Altered individual-level morphological similarity network in children with growth hormone deficiency / Yanglei CHENG in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Altered individual-level morphological similarity network in children with growth hormone deficiency Type de document : texte imprimé Auteurs : Yanglei CHENG, Auteur ; Liping LIN, Auteur ; Weifeng HOU, Auteur ; Huaqiong QIU, Auteur ; Chengfen DENG, Auteur ; Zi YAN, Auteur ; Long QIAN, Auteur ; Wei CUI, Auteur ; Yanbing LI, Auteur ; Zhiyun YANG, Auteur ; Qiuli CHEN, Auteur ; Shu SU, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Female  Child  Magnetic Resonance Imaging  Nerve Net/physiopathology/pathology/diagnostic imaging  Gray Matter/pathology/diagnostic imaging  Brain/pathology/diagnostic imaging/physiopathology  Dwarfism, Pituitary/physiopathology/pathology  Human Growth Hormone/deficiency/blood  Adolescent  Growth hormone deficiency  Morphological brain networks  Structural MRI  Topological organization Index. décimale : PER Périodiques Résumé : BACKGROUND: Accumulating evidences indicate regional grey matter (GM) morphology alterations in pediatric growth hormone deficiency (GHD); however, large-scale morphological brain networks (MBNs) undergo these patients remains unclear. OBJECTIVE: To investigate the topological organization of individual-level MBNs in pediatric GHD. METHODS: Sixty-one GHD and 42 typically developing controls (TDs) were enrolled. Inter-regional morphological similarity of GM was taken to construct individual-level MBNs. Between-group differences of topological parameters and network-based statistics analysis were compared. Finally, association relationship between network properties and clinical variables was analyzed. RESULTS: Compared to TDs, GHD indicated a disturbance in the normal small-world organization, reflected by increased L(p), γ, λ, σ and decreased C(p), E(glob) (all P(FDR) < 0.017). Regarding nodal properties, GHD exhibited increased nodal profiles at cerebellum 4-5, central executive network-related left inferior frontal gyrus, limbic regions-related right posterior cingulate gyrus, left hippocampus, and bilateral pallidum, thalamus (all P(FDR) < 0.05). Meanwhile, GHD exhibited decreased nodal profiles at sensorimotor network -related bilateral paracentral lobule, default-mode network-related left superior frontal gyrus, visual network -related right lingual gyrus, auditory network-related right superior temporal gyrus and bilateral amygdala, right cerebellum 3, bilateral cerebellum 10, vermis 1-2, 3, 4-5, 6 (all P(FDR) < 0.05). Furthermore, serum markers and behavior scores in GHD group were correlated with altered nodal profiles (P ≤ 0.046, uncorrected). CONCLUSION: GHD undergo an extensive reorganization in large-scale individual-level MBNs, probably due to abnormal cortico-striatal-thalamo-cerebellum loops, cortico-limbic-cerebellum, dorsal visual-sensorimotor-striatal, and auditory-cerebellum circuitry. This study highlights the crucial role of abnormal morphological connectivity underlying GHD, which might result in their relatively slower development in motor, cognitive, and linguistic functional within behavior problem performance. En ligne : https://dx.doi.org/10.1186/s11689-024-09566-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Altered individual-level morphological similarity network in children with growth hormone deficiency [texte imprimé] / Yanglei CHENG, Auteur ; Liping LIN, Auteur ; Weifeng HOU, Auteur ; Huaqiong QIU, Auteur ; Chengfen DENG, Auteur ; Zi YAN, Auteur ; Long QIAN, Auteur ; Wei CUI, Auteur ; Yanbing LI, Auteur ; Zhiyun YANG, Auteur ; Qiuli CHEN, Auteur ; Shu SU, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Male  Female  Child  Magnetic Resonance Imaging  Nerve Net/physiopathology/pathology/diagnostic imaging  Gray Matter/pathology/diagnostic imaging  Brain/pathology/diagnostic imaging/physiopathology  Dwarfism, Pituitary/physiopathology/pathology  Human Growth Hormone/deficiency/blood  Adolescent  Growth hormone deficiency  Morphological brain networks  