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Auteur John WRAY |
Documents disponibles écrits par cet auteur (9)



Are there differences in the behavioural phenotypes of Autism Spectrum Disorder probands from simplex and multiplex families? / Lauren J. TAYLOR in Research in Autism Spectrum Disorders, 11 (March 2015)
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[article]
Titre : Are there differences in the behavioural phenotypes of Autism Spectrum Disorder probands from simplex and multiplex families? Type de document : Texte imprimé et/ou numérique Auteurs : Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; John WRAY, Auteur ; David RAVINE, Auteur ; Anna HUNT, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.56-62 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Behavioural phenotype Simplex and multiplex families Index. décimale : PER Périodiques Résumé : Recent research suggests that different genetic pathways may operate for families with one child affected with Autism Spectrum Disorder (simplex ASD), compared to families that have multiple affected children (multiplex ASD). In this study, we investigated possible differences in the behavioural phenotypes of probands from simplex and multiplex ASD families using parent-report and standardised behavioural measures. Participants were 59 probands from multiplex ASD families (28 families), who were each matched on chronological age and sex with two probands from simplex families. Probands from multiplex families had greater social impairment (measured using the Social Responsiveness Scale) and worse pragmatic language (on the Children's Communication Checklist-2) than probands from simplex families. However, the multiplex children had less severe symptoms than the simplex children on the ADOS-G, and a significantly higher proportion of multiplex children did not meet autism spectrum cut-offs on this measure. These findings indicate that there are behavioural differences in children with ASD from simplex and multiplex families. In addition, the results reveal an important discrepancy between parent-report and clinician observation of autistic-like characteristics in siblings of an affected child, which may have implications for the assessment and diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 11 (March 2015) . - p.56-62[article] Are there differences in the behavioural phenotypes of Autism Spectrum Disorder probands from simplex and multiplex families? [Texte imprimé et/ou numérique] / Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; John WRAY, Auteur ; David RAVINE, Auteur ; Anna HUNT, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.56-62.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 11 (March 2015) . - p.56-62
Mots-clés : Autism Spectrum Disorder Behavioural phenotype Simplex and multiplex families Index. décimale : PER Périodiques Résumé : Recent research suggests that different genetic pathways may operate for families with one child affected with Autism Spectrum Disorder (simplex ASD), compared to families that have multiple affected children (multiplex ASD). In this study, we investigated possible differences in the behavioural phenotypes of probands from simplex and multiplex ASD families using parent-report and standardised behavioural measures. Participants were 59 probands from multiplex ASD families (28 families), who were each matched on chronological age and sex with two probands from simplex families. Probands from multiplex families had greater social impairment (measured using the Social Responsiveness Scale) and worse pragmatic language (on the Children's Communication Checklist-2) than probands from simplex families. However, the multiplex children had less severe symptoms than the simplex children on the ADOS-G, and a significantly higher proportion of multiplex children did not meet autism spectrum cut-offs on this measure. These findings indicate that there are behavioural differences in children with ASD from simplex and multiplex families. In addition, the results reveal an important discrepancy between parent-report and clinician observation of autistic-like characteristics in siblings of an affected child, which may have implications for the assessment and diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 Brief Report: Do the Nature of Communication Impairments in Autism Spectrum Disorders Relate to the Broader Autism Phenotype in Parents? / Lauren J. TAYLOR in Journal of Autism and Developmental Disorders, 43-12 (December 2013)
