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Auteur Brian M. D'ONOFRIO |
Documents disponibles écrits par cet auteur (17)
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Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders / Laura GHIRARDI in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)
[article]
Titre : Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Laura GHIRARDI, Auteur ; Qi CHEN, Auteur ; Zheng CHANG, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Charlotte SKOGLUND, Auteur ; Patrick D. QUINN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.140-147 Langues : Anglais (eng) Mots-clés : ADHD medication injuries neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is often associated with other neurodevelopmental disorders (NDs) and with risky behaviors and adverse health outcomes, including injuries. Treatment with ADHD medication has been associated with reduced risk of injuries. However, it is unknown whether the association is present in individuals with co-occurring NDs. The aim of the present study was to estimate the association between ADHD medication use and unintentional injuries in Sweden in children and adolescents with ADHD, including those with co-occurring NDs. METHODS: Using a linkage of several national registers via the unique personal identification number, we identified individuals with a diagnosis of ADHD and of other NDs, including autism spectrum disorder, intellectual disability, communication disorders, learning disorders and motor disorders. The primary outcome was unintentional injuries. Secondary outcome was traumatic brain injury (TBI). Individuals were followed from January 1st 2006 or their 5th birthday or the date of the first unintentional injury, whichever came last, to December 31st 2013 or their 18th birthday or death, whichever came first. We compared the rate of injuries during periods on-treatment with the rate of injuries during periods off-treatment within the same individual using stratified Cox regression to calculate hazard ratio (HR) with 95% confidence intervals (CIs). RESULTS: For children and adolescents with ADHD (N = 9,421) the rate of any unintentional injuries (HR = 0.85; 95% CI = 0.78-0.92) and TBIs (HR = 0.27; 95% CIs = 0.20-0.38) during medicated periods was lower than during non-medicated periods. Similar results were found among individuals with co-occurring NDs (N = 2,986), for unintentional injuries (HR = 0.88; 95% CI = 0.77-1.01) and for TBIs (HR = 0.27; 95% CI = 0.16-0.44). CONCLUSIONS: Beneficial effects of ADHD medication may extend beyond reduction of ADHD core symptoms to prevention of unintentional injuries in children and adolescents, including individuals with co-occurring NDs. En ligne : http://dx.doi.org/10.1111/jcpp.13136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.140-147[article] Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders [Texte imprimé et/ou numérique] / Laura GHIRARDI, Auteur ; Qi CHEN, Auteur ; Zheng CHANG, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Charlotte SKOGLUND, Auteur ; Patrick D. QUINN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik LARSSON, Auteur . - p.140-147.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.140-147
Mots-clés : ADHD medication injuries neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is often associated with other neurodevelopmental disorders (NDs) and with risky behaviors and adverse health outcomes, including injuries. Treatment with ADHD medication has been associated with reduced risk of injuries. However, it is unknown whether the association is present in individuals with co-occurring NDs. The aim of the present study was to estimate the association between ADHD medication use and unintentional injuries in Sweden in children and adolescents with ADHD, including those with co-occurring NDs. METHODS: Using a linkage of several national registers via the unique personal identification number, we identified individuals with a diagnosis of ADHD and of other NDs, including autism spectrum disorder, intellectual disability, communication disorders, learning disorders and motor disorders. The primary outcome was unintentional injuries. Secondary outcome was traumatic brain injury (TBI). Individuals were followed from January 1st 2006 or their 5th birthday or the date of the first unintentional injury, whichever came last, to December 31st 2013 or their 18th birthday or death, whichever came first. We compared the rate of injuries during periods on-treatment with the rate of injuries during periods off-treatment within the same individual using stratified Cox regression to calculate hazard ratio (HR) with 95% confidence intervals (CIs). RESULTS: For children and adolescents with ADHD (N = 9,421) the rate of any unintentional injuries (HR = 0.85; 95% CI = 0.78-0.92) and TBIs (HR = 0.27; 95% CIs = 0.20-0.38) during medicated periods was lower than during non-medicated periods. Similar results were found among individuals with co-occurring NDs (N = 2,986), for unintentional injuries (HR = 0.88; 95% CI = 0.77-1.01) and for TBIs (HR = 0.27; 95% CI = 0.16-0.44). CONCLUSIONS: Beneficial effects of ADHD medication may extend beyond reduction of ADHD core symptoms to prevention of unintentional injuries in children and adolescents, including individuals with co-occurring NDs. En ligne : http://dx.doi.org/10.1111/jcpp.13136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 Using epidemiologic methods to test hypotheses regarding causal influences on child and adolescent mental disorders / Benjamin B. LAHEY in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)
[article]
