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Auteur Helen TAGER-FLUSBERG |
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EEG power at 3 months in infants at high familial risk for autism / A. R. LEVIN in Journal of Neurodevelopmental Disorders, 9-1 (December 2017)
[article]
Titre : EEG power at 3 months in infants at high familial risk for autism Type de document : Texte imprimé et/ou numérique Auteurs : A. R. LEVIN, Auteur ; Kandice J. VARCIN, Auteur ; H. M. O'LEARY, Auteur ; Helen TAGER-FLUSBERG, Auteur ; C. A. NELSON, Auteur Article en page(s) : p.34 Langues : Anglais (eng) Mots-clés : Autism Biomarker Early development Electroencephalography Infant siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Alterations in brain development during infancy may precede the behavioral manifestation of developmental disorders. Infants at increased risk for autism are also at increased risk for other developmental disorders, including, quite commonly, language disorders. Here we assess the extent to which electroencephalographic (EEG) differences in infants at high versus low familial risk for autism are present by 3 months of age, and elucidate the functional significance of EEG power at 3 months in predicting later development. METHODS: EEG data were acquired at 3 months in infant siblings of children with autism (high risk; n = 29) and infant siblings of typically developing children (low risk; n = 19) as part of a prospective, longitudinal investigation. Development across multiple domains was assessed at 6, 9, 12, 18, 24, and 36 months. Diagnosis of autism was determined at 18-36 months. We assessed relationships between 3-month-olds' frontal EEG power and autism risk, autism outcome, language development, and development in other domains. RESULTS: Infants at high familial risk for autism had reduced frontal power at 3 months compared to infants at low familial risk for autism, across several frequency bands. Reduced frontal high-alpha power at 3 months was robustly associated with poorer expressive language at 12 months. CONCLUSIONS: Reduced frontal power at 3 months may indicate increased risk for reduced expressive language skills at 12 months. This finding aligns with prior studies suggesting reduced power is a marker for atypical brain function, and infants at familial risk for autism are also at increased risk for altered developmental functioning in non-autism-specific domains. En ligne : http://dx.doi.org/10.1186/s11689-017-9214-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.34[article] EEG power at 3 months in infants at high familial risk for autism [Texte imprimé et/ou numérique] / A. R. LEVIN, Auteur ; Kandice J. VARCIN, Auteur ; H. M. O'LEARY, Auteur ; Helen TAGER-FLUSBERG, Auteur ; C. A. NELSON, Auteur . - p.34.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 9-1 (December 2017) . - p.34
Mots-clés : Autism Biomarker Early development Electroencephalography Infant siblings Index. décimale : PER Périodiques Résumé : BACKGROUND: Alterations in brain development during infancy may precede the behavioral manifestation of developmental disorders. Infants at increased risk for autism are also at increased risk for other developmental disorders, including, quite commonly, language disorders. Here we assess the extent to which electroencephalographic (EEG) differences in infants at high versus low familial risk for autism are present by 3 months of age, and elucidate the functional significance of EEG power at 3 months in predicting later development. METHODS: EEG data were acquired at 3 months in infant siblings of children with autism (high risk; n = 29) and infant siblings of typically developing children (low risk; n = 19) as part of a prospective, longitudinal investigation. Development across multiple domains was assessed at 6, 9, 12, 18, 24, and 36 months. Diagnosis of autism was determined at 18-36 months. We assessed relationships between 3-month-olds' frontal EEG power and autism risk, autism outcome, language development, and development in other domains. RESULTS: Infants at high familial risk for autism had reduced frontal power at 3 months compared to infants at low familial risk for autism, across several frequency bands. Reduced frontal high-alpha power at 3 months was robustly associated with poorer expressive language at 12 months. CONCLUSIONS: Reduced frontal power at 3 months may indicate increased risk for reduced expressive language skills at 12 months. This finding aligns with prior studies suggesting reduced power is a marker for atypical brain function, and infants at familial risk for autism are also at increased risk for altered developmental functioning in non-autism-specific domains. En ligne : http://dx.doi.org/10.1186/s11689-017-9214-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=350 Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism / Mihaela D. BAROKOVA in Autism Research, 14-1 (January 2021)
[article]
