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Auteur Christine W. NORDAHL |
Documents disponibles écrits par cet auteur (21)
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Neural correlates of language variability in preschool-aged boys with autism spectrum disorder / Letitia R. NAIGLES in Autism Research, 10-6 (June 2017)
[article]
Titre : Neural correlates of language variability in preschool-aged boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.1107-1119 Langues : Anglais (eng) Mots-clés : DTI brain imaging language development preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309
in Autism Research > 10-6 (June 2017) . - p.1107-1119[article] Neural correlates of language variability in preschool-aged boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Letitia R. NAIGLES, Auteur ; Ryan JOHNSON, Auteur ; Ann MASTERGEORGE, Auteur ; Sally OZONOFF, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur ; Christine W. NORDAHL, Auteur . - p.1107-1119.
Langues : Anglais (eng)
in Autism Research > 10-6 (June 2017) . - p.1107-1119
Mots-clés : DTI brain imaging language development preschoolers Index. décimale : PER Périodiques Résumé : Children with autism vary widely in their language abilities, yet the neural correlates of this language variability remain unclear, especially early in development. Diffusion tensor imaging (DTI) was used to examine diffusivity measures along the length of 18 major fiber tracts in 104 preschool-aged boys with autism spectrum disorder (ASD). The boys were assigned to subgroups according to their level of language development (Low: no/low language, Middle: small vocabulary, High: large vocabulary and grammar), based on their raw scores on the expressive language (EL) and receptive language (RL) sections of the Mullen Scales of Early Learning (MSEL). Results indicate that the subgroups differed in fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) along the inferior longitudinal fasciculus (ILF) in both hemispheres. Moreover, FA correlated significantly with Mullen EL and RL raw scores, but not ADOS severity score, along the left and right ILF. Subgroups also differed in MD (but not FA) along the left superior longitudinal fasiculus and left corticospinal tract, but these differences were not correlated with language scores. These findings suggest that white matter microstructure in the left and right ILF varies in relation to lexical development in young males with ASD. The findings also support the use of raw scores on language-relevant standardized tests for assessing early language-brain relationships. En ligne : http://dx.doi.org/10.1002/aur.1756 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder / Lauren E. LIBERO in Autism Research, 9-11 (November 2016)
[article]
Titre : Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1169-1182 Langues : Anglais (eng) Mots-clés : autism spectrum disorder MRI longitudinal brain development disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1169-1182[article] Persistence of megalencephaly in a subgroup of young boys with autism spectrum disorder [Texte imprimé et/ou numérique] / Lauren E. LIBERO, Auteur ; Christine W. NORDAHL, Auteur ; Deana D. LI, Auteur ; Emilio FERRER, Auteur ; Sally J ROGERS, Auteur ; David G. AMARAL, Auteur . - p.1169-1182.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1169-1182
Mots-clés : autism spectrum disorder MRI longitudinal brain development disproportionate megalencephaly Index. décimale : PER Périodiques Résumé : A recurring finding in autism spectrum disorder research is that head and brain growth is disproportionate to body growth in early childhood. Nordahl et al. (2011) demonstrated that this occurs in approximately 15% of boys with autism. While the literature suggests that brain growth normalizes at older ages, this has never been evaluated in a longitudinal study. The current study evaluated head circumference and total cerebral volume in 129 male children with autism and 49 age-matched, typically developing controls. We determined whether 3-year-old boys with brain size disproportionate to height (which we call disproportionate megalencephaly) demonstrated an abnormal trajectory of head growth from birth and whether they maintained an enlarged brain at 5 years of age. Findings were based on longitudinal, structural MRI data collected around 3, 4, and 5 years of age and head circumference data from medical records. At 3 years of age, 19 boys with autism had enlarged brains while 110 had brain sizes in the normal range. Boys with disproportionate megalencephaly had greater total cerebral, gray matter, and white matter volumes from 3–5 years compared to boys with autism and normal sized brains and typically developing boys, but no differences in body size. While head circumference did not differ between groups at birth, it was significantly greater in the disproportionate megalencephaly group by around 2 years. These data suggest that there is a subgroup of boys with autism who have brains disproportionate to body size and that this continues until at least 5 years of age. En ligne : http://dx.doi.org/10.1002/aur.1643 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder / Christine W. NORDAHL in Molecular Autism, (May 2015)
[article]
Titre : Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277
in Molecular Autism > (May 2015) . - p.1-11[article] Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder [Texte imprimé et/ou numérique] / Christine W. NORDAHL, Auteur ; Ana-Maria IOSIF, Auteur ; Gregory S. YOUNG, Auteur ; Lee Michael PERRY, Auteur ; Robert DOUGHERTY, Auteur ; Aaron LEE, Auteur ; Deana LI, Auteur ; Michael H. BUONOCORE, Auteur ; Tony SIMON, Auteur ; Sally J ROGERS, Auteur ; Brian WANDELL, Auteur ; David G. AMARAL, Auteur . - p.1-11.