Titre : Using epidemiologic methods to test hypotheses regarding causal influences on child and adolescent mental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin B. LAHEY, Auteur ; Brian M. D'ONOFRIO, Auteur ; Irwin D. WALDMAN, Auteur Année de publication : 2009 Article en page(s) : p.53-62 Langues : Anglais (eng) Mots-clés : Epidemiology developmental-psychopathology taxonomy causal-models Index. décimale : PER Périodiques Résumé : Epidemiology uses strong sampling methods and study designs to test refutable hypotheses regarding the causes of important health, mental health, and social outcomes. Epidemiologic methods are increasingly being used to move developmental psychopathology from studies that catalogue correlates of child and adolescent mental health to designs that can test rival hypotheses regarding causal genetic and environmental influences. A two-part strategy is proposed for the next phase of epidemiologic research. First, to facilitate the most informed tests of causal hypotheses, it is necessary to develop and test models of the structure of hypothesized genetic and environmental influences on mental health phenotypes. This will involve testing the related hypotheses that there are both (a) dimensions of psychopathology that are distinct in the sense of having at least some unique genetic and/or environmental influences, and (b) higher-order domains of correlated dimensions that are all apparently influenced in part by the same genetic and/or environmental factors. The resulting causal taxonomy would organize tests of causal hypotheses regarding both factors that may broadly increase risk for multiple dimensions of psychopathology and factors that may specifically increase risk for each individual dimension. Second, it is necessary to make greater use of a number of powerful epidemiologic designs that allow rigorous tests of rival hypotheses regarding genetic and environmental causes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01980.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=694
in Journal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.53-62[article] Using epidemiologic methods to test hypotheses regarding causal influences on child and adolescent mental disorders [Texte imprimé et/ou numérique] / Benjamin B. LAHEY, Auteur ; Brian M. D'ONOFRIO, Auteur ; Irwin D. WALDMAN, Auteur . - 2009 . - p.53-62.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.53-62
Mots-clés : Epidemiology developmental-psychopathology taxonomy causal-models Index. décimale : PER Périodiques Résumé : Epidemiology uses strong sampling methods and study designs to test refutable hypotheses regarding the causes of important health, mental health, and social outcomes. Epidemiologic methods are increasingly being used to move developmental psychopathology from studies that catalogue correlates of child and adolescent mental health to designs that can test rival hypotheses regarding causal genetic and environmental influences. A two-part strategy is proposed for the next phase of epidemiologic research. First, to facilitate the most informed tests of causal hypotheses, it is necessary to develop and test models of the structure of hypothesized genetic and environmental influences on mental health phenotypes. This will involve testing the related hypotheses that there are both (a) dimensions of psychopathology that are distinct in the sense of having at least some unique genetic and/or environmental influences, and (b) higher-order domains of correlated dimensions that are all apparently influenced in part by the same genetic and/or environmental factors. The resulting causal taxonomy would organize tests of causal hypotheses regarding both factors that may broadly increase risk for multiple dimensions of psychopathology and factors that may specifically increase risk for each individual dimension. Second, it is necessary to make greater use of a number of powerful epidemiologic designs that allow rigorous tests of rival hypotheses regarding genetic and environmental causes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01980.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=694 Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population / Monica SIQUEIROS SANCHEZ in Journal of Autism and Developmental Disorders, 50-6 (June 2020)
[article]
Titre : Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population Type de document : Texte imprimé et/ou numérique Auteurs : Monica SIQUEIROS SANCHEZ, Auteur ; Erik PETTERSSON, Auteur ; Daniel P KENNEDY, Auteur ; Sven BÖLTE, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p.2188-2200 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Autistic traits Behavior genetics Gap-overlap task Visual disengagement Index. décimale : PER Périodiques Résumé : Visual disengagement has been hypothesized as an endophenotype for autism. In this study we used twin modelling to assess the role of genetics in basic measures of visual disengagement, and tested their putative association to autistic traits in the general population. We used the Gap Overlap task in a sample of 492 twins. Results showed that most of the covariance among eye movement latencies across conditions was shared and primarily genetic. Further, there were unique genetic contributions to the Gap condition, but not to the Overlap condition-i.e. the one theorized to capture visual disengagement. We found no phenotypic association between autistic traits and disengagement, thus not supporting the hypothesis of visual disengagement as an endophenotype for autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-019-03974-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2188-2200[article] Visual Disengagement: Genetic Architecture and Relation to Autistic Traits in the General Population [Texte imprimé et/ou numérique] / Monica SIQUEIROS SANCHEZ, Auteur ; Erik PETTERSSON, Auteur ; Daniel P KENNEDY, Auteur ; Sven BÖLTE, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Terje FALCK-YTTER, Auteur . - p.2188-2200.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2188-2200