Titre : Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mihaela D. BAROKOVA, Auteur ; Chelsea LA VALLE, Auteur ; Sommer HASSAN, Auteur ; Collin LEE, Auteur ; Mengyuan XU, Auteur ; Riley MCKECHNIE, Auteur ; Emily JOHNSTON, Auteur ; Manon A. KROL, Auteur ; Jennifer LEANO, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.112-126 Langues : Anglais (eng) Mots-clés : Elsa assessment autism spectrum disorder communication language measures outcome Index. décimale : PER Périodiques Résumé : Expressive language and communication are among the key targets of interventions for individuals with autism spectrum disorder (ASD), and natural language samples provide an optimal approach for their assessment. Currently, there are no protocols for collecting such samples that cover a wide range of ages or language abilities, particularly for children/adolescents who have very limited spoken language. We introduce a new protocol for collecting language samples, eliciting language samples for analysis (ELSA), and a novel approach for deriving basic measures of verbal communicative competence from it that bypasses the need for time-consuming transcription. Study 1 presents ELSA-adolescents (ELSA-A), designed for minimally and low-verbal older children/adolescents with ASD. The protocol successfully engaged and elicited speech from 46 participants across a wide range of ages (6;6-19;7) with samples averaging 20-25?min. The collected samples were segmented into speaker utterances (examiner and participant) using real-time coding as one is listening to the audio recording and two measures were derived: frequency of utterances and conversational turns per minute. These measures were shown to be reliable and valid. For Study 2, ELSA was adapted for younger children (ELSA-Toddler [ELSA-T]) with samples averaging 29?min from 19 toddlers (2;8-4;10?years) with ASD. Again, measures of frequency of utterances and conversational turns derived from ELSA-T were shown to have strong psychometric properties. In Study 3, we found that ELSA-A and ELSA-T were equivalent in eliciting language from 17 children with ASD (ages: 4;0-6;8), demonstrating their suitability for deriving robust objective assessments of expressive language that could be used to track change in ability over time. We introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA-T) to older adolescents (ELSA-A) with ASD who have minimal or low-verbal abilities. The measures of language and communication derived from them, frequency of utterances, and conversational turns per minute, using real-time coding methods, can be used to characterize ability and chart change in intervention research. LAY SUMMARY: We introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA-T) to older adolescents (ELSA-A) with autism spectrum disorder who have minimal or low-verbal abilities. The measures of language and communication derived from them, frequency of utterances and conversational turns per minute, using real-time coding methods, can be used to characterize ability and chart change in intervention research. En ligne : http://dx.doi.org/10.1002/aur.2380 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441
in Autism Research > 14-1 (January 2021) . - p.112-126[article] Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism [Texte imprimé et/ou numérique] / Mihaela D. BAROKOVA, Auteur ; Chelsea LA VALLE, Auteur ; Sommer HASSAN, Auteur ; Collin LEE, Auteur ; Mengyuan XU, Auteur ; Riley MCKECHNIE, Auteur ; Emily JOHNSTON, Auteur ; Manon A. KROL, Auteur ; Jennifer LEANO, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.112-126.
Langues : Anglais (eng)
in Autism Research > 14-1 (January 2021) . - p.112-126
Mots-clés : Elsa assessment autism spectrum disorder communication language measures outcome Index. décimale : PER Périodiques Résumé : Expressive language and communication are among the key targets of interventions for individuals with autism spectrum disorder (ASD), and natural language samples provide an optimal approach for their assessment. Currently, there are no protocols for collecting such samples that cover a wide range of ages or language abilities, particularly for children/adolescents who have very limited spoken language. We introduce a new protocol for collecting language samples, eliciting language samples for analysis (ELSA), and a novel approach for deriving basic measures of verbal communicative competence from it that bypasses the need for time-consuming transcription. Study 1 presents ELSA-adolescents (ELSA-A), designed for minimally and low-verbal older children/adolescents with ASD. The protocol successfully engaged and elicited speech from 46 participants across a wide range of ages (6;6-19;7) with samples averaging 20-25?min. The collected samples were segmented into speaker utterances (examiner and participant) using real-time coding as one is listening to the audio recording and two measures were derived: frequency of utterances and conversational turns per minute. These measures were shown to be reliable and valid. For Study 2, ELSA was adapted for younger children (ELSA-Toddler [ELSA-T]) with samples averaging 29?min from 19 toddlers (2;8-4;10?years) with ASD. Again, measures of frequency of utterances and conversational turns derived from ELSA-T were shown to have strong psychometric properties. In Study 3, we found that ELSA-A and ELSA-T were equivalent in eliciting language from 17 children with ASD (ages: 4;0-6;8), demonstrating their suitability for deriving robust objective assessments of expressive language that could be used to track change in ability over time. We introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA-T) to older adolescents (ELSA-A) with ASD who have minimal or low-verbal abilities. The measures of language and communication derived from them, frequency of utterances, and conversational