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Résultat de la recherche
6 recherche sur le mot-clé 'bipolar'




Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms / G. SUGRANYES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)
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[article]
Titre : Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms Type de document : Texte imprimé et/ou numérique Auteurs : G. SUGRANYES, Auteur ; E. DE LA SERNA, Auteur ; D. ILZARBE, Auteur ; J. C. PARIENTE, Auteur ; R. BORRAS, Auteur ; S. ROMERO, Auteur ; M. ROSA, Auteur ; I. BAEZA, Auteur ; M. D. MORENO, Auteur ; M. BERNARDO, Auteur ; E. VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur Article en page(s) : p.780-789 Langues : Anglais (eng) Mots-clés : Adolescent Bipolar Disorder/diagnostic imaging Brain/diagnostic imaging Cross-Sectional Studies Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Psychotic Disorders/diagnostic imaging Schizophrenia/diagnostic imaging/genetics High-risk studies bipolar psychosis schizophrenia structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456
in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789[article] Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms [Texte imprimé et/ou numérique] / G. SUGRANYES, Auteur ; E. DE LA SERNA, Auteur ; D. ILZARBE, Auteur ; J. C. PARIENTE, Auteur ; R. BORRAS, Auteur ; S. ROMERO, Auteur ; M. ROSA, Auteur ; I. BAEZA, Auteur ; M. D. MORENO, Auteur ; M. BERNARDO, Auteur ; E. VIETA, Auteur ; Josefina CASTRO-FORNIELES, Auteur . - p.780-789.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 62-6 (June 2021) . - p.780-789
Mots-clés : Adolescent Bipolar Disorder/diagnostic imaging Brain/diagnostic imaging Cross-Sectional Studies Genetic Predisposition to Disease Humans Magnetic Resonance Imaging Psychotic Disorders/diagnostic imaging Schizophrenia/diagnostic imaging/genetics High-risk studies bipolar psychosis schizophrenia structural MRI Index. décimale : PER Périodiques Résumé : BACKGROUND: The evaluation of child and adolescent offspring of patients with schizophrenia (SzO) or bipolar disorder (BpO) may help understand changes taking place in the brain in individuals at heightened risk for disease during a key developmental period. METHODS: One hundred twenty-eight individuals (33 SzO and 46 BpO, considered jointly as 'Familial High Risk' (FHR), and 49 controls) aged 6-17 years underwent clinical, cognitive and neuroimaging assessment at baseline, 2- and 4-year follow-up. Twenty FHR participants (11 SzO and 9 BpO) developed psychotic spectrum symptoms during follow-up, while 59 FHR participants did not. Magnetic resonance imaging was performed on a 3Tesla scanner; cortical surface reconstruction was applied to measure cortical thickness, surface area and grey matter volume. RESULTS: FHR participants who developed psychotic spectrum symptoms over time showed greater time-related mean cortical thinning than those who did not and than controls. By subgroups, this effect was present in both BpO and SzO in the occipital cortex. At baseline, FHR participants who developed psychotic spectrum symptoms over time had smaller total surface area and grey matter volume than those who did not and than controls. Over time, all FHR participants showed less longitudinal decrease in surface area than controls. In those who developed psychotic spectrum symptoms over time, this effect was driven by BpO, while in those who did not, this was due to SzO, who also showed less grey matter volume reduction. CONCLUSION: The emergence of psychotic spectrum symptoms in FHR was indexed by smaller cross-sectional surface area and progressive cortical thinning. Relative preservation of surface area over time may signal different processes according to familial risk. These findings lay the foundation for future studies aimed at stratification of FHR youth. En ligne : http://dx.doi.org/10.1111/jcpp.13321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 Practitioner Review: Long-term pharmacological treatment of pediatric bipolar disorder / Covadonga M. DIAZ-CANEJA in Journal of Child Psychology and Psychiatry, 55-9 (September 2014)
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Titre : Practitioner Review: Long-term pharmacological treatment of pediatric bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : Covadonga M. DIAZ-CANEJA, Auteur ; Carmen MORENO, Auteur ; Cloe LLORENTE, Auteur ; Ana ESPLIEGO, Auteur ; Celso ARANGO, Auteur ; Dolores MORENO, Auteur Article en page(s) : p.959-980 Langues : Anglais (eng) Mots-clés : Bipolar mania maintenance mood stabilizer antipsychotic child adolescent Index. décimale : PER Périodiques Résumé : Background Although long-term treatment is a core aspect of the management of children and adolescents with bipolar disorder (BD), most clinical recommendations are based on results from short-term studies or adult data. In order to guide clinical practice, we