Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin-differences study / Rebecca E. LACEY ; Louise ARSENEAULT ; Avshalom CASPI ; Eloise CRUSH ; Andrea DANESE ; Rachel M. LATHAM ; Terrie E. MOFFITT ; Joanne B. NEWBURY ; Jonathan D. SCHAEFER ; Helen L. FISHER ; Jessie R. BALDWIN in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.650-658 Titre : Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin-differences study Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca E. LACEY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Eloise CRUSH, Auteur ; Andrea DANESE, Auteur ; Rachel M. LATHAM, Auteur ; Terrie E. MOFFITT, Auteur ; Joanne B. NEWBURY, Auteur ; Jonathan D. SCHAEFER, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : Protective factors  ACEs  twin differences  adult social support  maternal warmth  psychopathology  resilience Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are associated with mental health problems, but many children who experience ACEs do not develop such difficulties. A warm and supportive adult presence in childhood is associated with a lower likelihood of developing mental health problems after exposure to ACEs. However, it is unclear whether this association is causal, as previous research has not accounted for genetic and environmental confounding. Methods We used the twin-difference design to strengthen causal inference about whether a warm and supportive adult presence protects children exposed to ACEs from mental health problems. Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 same-sex twins. ACEs were measured prospectively from ages 5 to 12. Maternal warmth was assessed at ages 5 and 10 through maternal speech samples. Adult support was assessed through child reports at age 12. Mental health problems were assessed through interviews at age 12 with parents and teachers and participants at age 18. Results Among children exposed to ACEs, those who experienced greater maternal warmth and adult support had lower levels of mental health problems at ages 12 and 18. In monozygotic twin-difference analyses, the protective effects of maternal warmth and adult support on mental health were attenuated by 70% for maternal warmth and 81% for adult support, compared to phenotypic analyses. Twins who experienced greater maternal warmth and adult support had minimal or no difference in mental health compared to their co-twins, concordant for ACE exposure. Conclusions The apparent protective effect of a warm, supportive adult against mental health problems following ACEs is largely explained by genetic and environmental confounding. This suggests that interventions which boost maternal warmth and adult support should be supplemented by components addressing wider family environments and heritable vulnerabilities in children exposed to adversity, to improve mental health. En ligne : https://doi.org/10.1111/jcpp.14070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Can a warm and supportive adult protect against mental health problems amongst children with experience of adversity? A twin-differences study [Texte imprimé et/ou numérique] / Rebecca E. LACEY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Eloise CRUSH, Auteur ; Andrea DANESE, Auteur ; Rachel M. LATHAM, Auteur ; Terrie E. MOFFITT, Auteur ; Joanne B. NEWBURY, Auteur ; Jonathan D. SCHAEFER, Auteur ; Helen L. FISHER, Auteur ; Jessie R. BALDWIN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.650-658 Mots-clés : Protective factors  ACEs  twin differences  adult social support  maternal warmth  psychopathology  resilience Index. décimale : PER Périodiques Résumé : Background Adverse childhood experiences (ACEs) are associated with mental health problems, but many children who experience ACEs do not develop such difficulties. A warm and supportive adult presence in childhood is associated with a lower likelihood of developing mental health problems after exposure to ACEs. However, it is unclear whether this association is causal, as previous research has not accounted for genetic and environmental confounding. Methods We used the twin-difference design to strengthen causal inference about whether a warm and supportive adult presence protects children exposed to ACEs from mental health problems. Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 same-sex twins. ACEs were measured prospectively from ages 5 to 12. Maternal warmth was assessed at ages 5 and 10 through maternal speech samples. Adult support was assessed through child reports at age 12. Mental health problems were assessed through interviews at age 12 with parents and teachers and participants at age 18. Results Among children exposed to ACEs, those who experienced greater maternal warmth and adult support had lower levels of mental health problems at ages 12 and 18. In monozygotic twin-difference analyses, the protective effects of maternal warmth and adult support on mental health were attenuated by 70% for maternal warmth and 81% for adult support, compared to phenotypic analyses. Twins who experienced greater maternal warmth and adult support had minimal or no difference in mental health compared to their co-twins, concordant for ACE exposure. Conclusions The apparent protective effect of a warm, supportive adult against mental health problems following ACEs is largely explained by genetic and environmental confounding. This suggests that interventions which boost maternal warmth and adult support should be supplemented by components addressing wider family environments and heritable vulnerabilities in children exposed to adversity, to improve mental health. En ligne : https://doi.org/10.1111/jcpp.14070 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Do