5 recherche sur le mot-clé 'P3a'

Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications / Yi-Ling CHIEN in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1684-1697 Titre : Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications Type de document : Texte imprimé et/ou numérique Auteurs : Yi-Ling CHIEN, Auteur ; M. H. HSIEH, Auteur ; S. S. GAU, Auteur Article en page(s) : p.1684-1697 Langues : Anglais (eng) Mots-clés : Autism spectrum  Correlates  Event-related potentials  Mismatch negativity  P3a Index. décimale : PER Périodiques Résumé : In a sample of 37 adolescents and young adults with autism spectrum disorder (ASD) and 35 typically-developing controls (TDC), we investigated sensory symptoms by clinical measures, and Mismatch Negativity and P3a component at Fz with the frequency and duration oddball paradigms of event-related potentials. Results showed that compared to TDC, ASD participants reported more sensory symptoms, and presented a shorter P3a peak latency in the duration paradigm, which was correlated with more social awareness deficits. In the frequency paradigm, P3a parameters were correlated with sensation avoiding and attention characteristics of ASD. Our findings suggest that sensory abnormality in ASD may extend into adolescence and young adulthood. P3a latency might be a potential neurophysiological marker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3426-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; M. H. HSIEH, Auteur ; S. S. GAU, Auteur . - p.1684-1697. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1684-1697 Mots-clés : Autism spectrum  Correlates  Event-related potentials  Mismatch negativity  P3a Index. décimale : PER Périodiques Résumé : In a sample of 37 adolescents and young adults with autism spectrum disorder (ASD) and 35 typically-developing controls (TDC), we investigated sensory symptoms by clinical measures, and Mismatch Negativity and P3a component at Fz with the frequency and duration oddball paradigms of event-related potentials. Results showed that compared to TDC, ASD participants reported more sensory symptoms, and presented a shorter P3a peak latency in the duration paradigm, which was correlated with more social awareness deficits. In the frequency paradigm, P3a parameters were correlated with sensation avoiding and attention characteristics of ASD. Our findings suggest that sensory abnormality in ASD may extend into adolescence and young adulthood. P3a latency might be a potential neurophysiological marker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3426-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

Attenuated Auditory Event-Related Potentials and Associations with Atypical Sensory Response Patterns in Children with Autism / Franc C L. DONKERS in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.506-523 Titre : Attenuated Auditory Event-Related Potentials and Associations with Atypical Sensory Response Patterns in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Franc C L. DONKERS, Auteur ; Sarah E. SCHIPUL, Auteur ; Grace T. BARANEK, Auteur ; Katherine M. CLEARY, Auteur ; Michael T. WILLOUGHBY, Auteur ; Anna M. EVANS, Auteur ; John C. BULLUCK, Auteur ; Jeanne E. LOVMO, Auteur ; Aysenil BELGER, Auteur Article en page(s) : p.506-523 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sensory processing  Event-related potentials  P1  N2  P3a Index. décimale : PER Périodiques Résumé : Neurobiological underpinnings of unusual sensory features in individuals with autism are unknown. Event-related potentials elicited by task-irrelevant sounds were used to elucidate neural correlates of auditory processing and associations with three common sensory response patterns (hyperresponsiveness; hyporesponsiveness; sensory seeking). Twenty-eight children with autism and 39 typically developing children (4–12 year-olds) completed an auditory oddball paradigm. Results revealed marginally attenuated P1 and N2 to standard tones and attenuated P3a to novel sounds in autism versus controls. Exploratory analyses suggested that within the autism group, attenuated N2 and P3a amplitudes were associated with greater sensory seeking behaviors for specific ranges of P1 responses. Findings suggest that attenuated early sensory as well as later attention-orienting neural responses to stimuli may underlie selective sensory features via complex mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-013-1948-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Attenuated Auditory Event-Related Potentials and Associations with Atypical Sensory Response Patterns in Children with Autism [Texte imprimé et/ou numérique] / Franc C L. DONKERS, Auteur ; Sarah E. SCHIPUL, Auteur ; Grace T. BARANEK, Auteur ; Katherine M. CLEARY, Auteur ; Michael T. WILLOUGHBY, Auteur ; Anna M. EVANS, Auteur ; John C. BULLUCK, Auteur ; Jeanne E. LOVMO, Auteur ; Aysenil BELGER, Auteur . - p.506-523. