Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder / Ulrika ROINE in Molecular Autism, (December 2015)  

Public ISBD [article]  inMolecular Autism > (December 2015) . - p.1-11 Titre : Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Article en page(s) : p.1-11 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Pekka TANI, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Karen CAEYENBERGHS, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - p.1-11. Langues : Anglais (eng) in Molecular Autism > (December 2015) . - p.1-11 Index. décimale : PER Périodiques Résumé : Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain’s wiring diagram, i.e., the connectome. En ligne : http://dx.doi.org/10.1186/s13229-015-0058-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome / Ulrika ROINE in Molecular Autism, (January 2015)  

Public ISBD [article]  inMolecular Autism > (January 2015) . - p.1-12 Titre : Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Juha SALMI, Auteur ; Timo ROINE, Auteur ; Taina Nieminen-von WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptoms of AS are severe impairments in social interactions and restricted or repetitive patterns of behaviors, interests or activities. En ligne : http://dx.doi.org/10.1186/2040-2392-6-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Juha SALMI, Auteur ; Timo ROINE, Auteur ; Taina Nieminen-von WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - p.1-12. Langues : Anglais (eng) in Molecular Autism > (January 2015) . - p.1-12 Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptoms of AS are severe impairments in social interactions and restricted or repetitive patterns of behaviors, interests or activities. En ligne : http://dx.doi.org/10.1186/2040-2392-6-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study / Ulrika ROINE in Autism Research, 6-6 (December 2013)  

Public ISBD [article]  inAutism Research > 6-6 (December 2013) . - p.642-650 Titre : Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur Année de publication : 2013 Article en page(s) : p.642-650 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging (DTI)  clinical psychiatry  neuroimaging  autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Timo ROINE, Auteur ; Juha SALMI, Auteur ; Taina NIEMINEN-VON WENDT, Auteur ; Sami LEPPAMAKI, Auteur ; Pertti RINTAHAKA, Auteur ; Pekka TANI, Auteur ; Alexander LEEMANS, Auteur ; Mikko SAMS, Auteur . - 2013 . - p.642-650. Langues : Anglais (eng) in Autism Research > 6-6 (December 2013) . - p.642-650 Mots-clés : diffusion tensor imaging (DTI)  clinical psychiatry  neuroimaging  autism spectrum disorder Index. décimale : PER Périodiques Résumé : To investigate whether there are global white matter (WM) differences between autistic and healthy adults, we performed diffusion tensor imaging (DTI) in 14 male adults with Asperger syndrome (AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder (ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy (FA) and mean diffusivity (MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient (CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. En ligne : http://dx.doi.org/10.1002/aur.1332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised / Ulrika ROINE in Autism - Open Access, 3-1 (March 2013)  

Public ISBD [article]  inAutism - Open Access > 3-1 (March 2013) . - 9 p. Titre : Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised Type de document : Texte imprimé et/ou numérique Auteurs : Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur Année de publication : 2013 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis. Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study. Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too. Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders. En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised [Texte imprimé et/ou numérique] / Ulrika ROINE, Auteur ; Samuli RIPATTI, Auteur ; Karola REHNSTROM, Auteur ; Timo ROINE, Auteur ; Helena KILPINEN, Auteur ; Ida SURAKKA, Auteur ; Juho WEDENOJA, Auteur ; Tero YLISAUKKO-OJA, Auteur ; Elli KEMPAS, Auteur ; Jaana WESSMAN, Auteur ; Irma MOILANEN, Auteur ; Marja-Leena MATTILA, Auteur ; Marko KIELINEN, Auteur ; Katja JUSSILA, Auteur ; Saara SUOMALAINEN, Auteur ; Esko PULKKINEN, Auteur ; Lennart VON WENDT, Auteur ; Leena PELTONEN, Auteur . - 2013 . - 9 p. Langues : Anglais (eng) in Autism - Open Access > 3-1 (March 2013) . - 9 p. Index. décimale : PER Périodiques Résumé : Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis. Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study. Results: The components were interpreted as Social Component (SC), communication component and Restricted and Stereotyped Behavior Component (RSBC). K-means clustering showed that, especially in SC, the range of the symptom severity was increased by the siblings. The association of neuroligin 1 with SC was increased, compared to a previous study where only the end-state diagnosis was used. In RSBC, the range of the symptom severity of siblings overlapped greatly with that of patients, which could explain why no association of reelin was found in previous studies in which only the end-state diagnosis was used, but a significant association of reelin with RSBC was now found in the Finnish families (Bonferroni-corrected p=0.029 for rs362644). Although, the Finnish sample is isolated and genetically very homogeneous, compared to the heterogeneous background of AGRE families, many single-nucleotide polymorphisms in reelin, showed modest association with RSBC in the AGRE sample, too. Conclusions: This study demonstrates how the quantitative phenotypes can affect the association analyses, and yields further support to the use of siblings in the study of complex neuropsychiatric disorders. En ligne : http://dx.doi.org/10.4172/2165-7890.1000107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

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