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Détail de l'auteur
Auteur M. INAGAKI |
Documents disponibles écrits par cet auteur (2)
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Brain hyperserotonemia causes autism-relevant social deficits in mice / M. TANAKA in Molecular Autism, 9 (2018)
[article]
Titre : Brain hyperserotonemia causes autism-relevant social deficits in mice Type de document : Texte imprimé et/ou numérique Auteurs : M. TANAKA, Auteur ; A. SATO, Auteur ; S. KASAI, Auteur ; Y. HAGINO, Auteur ; H. KOTAJIMA-MURAKAMI, Auteur ; H. KASHII, Auteur ; Y. TAKAMATSU, Auteur ; Y. NISHITO, Auteur ; M. INAGAKI, Auteur ; M. MIZUGUCHI, Auteur ; F. S. HALL, Auteur ; G. R. UHL, Auteur ; D. MURPHY, Auteur ; I. SORA, Auteur ; K. IKEDA, Auteur Article en page(s) : 60p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Heterozygous mice Serotonin transporter Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 60p.[article] Brain hyperserotonemia causes autism-relevant social deficits in mice [Texte imprimé et/ou numérique] / M. TANAKA, Auteur ; A. SATO, Auteur ; S. KASAI, Auteur ; Y. HAGINO, Auteur ; H. KOTAJIMA-MURAKAMI, Auteur ; H. KASHII, Auteur ; Y. TAKAMATSU, Auteur ; Y. NISHITO, Auteur ; M. INAGAKI, Auteur ; M. MIZUGUCHI, Auteur ; F. S. HALL, Auteur ; G. R. UHL, Auteur ; D. MURPHY, Auteur ; I. SORA, Auteur ; K. IKEDA, Auteur . - 60p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 60p.
Mots-clés : Autism spectrum disorder Heterozygous mice Serotonin transporter Tryptophan depletion Index. décimale : PER Périodiques Résumé : Background: Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms. Methods: We analyzed behavior and gene expression to unveil the causal mechanism of ASD-relevant social deficits using serotonin transporter (Sert) knockout mice. Results: Social deficits were observed in both heterozygous knockout mice (HZ) and homozygous knockout mice (KO), but increases in general anxiety were only observed in KO mice. Two weeks of dietary restriction of the serotonin precursor tryptophan ameliorated both brain hyperserotonemia and ASD-relevant social deficits in Sert HZ and KO mice. The expression of rather distinct sets of genes was altered in Sert HZ and KO mice, and a substantial portion of these genes was also affected by tryptophan depletion. Tryptophan depletion in Sert HZ and KO mice was associated with alterations in the expression of genes involved in signal transduction pathways initiated by changes in extracellular serotonin or melatonin, a derivative of serotonin. Only expression of the AU015836 gene was altered in both Sert HZ and KO mice. AU015836 expression and ASD-relevant social deficits normalized after dietary tryptophan restriction. Conclusions: These findings reveal a Sert gene dose-dependent effect on brain hyperserotonemia and related behavioral sequelae in ASD and a possible therapeutic target to normalize brain hyperserotonemia and ASD-relevant social deficits. En ligne : https://dx.doi.org/10.1186/s13229-018-0243-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students / K. SUZUKI in Journal of Autism and Developmental Disorders, 51-6 (June 2021)
[article]
Titre : The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students Type de document : Texte imprimé et/ou numérique Auteurs : K. SUZUKI, Auteur ; Y. OI, Auteur ; M. INAGAKI, Auteur Article en page(s) : p.2047-2056 Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/psychology Friends Humans Loneliness/psychology Male Phenotype Social Networking Social Skills Students/psychology Surveys and Questionnaires Young Adult Autism spectrum disorder (ASD) College students Friendship Loneliness Social networking services (SNS) Index. décimale : PER Périodiques Résumé : This study aimed to explore the relationships among autism spectrum disorder (ASD) traits, loneliness, and social networking services (SNS) use. We created a questionnaire to evaluate manners during LINE use, which included five factors: "low literacy," "inactive use," "low responsiveness," "lack of consideration," and "low group activity." Structural equation modeling revealed that difficulties in attention switching and low communication skills were associated with low literacy, low social skills were associated with inactive use, and low literacy and inactive use were associated with loneliness. We suggested that SNS use plays a role in maintaining and enhancing friendships, whereas college students with higher ASD traits tend to use inappropriate manners for SNS, which is associated with loneliness. En ligne : http://dx.doi.org/10.1007/s10803-020-04701-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2047-2056[article] The Relationships Among Autism Spectrum Disorder Traits, Loneliness, and Social Networking Service Use in College Students [Texte imprimé et/ou numérique] / K. SUZUKI, Auteur ; Y. OI, Auteur ; M. INAGAKI, Auteur . - p.2047-2056.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-6 (June 2021) . - p.2047-2056
Mots-clés : Adolescent Autism Spectrum Disorder/psychology Friends Humans Loneliness/psychology Male Phenotype Social Networking Social Skills Students/psychology Surveys and Questionnaires Young Adult Autism spectrum disorder (ASD) College students Friendship Loneliness Social networking services (SNS) Index. décimale : PER Périodiques Résumé : This study aimed to explore the relationships among autism spectrum disorder (ASD) traits, loneliness, and social networking services (SNS) use. We created a questionnaire to evaluate manners during LINE use, which included five factors: "low literacy," "inactive use," "low responsiveness," "lack of consideration," and "low group activity." Structural equation modeling revealed that difficulties in attention switching and low communication skills were associated with low literacy, low social skills were associated with inactive use, and low literacy and inactive use were associated with loneliness. We suggested that SNS use plays a role in maintaining and enhancing friendships, whereas college students with higher ASD traits tend to use inappropriate manners for SNS, which is associated with loneliness. En ligne : http://dx.doi.org/10.1007/s10803-020-04701-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452