meaningful dimensions of childhood adversity exist? Data-driven evidence from two prospective cohort studies / Jessie R. BALDWIN ; Lucy BOWES in Journal of Child Psychology and Psychiatry, 66-6 (June 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.868-880 Titre : Do meaningful dimensions of childhood adversity exist? Data-driven evidence from two prospective cohort studies Type de document : Texte imprimé et/ou numérique Auteurs : Jessie R. BALDWIN, Auteur ; Lucy BOWES, Auteur Article en page(s) : p.868-880 Langues : Anglais (eng) Mots-clés : Adverse childhood experiences  victimisation  data-driven methods  psychopathology  adolescence Index. décimale : PER Périodiques Résumé : Background There is not yet a consensus on the best way to conceptualise adverse childhood experiences (ACEs). We used data-driven methods across two populations to examine (a) if there were meaningful dimensions underlying ACEs and (b) whether dimensions were differentially associated with increased risk of adolescent psychopathology. Methods Participants were 18,539 British children from the UK Millennium Cohort Study (MCS) and 11,876 American children from the US Adolescent Brain Cognitive Development Study (ABCD). A wide range of ACEs (e.g., abuse, neglect, parental psychopathology, peer victimisation) were measured prospectively from infancy to mid-adolescence using interviews and questionnaires. Internalising and externalising symptoms were assessed with child and/or parent reports during adolescence. Results Our preregistered exploratory factor analysis revealed four latent dimensions in the MCS (parental threat, deprivation, victimisation, and parental discipline) and ABCD (parental threat, deprivation, victimisation, and traumatic events). All dimensions except deprivation were associated with increased risk for internalising and externalising symptoms. Over and above the other dimensions, victimisation was more strongly associated with internalising (MCS ??=?.34, 95% CI 0.33?0.36; ABCD ??=?.11, 95% CI 0.10?0.13) and externalising (MCS ??=?.31, 95% CI 0.30?0.33; ABCD ??=?.13, 95% CI 0.11?0.15) symptoms. Conclusions Across two distinct populations, we found that ACEs can be captured by common underlying dimensions of parental threat, deprivation, and victimisation, as well as additional sample-specific dimensions. Our findings expand dimensional theories of childhood adversity by suggesting that in addition to threat and deprivation, victimisation is a distinct dimension of adversity that has the strongest associations with adolescent psychopathology. En ligne : https://doi.org/10.1111/jcpp.14098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Do meaningful dimensions of childhood adversity exist? Data-driven evidence from two prospective cohort studies [Texte imprimé et/ou numérique] / Jessie R. BALDWIN, Auteur ; Lucy BOWES, Auteur . - p.868-880. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-6 (June 2025) . - p.868-880 Mots-clés : Adverse childhood experiences  victimisation  data-driven methods  psychopathology  adolescence Index. décimale : PER Périodiques Résumé : Background There is not yet a consensus on the best way to conceptualise adverse childhood experiences (ACEs). We used data-driven methods across two populations to examine (a) if there were meaningful dimensions underlying ACEs and (b) whether dimensions were differentially associated with increased risk of adolescent psychopathology. Methods Participants were 18,539 British children from the UK Millennium Cohort Study (MCS) and 11,876 American children from the US Adolescent Brain Cognitive Development Study (ABCD). A wide range of ACEs (e.g., abuse, neglect, parental psychopathology, peer victimisation) were measured prospectively from infancy to mid-adolescence using interviews and questionnaires. Internalising and externalising symptoms were assessed with child and/or parent reports during adolescence. Results Our preregistered exploratory factor analysis revealed four latent dimensions in the MCS (parental threat, deprivation, victimisation, and parental discipline) and ABCD (parental threat, deprivation, victimisation, and traumatic events). All dimensions except deprivation were associated with increased risk for internalising and externalising symptoms. Over and above the other dimensions, victimisation was more strongly associated with internalising (MCS ??=?.34, 95% CI 0.33?0.36; ABCD ??=?.11, 95% CI 0.10?0.13) and externalising (MCS ??=?.31, 95% CI 0.30?0.33; ABCD ??=?.13, 95% CI 0.11?0.15) symptoms. Conclusions Across two distinct populations, we found that ACEs can be captured by common underlying dimensions of parental threat, deprivation, and victimisation, as well as additional sample-specific dimensions. Our findings expand dimensional theories of childhood adversity by suggesting that in addition to threat and deprivation, victimisation is a distinct dimension of adversity that has the strongest associations with adolescent psychopathology. En ligne : https://doi.org/10.1111/jcpp.14098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Editorial Perspective: Misaligned incentives in mental health research ? the case for Registered Reports / Jessie R. BALDWIN in Journal of Child Psychology and Psychiatry, 65-2 (February 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-2 (February 2024) . - p.251-255 Titre : Editorial Perspective: Misaligned incentives in mental health research ? the case for Registered Reports Type de document : Texte imprimé et/ou numérique Auteurs : Jessie R. BALDWIN, Auteur Article en page(s) : p.251-255 Index. décimale : PER Périodiques Résumé : Current incentive structures reward mental health