Structural MRI  Topological organization Index. décimale : PER Périodiques Résumé : BACKGROUND: Accumulating evidences indicate regional grey matter (GM) morphology alterations in pediatric growth hormone deficiency (GHD); however, large-scale morphological brain networks (MBNs) undergo these patients remains unclear. OBJECTIVE: To investigate the topological organization of individual-level MBNs in pediatric GHD. METHODS: Sixty-one GHD and 42 typically developing controls (TDs) were enrolled. Inter-regional morphological similarity of GM was taken to construct individual-level MBNs. Between-group differences of topological parameters and network-based statistics analysis were compared. Finally, association relationship between network properties and clinical variables was analyzed. RESULTS: Compared to TDs, GHD indicated a disturbance in the normal small-world organization, reflected by increased L(p), γ, λ, σ and decreased C(p), E(glob) (all P(FDR) < 0.017). Regarding nodal properties, GHD exhibited increased nodal profiles at cerebellum 4-5, central executive network-related left inferior frontal gyrus, limbic regions-related right posterior cingulate gyrus, left hippocampus, and bilateral pallidum, thalamus (all P(FDR) < 0.05). Meanwhile, GHD exhibited decreased nodal profiles at sensorimotor network -related bilateral paracentral lobule, default-mode network-related left superior frontal gyrus, visual network -related right lingual gyrus, auditory network-related right superior temporal gyrus and bilateral amygdala, right cerebellum 3, bilateral cerebellum 10, vermis 1-2, 3, 4-5, 6 (all P(FDR) < 0.05). Furthermore, serum markers and behavior scores in GHD group were correlated with altered nodal profiles (P ≤ 0.046, uncorrected). CONCLUSION: GHD undergo an extensive reorganization in large-scale individual-level MBNs, probably due to abnormal cortico-striatal-thalamo-cerebellum loops, cortico-limbic-cerebellum, dorsal visual-sensorimotor-striatal, and auditory-cerebellum circuitry. This study highlights the crucial role of abnormal morphological connectivity underlying GHD, which might result in their relatively slower development in motor, cognitive, and linguistic functional within behavior problem performance. En ligne : https://dx.doi.org/10.1186/s11689-024-09566-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy / Huirong NIE in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy Type de document : texte imprimé Auteurs : Huirong NIE, Auteur ; Shasha LAN, Auteur ; Huan WANG, Auteur ; Pei XIANG, Auteur ; Mengzhen YAN, Auteur ; Yang FAN, Auteur ; Wanqing SHEN, Auteur ; Yijuan LI, Auteur ; Wen TANG, Auteur ; Zhiyun YANG, Auteur ; Yujian LIANG, Auteur ; Yingqian CHEN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Diffusion Tensor Imaging  Spinal Muscular Atrophies of Childhood/diagnostic imaging/pathology  Adolescent  Brain/diagnostic imaging/pathology  Nerve Net/diagnostic imaging/pathology  Prospective Studies  Spinal muscular atrophy  Structural magnetic resonance imaging  White matter  The First Affiliated Hospital of Sun Yat-Sen University (No. [2021]710). Informed  consent: Written informed consent was obtained from all subjects in this study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Spinal muscular atrophy (SMA) is caused by reduced expression of survival motor neuron (SMN) protein. Previous studies indicated SMA causes not only lower motor neuron degeneration but also extensive brain involvement. This study aimed to investigate the changes of brain white matter and structural network using diffusion tensor imaging (DTI) in children with type 2 and 3 SMA. METHODS: Forty-two type 2 and 3 pediatric SMA patients and 42 age- and gender-matched healthy controls (HC) were prospectively enrolled in this study. The tract-based spatial statistics (TBSS) was used to assess white matter integrity and the structural network properties were calculated based on DTI white matter fiber tracking and the graph theory approach. A partial correlation was performed to explore the relationship