Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism / Shlomit BEKER in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism Type de document : texte imprimé Auteurs : Shlomit BEKER, Auteur ; John J. FOXE, Auteur ; John VENTICINQUE, Auteur ; Juliana BATES, Auteur ; Elizabeth M. RIDGEWAY, Auteur ; Roseann C. SCHAAF, Auteur ; Sophie MOLHOLM, Auteur Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Evoked Potentials  Evoked Potentials, Visual  Humans  Infant  Reproducibility of Results  Asd  Biomarkers  Eeg  Erp  Icc  Inter-trial variability Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are associated with altered sensory processing and perception. Scalp recordings of electrical brain activity time-locked to sensory events (event-related potentials; ERPs) provide precise information on the time-course of related altered neural activity, and can be used to model the cortical loci of the underlying neural networks. Establishing the test-retest reliability of these sensory brain responses in ASD is critical to their use as biomarkers of neural dysfunction in this population. METHODS: EEG and behavioral data were acquired from 33 children diagnosed with ASD aged 6-9.4 years old, while they performed a child-friendly task at two different time-points, separated by an average of 5.2 months. In two blocked conditions, participants responded to the occurrence of an auditory target that was either preceded or not by repeating visual stimuli. Intraclass correlation coefficients (ICCs) were used to assess test-retest reliability of measures of sensory (auditory and visual) ERPs and performance, for the two experimental conditions. To assess the degree of reliability of the variability of responses within individuals, this analysis was performed on the variance of the measurements, in addition to their means. This yielded a total of 24 measures for which ICCs were calculated. RESULTS: The data yielded significant good ICC values for 10 of the 24 measurements. These spanned across behavioral and ERPs data, experimental conditions, and mean as well as variance measures. Measures of the visual evoked responses accounted for a disproportionately large number of the significant ICCs; follow-up analyses suggested that the contribution of a greater number of trials to the visual compared to the auditory ERP partially accounted for this. CONCLUSIONS: This analysis reveals that sensory ERPs and related behavior can be highly reliable across multiple measurement time-points in ASD. The data further suggest that the inter-trial and inter-participant variability reported in the ASD literature likely represents replicable individual participant neural processing differences. The stability of these neuronal readouts supports their use as biomarkers in clinical and translational studies on ASD. Given the minimum interval between test/retest sessions across our cohort, we also conclude that for the tested age-range of ~ 6 to 9.4 years, these reliability measures are valid for at least a 3-month interval. Limitations related to EEG task demands and study length in the context of a clinical trial are considered. En ligne : https://dx.doi.org/10.1186/s11689-021-09383-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism [texte imprimé] / Shlomit BEKER, Auteur ; John J. FOXE, Auteur ; John VENTICINQUE, Auteur ; Juliana BATES, Auteur ; Elizabeth M. RIDGEWAY, Auteur ; Roseann C. SCHAAF, Auteur ; Sophie MOLHOLM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Evoked Potentials  Evoked Potentials, Visual  Humans  Infant  Reproducibility of Results  Asd  Biomarkers  Eeg  Erp  Icc  Inter-trial variability Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are associated with altered sensory processing and perception. Scalp recordings of electrical brain activity time-locked to sensory events (event-related potentials; ERPs) provide precise information on the time-course of related altered neural activity, and can be used to model the cortical loci of the underlying neural networks. Establishing the test-retest reliability of these sensory brain responses in ASD is critical to their use as biomarkers of neural dysfunction in this population. METHODS: EEG and behavioral data were acquired from 33 children diagnosed with ASD aged 6-9.4 years old, while they performed a child-friendly task at two different time-points, separated by an average of 5.2 months. In two blocked conditions, participants responded to the occurrence of an auditory target that was either preceded or not by repeating visual stimuli. Intraclass correlation coefficients (ICCs) were used to assess test-retest reliability of measures of sensory (auditory and visual) ERPs and performance, for the two experimental conditions. To assess the degree of reliability of the variability of responses within individuals, this analysis was performed on the variance of the measurements, in addition to their means. This yielded a total of 24 measures for which ICCs were calculated. RESULTS: The data yielded significant good ICC values for 10 of the 24 measurements. These spanned across behavioral and ERPs data, experimental conditions, and mean as well as variance measures. Measures of the visual evoked responses accounted for a disproportionately large number of the significant ICCs; follow-up analyses suggested that the contribution of a greater number of trials to the visual compared to the auditory ERP partially accounted for this. CONCLUSIONS: This analysis reveals that sensory ERPs and related behavior can be highly reliable across multiple measurement time-points in ASD. The data further suggest that the inter-trial and inter-participant variability reported in the ASD literature likely represents replicable individual participant neural processing differences. The stability of these neuronal readouts supports their use as biomarkers in clinical and translational studies on ASD. Given the minimum interval between test/retest sessions across our cohort, we also conclude that for the tested age-range of ~ 6 to 9.4 years, these reliability measures are valid for at least a 3-month interval. Limitations related to EEG task demands and study length in the context of a clinical trial are considered. En ligne : https://dx.doi.org/10.1186/s11689-021-09383-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome / Tufikameni BRIMA in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome Type de document : texte imprimé Auteurs : Tufikameni BRIMA, Auteur ; Shlomit BEKER, Auteur ; Kevin D. PRINSLOO, Auteur ; John S. BUTLER, Auteur ; Aleksandra DJUKIC, Auteur ; Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Rett Syndrome/physiopathology/complications  Adolescent  Female  Evoked