Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ / Celeste H.M. CHEUNG in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.864-873 Titre : Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ Type de document : Texte imprimé et/ou numérique Auteurs : Celeste H.M. CHEUNG, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Yannis PALOYELIS, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Jan K. BUITELAAR, Auteur ; Barbara FRANKE, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur Année de publication : 2012 Article en page(s) : p.864-873 Langues : Anglais (eng) Mots-clés : ADHD  reading difficulties  IQ  familial  sibling-pair  comorbidity Index. décimale : PER Périodiques Résumé : Background:  Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods:  Multivariate familial models were run on data from 1,789 individuals at ages 6–19. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISC–III/WAIS–III). Results:  Significant phenotypic (.2–.4) and familial (.3–.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53%–72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions:  Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02527.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 [article] Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ [Texte imprimé et/ou numérique] / Celeste H.M. CHEUNG, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Yannis PALOYELIS, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Jan K. BUITELAAR, Auteur ; Barbara FRANKE, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur . - 2012 . - p.864-873. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.864-873 Mots-clés : ADHD  reading difficulties  IQ  familial  sibling-pair  comorbidity Index. décimale : PER Périodiques Résumé : Background:  Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods:  Multivariate familial models were run on data from 1,789 individuals at ages 6–19. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISC–III/WAIS–III). Results:  Significant phenotypic (.2–.4) and familial (.3–.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53%–72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions:  Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02527.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209 Titre : Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.197-209 Langues : Anglais (eng) Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683 [article] Autism symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders [Texte imprimé et/ou numérique] / Aisling MULLIGAN, Auteur ; Herbert ROEYERS, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Myra O’REGAN, Auteur ; Louise BUTLER, Auteur ; Judith NIJMEIJER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Robert D. OADES, Auteur ; Hanna CHRISTIANSEN, Auteur ; Isabel GABRIELS, Auteur ; Rafaela MARCO, Auteur ; Sheera MEIDAD, Auteur ; Ueli MUELLER, Auteur ; Jacques EISENBERG, Auteur ; Iris MANOR, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Ruud B. MINDERAA, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Henrik UEBEL, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Catharina A. HARTMAN, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur ; Jan K. BUITELAAR, Auteur ; Michael FITZGERALD, Auteur ; Nanda N. ROMMELSE, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Michael GILL, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.197-209. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.197-209 Mots-clés : ADHD Autism Familiality Oppositional-disorders Motor-disorder Language-disorder Index. décimale : PER Périodiques Résumé : It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders. En ligne : http://dx.doi.org/10.1007/s10803-008-0621-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683