between white matter parameters and clinical characteristics. RESULTS: In total, 42 patients (mean age, 10.86 ± 4.07 years; 23 men) were included. TBSS analysis revealed widespread white matter changes in SMA patients. The SMA patients showed changes in multiple small-world and network efficiency parameters. Compared to the HC group, SMA showed increased characteristic path length (L(p)), normalized clustering coefficient (γ), small-world characteristic (σ), and decreased global efficiency (E(glob)) (all p < 0.05). In the node properties, right supramarginal gyrus, right orbital part of superior frontal gyrus, right supplementary motor area, and left median cingulate and paracingulate gyri changed in SMA patients. A decreased axial diffusivity (AD) value was associated with lower Hammersmith Functional Motor Scale-Expanded scores (r = 0.45, p = 0.02), which means that the symptoms of SMA patients are more severe. CONCLUSIONS: This study found white matter and DTI-based brain network abnormalities in SMA patients, suggesting SMN protein deficiency may affect white matter development. En ligne : https://dx.doi.org/10.1186/s11689-025-09592-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy [texte imprimé] / Huirong NIE, Auteur ; Shasha LAN, Auteur ; Huan WANG, Auteur ; Pei XIANG, Auteur ; Mengzhen YAN, Auteur ; Yang FAN, Auteur ; Wanqing SHEN, Auteur ; Yijuan LI, Auteur ; Wen TANG, Auteur ; Zhiyun YANG, Auteur ; Yujian LIANG, Auteur ; Yingqian CHEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Diffusion Tensor Imaging  Spinal Muscular Atrophies of Childhood/diagnostic imaging/pathology  Adolescent  Brain/diagnostic imaging/pathology  Nerve Net/diagnostic imaging/pathology  Prospective Studies  Spinal muscular atrophy  Structural magnetic resonance imaging  White matter  The First Affiliated Hospital of Sun Yat-Sen University (No. [2021]710). Informed  consent: Written informed consent was obtained from all subjects in this study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Spinal muscular atrophy (SMA) is caused by reduced expression of survival motor neuron (SMN) protein. Previous studies indicated SMA causes not only lower motor neuron degeneration but also extensive brain involvement. This study aimed to investigate the changes of brain white matter and structural network using diffusion tensor imaging (DTI) in children with type 2 and 3 SMA. METHODS: Forty-two type 2 and 3 pediatric SMA patients and 42 age- and gender-matched healthy controls (HC) were prospectively enrolled in this study. The tract-based spatial statistics (TBSS) was used to assess white matter integrity and the structural network properties were calculated based on DTI white matter fiber tracking and the graph theory approach. A partial correlation was performed to explore the relationship between white matter parameters and clinical characteristics. RESULTS: In total, 42 patients (mean age, 10.86 ± 4.07 years; 23 men) were included. TBSS analysis revealed widespread white matter changes in SMA patients. The SMA patients showed changes in multiple small-world and network efficiency parameters. Compared to the HC group, SMA showed increased characteristic path length (L(p)), normalized clustering coefficient (γ), small-world characteristic (σ), and decreased global efficiency (E(glob)) (all p < 0.05). In the node properties, right supramarginal gyrus, right orbital part of superior frontal gyrus, right supplementary motor area, and left median cingulate and paracingulate gyri changed in SMA patients. A decreased axial diffusivity (AD) value was associated with lower Hammersmith Functional Motor Scale-Expanded scores (r = 0.45, p = 0.02), which means that the symptoms of SMA patients are more severe. CONCLUSIONS: This study found white matter and DTI-based brain network abnormalities in SMA patients, suggesting SMN protein deficiency may affect white matter development. En ligne : https://dx.doi.org/10.1186/s11689-025-09592-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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