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Auteur Yi HUANG |
Documents disponibles écrits par cet auteur (2)
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Associations of endocrine stress-related gene polymorphisms with risk of autism spectrum disorders: Evidence from an integrated meta-analysis / Ping-yuan YANG in Autism Research, 10-11 (November 2017)
[article]
Titre : Associations of endocrine stress-related gene polymorphisms with risk of autism spectrum disorders: Evidence from an integrated meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Ping-yuan YANG, Auteur ; Ya-jing MENGA, Auteur ; Tao LI, Auteur ; Yi HUANG, Auteur Article en page(s) : p.1722-1736 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD) catechol-O-methyl transferase (COMT) serotonin transporter stress response Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are related to serotonin transporter (5-HTT) and catechol-O-methyl transferase (COMT) as two most monoaminergic polymorphic variations. However, multiple studies assessing rs4680 and 5-HTTLPR variants in ASD have reported inconsistent results. Therefore, we conducted an integrated meta-analysis to combine case-control and transmission/disequilibrium test (TDT) studies to determine whether COMT and 5-HTT are associated with ASD. We searched multiple electronic databases (PubMed, EmBase and Web of Science) to identify studies assessing the rs4680 and 5-HTTLPR variants in ASD from Jan 1997 to Dec 2016. Then allelic data from case–control and TDT studies were analyzed by the Catmap package in the R software. A total of 5 studies were eligible for the meta-analysis of rs4680, including 3 case–control, 1 TDT and 1 TDT & case–control studies. Meanwhile, 22 studies of 5-HTTLPR were available, including 16 TDT, 4 case–control and 2 TDT & case–control studies. The current meta-analysis included 814 ASD cases, 741 controls and 311 families related to rs4680; 749 ASD cases, 1,118 controls and 1,861 families relevant to 5-HTTLPR were also evaluated. For rs4680, the pooled OR was 1.18 (95% CI?=?0.87–1.59, P?=?0.29, Pheterogeneity?0.00001). There was no significant association of rs4680 with risk of ASD between the two subgroups. For 5-HTTLPR, the pooled OR was 1.05 (95% CI?=?0.92–1.20, P?=?0.4652, Pheterogeneity?0.00001). Meanwhile, we found no significant risk in individual case–control or TDT studies. The above findings indicated that neither COMT rs4680 nor 5-HTT 5-HTTLPR polymorphism significantly affects ASD risk. Autism Res 2017, 10: 1722–1736. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Our results showed no evidence of significant association of either COMT rs4680 or 5-HTT 5-HTTLPR variants with ASD, showing that these two genes may not be major susceptible genetic factors in ASD occurrence, and may have a reciprocal action with each other in combination with environmental factors. These findings further provide evidence that a single gene variant may not dictate autism occurrence, but possibly contributes to a specific phenotype or subtype of ASD. En ligne : http://dx.doi.org/10.1002/aur.1822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1722-1736[article] Associations of endocrine stress-related gene polymorphisms with risk of autism spectrum disorders: Evidence from an integrated meta-analysis [Texte imprimé et/ou numérique] / Ping-yuan YANG, Auteur ; Ya-jing MENGA, Auteur ; Tao LI, Auteur ; Yi HUANG, Auteur . - p.1722-1736.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1722-1736