Childhood language skills as predictors of social, adaptive and behavior outcomes of adolescents with autism spectrum disorder / Ana MIRANDA in Research in Autism Spectrum Disorders, 103 (May 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 103 (May 2023) . - p.102143 Titre : Childhood language skills as predictors of social, adaptive and behavior outcomes of adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ana MIRANDA, Auteur ; Carmen BERENGUER, Auteur ; Inmaculada BAIXAULI, Auteur ; Belén ROSELLÓ, Auteur Article en page(s) : p.102143 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Structural language skills  Pragmatics  Follow-up  Socio-adaptive skills  Behaviour problems Index. décimale : PER Périodiques Résumé : Background Children with autism, including those without intellectual disability (ASD-ID), experience poor social and adaptive development in adolescence. Although language difficulties are commonly identified in children ASD-ID, there has been little empirical research that has analyzed the influence of these difficulties in social, adaptive and behavioural outcomes in adolescence. Methods and procedure Structural and pragmatic language of 45 children with ASD-ID were assessed at childhood (aged 7-11) through The Children Communication Checklist (CCC-2) completed by parents. More than four-years later, in the follow-up, prosocial behaviour and peer relationships, daily living and socialization skills and behavioural difficulties were evaluated. Results Multiple regression analysis exploring the relationships between structural and pragmatic language and the different developmental outcomes, showed that pragmatic language significantly predicted all three domains, especially stereotyped language and use of context. However, structural language (semantics in particular) only accounted for a significant proportion in the variance in prosocial behaviour and socialization skills. Conclusions and implications Taken together, these findings indicate that structural language and, particularly pragmatic language, are relevant predictors of ASD social and behavioural outcomes in adolescence. Therefore, a detailed language assessment might be an important target of ASD diagnostic practice for improving the development of children with ASD-ID. En ligne : https://doi.org/10.1016/j.rasd.2023.102143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Childhood language skills as predictors of social, adaptive and behavior outcomes of adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Ana MIRANDA, Auteur ; Carmen BERENGUER, Auteur ; Inmaculada BAIXAULI, Auteur ; Belén ROSELLÓ, Auteur . - p.102143. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 103 (May 2023) . - p.102143 Mots-clés : Autism spectrum disorder  Structural language skills  Pragmatics  Follow-up  Socio-adaptive skills  Behaviour problems Index. décimale : PER Périodiques Résumé : Background Children with autism, including those without intellectual disability (ASD-ID), experience poor social and adaptive development in adolescence. Although language difficulties are commonly identified in children ASD-ID, there has been little empirical research that has analyzed the influence of these difficulties in social, adaptive and behavioural outcomes in adolescence. Methods and procedure Structural and pragmatic language of 45 children with ASD-ID were assessed at childhood (aged 7-11) through The Children Communication Checklist (CCC-2) completed by parents. More than four-years later, in the follow-up, prosocial behaviour and peer relationships, daily living and socialization skills and behavioural difficulties were evaluated. Results Multiple regression analysis exploring the relationships between structural and pragmatic language and the different developmental outcomes, showed that pragmatic language significantly predicted all three domains, especially stereotyped language and use of context. However, structural language (semantics in particular) only accounted for a significant proportion in the variance in prosocial behaviour and socialization skills. Conclusions and implications Taken together, these findings indicate that structural language and, particularly pragmatic language, are relevant predictors of ASD social and behavioural outcomes in adolescence. Therefore, a detailed language assessment might be an important target of ASD diagnostic practice for improving the development of children with ASD-ID. En ligne : https://doi.org/10.1016/j.rasd.2023.102143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder / Edmund J. S. SONUGA-BARKE in Journal of Child Psychology and Psychiatry, 50-9 (September 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1052-1063 Titre : Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Herbert ROEYERS, Auteur ; Michael GIL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Wai CHEN, Auteur ; Richard ANNEY, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Joseph A. SERGEANT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2009 Article en page(s) : p.1052-1063 Langues : Anglais (eng) Mots-clés : ADHD gene-x-environment-interaction conduct-problems behaviour-problems emotional-problems emotional-symptoms expressed-emotion mothers teachers genetics serotonin-transports dopamine-transport Index. décimale : PER Périodiques Résumé : Background: Mothers' positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP). We examined whether this association with CP, and one with emotional problems (EMO), is moderated by variants within three genes, previously reported to be associated with ADHD and to moderate the impact of environmental risks on conduct and/or emotional problems; the dopamine transporter gene (SLC6A3/DAT1), the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (SLC6A4/5HTT). Methods: Seven hundred and twenty-eight males between the ages of 5 and 17 with a DSM-IV research diagnosis of combined type ADHD were included in these analyses. Parents and teachers rated children's conduct and emotional problems. Positive maternal expressed emotion (PMEE) was coded by independent observers on comments made during a clinical assessment with the mother based on current or recent medication-free periods. Results: Sensitivity to the effects of PMEE on CP was moderated by variants of the DAT1 and 5HTT genes. Only children who did not carry the DAT1 10R/10R or the 5HTT l/l genotypes showed altered levels of CP when exposed to PMEE. The effect was most marked where the child with ADHD had both these genotypes. For EMO, sensitivity to PMEE was found only with those who carried the DAT1 9R/9R. There was no effect of DRD4 on CP or EMO. Conclusion: The gene–environment interactions observed suggested that genetic make-up can alter the degree of sensitivity an ADHD patients has to their family environment. Further research should focus on distinguishing general sensitivity genotypes from those conferring risk or protective qualities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02095.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828 [article] Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Herbert ROEYERS, Auteur ; Michael GIL, Auteur ; Ana MIRANDA, Auteur ; Robert D. OADES, Auteur ; Wai CHEN, Auteur ; Richard ANNEY, Auteur ; Barbara FRANKE, Auteur ; Margaret J. THOMPSON, Auteur ; Lamprini PSYCHOGIOU, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Joseph A. SERGEANT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Aribert ROTHENBERGER, Auteur ; Richard P. EBSTEIN, Auteur . - 2009 . - p.1052-1063. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-9 (September 2009) . - p.1052-1063 Mots-clés : ADHD gene-x-environment-interaction conduct-problems behaviour-problems emotional-problems emotional-symptoms expressed-emotion mothers teachers genetics serotonin-transports dopamine-transport Index. décimale : PER Périodiques Résumé : Background: Mothers' positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP). We examined whether this association with CP, and one with emotional problems (EMO), is moderated by variants within three genes, previously reported to be associated with ADHD and to moderate the impact of environmental risks on conduct and/or emotional problems; the dopamine transporter gene (SLC6A3/DAT1), the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (SLC6A4/5HTT). Methods: Seven hundred and twenty-eight males between the ages of 5 and 17 with a DSM-IV research diagnosis of combined type ADHD were included in these analyses. Parents and teachers rated children's conduct and emotional problems. Positive maternal expressed emotion (PMEE) was coded by independent observers on comments made during a clinical assessment with the mother based on current or recent medication-free periods. Results: Sensitivity to the effects of PMEE on CP was moderated by variants of the DAT1 and 5HTT genes. Only children who did not carry the DAT1 10R/10R or the 5HTT l/l genotypes showed altered levels of CP when exposed to PMEE. The effect was most marked where the child with ADHD had both these genotypes. For EMO, sensitivity to PMEE was found only with those who carried the DAT1 9R/9R. There was no effect of DRD4 on CP or EMO. Conclusion: The gene–environment interactions observed suggested that genetic make-up can alter the degree of sensitivity an ADHD patients has to their family environment. Further research should focus on distinguishing general sensitivity genotypes from those conferring risk or protective qualities. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02095.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=828

Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence / Esther SOBANSKI in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923 Titre : Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence Type de document : Texte imprimé et/ou numérique Auteurs : Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.915-923 Langues : Anglais (eng) Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background:  The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD. Methods:  One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied. Results:  Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families. Conclusion:  EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Emotional lability in children and adolescents with attention deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence [Texte imprimé et/ou numérique] / Esther SOBANSKI, Auteur ; Herbert ROEYERS, Auteur ; Barbara FRANKE, Auteur ; Richard ANNEY, Auteur ; Wai CHEN, Auteur ; Robert D. OADES, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Argyris STRINGARIS, Auteur ; Bertram KRUMM, Auteur ; Eric TAYLOR, Auteur ; Michael GILL, Auteur ; Aribert ROTHENBERGER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Joseph A. SERGEANT, Auteur ; Hans-Christoph STEINHAUSEN, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jan K. BUITELAAR, Auteur ; Martin HOLTMANN, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.915-923. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-8 (August 2010) . - p.915-923 Mots-clés : Attention-deficit-hyperactivity-disorder emotional-lability affective-lability emotional-dysregulation Index. décimale : PER Périodiques Résumé : Background:  The goal of this study was to investigate the occurrence, severity and clinical correlates of emotional lability (EL) in children with attention deficit/hyperactivity disorder (ADHD), and to examine factors contributing to EL and familiality of EL in youth with ADHD. Methods:  One thousand, one hundred and eighty-six children with ADHD combined type and 1827 siblings (aged 6–18 years) were assessed for symptoms of EL, ADHD, associated psychopathology and comorbid psychiatric disorders with a structured diagnostic interview (PACS) as well as parent and teacher ratings of psychopathology (SDQ; CPRS-R:L; CTRS-R:L). Analyses of variance, regression analyses, χ2-tests or loglinear models were applied. Results:  Mean age and gender-standardized ratings of EL in children with ADHD were >1.5 SD above the mean in normative samples. Severe EL (>75th percentile) was associated with more severe ADHD core symptoms, primarily hyperactive-impulsive symptoms, and more comorbid oppositional defiant, affective and substance use disorders. Age, hyperactive-impulsive, oppositional, and emotional symptoms accounted for 30% of EL variance; hyperactive-impulsive symptoms did not account for EL variance when coexisting oppositional and emotional problems were taken into account, but oppositional symptoms explained 12% of EL variance specifically. Severity of EL in probands increased the severity of EL in siblings, but not the prevalence rates of ADHD or ODD. EL and ADHD does not co-segregate within families. Conclusion:  EL is a frequent clinical problem in children with ADHD. It is associated with increased severity of ADHD core symptoms, particularly hyperactivity-impulsivity, and more symptoms of comorbid psychopathology, primarily symptoms of oppositional defiant disorder (ODD), but also affective symptoms, and substance abuse. EL in ADHD seems to be more closely related to ODD than to ADHD core symptoms, and is only partly explainable by the severity of ADHD core symptoms and associated psychopathology. Although EL symptoms are transmitted within families, EL in children with ADHD does not increase the risk of ADHD and ODD in their siblings. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02217.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Erratum : Autism Symptoms in Attention-Deficit/Hyperactivity Disorder: A Familial Trait which Correlates with Conduct, Oppositional Defiant, Language and Motor Disorders / Aisling MULLIGAN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

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Neuropsychological correlates of emotional lability in children with ADHD / Tobias BANASCHEWSKI in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

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Performance variability, impulsivity errors and the impact of incentives as gender-independent endophenotypes for ADHD / Henrik UEBEL in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

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The hierarchical factor model of ADHD: invariant across age and national groupings? / Maggie E. TOPLAK in Journal of Child Psychology and Psychiatry, 53-3 (March 2012)  

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