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Auteur A. SOURANDER |
Documents disponibles écrits par cet auteur (2)
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A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort / K. CHESLACK-POSTAVA in Autism Research, 14-11 (November 2021)
[article]
Titre : A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur Article en page(s) : p.2444-2453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2444-2453[article] A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort [Texte imprimé et/ou numérique] / K. CHESLACK-POSTAVA, Auteur ; A. SOURANDER, Auteur ; S. HINKKA-YLI-SALOMÄKI, Auteur ; I. W. MCKEAGUE, Auteur ; H. M. SURCEL, Auteur ; A. S. BROWN, Auteur . - p.2444-2453.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2444-2453
Mots-clés : Autism Spectrum Disorder Autistic Disorder Biomarkers Case-Control Studies Child Female Finland/epidemiology Humans Maternal Exposure Pregnancy Prenatal Exposure Delayed Effects/epidemiology Smoking autism cotinine prenatal exposure delayed effects smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30?days), sex, and place of birth (N =?962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 Risk for Premature Mortality and Intentional Self-harm in Autism Spectrum Disorders / E. JOKIRANTA-OLKONIEMI in Journal of Autism and Developmental Disorders, 51-9 (September 2021)
[article]
Titre : Risk for Premature Mortality and Intentional Self-harm in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : E. JOKIRANTA-OLKONIEMI, Auteur ; D. GYLLENBERG, Auteur ; D. SUCKSDORFF, Auteur ; A. SUOMINEN, Auteur ; K. KRONSTRÖM, Auteur ; R. CHUDAL, Auteur ; A. SOURANDER, Auteur Article en page(s) : p.3098-3108 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/epidemiology Child Humans Mortality, Premature Risk Factors Self-Injurious Behavior/epidemiology Suicide Autism Mortality Natural cause Psychiatric disorders Index. décimale : PER Périodiques Résumé : To examine the risk for premature mortality and intentional self-harm in autism spectrum disorders (ASD). Based on a national birth cohort. Children born in 1987-2005, diagnosed with ASD by 2007 (n?=?4695) were matched with four non-ASD subjects (n?=?18,450) and followed until 2015 for mortality and intentional self-harm. The risk among ASD subjects was elevated only for natural cause of death. The risk for intentional self-harm was increased in the unadjusted analyses, but decreased to non-significant after adjusting for comorbid psychiatric disorders. ASD subjects are at increased risk for premature mortality due to natural causes of death. While ASD subjects die of suicide and present with more self-harm, the association is explained by comorbid psychiatric disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04768-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3098-3108[article] Risk for Premature Mortality and Intentional Self-harm in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / E. JOKIRANTA-OLKONIEMI, Auteur ; D. GYLLENBERG, Auteur ; D. SUCKSDORFF, Auteur ; A. SUOMINEN, Auteur ; K. KRONSTRÖM, Auteur ; R. CHUDAL, Auteur ; A. SOURANDER, Auteur . - p.3098-3108.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-9 (September 2021) . - p.3098-3108
Mots-clés : Adult Autism Spectrum Disorder/epidemiology Child Humans Mortality, Premature Risk Factors Self-Injurious Behavior/epidemiology Suicide Autism Mortality Natural cause Psychiatric disorders Index. décimale : PER Périodiques Résumé : To examine the risk for premature mortality and intentional self-harm in autism spectrum disorders (ASD). Based on a national birth cohort. Children born in 1987-2005, diagnosed with ASD by 2007 (n?=?4695) were matched with four non-ASD subjects (n?=?18,450) and followed until 2015 for mortality and intentional self-harm. The risk among ASD subjects was elevated only for natural cause of death. The risk for intentional self-harm was increased in the unadjusted analyses, but decreased to non-significant after adjusting for comorbid psychiatric disorders. ASD subjects are at increased risk for premature mortality due to natural causes of death. While ASD subjects die of suicide and present with more self-harm, the association is explained by comorbid psychiatric disorders. En ligne : http://dx.doi.org/10.1007/s10803-020-04768-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453