Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation / Brittany G. TRAVERS in Molecular Autism, (March 2015)  

Public ISBD [article]  inMolecular Autism > (March 2015) . - p.1-15 Titre : Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur Article en page(s) : p.1-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur . - p.1-15. Langues : Anglais (eng) in Molecular Autism > (March 2015) . - p.1-15 Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children / Olivia SURGENT in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 48 p. Titre : Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children [Texte imprimé et/ou numérique] / Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 48 p. Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism / Brittany G. TRAVERS in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Titre : Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.3030-3040 Langues : Anglais (eng) Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.3030-3040. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood / Molly B. D. PRIGGE in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4490-4504 Titre : Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Molly B. D. PRIGGE, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Jubel MORGAN, Auteur ; Alyson FROEHLICH, Auteur ; Abigail FREEMAN, Auteur ; Kristina KELLETT, Auteur ; Karen L. KANE, Auteur ; Carolyn K. KING, Auteur ; June TAYLOR, Auteur ; Douglas C. 3rd DEAN, Auteur ; Jace B. KING, Auteur ; Jeff S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.4490-4504 Langues : Anglais (eng) Mots-clés : Asd  Autism spectrum disorder  Cognitive development  Intelligence  Longitudinal study  Stability Index. décimale : PER Périodiques Résumé : Intelligence (IQ) scores are used in educational and vocational planning for individuals with autism spectrum disorder (ASD) yet little is known about the stability of IQ throughout development. We examined longitudinal age-related IQ stability in 119 individuals with ASD (3-36 years of age at first visit) and 128 typically developing controls. Intelligence measures were collected over a 20-year period. In ASD, Full Scale (FSIQ) and Verbal (VIQ) Intelligence started lower in childhood and increased at a greater rate with age relative to the control group. By early adulthood, VIQ and working memory stabilized, whereas nonverbal and perceptual scores continued to change. Our results suggest that in individuals with ASD, IQ estimates may be dynamic in childhood and young adulthood. En ligne : http://dx.doi.org/10.1007/s10803-021-05227-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood [Texte imprimé et/ou numérique] / Molly B. D. PRIGGE, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Jubel MORGAN, Auteur ; Alyson FROEHLICH, Auteur ; Abigail FREEMAN, Auteur ; Kristina KELLETT, Auteur ; Karen L. KANE, Auteur ; Carolyn K. KING, Auteur ; June TAYLOR, Auteur ; Douglas C. 3rd DEAN, Auteur ; Jace B. KING, Auteur ; Jeff S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.4490-4504. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-10 (October 2022) . - p.4490-4504 Mots-clés : Asd  Autism spectrum disorder  Cognitive development  Intelligence  Longitudinal study  Stability Index. décimale : PER Périodiques Résumé : Intelligence (IQ) scores are used in educational and vocational planning for individuals with autism spectrum disorder (ASD) yet little is known about the stability of IQ throughout development. We examined longitudinal age-related IQ stability in 119 individuals with ASD (3-36 years of age at first visit) and 128 typically developing controls. Intelligence measures were collected over a 20-year period. In ASD, Full Scale (FSIQ) and Verbal (VIQ) Intelligence started lower in childhood and increased at a greater rate with age relative to the control group. By early adulthood, VIQ and working memory stabilized, whereas nonverbal and perceptual scores continued to change. Our results suggest that in individuals with ASD, IQ estimates may be dynamic in childhood and young adulthood. En ligne : http://dx.doi.org/10.1007/s10803-021-05227-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features / Brittany G. TRAVERS in Autism Research, 17-2 (February 2024)  