Mots-clés : Autism spectrum disorders Autistic traits Behavior genetics Gap-overlap task Visual disengagement Index. décimale : PER Périodiques Résumé : Visual disengagement has been hypothesized as an endophenotype for autism. In this study we used twin modelling to assess the role of genetics in basic measures of visual disengagement, and tested their putative association to autistic traits in the general population. We used the Gap Overlap task in a sample of 492 twins. Results showed that most of the covariance among eye movement latencies across conditions was shared and primarily genetic. Further, there were unique genetic contributions to the Gap condition, but not to the Overlap condition-i.e. the one theorized to capture visual disengagement. We found no phenotypic association between autistic traits and disengagement, thus not supporting the hypothesis of visual disengagement as an endophenotype for autistic traits. En ligne : http://dx.doi.org/10.1007/s10803-019-03974-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 Volitional eye movement control and ADHD traits: a twin study / Monica SIQUEIROS SANCHEZ in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)
[article]
Titre : Volitional eye movement control and ADHD traits: a twin study Type de document : Texte imprimé et/ou numérique Auteurs : Monica SIQUEIROS SANCHEZ, Auteur ; Terje FALCK-YTTER, Auteur ; Daniel P KENNEDY, Auteur ; Sven BÖLTE, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Erik PETTERSSON, Auteur Article en page(s) : p.1309-1316 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder attention behavioral genetics executive function eye movements inhibition oculomotor function Index. décimale : PER Périodiques Résumé : BACKGROUND: Top-down volitional command of eye movements may serve as a candidate endophenotype of ADHD, an important function underlying goal-directed action in everyday life. In this twin study, we examined the relation between performance on a response inhibition eye-tracking paradigm and parent-rated ADHD traits in a population-based twin sample. We hypothesized that altered eye movement control is associated with the severity of ADHD traits and that this association is attributable to genetic factors. METHODS: A total of 640 twins (320 pairs, 50% monozygotic) aged 9-14 years) from the Child and Adolescent Twin Study in Sweden (CATSS) participated. Twins performed the antisaccade task indexing inhibitory alterations as either direction errors (following exogenous cues rather than instructions) or premature anticipatory eye movements (failure to wait for cues). We calculated the associations of eye movement control and ADHD traits using linear regression mixed-effects models and genetic and environmental influences with multivariate twin models. RESULTS: Premature anticipatory eye movements were positively associated with inattentive traits (? = .17; 95% CI: 0.04, 0.31), while controlling for hyperactive behaviors and other covariates. Both premature anticipatory eye movements and inattention were heritable (h(2) = 0.40, 95% CI: 0.22, 0.56; h(2) = 0.55; 95% CI: 0.42, 0.65; respectively), and their genetic correlation was small but statistically significant (r = .19, 95% CI: 0.02, 0.36). However, the genetic correlation did not remain significant after adjusting for covariates (age, sex, hyperactivity traits, IQ). No link was found between direction errors and ADHD traits. CONCLUSIONS: This study indicates that there is a specific, genetically influenced, relation between top-down eye movement control and the inattentive traits typical of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1309-1316[article] Volitional eye movement control and ADHD traits: a twin study [Texte imprimé et/ou numérique] / Monica SIQUEIROS SANCHEZ, Auteur ; Terje FALCK-YTTER, Auteur ; Daniel P KENNEDY, Auteur ; Sven BÖLTE, Auteur ; Paul LICHTENSTEIN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Erik PETTERSSON, Auteur . - p.1309-1316.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1309-1316
Mots-clés : Attention-deficit/hyperactivity disorder attention behavioral genetics executive function eye movements inhibition oculomotor function Index. décimale : PER Périodiques Résumé : BACKGROUND: Top-down volitional command of eye movements may serve as a candidate endophenotype of ADHD, an important function underlying goal-directed action in everyday life. In this twin study, we examined the relation between performance on a response inhibition eye-tracking paradigm and parent-rated ADHD traits in a population-based twin sample. We hypothesized that altered eye movement control is associated with the severity of ADHD traits and that this association is attributable to genetic factors. METHODS: A total of 640 twins (320 pairs, 50% monozygotic) aged 9-14 years) from the Child and Adolescent Twin Study in Sweden (CATSS) participated. Twins performed the antisaccade task indexing inhibitory alterations as either direction errors (following exogenous cues rather than instructions) or premature anticipatory eye movements (failure to wait for cues). We calculated the associations of eye movement control and ADHD traits using linear regression mixed-effects models and genetic and environmental influences with multivariate twin models. RESULTS: Premature anticipatory eye movements were positively associated with inattentive traits (? = .17; 95% CI: 0.04, 0.31), while controlling for hyperactive behaviors and other covariates. Both premature anticipatory eye movements and inattention were heritable (h(2) = 0.40, 95% CI: 0.22, 0.56; h(2) = 0.55; 95% CI: 0.42, 0.65; respectively), and their genetic correlation was small but statistically significant (r = .19, 95% CI: 0.02, 0.36). However, the genetic correlation did not remain significant after adjusting for covariates (age, sex, hyperactivity traits, IQ). No link was found between direction errors and ADHD traits. CONCLUSIONS: This study indicates that there is a specific, genetically influenced, relation between top-down eye movement control and the inattentive traits typical of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.13210 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434