researchers for producing positive, novel, and clean results. This can promote questionable research practices which contribute to a distorted evidence base, in turn limiting progress in mental health research. Registered Reports (RRs) offer a solution to realign the incentives towards conducting high-quality, rigorous, and accurate studies, by preventing publication and reporting biases. However, the uptake of RRs in mental health research has so far been limited. This editorial perspective highlights the advantages of RRs for mental health research, before discussing potential challenges and how they can be addressed. Greater uptake of RRs in mental health research could help to promote a fairer research culture, limit publication bias and questionable research practices, and ultimately, improve understanding of mental health. En ligne : https://doi.org/10.1111/jcpp.13898 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Editorial Perspective: Misaligned incentives in mental health research ? the case for Registered Reports [Texte imprimé et/ou numérique] / Jessie R. BALDWIN, Auteur . - p.251-255. in Journal of Child Psychology and Psychiatry > 65-2 (February 2024) . - p.251-255 Index. décimale : PER Périodiques Résumé : Current incentive structures reward mental health researchers for producing positive, novel, and clean results. This can promote questionable research practices which contribute to a distorted evidence base, in turn limiting progress in mental health research. Registered Reports (RRs) offer a solution to realign the incentives towards conducting high-quality, rigorous, and accurate studies, by preventing publication and reporting biases. However, the uptake of RRs in mental health research has so far been limited. This editorial perspective highlights the advantages of RRs for mental health research, before discussing potential challenges and how they can be addressed. Greater uptake of RRs in mental health research could help to promote a fairer research culture, limit publication bias and questionable research practices, and ultimately, improve understanding of mental health. En ligne : https://doi.org/10.1111/jcpp.13898 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence / Joanne B. NEWBURY in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1823-1837 Titre : In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Joanne B. NEWBURY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Candice L. ODGERS, Auteur ; Jessie R. BALDWIN, Auteur ; Helena M. S. ZAVOS, Auteur ; Helen L. FISHER, Auteur Article en page(s) : p.1823-1837 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Adolescent psychotic experiences increase risk for schizophrenia and other severe psychopathology in adulthood. Converging evidence implicates urban and adverse neighborhood conditions in the etiology of adolescent psychotic experiences, but the role of young people's personal perceptions of disorder (i.e., physical and social signs of threat) in their neighborhood is unknown. This was examined using data from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 British twins. Participants were interviewed at age 18 about psychotic phenomena and perceptions of disorder in the neighborhood. Multilevel, longitudinal, and genetically sensitive analyses investigated the association between perceptions of neighborhood disorder and adolescent psychotic experiences. Adolescents who perceived higher levels of neighborhood disorder were significantly more likely to have psychotic experiences, even after accounting for objectively/independently measured levels of crime and disorder, neighborhood- and family-level socioeconomic status, family psychiatric history, adolescent substance and mood problems, and childhood psychotic symptoms: odds ratio = 1.62, 95% confidence interval [1.27, 2.05], p < .001. The phenotypic overlap between adolescent psychotic experiences and perceptions of neighborhood disorder was explained by overlapping common environmental influences, rC = .88, 95% confidence interval [0.26, 1.00]. Findings suggest that early psychological interventions to prevent adolescent psychotic experiences should explore the role of young people's (potentially modifiable) perceptions of threatening neighborhood conditions. En ligne : http://dx.doi.org/10.1017/S0954579417001420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] In the eye of the beholder: Perceptions of neighborhood adversity and psychotic experiences in adolescence [Texte imprimé et/ou numérique] / Joanne B. NEWBURY, Auteur ; Louise ARSENEAULT, Auteur ; Avshalom CASPI, Auteur ; Terrie E. MOFFITT, Auteur ; Candice L. ODGERS, Auteur ; Jessie R. BALDWIN, Auteur ; Helena M. S. ZAVOS, Auteur ; Helen L. FISHER, Auteur . - p.1823-1837. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1823-1837 Index. décimale : PER Périodiques Résumé : Adolescent psychotic experiences increase risk for schizophrenia and other severe psychopathology in adulthood. Converging evidence implicates urban and adverse neighborhood conditions in the etiology of adolescent psychotic experiences, but the role of young people's personal perceptions of disorder (i.e., physical and social signs of threat) in their neighborhood is unknown. This was examined using data from the Environmental Risk Longitudinal Twin Study, a nationally representative birth cohort of 2,232 British twins. Participants were interviewed at age 18 about psychotic phenomena and perceptions of disorder in the neighborhood. Multilevel, longitudinal, and genetically sensitive analyses investigated the association between perceptions of neighborhood disorder and adolescent psychotic experiences. Adolescents who