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Titre : Brief Report: Do the Nature of Communication Impairments in Autism Spectrum Disorders Relate to the Broader Autism Phenotype in Parents? Type de document : Texte imprimé et/ou numérique Auteurs : Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; John WRAY, Auteur ; David RAVINE, Auteur ; Anna HUNT, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.2984-2989 Langues : Anglais (eng) Mots-clés : Heritable language phenotype Broader autism phenotype Communication impairment Index. décimale : PER Périodiques Résumé : Extensive empirical evidence indicates that the lesser variant of Autism Spectrum Disorders (ASD) involves a communication impairment that is similar to, but milder than, the deficit in clinical ASD. This research explored the relationship between the broader autism phenotype (BAP) among parents, an index of genetic liability for ASD, and proband communication difficulties. ASD probands with at least one BAP parent (identified using the Autism Spectrum Quotient) had greater structural and pragmatic language difficulties (assessed using the Children’s Communication Checklist-2) than ASD probands with no BAP parent. This finding provides support for the position that genetic liability for ASD is associated with increased communication difficulties across structural and pragmatic domains. En ligne : http://dx.doi.org/10.1007/s10803-013-1838-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2984-2989[article] Brief Report: Do the Nature of Communication Impairments in Autism Spectrum Disorders Relate to the Broader Autism Phenotype in Parents? [Texte imprimé et/ou numérique] / Lauren J. TAYLOR, Auteur ; Murray T. MAYBERY, Auteur ; John WRAY, Auteur ; David RAVINE, Auteur ; Anna HUNT, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.2984-2989.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-12 (December 2013) . - p.2984-2989
Mots-clés : Heritable language phenotype Broader autism phenotype Communication impairment Index. décimale : PER Périodiques Résumé : Extensive empirical evidence indicates that the lesser variant of Autism Spectrum Disorders (ASD) involves a communication impairment that is similar to, but milder than, the deficit in clinical ASD. This research explored the relationship between the broader autism phenotype (BAP) among parents, an index of genetic liability for ASD, and proband communication difficulties. ASD probands with at least one BAP parent (identified using the Autism Spectrum Quotient) had greater structural and pragmatic language difficulties (assessed using the Children’s Communication Checklist-2) than ASD probands with no BAP parent. This finding provides support for the position that genetic liability for ASD is associated with increased communication difficulties across structural and pragmatic domains. En ligne : http://dx.doi.org/10.1007/s10803-013-1838-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis / Mirko ULJAREVIC in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)
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Titre : Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1030-1042 Langues : Anglais (eng) Mots-clés : Repetitive behaviours autism social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042[article] Deconstructing the repetitive behaviour phenotype in autism spectrum disorder through a large population-based analysis [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Emma J. GLASSON, Auteur ; Murray T. MAYBERY, Auteur ; Kandice J. VARCIN, Auteur ; Gail A. ALVARES, Auteur ; John WRAY, Auteur ; Susan R LEEKAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1030-1042.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1030-1042
Mots-clés : Repetitive behaviours autism social and communication impairments Index. décimale : PER Périodiques Résumé : OBJECTIVE: Restricted and repetitive pattern of behaviours and interests (RRB) are a cardinal feature of autism spectrum disorder (ASD), but there remains uncertainty about how these diverse behaviours vary according to individual characteristics. This study provided the largest exploration to date of the relationship between Repetitive Motor Behaviours, Rigidity/Insistence on Sameness and Circumscribed Interests with other individual characteristics in newly diagnosed individuals with ASD. METHOD: Participants (N = 3,647; 17.7% females; Mage = 6.6 years [SD = 4.7]) were part of the Western Australian (WA) Register for ASD, an independent, prospective collection of demographic and diagnostic data of newly diagnosed cases of ASD in WA. Diagnosticians rated each of the DSM-IV-TR criteria on a 4-point Likert severity scale, and here we focused on the Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests symptoms. RESULTS: The associations between RRB domains, indexed by Kendall's Tau, were weak, ranging from non-significant for both Circumscribed Interests and Repetitive Motor Behaviours to significant (.20) for Insistence on Sameness and Repetitive Motor Behaviours. Older age at diagnosis was significantly associated with lower Circumscribed Interests and significantly associated with higher