18 recherche sur le mot-clé 'Gene-Environment Interaction'

Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses / Jay BELSKY in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Titre : Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur Article en page(s) : p.1135-1143 Langues : Anglais (eng) Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Confirmatory and competitive evaluation of alternative gene-environment interaction hypotheses [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Michael PLUESS, Auteur ; Keith F. WIDAMAN, Auteur . - p.1135-1143. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1135-1143 Mots-clés : Gene-environment interaction  diathesis-stress  differential susceptibility  child care  DRD4 Index. décimale : PER Périodiques Résumé : Background Most gene-environment interaction (GXE) research, though based on clear, vulnerability-oriented hypotheses, is carried out using exploratory rather than hypothesis-informed statistical tests, limiting power and making formal evaluation of competing GXE propositions difficult. Method We present and illustrate a new regression technique which affords direct testing of theory-derived predictions, as well as competitive evaluation of alternative diathesis-stress and differential-susceptibility propositions, using data on the moderating effect of DRD4 with regard to the effect of childcare quality on children's social functioning. Results Results show that (a) the new approach detects interactions that the traditional one does not; (b) the discerned GXE fit the differential-susceptibility model better than the diathesis-stress one; and (c) a strong rather than weak version of differential susceptibility is empirically supported. Conclusion The new method better fits the theoretical ‘glove’ to the empirical ‘hand,’ raising the prospect that some failures to replicate GXE results may derive from standard statistical approaches being less than ideal. En ligne : http://dx.doi.org/10.1111/jcpp.12075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Commentary: Will genomics revolutionise research on gene-environment interplay? / Robert PLOMIN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1214-1218 Titre : Commentary: Will genomics revolutionise research on gene-environment interplay? Type de document : Texte imprimé et/ou numérique Auteurs : Robert PLOMIN, Auteur ; Essi VIDING, Auteur Année de publication : 2022 Article en page(s) : p.1214-1218 Langues : Anglais (eng) Mots-clés : Gene-Environment Interaction  Genomics  Humans  Multifactorial Inheritance/genetics  Psychopathology  gene-environment correlation  polygenic scores  quantitative genomics Index. décimale : PER Périodiques Résumé : The synthesis of quantitative genetics and molecular genetics is transforming research in the behavioural sciences. The ability to measure inherited DNA differences directly has led to polygenic scores and to new methods to estimate heritability and genetic correlations. This issue provides examples of how these advances can be appllied to research on gene-environment interplay in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Commentary: Will genomics revolutionise research on gene-environment interplay? [Texte imprimé et/ou numérique] / Robert PLOMIN, Auteur ; Essi VIDING, Auteur . - 2022 . - p.1214-1218. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1214-1218 Mots-clés : Gene-Environment Interaction  Genomics  Humans  Multifactorial Inheritance/genetics  Psychopathology  gene-environment correlation  polygenic scores  quantitative genomics Index. décimale : PER Périodiques Résumé : The synthesis of quantitative genetics and molecular genetics is transforming research in the behavioural sciences. The ability to measure inherited DNA differences directly has led to polygenic scores and to new methods to estimate heritability and genetic correlations. This issue provides examples of how these advances can be appllied to research on gene-environment interplay in developmental psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Gene-environment interplays between family chaos and emotional problems among Nigerian adolescents: A twin study / Olakunle A. OGINNI in Development and Psychopathology, 36-1 (February 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-1 (February 2024) . - p.62-68 Titre : Gene-environment interplays between family chaos and emotional problems among Nigerian adolescents: A twin study Type de document : Texte imprimé et/ou numérique Auteurs : Olakunle A. OGINNI, Auteur ; Yoon-Mi HUR, Auteur Article en page(s) : p.62-68 Langues : Anglais (eng) Mots-clés : adolescents  emotional problems  family chaos  gene-environment correlation  gene-environment interaction Index. décimale : PER Périodiques Résumé : Gene-environment correlations and interactions for the relationship between emotional problems (EP) and family environment in adolescents in low- to middle-income countries (LMIC) have been rarely investigated. In total, 3207 adolescent twins aged 12-18 (Mean = 14.6 + 1.73) years attending public schools in Lagos State in Nigeria completed measures of EP and Family Chaos (FC). Model-fitting analyses suggested that genetic and non-shared environmental influences on EP were 21% and 71%, respectively, and the corresponding estimates were 23% and 71% for FC. Shared environmental influences were not significant (8% and 6% respectively). Phenotypic correlation between EP and FC was .30 (95% CI = .27-.34), which was significantly influenced by genetic (A - 49%, 95% CI: 0.01-0.97) and non-shared environmental factors (E - 32%, 95% CI: 0.10-0.54). Shared environmental influences were not significant (C - 19%, 95% CI: ?0.13 to 0.50). Moderation effects were significant whereby as FC increased, A on EP decreased (?A = ?0.07, 95% CI: ?0.12 to ?0.02) while E increased (?E = 0.06, 95% CI: 0.03-0.09). Our findings indicate that genetic and non-shared environmental risk factors may mediate the relationship between EP and FC, and that as FC increases, protective genetic influences on EP may be attenuated, whereas environmental influences may become stronger in adolescents in LMIC. En ligne : https://dx.doi.org/10.1017/S0954579422000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Gene-environment interplays between family chaos and emotional problems among Nigerian adolescents: A twin study [Texte imprimé et/ou numérique] / Olakunle A. OGINNI, Auteur ; Yoon-Mi