review the efficacy and safety profile of mood stabilizers, antipsychotics, and other pharmacological strategies for the long-term treatment of BD in pediatric patients. Methods A MEDLINE, EMBASE, Cochrane and PsycInfo search (inception through November 2013) was performed to identify prospective studies longer than 12 weeks assessing the use of pharmacological strategies for the long-term treatment of BD in pediatric patients (0–18 years of age). Results Four randomized controlled trials (RCT) [three placebo-controlled (assessing aripiprazole (2) and flax oil), and one head-to-head comparison of lithium vs. divalproex], and thirteen noncontrolled studies (six open-label studies assessing lithium or anticonvulsants, five assessing second-generation antipsychotics (SGAs) and four assessing combination strategies) were included in the review. Aripiprazole has shown efficacy for relapse prevention in children with pediatric bipolar disorder (PBD) 4–9 years of age in one placebo-controlled RCT. Positive results have been reported in noncontrolled studies with quetiapine and lithium for relapse prevention, as well as with lithium, quetiapine, ziprasidone, and the combination of risperidone and divalproex or lithium for long-term symptom reduction in PBD. The most frequently reported adverse events in children and adolescents treated with lithium and anticonvulsants are gastrointestinal and neurological, whereas use of SGAs is mainly related to weight gain and sedation. Conclusion According to the limited empirical evidence, aripiprazole can be useful for relapse prevention in children with PBD. Given the lack of consistent efficacy data, clinical decision making should be based on individual clinical aspects and safety concerns. En ligne : http://dx.doi.org/10.1111/jcpp.12271 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238
in Journal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.959-980[article] Practitioner Review: Long-term pharmacological treatment of pediatric bipolar disorder [Texte imprimé et/ou numérique] / Covadonga M. DIAZ-CANEJA, Auteur ; Carmen MORENO, Auteur ; Cloe LLORENTE, Auteur ; Ana ESPLIEGO, Auteur ; Celso ARANGO, Auteur ; Dolores MORENO, Auteur . - p.959-980.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-9 (September 2014) . - p.959-980
Mots-clés : Bipolar mania maintenance mood stabilizer antipsychotic child adolescent Index. décimale : PER Périodiques Résumé : Background Although long-term treatment is a core aspect of the management of children and adolescents with bipolar disorder (BD), most clinical recommendations are based on results from short-term studies or adult data. In order to guide clinical practice, we review the efficacy and safety profile of mood stabilizers, antipsychotics, and other pharmacological strategies for the long-term treatment of BD in pediatric patients. Methods A MEDLINE, EMBASE, Cochrane and PsycInfo search (inception through November 2013) was performed to identify prospective studies longer than 12 weeks assessing the use of pharmacological strategies for the long-term treatment of BD in pediatric patients (0–18 years of age). Results Four randomized controlled trials (RCT) [three placebo-controlled (assessing aripiprazole (2) and flax oil), and one head-to-head comparison of lithium vs. divalproex], and thirteen noncontrolled studies (six open-label studies assessing lithium or anticonvulsants, five assessing second-generation antipsychotics (SGAs) and four assessing combination strategies) were included in the review. Aripiprazole has shown efficacy for relapse prevention in children with pediatric bipolar disorder (PBD) 4–9 years of age in one placebo-controlled RCT. Positive results have been reported in noncontrolled studies with quetiapine and lithium for relapse prevention, as well as with lithium, quetiapine, ziprasidone, and the combination of risperidone and divalproex or lithium for long-term symptom reduction in PBD. The most frequently reported adverse events in children and adolescents treated with lithium and anticonvulsants are gastrointestinal and neurological, whereas use of SGAs is mainly related to weight gain and sedation. Conclusion According to the limited empirical evidence, aripiprazole can be useful for relapse prevention in children with PBD. Given the lack of consistent efficacy data, clinical decision making should be based on individual clinical aspects and safety concerns. En ligne : http://dx.doi.org/10.1111/jcpp.12271 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 Physiological regulation in infants of women with a mood disorder: examining associations with maternal symptoms and stress / Katrina C. JOHNSON in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)