Insistence on Sameness and Repetitive Motor Behaviours. Male sex was significantly associated with higher Repetitive Motor Behaviours but not Insistence on Sameness or Circumscribed Interests. CONCLUSIONS: The pattern of associations identified in this study provides suggestive evidence for the distinctiveness of Repetitive Motor Behaviours, Insistence on Sameness and Circumscribed Interests, highlighting the potential utility of RRB domains for stratifying the larger ASD population into smaller, more phenotypically homogeneous subgroups that can help to facilitate efforts to understand diverse ASD aetiology and inform design of future interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13203 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses / Andrew J. O. WHITEHOUSE in Autism Research, 10-1 (January 2017)
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Titre : Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Gail A. ALVARES, Auteur ; Ashleigh LIN, Auteur ; John WRAY, Auteur ; Emma J. GLASSON, Auteur Article en page(s) : p.179-187 Langues : Anglais (eng) Mots-clés : autistic disorder autism spectrum disorder epidemiology diagnosis prevalence Index. décimale : PER Périodiques Résumé : The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n?=?1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme). Linear regression determined there was a statistically significant reduction from 2000 to 2006 in the percentage of new diagnoses meeting two of 12 criteria. There was also a reduction across the study period in the proportion of new cases rated as having extreme severity on six criteria. There was a reduction in the proportion of individuals with three or more criteria rated as extreme from 2000 (16.0%) to 2006 (1.6%), while percentage of new cases with no “extreme” rating on any criteria increased from 58.5% to 86.6% across the same period. This study provides the first clear evidence of a reduction over time in the behavioral severity of individuals diagnosed with Autistic Disorder during a period of stability in diagnostic criteria. A shift toward diagnosing individuals with less severe behavioral symptoms may have contributed to the increasing prevalence of Autistic Disorder diagnoses. En ligne : http://dx.doi.org/10.1002/aur.1740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.179-187[article] Evidence of a reduction over time in the behavioral severity of autistic disorder diagnoses [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Matthew N. COOPER, Auteur ; Keely BEBBINGTON, Auteur ; Gail A. ALVARES, Auteur ; Ashleigh LIN, Auteur ; John WRAY, Auteur ; Emma J. GLASSON, Auteur . - p.179-187.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.179-187
Mots-clés : autistic disorder autism spectrum disorder epidemiology diagnosis prevalence Index. décimale : PER Périodiques Résumé : The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n?=?1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme). Linear regression determined there was a statistically significant reduction from 2000 to 2006 in the percentage of new diagnoses meeting two of 12 criteria. There was also a reduction across the study period in the proportion of new cases rated as having extreme severity on six criteria. There was a reduction in the proportion of individuals with three or more criteria rated as extreme from 2000 (16.0%) to 2006 (1.6%), while percentage of new cases with no “extreme” rating on any criteria increased from 58.5% to 86.6% across the same period. This study provides the first clear evidence of a reduction over time in the behavioral severity of individuals diagnosed with Autistic Disorder during a period of stability in diagnostic criteria. A shift toward diagnosing individuals with less severe behavioral symptoms may have contributed to the increasing prevalence of Autistic Disorder diagnoses. En ligne : http://dx.doi.org/10.1002/aur.1740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Get it right, make it easy, see it all: Viewpoints of autistic individuals and parents of autistic individuals about the autism diagnostic process in Australia / Emily D’ARCY in Research in Autism Spectrum Disorders, 85 (July 2021)
