6 recherche sur le mot-clé 'Brain/diagnostic imaging/pathology'

A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children / Derek Sayre ANDREWS in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 32 Titre : A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children Type de document : texte imprimé Auteurs : Derek Sayre ANDREWS, Auteur ; Joshua K. LEE, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur Article en page(s) : 32 Langues : Anglais (eng) Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Child, Preschool  Cross-Sectional Studies  Diffusion Magnetic Resonance Imaging  Female  Humans  Image Processing, Computer-Assisted  Male  Sex Characteristics  White Matter/diagnostic imaging/pathology Index. décimale : PER Périodiques Résumé : BACKGROUND: The core symptoms of autism spectrum disorder (ASD) are widely theorized to result from altered brain connectivity. Diffusion-weighted magnetic resonance imaging (DWI) has been a versatile method for investigating underlying microstructural properties of white matter (WM) in ASD. Despite phenotypic and etiological heterogeneity, DWI studies in majority male samples of older children, adolescents, and adults with ASD have largely reported findings of decreased fractional anisotropy (FA) across several commissural, projection, and association fiber tracts. However, studies in preschool-aged children (i.e., < 30-40 months) suggest individuals with ASD have increased measures of WM FA earlier in development. METHODS: We analyzed 127 individuals with ASD (85♂, 42♀) and 54 typically developing (TD) controls (42♂, 26♀), aged 25.1-49.6 months. Voxel-wise effects of ASD diagnosis, sex, age, and their interaction on DWI measures of FA, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were investigated using tract-based spatial statistics (TBSS) while controlling mean absolute and relative motion. RESULTS: Compared to TD controls, males and females with ASD had significantly increased measures of FA in eight clusters (threshold-free cluster enhancement p < 0.05) that incorporated several WM tracts including regions of the genu, body, and splenium of the corpus callosum, inferior frontal-occipital fasciculi, inferior and superior longitudinal fasciculi, middle and superior cerebellar peduncles, and corticospinal tract. A diagnosis by sex interaction was observed in measures of AD across six significant clusters incorporating areas of the body, genu, and splenium of the corpus collosum. In these tracts, females with ASD showed increased AD compared to TD females, while males with ASD showed decreased AD compared to TD males. CONCLUSIONS: The current findings support growing evidence that preschool-aged children with ASD have atypical measures of WM microstructure that appear to differ in directionality from alterations observed in older individuals with the condition. To our knowledge, this study represents the largest sample of preschool-aged females with ASD to be evaluated using DWI. Microstructural differences associated with ASD largely overlapped between sexes. However, differential relationships of AD measures indicate that sex likely modulates ASD neuroanatomical phenotypes. Further longitudinal study is needed to confirm and quantify the developmental relationship of WM structure in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9291-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children [texte imprimé] / Derek Sayre ANDREWS, Auteur ; Joshua K. LEE, Auteur ; Marjorie SOLOMON, Auteur ; Sally J. ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur . - 32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 32 Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/pathology  Brain/diagnostic imaging/pathology  Child, Preschool  Cross-Sectional Studies  Diffusion Magnetic Resonance Imaging  Female  Humans  Image Processing, Computer-Assisted  Male  Sex Characteristics  White Matter/diagnostic imaging/pathology Index. décimale : PER Périodiques Résumé : BACKGROUND: The core symptoms of autism spectrum disorder (ASD) are widely theorized to result from altered brain connectivity. Diffusion-weighted magnetic resonance imaging (DWI) has been a versatile method for investigating underlying microstructural properties of white matter (WM) in ASD. Despite phenotypic and etiological heterogeneity, DWI studies in majority male samples of older children, adolescents, and adults with ASD have largely reported findings of decreased fractional anisotropy (FA) across several commissural, projection, and association fiber tracts. However, studies in preschool-aged children (i.e., < 30-40 months) suggest individuals with ASD have increased measures of WM FA earlier in development. METHODS: We analyzed 127 individuals with ASD (85♂, 42♀) and 54 typically developing (TD) controls (42♂, 26♀), aged 25.1-49.6 months. Voxel-wise effects of ASD diagnosis, sex, age, and their interaction on DWI measures of FA, mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were investigated using tract-based spatial statistics (TBSS) while controlling mean absolute and relative motion. RESULTS: Compared to TD controls, males and females with ASD had significantly increased measures of FA in eight clusters (threshold-free cluster enhancement p < 0.05) that incorporated several WM tracts including regions of the genu, body, and splenium of the corpus callosum, inferior frontal-occipital fasciculi, inferior and superior longitudinal fasciculi, middle and superior cerebellar peduncles, and corticospinal tract. A diagnosis by sex interaction was observed in measures of AD across six significant clusters incorporating areas of the body, genu, and splenium of the corpus collosum. In these tracts, females with ASD showed increased AD compared to TD females, while males with ASD showed decreased AD compared to TD males. CONCLUSIONS: The current findings support growing evidence that preschool-aged children with ASD have atypical measures of WM microstructure that appear to differ in directionality from alterations observed in older individuals with the condition. To our knowledge, this study represents the largest sample of preschool-aged females with ASD to be evaluated using DWI. Microstructural differences associated with ASD largely overlapped between sexes. However, differential relationships of AD measures indicate that sex likely modulates ASD neuroanatomical phenotypes. Further longitudinal study is needed to confirm and quantify the developmental relationship of WM structure in ASD. En ligne : https://dx.doi.org/10.1186/s11689-019-9291-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy / Huirong NIE in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy Type de document : texte imprimé Auteurs : Huirong NIE, Auteur ; Shasha LAN, Auteur ; Huan WANG, Auteur ; Pei XIANG, Auteur ; Mengzhen YAN, Auteur ; Yang FAN, Auteur ; Wanqing SHEN, Auteur ; Yijuan LI, Auteur ; Wen TANG, Auteur ; Zhiyun YANG, Auteur ; Yujian LIANG, Auteur ; Yingqian CHEN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Diffusion Tensor Imaging  Spinal Muscular Atrophies of Childhood/diagnostic imaging/pathology  Adolescent  Brain/diagnostic imaging/pathology  Nerve Net/diagnostic imaging/pathology  Prospective Studies  Spinal muscular atrophy  Structural magnetic resonance imaging  White matter  The First Affiliated Hospital of Sun Yat-Sen University (No. [2021]710). Informed  consent: Written informed consent was obtained from all subjects in this study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Spinal muscular atrophy (SMA) is caused by reduced expression of survival motor neuron (SMN) protein. Previous studies indicated SMA causes not only lower motor neuron degeneration but also extensive brain involvement. This study aimed to investigate the changes of brain white matter and structural network using diffusion tensor imaging (DTI) in children with type 2 and 3 SMA. METHODS: Forty-two type 2 and 3 pediatric SMA patients and 42 age- and gender-matched healthy controls (HC) were prospectively enrolled in this study. The tract-based spatial statistics (TBSS) was used to assess white matter integrity and the structural network properties were calculated based on DTI white matter fiber tracking and the graph theory approach. A partial correlation was performed to explore the relationship between white matter parameters and clinical characteristics. RESULTS: In total, 42 patients (mean age, 10.86 ± 4.07 years; 23 men) were included. TBSS analysis revealed widespread white matter changes in SMA patients. The SMA patients showed changes in multiple small-world and network efficiency parameters. Compared to the HC group, SMA showed increased characteristic path length (L(p)), normalized clustering coefficient (γ), small-world characteristic (σ), and decreased global efficiency (E(glob)) (all p < 0.05). In the node properties, right supramarginal gyrus, right orbital part of superior frontal gyrus, right supplementary motor area, and left median cingulate and paracingulate gyri changed in SMA patients. A decreased axial diffusivity (AD) value was associated with lower Hammersmith Functional Motor Scale-Expanded scores (r = 0.45, p = 0.02), which means that the symptoms of SMA patients are more severe. CONCLUSIONS: This study found white matter and DTI-based brain network abnormalities in SMA patients, suggesting SMN protein deficiency may affect white matter development. En ligne : https://dx.doi.org/10.1186/s11689-025-09592-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Reduced white matter integrity and