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.506-523 Mots-clés : Autism spectrum disorder  Sensory processing  Event-related potentials  P1  N2  P3a Index. décimale : PER Périodiques Résumé : Neurobiological underpinnings of unusual sensory features in individuals with autism are unknown. Event-related potentials elicited by task-irrelevant sounds were used to elucidate neural correlates of auditory processing and associations with three common sensory response patterns (hyperresponsiveness; hyporesponsiveness; sensory seeking). Twenty-eight children with autism and 39 typically developing children (4–12 year-olds) completed an auditory oddball paradigm. Results revealed marginally attenuated P1 and N2 to standard tones and attenuated P3a to novel sounds in autism versus controls. Exploratory analyses suggested that within the autism group, attenuated N2 and P3a amplitudes were associated with greater sensory seeking behaviors for specific ranges of P1 responses. Findings suggest that attenuated early sensory as well as later attention-orienting neural responses to stimuli may underlie selective sensory features via complex mechanisms. En ligne : http://dx.doi.org/10.1007/s10803-013-1948-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study / Alessandra PIATTI in Research in Autism Spectrum Disorders, 86 (August 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 86 (August 2021) . - 101805 Titre : Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study Type de document : Texte imprimé et/ou numérique Auteurs : Alessandra PIATTI, Auteur ; Sara VAN DER PAELT, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : 101805 Langues : Anglais (eng) Mots-clés : Auditory oddball  MMN  P3a  ASD  Developmental delay  Neural adaptation Index. décimale : PER Périodiques Résumé : Background Sound perception in autism spectrum disorder (ASD) is usually at typical levels, even when auditory stimuli carry a social value, as it is the case for speech. Nevertheless, orienting to sounds in a speech context might be atypical in some individuals with ASD, which in ERP studies is reflected by a diminished P3a component. As P3 values and cognitive abilities seem to be inversely related under some circumstances, the current study investigates whether diminished attentional orienting to sounds in speech is equally observable in children with ASD with and without developmental delay (DD). Method Children with typical development (TD, n = 17) or ASD, with or without comorbid DD (ASD/DD, n = 22, and ASD/noDD, n = 12), aged 1.5 through 4 years took part in a passive auditory oddball task while EEG data were recorded. The paradigm consisted in the presentation of two deviant stimuli (one vowel sound and one complex tone) either in a speech or in a non-speech context. Results We found overall more negative MMN voltages in both ASD groups compared to TD. For P3a mean voltages, we found an attenuated response in children ASD/noDD when deviant tones were presented in speech, but not in other conditions. Children with ASD/DD did not differ from TD in P3a mean voltages. Conclusion Atypical speech sound processing might be more accentuated in children with ASD/noDD than in their peers with comorbid DD. This finding is interpreted within the theoretical framework of neural adaptation. En ligne : https://doi.org/10.1016/j.rasd.2021.101805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study [Texte imprimé et/ou numérique] / Alessandra PIATTI, Auteur ; Sara VAN DER PAELT, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - 101805. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 86 (August 2021) . - 101805 Mots-clés : Auditory oddball  MMN  P3a  ASD  Developmental delay  Neural adaptation Index. décimale : PER Périodiques Résumé : Background Sound perception in autism spectrum disorder (ASD) is usually at typical levels, even when auditory stimuli carry a social value, as it is the case for speech. Nevertheless, orienting to sounds in a speech context might be atypical in some individuals with ASD, which in ERP studies is reflected by a diminished P3a component. As P3 values and cognitive abilities seem to be inversely related under some circumstances, the current study investigates whether diminished attentional orienting to sounds in speech is equally