perceived higher levels of neighborhood disorder were significantly more likely to have psychotic experiences, even after accounting for objectively/independently measured levels of crime and disorder, neighborhood- and family-level socioeconomic status, family psychiatric history, adolescent substance and mood problems, and childhood psychotic symptoms: odds ratio = 1.62, 95% confidence interval [1.27, 2.05], p < .001. The phenotypic overlap between adolescent psychotic experiences and perceptions of neighborhood disorder was explained by overlapping common environmental influences, rC = .88, 95% confidence interval [0.26, 1.00]. Findings suggest that early psychological interventions to prevent adolescent psychotic experiences should explore the role of young people's (potentially modifiable) perceptions of threatening neighborhood conditions. En ligne : http://dx.doi.org/10.1017/S0954579417001420 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Research Review: A guide to computing and implementing polygenic scores in developmental research / Andrea G. ALLEGRINI in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1111-1124 Titre : Research Review: A guide to computing and implementing polygenic scores in developmental research Type de document : Texte imprimé et/ou numérique Auteurs : Andrea G. ALLEGRINI, Auteur ; Jessie R. BALDWIN, Auteur ; Wikus BARKHUIZEN, Auteur ; Jean-Baptiste PINGAULT, Auteur Année de publication : 2022 Article en page(s) : p.1111-1124 Langues : Anglais (eng) Mots-clés : Adolescent  Child  Genotype  Humans  Multifactorial Inheritance/genetics  Polygenic scores  developmental research  longitudinal models Index. décimale : PER Périodiques Résumé : The increasing availability of genotype data in longitudinal population- and family-based samples provides opportunities for using polygenic scores (PGS) to study developmental questions in child and adolescent psychology and psychiatry. Here, we aim to provide a comprehensive overview of how PGS can be generated and implemented in developmental psycho(patho)logy, with a focus on longitudinal designs. As such, the paper is organized into three parts: First, we provide a formal definition of polygenic scores and related concepts, focusing on assumptions and limitations. Second, we give a general overview of the methods used to compute polygenic scores, ranging from the classic approach to more advanced methods. We include recommendations and reference resources available to researchers aiming to conduct PGS analyses. Finally, we focus on the practical applications of PGS in the analysis of longitudinal data. We describe how PGS have been used to research developmental outcomes, and how they can be applied to longitudinal data to address developmental questions. En ligne : http://dx.doi.org/10.1111/jcpp.13611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Research Review: A guide to computing and implementing polygenic scores in developmental research [Texte imprimé et/ou numérique] / Andrea G. ALLEGRINI, Auteur ; Jessie R. BALDWIN, Auteur ; Wikus BARKHUIZEN, Auteur ; Jean-Baptiste PINGAULT, Auteur . - 2022 . - p.1111-1124. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1111-1124 Mots-clés : Adolescent  Child  Genotype  Humans  Multifactorial Inheritance/genetics  Polygenic scores  developmental research  longitudinal models Index. décimale : PER Périodiques Résumé : The increasing availability of genotype data in longitudinal population- and family-based samples provides opportunities for using polygenic scores (PGS) to study developmental questions in child and adolescent psychology and psychiatry. Here, we aim to provide a comprehensive overview of how PGS can be generated and implemented in developmental psycho(patho)logy, with a focus on longitudinal designs. As such, the paper is organized into three parts: First, we provide a formal definition of polygenic scores and related concepts, focusing on assumptions and limitations. Second, we give a general overview of the methods used to compute polygenic scores, ranging from the classic approach to more advanced methods. We include recommendations and reference resources available to researchers aiming to conduct PGS analyses. Finally, we focus on the practical applications of PGS in the analysis of longitudinal data. We describe how PGS have been used to research developmental outcomes, and how they can be applied to longitudinal data to address developmental questions. En ligne : http://dx.doi.org/10.1111/jcpp.13611 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes / Jean-Baptiste PINGAULT in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

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Research Review: Why do prospective and retrospective measures of maltreatment differ? A narrative review / Oonagh COLEMAN in Journal of Child Psychology and Psychiatry, 65-12 (December 2024)  

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Subjective and objective experiences of childhood adversity: a meta-analysis of their agreement and relationships with psychopathology / Emma R. FRANCIS in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

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The relationship between type, timing and duration of exposure to adverse childhood experiences and adolescent self-harm and depression: findings from three UK prospective population-based cohorts / Abigail E. RUSSELL ; Laura D. HOWE ; Annie HERBERT ; Andrew D. A. C. SMITH ; Helen L. FISHER ; Jessie R. BALDWIN ; Louise ARSENEAULT ; Andrea DANESE ; Becky MARS in Journal of Child Psychology and Psychiatry, 65-10 (October 2024)  

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