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Titre : Get it right, make it easy, see it all: Viewpoints of autistic individuals and parents of autistic individuals about the autism diagnostic process in Australia Type de document : Texte imprimé et/ou numérique Auteurs : Emily D’ARCY, Auteur ; Sonya GIRDLER, Auteur ; Marita FALKMER, Auteur ; Torbjörn FALKMER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; John WRAY, Auteur ; Valsamma EAPEN, Auteur ; Kiah EVANS, Auteur Article en page(s) : 101792 Langues : Anglais (eng) Mots-clés : ASD Diagnosis Consumer perspective Assessment Index. décimale : PER Périodiques Résumé : Background The clinical process for being evaluated for an autism diagnosis is often time consuming and stressful for individuals and their caregivers. While experience of and satisfaction with the diagnostic process has been reviewed in the literature, few studies have directly investigated the viewpoints of individuals diagnosed with autism and caregivers of autistic individuals about what is important in the autism diagnostic process. Method A Q methodological design was employed to capture the subjective viewpoints about the diagnostic process of individuals on the autism spectrum and caregivers of autistic individuals. Thirty-eight participants responded to a set of 66 statements representing different aspects of the autism diagnostic process. Results The analysis identified three significant viewpoints: Get it Right, Make it Easy, and See it All. Participants reflected upon the importance of a comprehensive diagnostic assessment process, ease of diagnostic processes, and a holistic approach to autism diagnosis for autistic individuals and caregivers of autistic individuals. Conclusions The findings provide a consumer perspective that encourages reform of the current process for diagnosing autism in Australia, and an insight into what consumers are wanting from diagnostic services. This information is useful for policy-makers and service providers to create a more supportive and client-centred diagnostic process at all levels of service delivery. En ligne : https://doi.org/10.1016/j.rasd.2021.101792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101792[article] Get it right, make it easy, see it all: Viewpoints of autistic individuals and parents of autistic individuals about the autism diagnostic process in Australia [Texte imprimé et/ou numérique] / Emily D’ARCY, Auteur ; Sonya GIRDLER, Auteur ; Marita FALKMER, Auteur ; Torbjörn FALKMER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; John WRAY, Auteur ; Valsamma EAPEN, Auteur ; Kiah EVANS, Auteur . - 101792.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 85 (July 2021) . - 101792
Mots-clés : ASD Diagnosis Consumer perspective Assessment Index. décimale : PER Périodiques Résumé : Background The clinical process for being evaluated for an autism diagnosis is often time consuming and stressful for individuals and their caregivers. While experience of and satisfaction with the diagnostic process has been reviewed in the literature, few studies have directly investigated the viewpoints of individuals diagnosed with autism and caregivers of autistic individuals about what is important in the autism diagnostic process. Method A Q methodological design was employed to capture the subjective viewpoints about the diagnostic process of individuals on the autism spectrum and caregivers of autistic individuals. Thirty-eight participants responded to a set of 66 statements representing different aspects of the autism diagnostic process. Results The analysis identified three significant viewpoints: Get it Right, Make it Easy, and See it All. Participants reflected upon the importance of a comprehensive diagnostic assessment process, ease of diagnostic processes, and a holistic approach to autism diagnosis for autistic individuals and caregivers of autistic individuals. Conclusions The findings provide a consumer perspective that encourages reform of the current process for diagnosing autism in Australia, and an insight into what consumers are wanting from diagnostic services. This information is useful for policy-makers and service providers to create a more supportive and client-centred diagnostic process at all levels of service delivery. En ligne : https://doi.org/10.1016/j.rasd.2021.101792 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 Obesity and associated factors in youth with an autism spectrum disorder / Joanna GRANICH in Autism, 20-8 (November 2016)
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PermalinkParent-Child Interactions May Help to Explain Relations Between Parent Characteristics and Clinically Observed Child Autistic Behaviours / Murray T. MAYBERY ; Josephine BARBARO ; Cheryl DISSANAYAKE ; Jonathan GREEN ; Kristelle HUDRY ; Teresa IACONO ; Vicky SLONIMS ; Kandice J. VARCIN ; Ming Wai WAN ; John WRAY ; Andrew J. O. WHITEHOUSE in Journal of Autism and Developmental Disorders, 54-7 (July 2024)
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PermalinkPrevalence of Motor Difficulties in Autism Spectrum Disorder: Analysis of a Population-Based Cohort / Melissa K. LICARI in Autism Research, 13-2 (February 2020)
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PermalinkRandomised Controlled Trial of a Therapeutic Playgroup for Children with Developmental Delays / Jodie ARMSTRONG in Journal of Autism and Developmental Disorders, 51-4 (April 2021)
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