disrupted brain network in children with type 2 and 3 spinal muscular atrophy [texte imprimé] / Huirong NIE, Auteur ; Shasha LAN, Auteur ; Huan WANG, Auteur ; Pei XIANG, Auteur ; Mengzhen YAN, Auteur ; Yang FAN, Auteur ; Wanqing SHEN, Auteur ; Yijuan LI, Auteur ; Wen TANG, Auteur ; Zhiyun YANG, Auteur ; Yujian LIANG, Auteur ; Yingqian CHEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Male  Female  White Matter/diagnostic imaging/pathology  Child  Diffusion Tensor Imaging  Spinal Muscular Atrophies of Childhood/diagnostic imaging/pathology  Adolescent  Brain/diagnostic imaging/pathology  Nerve Net/diagnostic imaging/pathology  Prospective Studies  Spinal muscular atrophy  Structural magnetic resonance imaging  White matter  The First Affiliated Hospital of Sun Yat-Sen University (No. [2021]710). Informed  consent: Written informed consent was obtained from all subjects in this study.  Competing interests: The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Spinal muscular atrophy (SMA) is caused by reduced expression of survival motor neuron (SMN) protein. Previous studies indicated SMA causes not only lower motor neuron degeneration but also extensive brain involvement. This study aimed to investigate the changes of brain white matter and structural network using diffusion tensor imaging (DTI) in children with type 2 and 3 SMA. METHODS: Forty-two type 2 and 3 pediatric SMA patients and 42 age- and gender-matched healthy controls (HC) were prospectively enrolled in this study. The tract-based spatial statistics (TBSS) was used to assess white matter integrity and the structural network properties were calculated based on DTI white matter fiber tracking and the graph theory approach. A partial correlation was performed to explore the relationship between white matter parameters and clinical characteristics. RESULTS: In total, 42 patients (mean age, 10.86 ± 4.07 years; 23 men) were included. TBSS analysis revealed widespread white matter changes in SMA patients. The SMA patients showed changes in multiple small-world and network efficiency parameters. Compared to the HC group, SMA showed increased characteristic path length (L(p)), normalized clustering coefficient (γ), small-world characteristic (σ), and decreased global efficiency (E(glob)) (all p < 0.05). In the node properties, right supramarginal gyrus, right orbital part of superior frontal gyrus, right supplementary motor area, and left median cingulate and paracingulate gyri changed in SMA patients. A decreased axial diffusivity (AD) value was associated with lower Hammersmith Functional Motor Scale-Expanded scores (r = 0.45, p = 0.02), which means that the symptoms of SMA patients are more severe. CONCLUSIONS: This study found white matter and DTI-based brain network abnormalities in SMA patients, suggesting SMN protein deficiency may affect white matter development. En ligne : https://dx.doi.org/10.1186/s11689-025-09592-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients / Chia-Jui HSU in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients Type de document : texte imprimé Auteurs : Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients [texte imprimé] / Chia-Jui HSU, Auteur ; Lee Chin WONG, Auteur ; Hsin-Pei WANG, Auteur ; Yi-Chun CHUNG, Auteur ; Te-Wei KAO, Auteur ; Chen-Hsiang WENG, Auteur ; Wen-Chau WU, Auteur ; Shinn-Forng PENG, Auteur ; Wen-Yih Isaac TSENG, Auteur ; Wang-Tso LEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Humans  Child  Tourette Syndrome/diagnostic imaging/pathology  Prospective Studies  Brain/diagnostic imaging/pathology  Diffusion Magnetic Resonance Imaging  Brain Mapping  Diffusion spectrum imaging  False discovery rate  Frontostriatal  Gilles de la Tourette syndrome  Pediatric neurology Index. décimale : PER Périodiques Résumé : BACKGROUND: Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging. METHODS: This single-center prospective study involved 30 patients and 30 age- and gender-matched healthy volunteers who underwent sagittal T1-weighted MRI and DSI. We analyzed generalized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. RESULTS: No significant differences were observed in mean diffusivity and axial diffusivity values between the two groups. However, the patient group exhibited significantly higher generalized fractional anisotropy values in the right frontostriatal tract of the dorsolateral prefrontal cortex, the right frontostriatal tract of the precentral gyrus, and bilateral thalamic radiation of the dorsolateral prefrontal cortex. Additionally, the generalized fractional anisotropy value of the right frontostriatal tract of the precentral gyrus is inversely correlated with the total tic severity scores at the most severe condition. CONCLUSION: Treatment-naïve pediatric GTS patients