HUR, Auteur . - p.62-68. Langues : Anglais (eng) in Development and Psychopathology > 36-1 (February 2024) . - p.62-68 Mots-clés : adolescents  emotional problems  family chaos  gene-environment correlation  gene-environment interaction Index. décimale : PER Périodiques Résumé : Gene-environment correlations and interactions for the relationship between emotional problems (EP) and family environment in adolescents in low- to middle-income countries (LMIC) have been rarely investigated. In total, 3207 adolescent twins aged 12-18 (Mean = 14.6 + 1.73) years attending public schools in Lagos State in Nigeria completed measures of EP and Family Chaos (FC). Model-fitting analyses suggested that genetic and non-shared environmental influences on EP were 21% and 71%, respectively, and the corresponding estimates were 23% and 71% for FC. Shared environmental influences were not significant (8% and 6% respectively). Phenotypic correlation between EP and FC was .30 (95% CI = .27-.34), which was significantly influenced by genetic (A - 49%, 95% CI: 0.01-0.97) and non-shared environmental factors (E - 32%, 95% CI: 0.10-0.54). Shared environmental influences were not significant (C - 19%, 95% CI: ?0.13 to 0.50). Moderation effects were significant whereby as FC increased, A on EP decreased (?A = ?0.07, 95% CI: ?0.12 to ?0.02) while E increased (?E = 0.06, 95% CI: 0.03-0.09). Our findings indicate that genetic and non-shared environmental risk factors may mediate the relationship between EP and FC, and that as FC increases, protective genetic influences on EP may be attenuated, whereas environmental influences may become stronger in adolescents in LMIC. En ligne : https://dx.doi.org/10.1017/S0954579422000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study / Jessica AGNEW-BLAIS in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Titre : Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study Type de document : Texte imprimé et/ou numérique Auteurs : Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur Année de publication : 2022 Article en page(s) : p.1153-1163 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study [Texte imprimé et/ou numérique] / Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur . - 2022 . - p.1153-1163. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation / Sandra MACHLITT-NORTHEN in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152 Titre : Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation Type de document : Texte imprimé et/ou numérique Auteurs : Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur Année de publication : 2022 Article en page(s) : p.1140-1152 Langues : Anglais (eng) Mots-clés : Cohort Studies  Depression  Depressive Disorder, Major/etiology/genetics  Gene-Environment Interaction  Genetic Predisposition to Disease  Genome-Wide Association Study  Humans  Multifactorial Inheritance  Risk Factors  Schizophrenia/epidemiology/genetics  Environment  genetics  major depressive disorder  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene-environment correlation [Texte imprimé et/ou numérique] / Sandra MACHLITT-NORTHEN, Auteur ; Robert KEERS, Auteur ; Patricia B. MUNROE, Auteur ; David M. HOWARD, Auteur ; Vassily TRUBETSKOY, Auteur ; Michael PLUESS, Auteur . - 2022 . - p.1140-1152. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1140-1152 Mots-clés : Cohort Studies  Depression  Depressive Disorder, Major/etiology/genetics  Gene-Environment Interaction  Genetic Predisposition to Disease  Genome-Wide Association Study  Humans  Multifactorial Inheritance  Risk Factors  Schizophrenia/epidemiology/genetics  Environment  genetics  major depressive disorder  schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene-environment correlation (rGE). STUDY OBJECTIVE: This study aims to investigate: (a) whether the genetic risk for SCZ/MDD in children is correlated with established environmental and psychosocial risk factors in two British community samples, the 1958 National Child Development Study (NCDS) and the Millennium Cohort Study (MCS), (b) whether these associations vary between both psychopathologies, and (c) whether findings differ across the two cohorts which were born 42years apart. METHODS: Polygenic risk scores (PRS) from existing large genome-wide associations studies (GWAS) were applied to test the correlation between the child genetic risk for SCZ/MDD and known environmental risk factors. In addition, parental and child genetic data from MCS were used to distinguish between passive and evocative rGE. RESULTS: The child polygenic risk for SCZ and MDD was correlated with single parenthood in MCS. Moreover, the lack of father's involvement in child care was associated with the genetic risk for SCZ in NCDS. However, we also found associations between several indicators of low socioeconomic status and heightened genetic risk for MDD in children in both cohorts. Further, the genetic risk for MDD was associated with parental lack of interest in the child's education in NCDS as well as more maternal smoking and less maternal alcohol consumption during childhood in MCS. According to sensitivity analyses in MCS (controlling for parental genotype), more than half of our significant correlations reflected passive rGE. CONCLUSIONS: Findings suggest that several established environmental and psychosocial risk factors for SCZ and MDD are at least partially associated with children's genetic risk for these psychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development / E. FRIEDLANDER in Autism Research, 12-7 (July 2019)  

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Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis / James J. LI in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

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Early warm-rewarding parenting moderates the genetic contributions to callous-unemotional traits in childhood / J. HENRY in Journal of Child Psychology and Psychiatry, 59-12 (December 2018)  

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Understanding environmental contributions to autism: Causal concepts and the state of science / I. HERTZ-PICCIOTTO in Autism Research, 11-4 (April 2018)  

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HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents / L. R. STARR in Development and Psychopathology, 31-4 (October 2019)  

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