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Titre : Physiological regulation in infants of women with a mood disorder: examining associations with maternal symptoms and stress Type de document : Texte imprimé et/ou numérique Auteurs : Katrina C. JOHNSON, Auteur ; Patricia A. BRENNAN, Auteur ; Zachary N. STOWE, Auteur ; Ellen LEIBENLUFT, Auteur ; D. Jeffrey NEWPORT, Auteur Article en page(s) : p.191-198 Langues : Anglais (eng) Mots-clés : Bipolar depression RSA heart rate vagal stress infants human Index. décimale : PER Périodiques Résumé : Background The offspring of mothers with mood disorders may evidence increased behavioral problems as early as preschool; however, no study to date has examined psychophysiological characteristics during infancy, particularly among offspring of mothers diagnosed with bipolar disorder. Elucidating psychobiological mechanisms of risk early in development is critical to inform prevention and early intervention efforts. Method This study compared physiological and behavioral responsivity in 6-month-old infants (N = 329) of mothers with lifetime histories of bipolar disorder (BD, n = 44), major depressive disorder (MDD, n = 244), or no history of Axis I disorders (CTL, n = 41). Infant respiratory sinus arrhythmia (RSA) was measured in a laboratory stressor paradigm. Measures of infant affect and behavior during mother–infant interaction, current maternal depressive symptoms, and exposure to stressful life events were examined with respect to diagnostic group and RSA. Results Groups did not differ in baseline RSA or infant affect measures. However, during the stressor task, infants of mothers with BD evidenced increases in RSA, while infants of MDD and CTL mothers evidenced decreases in RSA. Though levels of postnatal stress and current levels of maternal depressive symptoms differed among groups, neither of these factors predicted infant psychophysiological responses. Conclusions At 6 months of age, infants of motrs with BD show differences in psychophysiological regulation. These differences cannot be accounted for by perinatal outcome, current maternal depressive symptoms, or exposure to stressful life events, and thus may reflect endophenotypic markers of psychopathological risk. En ligne : http://dx.doi.org/10.1111/jcpp.12130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221
in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.191-198[article] Physiological regulation in infants of women with a mood disorder: examining associations with maternal symptoms and stress [Texte imprimé et/ou numérique] / Katrina C. JOHNSON, Auteur ; Patricia A. BRENNAN, Auteur ; Zachary N. STOWE, Auteur ; Ellen LEIBENLUFT, Auteur ; D. Jeffrey NEWPORT, Auteur . - p.191-198.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.191-198
Mots-clés : Bipolar depression RSA heart rate vagal stress infants human Index. décimale : PER Périodiques Résumé : Background The offspring of mothers with mood disorders may evidence increased behavioral problems as early as preschool; however, no study to date has examined psychophysiological characteristics during infancy, particularly among offspring of mothers diagnosed with bipolar disorder. Elucidating psychobiological mechanisms of risk early in development is critical to inform prevention and early intervention efforts. Method This study compared physiological and behavioral responsivity in 6-month-old infants (N = 329) of mothers with lifetime histories of bipolar disorder (BD, n = 44), major depressive disorder (MDD, n = 244), or no history of Axis I disorders (CTL, n = 41). Infant respiratory sinus arrhythmia (RSA) was measured in a laboratory stressor paradigm. Measures of infant affect and behavior during mother–infant interaction, current maternal depressive symptoms, and exposure to stressful life events were examined with respect to diagnostic group and RSA. Results Groups did not differ in baseline RSA or infant affect measures. However, during the stressor task, infants of mothers with BD evidenced increases in RSA, while infants of MDD and CTL mothers evidenced decreases in RSA. Though levels of postnatal stress and current levels of maternal depressive symptoms differed among groups, neither of these factors predicted infant psychophysiological responses. Conclusions At 6 months of age, infants of motrs with BD show differences in psychophysiological regulation. These differences cannot be accounted for by perinatal outcome, current maternal depressive symptoms, or exposure to stressful life events, and thus may reflect endophenotypic markers of psychopathological risk. En ligne : http://dx.doi.org/10.1111/jcpp.12130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 The Affective Reactivity Index: a concise irritability scale for clinical and research settings / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)