Langues : Anglais (eng)
in Molecular Autism > (May 2015) . - p.1-11
Index. décimale : PER Périodiques Résumé : Abnormalities in the corpus callosum have been reported in individuals with autism spectrum disorder (ASD), but few studies have evaluated young children. Sex differences in callosal organization and diffusion characteristics have also not been evaluated fully in ASD. En ligne : http://dx.doi.org/10.1186/s13229-015-0005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 The Amygdala in Autism Spectrum Disorders / John T. MORGAN
Titre : The Amygdala in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : John T. MORGAN, Auteur ; Christine W. NORDAHL, Auteur ; Cynthia M. SCHUMANN, Auteur Année de publication : 2013 Importance : p.297-312 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The amygdala plays a critical role in detecting and responding to biologically relevant environmental stimuli. It is also considered a major component of a network of brain regions often referred to as the ‘social brain’. Given the social abnormalities that are a hallmark of autism spectrum disorders (ASD), the amygdala has long been suspected to be aberrant in the disorder. Functional magnetic resonance imaging (MRI) studies reveal abnormalities in amygdala activation to social stimuli, such as emotional facial expressions. Structural MRI studies have shown that the amygdala undergoes an abnormal developmental trajectory including early overgrowth that may be primarily driven by a specific subgroup of individuals with ASD. Postmortem cellular studies reveal that abnormalities in the neuronal and glial composition of the amygdala likely underlie these functional and structural alterations. Interdisciplinary integration of an array of experimental approaches will hold the key to a full understanding of amygdala abnormality in ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 The Amygdala in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / John T. MORGAN, Auteur ; Christine W. NORDAHL, Auteur ; Cynthia M. SCHUMANN, Auteur . - 2013 . - p.297-312.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The amygdala plays a critical role in detecting and responding to biologically relevant environmental stimuli. It is also considered a major component of a network of brain regions often referred to as the ‘social brain’. Given the social abnormalities that are a hallmark of autism spectrum disorders (ASD), the amygdala has long been suspected to be aberrant in the disorder. Functional magnetic resonance imaging (MRI) studies reveal abnormalities in amygdala activation to social stimuli, such as emotional facial expressions. Structural MRI studies have shown that the amygdala undergoes an abnormal developmental trajectory including early overgrowth that may be primarily driven by a specific subgroup of individuals with ASD. Postmortem cellular studies reveal that abnormalities in the neuronal and glial composition of the amygdala likely underlie these functional and structural alterations. Interdisciplinary integration of an array of experimental approaches will hold the key to a full understanding of amygdala abnormality in ASD. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Trajectories of Autism Symptom Severity Change During Early Childhood / Einat WAIZBARD-BARTOV in Journal of Autism and Developmental Disorders, 51-1 (January 2021)
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Titre : Trajectories of Autism Symptom Severity Change During Early Childhood Type de document : Texte imprimé et/ou numérique Auteurs : Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Gregory S. YOUNG, Auteur ; Brianna HEATH, Auteur ; Sally ROGERS, Auteur ; Christine W. NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur Article en page(s) : p.227-242 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Early childhood Sex differences Symptom severity Index. décimale : PER Périodiques Résumé : Autism symptom severity change was evaluated during early childhood in 125 children diagnosed with autism spectrum disorder (ASD). Children were assessed at approximately 3 and 6 years of age for autism symptom severity, IQ and adaptive functioning. Each child was assigned a change score, representing the difference between ADOS Calibrated Severity Scores (CSS) at the two ages. A Decreased Severity Group (28.8%) decreased by 2 or more points; a Stable Severity Group (54.4%) changed by 1 point or less; and an Increased Severity Group (16.8%) increased by 2 or more points. Girls tended to decrease in severity more than boys and increase in severity less than boys. There was no clear relationship between intervention history and membership in the groups. En ligne : http://dx.doi.org/10.1007/s10803-020-04526-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.227-242[article] Trajectories of Autism Symptom Severity Change During Early Childhood [Texte imprimé et/ou numérique] / Einat WAIZBARD-BARTOV, Auteur ; Emilio FERRER, Auteur ; Gregory S. YOUNG, Auteur ; Brianna HEATH, Auteur ; Sally ROGERS, Auteur ; Christine W. NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur . - p.227-242.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.227-242
Mots-clés : Autism spectrum disorder Early childhood Sex differences Symptom severity Index. décimale : PER Périodiques Résumé : Autism symptom severity change was evaluated during early childhood in 125 children diagnosed with autism spectrum disorder (ASD). Children were assessed at approximately 3 and 6 years of age for autism symptom severity, IQ and adaptive functioning. Each child was assigned a change score, representing the difference between ADOS Calibrated Severity Scores (CSS) at the two ages. A Decreased Severity Group (28.8%) decreased by 2 or more points; a Stable Severity Group (54.4%) changed by 1 point or less; and an Increased Severity Group (16.8%) increased by 2 or more points. Girls tended to decrease in severity more than boys and increase in severity less than boys. There was no clear relationship between intervention history and membership in the groups. En ligne : http://dx.doi.org/10.1007/s10803-020-04526-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 What will my child's future hold? phenotypes of intellectual development in 2–8?year?olds with autism spectrum disorder / Marjorie SOLOMON in Autism Research, 11-1 (January 2018)
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