turns per minute, using real-time coding methods, can be used to characterize ability and chart change in intervention research. LAY SUMMARY: We introduce a new protocol for collecting expressive language samples, ELSA, that can be used with a wide age range, from toddlers (ELSA-T) to older adolescents (ELSA-A) with autism spectrum disorder who have minimal or low-verbal abilities. The measures of language and communication derived from them, frequency of utterances and conversational turns per minute, using real-time coding methods, can be used to characterize ability and chart change in intervention research. En ligne : http://dx.doi.org/10.1002/aur.2380 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=441 Erratum to Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism / Mihaela D. BAROKOVA in Autism Research, 14-7 (July 2021)
[article]
Titre : Erratum to Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Mihaela D. BAROKOVA, Auteur ; C. LA VALLE, Auteur ; S. HASSAN, Auteur ; C. LEE, Auteur ; M. XU, Auteur ; R. MCKECHNIE, Auteur ; E. JOHNSTON, Auteur ; M. A. KROL, Auteur ; J. LEANO, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.1529 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2544 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-7 (July 2021) . - p.1529[article] Erratum to Eliciting Language Samples for Analysis (ELSA): A New Protocol for Assessing Expressive Language and Communication in Autism [Texte imprimé et/ou numérique] / Mihaela D. BAROKOVA, Auteur ; C. LA VALLE, Auteur ; S. HASSAN, Auteur ; C. LEE, Auteur ; M. XU, Auteur ; R. MCKECHNIE, Auteur ; E. JOHNSTON, Auteur ; M. A. KROL, Auteur ; J. LEANO, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.1529.
Langues : Anglais (eng)
in Autism Research > 14-7 (July 2021) . - p.1529
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2544 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 Event-related potentials to repeated speech in 9-month-old infants at risk for autism spectrum disorder / A. SEERY in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)
[article]
Titre : Event-related potentials to repeated speech in 9-month-old infants at risk for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. SEERY, Auteur ; Helen TAGER-FLUSBERG, Auteur ; C. A. NELSON, Auteur Article en page(s) : p.43 Langues : Anglais (eng) Mots-clés : Auditory evoked potentials Autism spectrum disorders Endophenotype Event-related potentials Infancy Language Speech processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical neural responses to repeated auditory and linguistic stimuli have been reported both in individuals with autism spectrum disorder (ASD) and their first-degree relatives. Recent work suggests that the younger siblings of children with ASD have atypical event-related potentials (ERPs) to repeated tones at 9 months of age; however, the functional significance is unclear, and it is unknown whether this atypicality is also present in response to linguistic stimuli. METHODS: We analyzed ERPs to repetitive and deviant consonant-vowel stimuli at 9 months in 35 unaffected high-risk-for-autism (HRA) infant siblings of children with ASD and 45 low-risk control (LRC) infants. We examined a positive component, the P150, over frontal and central electrode sites and investigated the relationships between this component and later behavior. RESULTS: Over frontal electrodes, HRA infants had larger-amplitude ERPs to repetitions of the standard than LRC infants, whereas ERPs to the deviant did not differ between HRA and LRC infants. Furthermore, for HRA infants, the amplitude of ERPs to the standards was positively correlated with later language ability. CONCLUSIONS: Our work suggests that atypical ERPs to repeated speech during infancy are a possible endophenotype of ASD but that this atypicality is associated with beneficial, rather than disordered, language development. Potential mechanisms driving these relationships and implications for development are discussed. En ligne : http://dx.doi.org/10.1186/1866-1955-6-43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.43[article] Event-related potentials to repeated speech in 9-month-old infants at risk for autism spectrum disorder [Texte imprimé et/ou numérique] / A. SEERY, Auteur ; Helen TAGER-FLUSBERG, Auteur ; C. A. NELSON, Auteur . - p.43.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.43
Mots-clés : Auditory evoked potentials Autism spectrum disorders Endophenotype Event-related potentials Infancy Language Speech processing Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical neural responses to repeated auditory and linguistic stimuli have been reported both in individuals with autism spectrum disorder (ASD) and their first-degree relatives. Recent work suggests that the younger siblings of children with ASD have atypical event-related potentials (ERPs) to repeated tones at 9 months of age; however, the functional significance is unclear, and it is unknown whether this atypicality is also present in response to linguistic stimuli. METHODS: We analyzed ERPs to repetitive and deviant consonant-vowel stimuli at 9 months in 35 unaffected high-risk-for-autism (HRA) infant siblings of children with ASD and 45 low-risk control (LRC) infants. We examined a positive component, the P150, over frontal and central electrode sites and investigated the relationships between this component and