term benefits of choline as a neurodevelopmental intervention for FASD and suggest that choline may affect white matter development, representing a potential target of choline in this population. TRIAL REGISTRATION: Prior to enrollment, this trial was registered with clinicaltrials.gov ( NCT01149538 ) on June 23, 2010. En ligne : https://dx.doi.org/10.1186/s11689-022-09470-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure / Blake A. GIMBEL in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure Type de document : texte imprimé Auteurs : Blake A. GIMBEL, Auteur ; Jeffrey R. WOZNIAK, Auteur ; Bryon A. MUELLER, Auteur ; Kent A. TUOMINEN, Auteur ; Abigail M. ERNST, Auteur ; Mary E. ANTHONY, Auteur ; Erik DE WATER, Auteur ; CIFASD, Auteur ; Donovan J. ROEDIGER, Auteur Langues : Anglais (eng) Mots-clés : Humans  Hippocampus/diagnostic imaging/pathology/abnormalities  Female  Child  Adolescent  Male  Magnetic Resonance Imaging  Fetal Alcohol Spectrum Disorders/diagnostic imaging/pathology  Pregnancy  Prenatal Exposure Delayed Effects/diagnostic imaging/pathology  Neuropsychological Tests  Cognition  Fetal alcohol spectrum disorders  Hippocampal gyrification  Hippocampal thickness  Memory  Prenatal alcohol exposure  study were approved by the University of Minnesota IRB and all participants'  parents/guardians participated in a comprehensive informed consent procedure and  signed consent forms. Consent for publication: Not applicable. Competing  interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals. Here, we evaluate hippocampal anomalies in children with PAE and an unexposed comparison group using advanced MRI methods that characterize hippocampal curvature and thickness. METHODS: Participants, ages 8 to 16 years, included children with PAE (n = 48) and an unexposed comparison group (n = 46) who underwent a dysmorphology exam, neuropsychological assessment, and an MRI scan. Height, weight, head circumference, and dysmorphic facial features were evaluated. Of those with PAE, 4.2% had fetal alcohol syndrome (FAS), 22.9% had partial FAS, and 72.9% had alcohol-related neurodevelopmental disorder. Neuropsychological testing included measures of intelligence and memory functioning. T1-weighted anatomical data were processed with the Hippunfold pipeline, which "unfolds" the complex hippocampal structure onto a template surface and provides measures of thickness and gyrification/curvature at each vertex. Permutation Analysis of Linear Models (PALM) was used to test for group differences (PAE vs. comparison) in hippocampal thickness and gyrification at each vertex and also to assess correlations with cognitive functioning. RESULTS: There were significant regional differences in thickness and gyrification across bilateral hippocampi, with the PAE group showing substantially thinner tissue and less curvature than the comparison group, especially in CA1 and subiculum regions. For those with PAE, thinner subicular tissue (bilateral) was associated with lower IQ. Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group. CONCLUSIONS: We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE. En ligne : https://dx.doi.org/10.1186/s11689-025-09595-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure [texte imprimé] / Blake A. GIMBEL, Auteur ; Jeffrey R. WOZNIAK, Auteur ; Bryon A. MUELLER, Auteur ; Kent A. TUOMINEN, Auteur ; Abigail M. ERNST, Auteur ; Mary E. ANTHONY, Auteur ; Erik DE WATER, Auteur ; CIFASD, Auteur ; Donovan J. ROEDIGER, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Hippocampus/diagnostic imaging/pathology/abnormalities  Female  Child  Adolescent  Male  Magnetic Resonance Imaging  Fetal Alcohol Spectrum Disorders/diagnostic imaging/pathology  Pregnancy  Prenatal Exposure Delayed Effects/diagnostic imaging/pathology  Neuropsychological Tests  Cognition  Fetal alcohol spectrum disorders  Hippocampal gyrification  Hippocampal thickness  Memory  Prenatal alcohol exposure  study were approved by the University of Minnesota IRB and all participants'  parents/guardians participated in a comprehensive informed consent procedure and  signed consent forms. Consent for publication: Not applicable. Competing  interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory and decision-making in affected individuals. Here, we evaluate hippocampal anomalies in children with PAE and an unexposed comparison group using advanced MRI methods that characterize hippocampal curvature and thickness. METHODS: Participants, ages 8 to 16 years, included children with PAE (n = 48) and an unexposed comparison group (n = 46) who underwent a dysmorphology exam, neuropsychological assessment, and an MRI scan. Height, weight, head circumference, and dysmorphic facial features were evaluated. Of those with PAE, 4.2% had fetal alcohol syndrome (FAS), 22.9% had partial FAS, and 72.9% had alcohol-related neurodevelopmental disorder. Neuropsychological testing included measures of intelligence and memory functioning. T1-weighted anatomical data were processed with the Hippunfold pipeline, which "unfolds" the complex hippocampal structure onto a template surface and provides measures of thickness and gyrification/curvature at each vertex. Permutation Analysis of Linear Models (PALM) was used to test for group differences (PAE vs. comparison) in hippocampal thickness and gyrification at each vertex and also to assess correlations with cognitive functioning. RESULTS: There were significant regional differences in thickness and gyrification across bilateral hippocampi, with the PAE group showing substantially thinner tissue and less curvature than the comparison group, especially in CA1 and subiculum regions. For those with PAE, thinner subicular tissue (bilateral) was associated with lower IQ. Also in the PAE group, lower episodic memory performance was associated with thinness in the right hippocampus, especially in the subiculum region. There were no significant regional hippocampal patterns that were associated with cognitive functioning for individuals in the unexposed comparison group. CONCLUSIONS: We used a novel MRI method to evaluate hippocampal structure in children with PAE and an unexposed comparison group. The data suggest that PAE disrupts hippocampal development, impacting both the early-stage folding of the structure and its ultimate thickness. The data also demonstrate that these developmental anomalies have functional consequences in terms of core memory functions as well as global intellectual functioning in children with PAE. En ligne : https://dx.doi.org/10.1186/s11689-025-09595-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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