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Titre : The Affective Reactivity Index: a concise irritability scale for clinical and research settings Type de document : Texte imprimé et/ou numérique Auteurs : Argyris STRINGARIS, Auteur ; Robert GOODMAN, Auteur ; Sumudu FERDINANDO, Auteur ; Varun RAZDAN, Auteur ; Eli MUHRER, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Année de publication : 2012 Article en page(s) : p.1109-1117 Langues : Anglais (eng) Mots-clés : Mood dysregulation Affective Reactivity Index irritability depression bipolar Index. décimale : PER Périodiques Résumé : Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure of irritability. Methods: The US sample (n = 218) consisted of children and adolescents recruited at the National Institute of Mental Health meeting criteria for bipolar disorder (BD, n = 39), severe mood dysregulation (SMD, n = 67), children at family risk for BD (n = 35), or were healthy volunteers (n = 77). The UK sample (n = 88) was comprised of children from a generic mental health setting and healthy volunteers from primary and secondary schools. Results: Parent- and self-report scales of the ARI showed excellent internal consistencies and formed a single factor in the two samples. In the US sample, the ARI showed a gradation with irritability significantly increasing from healthy volunteers through to SMD. Irritability was significantly higher in SMD than in BD by parent-report, but this did not reach significance by self-report. In the UK sample, parent-rated irritability was differentially related to emotional problems. Conclusions: Irritability can be measured using a concise instrument both in a highly specialized US, as well as a general UK child mental health setting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1109-1117[article] The Affective Reactivity Index: a concise irritability scale for clinical and research settings [Texte imprimé et/ou numérique] / Argyris STRINGARIS, Auteur ; Robert GOODMAN, Auteur ; Sumudu FERDINANDO, Auteur ; Varun RAZDAN, Auteur ; Eli MUHRER, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - 2012 . - p.1109-1117.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-11 (November 2012) . - p.1109-1117
Mots-clés : Mood dysregulation Affective Reactivity Index irritability depression bipolar Index. décimale : PER Périodiques Résumé : Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure of irritability. Methods: The US sample (n = 218) consisted of children and adolescents recruited at the National Institute of Mental Health meeting criteria for bipolar disorder (BD, n = 39), severe mood dysregulation (SMD, n = 67), children at family risk for BD (n = 35), or were healthy volunteers (n = 77). The UK sample (n = 88) was comprised of children from a generic mental health setting and healthy volunteers from primary and secondary schools. Results: Parent- and self-report scales of the ARI showed excellent internal consistencies and formed a single factor in the two samples. In the US sample, the ARI showed a gradation with irritability significantly increasing from healthy volunteers through to SMD. Irritability was significantly higher in SMD than in BD by parent-report, but this did not reach significance by self-report. In the UK sample, parent-rated irritability was differentially related to emotional problems. Conclusions: Irritability can be measured using a concise instrument both in a highly specialized US, as well as a general UK child mental health setting. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02561.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis / Martin HOLTMANN in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)
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Titre : The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis Type de document : Texte imprimé et/ou numérique Auteurs : Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur Année de publication : 2011 Article en page(s) : p.139-147 Langues : Anglais (eng) Mots-clés : Dysregulation childhood comorbidity longitudinal irritability depression ADHD substance use suicidality CBCL bipolar Index. décimale : PER Périodiques Résumé : Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP.
Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment.
Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general.
Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147[article] The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis [Texte imprimé et/ou numérique] / Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur . - 2011 . - p.139-147.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147
Mots-clés : Dysregulation childhood comorbidity longitudinal irritability depression ADHD substance use suicidality CBCL bipolar Index. décimale : PER Périodiques Résumé : Background: Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP.
Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment.
Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general.
Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample / Argyris STRINGARIS in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)
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