later behavior. RESULTS: Over frontal electrodes, HRA infants had larger-amplitude ERPs to repetitions of the standard than LRC infants, whereas ERPs to the deviant did not differ between HRA and LRC infants. Furthermore, for HRA infants, the amplitude of ERPs to the standards was positively correlated with later language ability. CONCLUSIONS: Our work suggests that atypical ERPs to repeated speech during infancy are a possible endophenotype of ASD but that this atypicality is associated with beneficial, rather than disordered, language development. Potential mechanisms driving these relationships and implications for development are discussed. En ligne : http://dx.doi.org/10.1186/1866-1955-6-43 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 Eye-Tracking Measurements of Language Processing: Developmental Differences in Children at High Risk for ASD / Meia CHITA-TEGMARK in Journal of Autism and Developmental Disorders, 45-10 (October 2015)
[article]
Titre : Eye-Tracking Measurements of Language Processing: Developmental Differences in Children at High Risk for ASD Type de document : Texte imprimé et/ou numérique Auteurs : Meia CHITA-TEGMARK, Auteur ; Sudha ARUNACHALAM, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.3327-3338 Langues : Anglais (eng) Mots-clés : Autism Development Word comprehension Processing speed Eye tracking Index. décimale : PER Périodiques Résumé : To explore how being at high risk for autism spectrum disorder (ASD), based on having an older sibling diagnosed with ASD, affects word comprehension and language processing speed, 18-, 24- and 36-month-old children, at high and low risk for ASD were tested in a cross- sectional study, on an eye gaze measure of receptive language that measured how accurately and rapidly the children looked at named target images. There were no significant differences between the high risk ASD group and the low risk control group of 18- and 24-month-olds. However, 36-month-olds in the high risk for ASD group performed significantly worse on the accuracy measure, but not on the speed measure. We propose that the language processing efficiency of the high risk group is not compromised, but other vocabulary acquisition factors might have lead to the high risk 36-month-olds to comprehend significantly fewer nouns on our measure. En ligne : http://dx.doi.org/10.1007/s10803-015-2495-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3327-3338[article] Eye-Tracking Measurements of Language Processing: Developmental Differences in Children at High Risk for ASD [Texte imprimé et/ou numérique] / Meia CHITA-TEGMARK, Auteur ; Sudha ARUNACHALAM, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.3327-3338.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-10 (October 2015) . - p.3327-3338
Mots-clés : Autism Development Word comprehension Processing speed Eye tracking Index. décimale : PER Périodiques Résumé : To explore how being at high risk for autism spectrum disorder (ASD), based on having an older sibling diagnosed with ASD, affects word comprehension and language processing speed, 18-, 24- and 36-month-old children, at high and low risk for ASD were tested in a cross- sectional study, on an eye gaze measure of receptive language that measured how accurately and rapidly the children looked at named target images. There were no significant differences between the high risk ASD group and the low risk control group of 18- and 24-month-olds. However, 36-month-olds in the high risk for ASD group performed significantly worse on the accuracy measure, but not on the speed measure. We propose that the language processing efficiency of the high risk group is not compromised, but other vocabulary acquisition factors might have lead to the high risk 36-month-olds to comprehend significantly fewer nouns on our measure. En ligne : http://dx.doi.org/10.1007/s10803-015-2495-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 Face and Gaze Processing in Autism / Robert M. JOSEPH
PermalinkFine motor skill and expressive language in minimally verbal and verbal school-aged autistic children / Lindsay K. BUTLER in Autism Research, 16-3 (March 2023)
PermalinkGesture Development, Caregiver Responsiveness, and Language and Diagnostic Outcomes in Infants at High and Low Risk for Autism / Boin CHOI in Journal of Autism and Developmental Disorders, 50-7 (July 2020)
PermalinkHow do minimally verbal children and adolescents with autism spectrum disorder use communicative gestures to complement their spoken language abilities? / Chelsea La VALLE in Autism & Developmental Language Impairments, 6 (January-December 2021)
PermalinkHow effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts? / R. M. JONES in Autism Research, 12-4 (April 2019)
PermalinkIncreased intra-subject variability of neural activity during speech production in people with autism spectrum disorder / Elizabeth S. HELLER MURRAY in Research in Autism Spectrum Disorders, 94 (June 2022)
PermalinkInternational Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-1 (February 2012)
PermalinkInternational Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-2 (April 2012)
PermalinkInternational Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-5 (October 2012)
PermalinkInternational Society for Autism Research News / Helen TAGER-FLUSBERG in Autism Research, 5-6 (December 2012)
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