Potentials, Auditory/physiology  Child  Young Adult  Electroencephalography  Auditory Perception/physiology  Reproducibility of Results  Acoustic Stimulation  Male  Signal-To-Noise Ratio  Adult  Auditory Evoked Potential  AEP  Auditory discrimination  Denoising Source Separation (DSS)  Eeg  Event-related potential  ERP  Females  High-density electrical mapping  Inter-Trial Phase Coherence (ITPC)  Inter-trial variability (ITV)  Neurodevelopmental disorder  Rett Syndrome Severity Scale (RSSS)  Signal-noise ratio (SNR)  X-linked mutation  MECP2  to the results of this study. Index. décimale : PER Périodiques Résumé : BACKGROUND: In the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic efficacy in clinical trials, recordings of sensory-perceptual functioning using event-related potential (ERP) approaches have emerged as potentially powerful tools. Considerable work points to highly anomalous auditory evoked potentials (AEPs) in RTT. However, an assumption of the typical signal-averaging method used to derive these measures is "stationarity" of the underlying responses - i.e. neural responses to each input are highly stereotyped. An alternate possibility is that responses to repeated stimuli are highly variable in RTT. If so, this will significantly impact the validity of assumptions about underlying neural dysfunction, and likely lead to overestimation of underlying neuropathology. To assess this possibility, analyses at the single-trial level assessing signal-to-noise ratios (SNR), inter-trial variability (ITV) and inter-trial phase coherence (ITPC) are necessary. METHODS: AEPs were recorded to simple 100 Hz tones from 18 RTT and 27 age-matched controls (Ages: 6-22 years). We applied standard AEP averaging, as well as measures of neuronal reliability at the single-trial level (i.e. SNR, ITV, ITPC). To separate signal-carrying components from non-neural noise sources, we also applied a denoising source separation (DSS) algorithm and then repeated the reliability measures. RESULTS: Substantially increased ITV, lower SNRs, and reduced ITPC were observed in auditory responses of RTT participants, supporting a "neural unreliability" account. Application of the DSS technique made it clear that non-neural noise sources contribute to overestimation of the extent of processing deficits in RTT. Post-DSS, ITV measures were substantially reduced, so much so that pre-DSS ITV differences between RTT and TD populations were no longer detected. In the case of SNR and ITPC, DSS substantially improved these estimates in the RTT population, but robust differences between RTT and TD were still fully evident. CONCLUSIONS: To accurately represent the degree of neural dysfunction in RTT using the ERP technique, a consideration of response reliability at the single-trial level is highly advised. Non-neural sources of noise lead to overestimation of the degree of pathological processing in RTT, and denoising source separation techniques during signal processing substantially ameliorate this issue. En ligne : https://dx.doi.org/10.1186/s11689-024-09544-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome [texte imprimé] / Tufikameni BRIMA, Auteur ; Shlomit BEKER, Auteur ; Kevin D. PRINSLOO, Auteur ; John S. BUTLER, Auteur ; Aleksandra DJUKIC, Auteur ; Edward G. FREEDMAN, Auteur ; Sophie MOLHOLM, Auteur ; John J. FOXE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Rett Syndrome/physiopathology/complications  Adolescent  Female  Evoked Potentials, Auditory/physiology  Child  Young Adult  Electroencephalography  Auditory Perception/physiology  Reproducibility of Results  Acoustic Stimulation  Male  Signal-To-Noise Ratio  Adult  Auditory Evoked Potential  AEP  Auditory discrimination  Denoising Source Separation (DSS)  Eeg  Event-related potential  ERP  Females  High-density electrical mapping  Inter-Trial Phase Coherence (ITPC)  Inter-trial variability (ITV)  Neurodevelopmental disorder  Rett Syndrome Severity Scale (RSSS)  Signal-noise ratio (SNR)  X-linked mutation  MECP2  to the results of this study. Index. décimale : PER Périodiques Résumé : BACKGROUND: In the search for objective tools to quantify neural function in Rett Syndrome (RTT), which are crucial in the evaluation of therapeutic efficacy in clinical trials, recordings of sensory-perceptual functioning using event-related potential (ERP) approaches have emerged as potentially powerful tools. Considerable work points to highly anomalous auditory evoked potentials (AEPs) in RTT. However, an assumption of the typical signal-averaging method used to derive these measures is "stationarity" of the underlying responses - i.e. neural responses to each input are highly stereotyped. An alternate possibility is that responses to repeated stimuli are highly variable in RTT. If so, this will significantly impact the validity of assumptions about underlying neural dysfunction, and likely lead to overestimation of underlying neuropathology. To assess this possibility, analyses at the single-trial level assessing signal-to-noise ratios (SNR), inter-trial variability (ITV) and inter-trial phase coherence (ITPC) are necessary. METHODS: AEPs were recorded to simple 100 Hz tones from 18 RTT and 27 age-matched controls (Ages: 6-22 years). We applied standard AEP averaging, as well as measures of neuronal reliability at the single-trial level (i.e. SNR, ITV, ITPC). To separate signal-carrying components from non-neural noise sources, we also applied a denoising source separation (DSS) algorithm and then repeated the reliability measures. RESULTS: Substantially increased ITV, lower SNRs, and reduced ITPC were observed in auditory responses of RTT participants, supporting a "neural unreliability" account. Application of the DSS technique made it clear that non-neural noise sources contribute to overestimation of the extent of processing deficits in RTT. Post-DSS, ITV measures were substantially reduced, so much so that pre-DSS ITV differences between RTT and TD populations were no longer detected. In the case of SNR and ITPC, DSS substantially improved these estimates in the RTT population, but robust differences between RTT and TD were still fully evident. CONCLUSIONS: To accurately represent the degree of neural dysfunction in RTT using the ERP technique, a consideration of response reliability at the single-trial level is highly advised. Non-neural sources of noise lead to overestimation of the degree of pathological processing in RTT, and denoising source separation techniques during signal processing substantially ameliorate this issue. En ligne : https://dx.doi.org/10.1186/s11689-024-09544-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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