observable in children with ASD with and without developmental delay (DD). Method Children with typical development (TD, n = 17) or ASD, with or without comorbid DD (ASD/DD, n = 22, and ASD/noDD, n = 12), aged 1.5 through 4 years took part in a passive auditory oddball task while EEG data were recorded. The paradigm consisted in the presentation of two deviant stimuli (one vowel sound and one complex tone) either in a speech or in a non-speech context. Results We found overall more negative MMN voltages in both ASD groups compared to TD. For P3a mean voltages, we found an attenuated response in children ASD/noDD when deviant tones were presented in speech, but not in other conditions. Children with ASD/DD did not differ from TD in P3a mean voltages. Conclusion Atypical speech sound processing might be more accentuated in children with ASD/noDD than in their peers with comorbid DD. This finding is interpreted within the theoretical framework of neural adaptation. En ligne : https://doi.org/10.1016/j.rasd.2021.101805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Auditory processing in autism spectrum disorder: Mismatch negativity deficits / Chantal VLASKAMP in Autism Research, 10-11 (November 2017)  

Public ISBD [article]  inAutism Research > 10-11 (November 2017) . - p.1857-1865 Titre : Auditory processing in autism spectrum disorder: Mismatch negativity deficits Type de document : Texte imprimé et/ou numérique Auteurs : Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur Article en page(s) : p.1857-1865 Langues : Anglais (eng) Mots-clés : auditory processing  ASD  MMN  P3a  schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 [article] Auditory processing in autism spectrum disorder: Mismatch negativity deficits [Texte imprimé et/ou numérique] / Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur . - p.1857-1865. Langues : Anglais (eng) in Autism Research > 10-11 (November 2017) . - p.1857-1865 Mots-clés : auditory processing  ASD  MMN  P3a  schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322

Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism / Marie GOMOT in Journal of Autism and Developmental Disorders, 41-6 (June 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.705-714 Titre : Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Marie GOMOT, Auteur ; Romuald BLANC, Auteur ; Helen CLERY, Auteur ; Sylvie ROUX, Auteur ; Catherine BARTHELEMY, Auteur ; Nicole BRUNEAU, Auteur Année de publication : 2011 Article en page(s) : p.705-714 Langues : Anglais (eng) Mots-clés : Autism  Change processing  Auditory evoked potential (AEP)  Mismatch negativity (MMN)  P3a  Children Index. décimale : PER Périodiques Résumé : Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test whether these are quantitatively related to intolerance of change (using the BSE-R scale). ASD displayed significantly shorter MMN latency and larger P3a than controls, indicating a greater tendency to switch attention to deviant events. These electrophysiological abnormalities were significantly more marked in children who displayed greater difficulties in tolerating change. The atypical neurophysiological mechanism of change perception identified might thus be associated with one of the hallmark behavioural manifestations of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1091-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127 [article] Candidate Electrophysiological Endophenotypes of Hyper-Reactivity to Change in Autism [Texte imprimé et/ou numérique] / Marie GOMOT, Auteur ; Romuald BLANC, Auteur ; Helen CLERY, Auteur ; Sylvie ROUX, Auteur ; Catherine BARTHELEMY, Auteur ; Nicole BRUNEAU, Auteur . - 2011 . - p.705-714. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-6 (June 2011) . - p.705-714 Mots-clés : Autism  Change processing  Auditory evoked potential (AEP)  Mismatch negativity (MMN)  P3a  Children Index. décimale : PER Périodiques Résumé : Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test whether these are quantitatively related to intolerance of change (using the BSE-R scale). ASD displayed significantly shorter MMN latency and larger P3a than controls, indicating a greater tendency to switch attention to deviant events. These electrophysiological abnormalities were significantly more marked in children who displayed greater difficulties in tolerating change. The atypical neurophysiological mechanism of change perception identified might thus be associated with one of the hallmark behavioural manifestations of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1091-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127