Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk / Wanze XIE in Journal of Child Psychology and Psychiatry, 67-7 (July 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1203-1217 Titre : Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk Type de document : texte imprimé Auteurs : Wanze XIE, Auteur ; Yiyi WANG, Auteur ; Dashiell D. SACKS, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.1203-1217 Langues : Anglais (eng) Mots-clés : Temperament  developmental psychopathology  internalizing disorder  electroencephalography  neural networks Index. décimale : PER Périodiques Résumé : Background Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. Methods Using a longitudinal cohort followed from infancy to age 7 (N?=?749 collected at infancy), we assessed temperament through two approaches: data-driven profiles extracted from parent-reported questionnaires collected from infancy to age 3 and lab-based assessments of behavioral inhibition (BI) at age 3. Symptoms of psychopathology were measured at age 7 with the parent-reported Child Behavior Checklist (CBCL). Resting-state EEG data collected at ages 3, 5, and 7, along with source-space connectivity methods, were used to examine FC within brain networks. Results Children with an emotionally and behaviorally dysregulated (EBD) profile, an identified risk factor for psychopathology, exhibited reduced FC in the frontoparietal network compared to their emotionally and behaviorally regulated (EBR) peers. BI at age 3 was also negatively correlated with FC in the ventral attention network at age 3 and the frontoparietal network at age 7. Additionally, frontoparietal FC moderated the relationship between early temperament and later attention-deficit symptoms: EBD children showed higher levels of attention problems than their EBR peers, but only when frontoparietal FC was low. Conclusions These findings underscore the importance of network connectivity in understanding early temperament and its socioemotional outcomes. Specifically, they highlight the role of attention and control networks in the development of psychopathology, suggesting potential targets for early interventions aimed at at-risk children. En ligne : https://doi.org/10.1111/jcpp.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk [texte imprimé] / Wanze XIE, Auteur ; Yiyi WANG, Auteur ; Dashiell D. SACKS, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.1203-1217. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1203-1217 Mots-clés : Temperament  developmental psychopathology  internalizing disorder  electroencephalography  neural networks Index. décimale : PER Périodiques Résumé : Background Early temperament has been shown to predict socioemotional outcomes, but its neural correlates are not yet fully understood. In the current study, we investigated the relationship between early temperament and neuronal network functional connectivity (FC), and how these factors contribute to the risk of psychopathology. Methods Using a longitudinal cohort followed from infancy to age 7 (N?=?749 collected at infancy), we assessed temperament through two approaches: data-driven profiles extracted from parent-reported questionnaires collected from infancy to age 3 and lab-based assessments of behavioral inhibition (BI) at age 3. Symptoms of psychopathology were measured at age 7 with the parent-reported Child Behavior Checklist (CBCL). Resting-state EEG data collected at ages 3, 5, and 7, along with source-space connectivity methods, were used to examine FC within brain networks. Results Children with an emotionally and behaviorally dysregulated (EBD) profile, an identified risk factor for psychopathology, exhibited reduced FC in the frontoparietal network compared to their emotionally and behaviorally regulated (EBR) peers. BI at age 3 was also negatively correlated with FC in the ventral attention network at age 3 and the frontoparietal network at age 7. Additionally, frontoparietal FC moderated the relationship between early temperament and later attention-deficit symptoms: EBD children showed higher levels of attention problems than their EBR peers, but only when frontoparietal FC was low. Conclusions These findings underscore the importance of network connectivity in understanding early temperament and its socioemotional outcomes. Specifically, they highlight the role of attention and control networks in the development of psychopathology, suggesting potential targets for early interventions aimed at at-risk children. En ligne : https://doi.org/10.1111/jcpp.70095 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

Neurophysiological sensitivity in early childhood: EEG aperiodic slope moderates the association between maternal anxiety and child internalizing symptoms / Dashiell D. SACKS in Development and Psychopathology, 38-4 (October 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-4 (October 2026) . - p.1668-1676 Titre : Neurophysiological sensitivity in early childhood: EEG aperiodic slope moderates the association between maternal anxiety and child internalizing symptoms Type de document : texte imprimé Auteurs : Dashiell D. SACKS, Auteur ; Viviane VALDES, Auteur ; April R. LEVIN, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.1668-1676 Langues : Anglais (eng) Mots-clés : Aperiodic exponent  EEG  child psychopathology  early childhood  maternal anxiety Index. décimale : PER Périodiques Résumé : Maternal internalizing (anxiety and depressive) symptoms are a robust risk factor for the development of internalizing symptoms in offspring, yet the neurobiological mechanisms that influence this association remain relatively unexplored. The aperiodic “slope” of the EEG power spectrum (i.e., aperiodic exponent) is hypothesized to index the cortical excitatory-inhibitory balance and may serve as an early neurophysiological marker of mental health risk. In a prospective longitudinal cohort (N = 323 mother–child dyads), we examined associations among maternal anxiety and depressive symptoms in infancy and at age 5 years, child EEG aperiodic slope at age 3 years, and child internalizing symptoms at age 5 years. We investigated whether the aperiodic slope at 3 years (a) mediated associations between maternal internalizing symptoms in infancy and child internalizing symptoms at age 5 years and/or (b) moderated associations between maternal internalizing symptoms and child internalizing symptoms at age 5 years. There were no significant mediation effects. The aperiodic slope moderated the association between maternal anxiety symptoms and child internalizing symptoms: A steeper slope was associated with a stronger association between maternal and child symptoms. Findings suggest that the EEG aperiodic slope may represent a moderator of intergenerational risk for internalizing symptoms in early childhood. En ligne : https://dx.doi.org/10.1017/S0954579426101400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593 [article] Neurophysiological sensitivity in early childhood: EEG aperiodic slope moderates the association between maternal anxiety and child internalizing symptoms [texte imprimé] / Dashiell D. SACKS, Auteur ; Viviane VALDES, Auteur ; April R. LEVIN, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.1668-1676. Langues : Anglais (eng) in Development and Psychopathology > 38-4 (October 2026) . - p.1668-1676 Mots-clés : Aperiodic exponent  EEG  child psychopathology  early childhood  maternal anxiety Index. décimale : PER Périodiques Résumé : Maternal internalizing (anxiety and depressive) symptoms are a robust risk factor for the development of internalizing symptoms in offspring, yet the neurobiological mechanisms that influence this association remain relatively unexplored. The aperiodic “slope” of the EEG power spectrum (i.e., aperiodic exponent) is hypothesized to index the cortical excitatory-inhibitory balance and may serve as an early neurophysiological marker of mental health risk. In a prospective longitudinal cohort (N = 323 mother–child dyads), we examined associations among maternal anxiety and depressive symptoms in infancy and at age 5 years, child EEG aperiodic slope at age 3 years, and child internalizing symptoms at age 5 years. We investigated whether the aperiodic slope at 3 years (a) mediated associations between maternal internalizing symptoms in infancy and child internalizing symptoms at age 5 years and/or (b) moderated associations between maternal internalizing symptoms and child internalizing symptoms at age 5 years. There were no significant mediation effects. The aperiodic slope moderated the association between maternal anxiety symptoms and child internalizing symptoms: A steeper slope was associated with a stronger association between maternal and child symptoms. Findings suggest that the EEG aperiodic slope may represent a moderator of intergenerational risk for internalizing symptoms in early childhood. En ligne : https://dx.doi.org/10.1017/S0954579426101400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=593

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