demonstrated increased connectivity within the CSTC circuit as per diffusion spectrum imaging, indicating possible CSTC circuit dysregulation. This finding could also suggest a compensatory change. It thus underscores the necessity of further investigation into the fundamental pathological changes in GTS. Nevertheless, the observed altered connectivity in GTS patients might serve as a potential target for therapeutic intervention. En ligne : https://dx.doi.org/10.1186/s11689-023-09501-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels / Jèssica PARDO in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels Type de document : texte imprimé Auteurs : Jèssica PARDO, Auteur ; Clara CAPDEVILA-LACASA, Auteur ; Bàrbara SEGURA, Auteur ; Adriana PANÉ, Auteur ; Cristina MONTSERRAT, Auteur ; Maria DE TALLÓ FORGA-VISA, Auteur ; Pedro J. MORENO, Auteur ; Glòria GARRABOU, Auteur ; Josep M. GRAU-JUNYENT, Auteur ; Carme JUNQUÉ, Auteur Langues : Anglais (eng) Mots-clés : Humans  Phenylketonurias/blood/pathology/diagnostic imaging  Phenylalanine/blood  Male  Female  Adult  Magnetic Resonance Imaging  Brain/diagnostic imaging/pathology  Young Adult  Neuropsychological Tests  Adult early-treated patients  Blood phenylalanine levels  Neuroimaging  Neuropsychological assessment  Phenylketonuria  Volumetry Index. décimale : PER Périodiques Résumé : BACKGROUND: Continued dietary treatment since early diagnosis through newborn screening programs usually prevents brain-related complications in phenylketonuria (PKU). However, subtle neurocognitive and brain alterations may be observed in some adult patients despite early treatment. Nevertheless, neuropsychological and neuroimaging studies in the field remain scarce. OBJECTIVES: This work aimed to determine possible neuropsychological and structural brain alterations in treated adult patients with PKU. METHODS: Thirty-five patients with PKU and 22 healthy controls (HC) underwent neuropsychological assessment and T1-weighted magnetic resonance imaging on a 3 T scanner. FreeSurfer (v.7.1) was used to obtain volumetric measures and SPSS (v27.0.1.0) was used to analyze sociodemographic, neuropsychological, volumetric, and clinical data (p < 0.05). RESULTS: Adult patients with PKU showed significantly lower performance than HC in Full Scale IQ (t = 2.67; p = .010) from the WAIS-IV. The PKU group also showed significantly lower volumes than HC in the pallidum (U = 224.000; p = .008), hippocampus (U = 243.000; p = .020), amygdala (U = 200.000; p = .002), and brainstem (t = 3.17; p = .006) as well as in total cerebral white matter volume (U = 175.000; p = .001). Blood phenylalanine (Phe) levels in PKU patients were negatively correlated with the pallidum (r = -0.417; p = .013) and brainstem (r = -0.455, p = .006) volumes. CONCLUSIONS: Adult patients with early-treated PKU showed significantly lower global intelligence than HC. Moreover, these patients showed reduced global white matter volume as well as reductions in the volume of several subcortical grey matter structures, which might be related to the existence of underlying neurodevelopmental alterations. Higher blood Phe levels were also negatively correlated with pallidum and brainstem, suggesting a higher vulnerability of these structures to Phe toxicity. En ligne : https://dx.doi.org/10.1186/s11689-024-09553-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels [texte imprimé] / Jèssica PARDO, Auteur ; Clara CAPDEVILA-LACASA, Auteur ; Bàrbara SEGURA, Auteur ; Adriana PANÉ, Auteur ; Cristina MONTSERRAT, Auteur ; Maria DE TALLÓ FORGA-VISA, Auteur ; Pedro J. MORENO, Auteur ; Glòria GARRABOU, Auteur ; Josep M. GRAU-JUNYENT, Auteur ; Carme JUNQUÉ, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Humans  Phenylketonurias/blood/pathology/diagnostic imaging  Phenylalanine/blood  Male  Female  Adult  Magnetic Resonance Imaging  Brain/diagnostic imaging/pathology  Young Adult  Neuropsychological Tests  Adult early-treated patients  Blood phenylalanine levels  Neuroimaging  Neuropsychological assessment  Phenylketonuria  Volumetry Index. décimale : PER Périodiques Résumé : BACKGROUND: Continued dietary treatment since early diagnosis through newborn screening programs usually prevents brain-related complications in phenylketonuria (PKU). However, subtle neurocognitive and brain alterations may be observed in some adult patients despite early treatment. Nevertheless, neuropsychological and neuroimaging studies in the field remain scarce. OBJECTIVES: This work aimed to determine possible neuropsychological and structural brain alterations in treated adult patients with PKU. METHODS: Thirty-five patients with PKU and 22 healthy controls (HC) underwent neuropsychological assessment and T1-weighted magnetic resonance imaging on a 3 T scanner. FreeSurfer (v.7.1) was used to obtain volumetric measures and SPSS (v27.0.1.0) was used to analyze sociodemographic, neuropsychological, volumetric, and clinical data (p < 0.05). RESULTS: Adult patients with PKU showed significantly lower performance than HC in Full Scale IQ (t = 2.67; p = .010) from the WAIS-IV. The PKU group also showed significantly lower volumes than HC in the pallidum (U = 224.000; p = .008), hippocampus (U = 243.000; p = .020), amygdala (U = 200.000; p = .002), and brainstem (t = 3.17; p = .006) as well as in total cerebral white matter volume (U = 175.000; p = .001). Blood phenylalanine (Phe) levels in PKU patients were negatively correlated with the pallidum (r = -0.417; p = .013) and brainstem (r = -0.455, p = .006) volumes. CONCLUSIONS: Adult patients with early-treated PKU showed significantly lower global intelligence than HC. Moreover, these patients showed reduced global white matter volume as well as reductions in the volume of several subcortical grey matter structures, which might be related to the existence of underlying neurodevelopmental alterations. Higher blood Phe levels were also negatively correlated with pallidum and brainstem, suggesting a higher vulnerability of these structures to Phe toxicity. En ligne : https://dx.doi.org/10.1186/s11689-024-09553-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study / In-Seong HWANG in Autism Research, 15-12 (December 2022)  

Public ISBD [article]  inAutism Research > 15-12 (December 2022) . - p.2238-2249 Titre : Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study Type de document : texte imprimé Auteurs : In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur Article en page(s) : p.2238-2249 Langues : Anglais (eng) Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (ÃŽ2 = -0.384, p = 0.010; ÃŽ2 = -0.336, p = 0.030; ÃŽ2 = -0.317, p = 0.040; ÃŽ2 = 0.322, p = 0.010; ÃŽ2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (ÃŽ2 = 0.434, p = 0.014; ÃŽ2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association between body mass index and subcortical volume in pre-adolescent children with autism spectrum disorder: An exploratory study [texte imprimé] / In-Seong HWANG, Auteur ; Soon-Beom HONG, Auteur . - p.2238-2249. Langues : Anglais (eng) in Autism Research > 15-12 (December 2022) . - p.2238-2249 Mots-clés : Child  Humans  Adolescent  Autism Spectrum Disorder/diagnostic imaging/pathology  Body Mass Index  Pediatric Obesity/complications/diagnostic imaging  Magnetic Resonance Imaging/methods  Brain/diagnostic imaging/pathology  autism spectrum disorder  caudate nucleus  obesity  subcortical volume  ventral diencephalon Index. décimale : PER Périodiques Résumé : Conflicting associations exist between autism spectrum disorder (ASD) and subcortical brain volumes. This study assessed whether obesity might have a confounding influence on associations between ASD and brain subcortical volumes. A comprehensive investigation evaluating the relationship between ASD, obesity, and subcortical structure volumes was conducted. Data obtained included body mass index (BMI) and T1-weighted structural magnetic resonance images for children with and without ASD diagnoses from the Autism Brain Imaging Data Exchange database. Brain subcortical volumes were calculated using vol2Brain software. Hierarchical linear regression analyses were performed to explore the subcortical volumes similarly or differentially associated with BMI in children with or without ASD and examine association and interaction effects regarding ASD and subcortical volume impact on the Social Responsiveness Scale and Vineland Adaptive Behavior Scale (VABS) scores. Bilateral caudate nuclei were smaller in children with ASD than in control participants. Significant interactions were observed between ASD diagnosis and BMI regarding the left caudate, right and left putamen, and right and left ventral diencephalon (DC) volumes (ÃŽ2 = -0.384, p = 0.010; ÃŽ2 = -0.336, p = 0.030; ÃŽ2 = -0.317, p = 0.040; ÃŽ2 = 0.322, p = 0.010; ÃŽ2 = 0.295, p = 0.021, respectively) and between ASD diagnosis and right and left ventral DC volumes regarding the VABS scores (ÃŽ2 = 0.434, p = 0.014; ÃŽ2 = 0.495, p = 0.007, respectively). However, each subcortical structure volume included in the ventral DC area could not be measured separately. The results identified subcortical volumes differentially associated with obesity in children with ASD compared with typically developing peers. BMI may need to be considered an important confounder in future research examining brain subcortical volumes within ASD. En ligne : http://dx.doi.org/10.1002/aur.2834 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities / Chun-Hung YEH in Molecular Autism, 13 (2022)  

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