Public ISBD [article]  inAutism Research > 17-2 (February 2024) . - p.266-279 Titre : Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Olivia SURGENT, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Douglas C. DEAN III, Auteur ; Nagesh ADLURU, Auteur ; Steven R. KECSKEMETI, Auteur ; Gregory R. KIRK, Auteur ; Andrew L. ALEXANDER, Auteur ; Jun ZHU, Auteur ; Emily C. SKALETSKI, Auteur ; Sonali NAIK, Auteur ; Monica DURAN, Auteur Article en page(s) : p.266-279 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Although multiple theories have speculated about the brainstem reticular formation's involvement in autistic behaviors, the in vivo imaging of brainstem nuclei needed to test these theories has proven technologically challenging. Using methods to improve brainstem imaging in children, this study set out to elucidate the role of the autonomic, nociceptive, and limbic brainstem nuclei in the autism features of 145 children (74 autistic children, 6.0-10.9?years). Participants completed an assessment of core autism features and diffusion- and T1-weighted imaging optimized to improve brainstem images. After data reduction via principal component analysis, correlational analyses examined associations among autism features and the microstructural properties of brainstem clusters. Independent replication was performed in 43 adolescents (24 autistic, 13.0-17.9?years). We found specific nuclei, most robustly the parvicellular reticular formation-alpha (PCRtA) and to a lesser degree the lateral parabrachial nucleus (LPB) and ventral tegmental parabrachial pigmented complex (VTA-PBP), to be associated with autism features. The PCRtA and some of the LPB associations were independently found in the replication sample, but the VTA-PBP associations were not. Consistent with theoretical perspectives, the findings suggest that individual differences in pontine reticular formation nuclei contribute to the prominence of autistic features. Specifically, the PCRtA, a nucleus involved in mastication, digestion, and cardio-respiration in animal models, was associated with social communication in children, while the LPB, a pain-network nucleus, was associated with repetitive behaviors. These findings highlight the contributions of key autonomic brainstem nuclei to the expression of core autism features. En ligne : https://doi.org/10.1002/aur.3096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522 [article] Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Olivia SURGENT, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Douglas C. DEAN III, Auteur ; Nagesh ADLURU, Auteur ; Steven R. KECSKEMETI, Auteur ; Gregory R. KIRK, Auteur ; Andrew L. ALEXANDER, Auteur ; Jun ZHU, Auteur ; Emily C. SKALETSKI, Auteur ; Sonali NAIK, Auteur ; Monica DURAN, Auteur . - p.266-279. Langues : Anglais (eng) in Autism Research > 17-2 (February 2024) . - p.266-279 Index. décimale : PER Périodiques Résumé : Abstract Although multiple theories have speculated about the brainstem reticular formation's involvement in autistic behaviors, the in vivo imaging of brainstem nuclei needed to test these theories has proven technologically challenging. Using methods to improve brainstem imaging in children, this study set out to elucidate the role of the autonomic, nociceptive, and limbic brainstem nuclei in the autism features of 145 children (74 autistic children, 6.0-10.9?years). Participants completed an assessment of core autism features and diffusion- and T1-weighted imaging optimized to improve brainstem images. After data reduction via principal component analysis, correlational analyses examined associations among autism features and the microstructural properties of brainstem clusters. Independent replication was performed in 43 adolescents (24 autistic, 13.0-17.9?years). We found specific nuclei, most robustly the parvicellular reticular formation-alpha (PCRtA) and to a lesser degree the lateral parabrachial nucleus (LPB) and ventral tegmental parabrachial pigmented complex (VTA-PBP), to be associated with autism features. The PCRtA and some of the LPB associations were independently found in the replication sample, but the VTA-PBP associations were not. Consistent with theoretical perspectives, the findings suggest that individual differences in pontine reticular formation nuclei contribute to the prominence of autistic features. Specifically, the PCRtA, a nucleus involved in mastication, digestion, and cardio-respiration in animal models, was associated with social communication in children, while the LPB, a pain-network nucleus, was associated with repetitive behaviors. These findings highlight the contributions of key autonomic brainstem nuclei to the expression of core autism features. En ligne : https://doi.org/10.1002/aur.3096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=522

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