Mots-clés : autism spectrum disorders (ASD) catechol-O-methyl transferase (COMT) serotonin transporter stress response Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are related to serotonin transporter (5-HTT) and catechol-O-methyl transferase (COMT) as two most monoaminergic polymorphic variations. However, multiple studies assessing rs4680 and 5-HTTLPR variants in ASD have reported inconsistent results. Therefore, we conducted an integrated meta-analysis to combine case-control and transmission/disequilibrium test (TDT) studies to determine whether COMT and 5-HTT are associated with ASD. We searched multiple electronic databases (PubMed, EmBase and Web of Science) to identify studies assessing the rs4680 and 5-HTTLPR variants in ASD from Jan 1997 to Dec 2016. Then allelic data from case–control and TDT studies were analyzed by the Catmap package in the R software. A total of 5 studies were eligible for the meta-analysis of rs4680, including 3 case–control, 1 TDT and 1 TDT & case–control studies. Meanwhile, 22 studies of 5-HTTLPR were available, including 16 TDT, 4 case–control and 2 TDT & case–control studies. The current meta-analysis included 814 ASD cases, 741 controls and 311 families related to rs4680; 749 ASD cases, 1,118 controls and 1,861 families relevant to 5-HTTLPR were also evaluated. For rs4680, the pooled OR was 1.18 (95% CI?=?0.87–1.59, P?=?0.29, Pheterogeneity?0.00001). There was no significant association of rs4680 with risk of ASD between the two subgroups. For 5-HTTLPR, the pooled OR was 1.05 (95% CI?=?0.92–1.20, P?=?0.4652, Pheterogeneity?0.00001). Meanwhile, we found no significant risk in individual case–control or TDT studies. The above findings indicated that neither COMT rs4680 nor 5-HTT 5-HTTLPR polymorphism significantly affects ASD risk. Autism Res 2017, 10: 1722–1736. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Our results showed no evidence of significant association of either COMT rs4680 or 5-HTT 5-HTTLPR variants with ASD, showing that these two genes may not be major susceptible genetic factors in ASD occurrence, and may have a reciprocal action with each other in combination with environmental factors. These findings further provide evidence that a single gene variant may not dictate autism occurrence, but possibly contributes to a specific phenotype or subtype of ASD. En ligne : http://dx.doi.org/10.1002/aur.1822 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis / Weili YAN in Autism, 26-7 (October 2022)
[article]
Titre : Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis Type de document : Texte imprimé et/ou numérique Auteurs : Weili YAN, Auteur ; Richard J. SIEGERT, Auteur ; Hao ZHOU, Auteur ; Xiaobing ZOU, Auteur ; Lijie WU, Auteur ; Xuerong LUO, Auteur ; Tingyu LI, Auteur ; Yi HUANG, Auteur ; Hongyan GUAN, Auteur ; Xiang CHEN, Auteur ; Meng MAO, Auteur ; Kun XIA, Auteur ; Lan ZHANG, Auteur ; Erzhen LI, Auteur ; Chunpei LI, Auteur ; Xudong ZHANG, Auteur ; Yuanfeng ZHOU, Auteur ; Andy SHIH, Auteur ; Eric FOMBONNE, Auteur ; Yi ZHENG, Auteur ; Jisheng HAN, Auteur ; Zhongsheng SUN, Auteur ; Yong-hui JIANG, Auteur ; Yi WANG, Auteur Article en page(s) : p.1872-1884 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child China Humans Parents Psychometrics Reproducibility of Results Autism Spectrum Rating Scale Rasch analysis autism spectrum disorders parent version school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484
in Autism > 26-7 (October 2022) . - p.1872-1884[article] Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis [Texte imprimé et/ou numérique] / Weili YAN, Auteur ; Richard J. SIEGERT, Auteur ; Hao ZHOU, Auteur ; Xiaobing ZOU, Auteur ; Lijie WU, Auteur ; Xuerong LUO, Auteur ; Tingyu LI, Auteur ; Yi HUANG, Auteur ; Hongyan GUAN, Auteur ; Xiang CHEN, Auteur ; Meng MAO, Auteur ; Kun XIA, Auteur ; Lan ZHANG, Auteur ; Erzhen LI, Auteur ; Chunpei LI, Auteur ; Xudong ZHANG, Auteur ; Yuanfeng ZHOU, Auteur ; Andy SHIH, Auteur ; Eric FOMBONNE, Auteur ; Yi ZHENG, Auteur ; Jisheng HAN, Auteur ; Zhongsheng SUN, Auteur ; Yong-hui JIANG, Auteur ; Yi WANG, Auteur . - p.1872-1884.
Langues : Anglais (eng)
in Autism > 26-7 (October 2022) . - p.1872-1884
Mots-clés : Autism Spectrum Disorder/diagnosis Autistic Disorder Child China Humans Parents Psychometrics Reproducibility of Results Autism Spectrum Rating Scale Rasch analysis autism spectrum disorders parent version school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484