[article]
| Titre : |
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur |
| Article en page(s) : |
p.2748-2757 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-018-3536-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 |
in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757
[article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur . - p.2748-2757. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757
| Mots-clés : |
Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. |
| En ligne : |
http://dx.doi.org/10.1007/s10803-018-3536-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 |
|
Faire une suggestion Affiner la recherche2010 in Review in Journal of Autism and Developmental Disorders, 41-4 (April 2011)
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