The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts / Abigail E. RUSSELL ; Laura D. HOWE ; Annie HERBERT ; Andrew D. A. C. SMITH ; Helen L. FISHER ; Jessie R. BALDWIN ; Louise ARSENEAULT ; Andrea DANESE ; Becky MARS in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1369-1387 Titre : The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Abigail E. RUSSELL, Auteur ; Laura D. HOWE, Auteur ; Annie HERBERT, Auteur ; Andrew D. A. C. SMITH, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur ; Louise ARSENEAULT, Auteur ; Andrea DANESE, Auteur ; Becky MARS, Auteur Article en page(s) : p.1369-1387 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  self-harm  depression  ALSPAC  E-Risk  MCS  cohort  developmental timing  accumulation of risk Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure to ACEs on co-occurring self-harm and depression. Methods Data were utilised from over 22,000 children and adolescents participating in three UK cohorts, followed up longitudinally for 14?18?years: the Avon Longitudinal Study of Parents and Children (ALSPAC), the Millennium Cohort Study (MCS) and the Environmental Risk (E-Risk) Longitudinal Twin Study. Multinomial logistic regression models estimated associations between each ACE type and a four-category outcome: no self-harm or depression, self-harm alone, depression alone and self-harm with co-occurring depression. A structured life course modelling approach was used to examine whether the accumulation (duration) of exposure to each ACE, or a critical period (timing of ACEs) had the strongest effects on self-harm and depression in adolescence. Results The majority of ACEs were associated with co-occurring self-harm and depression, with consistent findings across cohorts. The importance of timing and duration of ACEs differed across ACEs and across cohorts. For parental mental health problems, longer duration of exposure was strongly associated with co-occurring self-harm and depression in both ALSPAC (adjusted OR: 1.18, 95% CI: 1.10?1.25) and MCS (1.18, 1.11?1.26) cohorts. For other ACEs in ALSPAC, exposure in middle childhood was most strongly associated with co-occurring self-harm and depression, and ACE occurrence in early childhood and adolescence was more important in the MCS. Conclusions Efforts to mitigate the impact of ACEs should start in early life with continued support throughout childhood, to prevent long-term exposure to ACEs contributing to risk of self-harm and depression in adolescence. En ligne : https://doi.org/10.1111/jcpp.13986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535 [article] The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts [Texte imprimé et/ou numérique] / Abigail E. RUSSELL, Auteur ; Laura D. HOWE, Auteur ; Annie HERBERT, Auteur ; Andrew D. A. C. SMITH, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur ; Louise ARSENEAULT, Auteur ; Andrea DANESE, Auteur ; Becky MARS, Auteur . - p.1369-1387. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-10 (October 2024) . - p.1369-1387 Mots-clés : Adverse childhood experiences  self-harm  depression  ALSPAC  E-Risk  MCS  cohort  developmental timing  accumulation of risk Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are well-established risk factors for self-harm and depression. However, despite their high comorbidity, there has been little focus on the impact of developmental timing and the duration of exposure to ACEs on co-occurring self-harm and depression. Methods Data were utilised from over 22,000 children and adolescents participating in three UK cohorts, followed up longitudinally for 14?18?years: the Avon Longitudinal Study of Parents and Children (ALSPAC), the Millennium Cohort Study (MCS) and the Environmental Risk (E-Risk) Longitudinal Twin Study. Multinomial logistic regression models estimated associations between each ACE type and a four-category outcome: no self-harm or depression, self-harm alone, depression alone and self-harm with co-occurring depression. A structured life course modelling approach was used to examine whether the accumulation (duration) of exposure to each ACE, or a critical period (timing of ACEs) had the strongest effects on self-harm and depression in adolescence. Results The majority of ACEs were associated with co-occurring self-harm and depression, with consistent findings across cohorts. The importance of timing and duration of ACEs differed across ACEs and across cohorts. For parental mental health problems, longer duration of exposure was strongly associated with co-occurring self-harm and depression in both ALSPAC (adjusted OR: 1.18, 95% CI: 1.10?1.25) and MCS (1.18, 1.11?1.26) cohorts. For other ACEs in ALSPAC, exposure in middle childhood was most strongly associated with co-occurring self-harm and depression, and ACE occurrence in early childhood and adolescence was more important in the MCS. Conclusions Efforts to mitigate the impact of ACEs should start in early life with continued support throughout childhood, to prevent long-term exposure to ACEs contributing to risk of self-harm and depression in adolescence. En ligne : https://doi.org/10.1111/jcpp.13986 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=535

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