
- <Centre d'Information et de documentation du CRA Rhône-Alpes
- CRA
- Informations pratiques
-
Adresse
Centre d'information et de documentation
Horaires
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexLundi au Vendredi
Contact
9h00-12h00 13h30-16h00Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Adresse
Résultat de la recherche
8 recherche sur le mot-clé 'Mismatch negativity'




Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications / Yi-Ling CHIEN in Journal of Autism and Developmental Disorders, 48-5 (May 2018)
![]()
[article]
Titre : Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications Type de document : Texte imprimé et/ou numérique Auteurs : Yi-Ling CHIEN, Auteur ; M. H. HSIEH, Auteur ; S. S. GAU, Auteur Article en page(s) : p.1684-1697 Langues : Anglais (eng) Mots-clés : Autism spectrum Correlates Event-related potentials Mismatch negativity P3a Index. décimale : PER Périodiques Résumé : In a sample of 37 adolescents and young adults with autism spectrum disorder (ASD) and 35 typically-developing controls (TDC), we investigated sensory symptoms by clinical measures, and Mismatch Negativity and P3a component at Fz with the frequency and duration oddball paradigms of event-related potentials. Results showed that compared to TDC, ASD participants reported more sensory symptoms, and presented a shorter P3a peak latency in the duration paradigm, which was correlated with more social awareness deficits. In the frequency paradigm, P3a parameters were correlated with sensation avoiding and attention characteristics of ASD. Our findings suggest that sensory abnormality in ASD may extend into adolescence and young adulthood. P3a latency might be a potential neurophysiological marker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3426-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355
in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1684-1697[article] Mismatch Negativity and P3a in Adolescents and Young Adults with Autism Spectrum Disorders: Behavioral Correlates and Clinical Implications [Texte imprimé et/ou numérique] / Yi-Ling CHIEN, Auteur ; M. H. HSIEH, Auteur ; S. S. GAU, Auteur . - p.1684-1697.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1684-1697
Mots-clés : Autism spectrum Correlates Event-related potentials Mismatch negativity P3a Index. décimale : PER Périodiques Résumé : In a sample of 37 adolescents and young adults with autism spectrum disorder (ASD) and 35 typically-developing controls (TDC), we investigated sensory symptoms by clinical measures, and Mismatch Negativity and P3a component at Fz with the frequency and duration oddball paradigms of event-related potentials. Results showed that compared to TDC, ASD participants reported more sensory symptoms, and presented a shorter P3a peak latency in the duration paradigm, which was correlated with more social awareness deficits. In the frequency paradigm, P3a parameters were correlated with sensation avoiding and attention characteristics of ASD. Our findings suggest that sensory abnormality in ASD may extend into adolescence and young adulthood. P3a latency might be a potential neurophysiological marker for ASD. En ligne : http://dx.doi.org/10.1007/s10803-017-3426-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder / Francisco J. RUIZ-MARTINEZ in Journal of Autism and Developmental Disorders, 50-2 (February 2020)
![]()
[article]
Titre : Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Francisco J. RUIZ-MARTINEZ, Auteur ; Elena I. RODRIGUEZ-MARTINEZ, Auteur ; C. Ellie WILSON, Auteur ; Shu YAU, Auteur ; David SALDANA, Auteur ; Carlos M. GOMEZ, Auteur Article en page(s) : p.603-616 Langues : Anglais (eng) Mots-clés : Auditory P1 Autism Habituation Mismatch negativity Sensory perception Index. décimale : PER Périodiques Résumé : Passive testing of auditory function is an important objective in individuals with ASD due to known difficulties in understanding and/or following task instructions. In present study the habituation to standard tones following deviants and the auditory discriminative processes were examined in two conditions: electronic and human sounds, in a sample of 16 ASD children. ASD children presented a reduced habituation in the P1 component and a decrease in the amplitude of the mismatch negativity indicating a lower auditory discrimination with respect to controls. MMN amplitude was related to sensory sensitivity. Results suggest an increased activation to repeatedly auditory stimulus and a poor auditory discrimination, for both: electronic and human sounds with consequences on the impaired sensory behavior of ASD subjects. En ligne : http://dx.doi.org/10.1007/s10803-019-04299-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416
in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.603-616[article] Impaired P1 Habituation and Mismatch Negativity in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Francisco J. RUIZ-MARTINEZ, Auteur ; Elena I. RODRIGUEZ-MARTINEZ, Auteur ; C. Ellie WILSON, Auteur ; Shu YAU, Auteur ; David SALDANA, Auteur ; Carlos M. GOMEZ, Auteur . - p.603-616.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.603-616
Mots-clés : Auditory P1 Autism Habituation Mismatch negativity Sensory perception Index. décimale : PER Périodiques Résumé : Passive testing of auditory function is an important objective in individuals with ASD due to known difficulties in understanding and/or following task instructions. In present study the habituation to standard tones following deviants and the auditory discriminative processes were examined in two conditions: electronic and human sounds, in a sample of 16 ASD children. ASD children presented a reduced habituation in the P1 component and a decrease in the amplitude of the mismatch negativity indicating a lower auditory discrimination with respect to controls. MMN amplitude was related to sensory sensitivity. Results suggest an increased activation to repeatedly auditory stimulus and a poor auditory discrimination, for both: electronic and human sounds with consequences on the impaired sensory behavior of ASD subjects. En ligne : http://dx.doi.org/10.1007/s10803-019-04299-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning / Jonathan LASSEN in Autism Research, 15-8 (August 2022)
![]()
[article]
Titre : Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning Type de document : Texte imprimé et/ou numérique Auteurs : Jonathan LASSEN, Auteur ; Bob ORANJE, Auteur ; Martin VESTERGAARD, Auteur ; Malene FOLDAGER, Auteur ; Troels W. KJAER, Auteur ; Sidse ARNFRED, Auteur ; Bodil AGGERNAES, Auteur Article en page(s) : p.1469-1481 Langues : Anglais (eng) Mots-clés : Acoustic Stimulation/methods Adolescent Autism Spectrum Disorder/complications Autistic Disorder Brain Child Electroencephalography/methods Humans Asd Eeg adaptive behavior autism mismatch negativity Index. décimale : PER Périodiques Résumé : Children and adolescents on the autism spectrum display sensory disturbances, rigid and repetitive behavior, social communication problems and a high prevalence of impaired adaptive functioning. Autism is associated with slowed behavioral and neural habituation to repeated sensory input and decreased responses to sensory deviations. Mismatch negativity (MMN) reflects a pre-attentive difference in the neural response to sensory deviations relative to regularities and studies overall suggest that children and adolescents with autism tend to have smaller MMN. However, it remains unclear whether reduced MMN in autism is coupled to severity of specific autistic symptoms or more generally to lower level of adaptive functioning. To address these questions, the present study used electroencephalography (EEG) to assess whether auditory MMN in 59 children and adolescents with autism aged 7-14years compared to 59 typically developing children and adolescents were related to specific autistic symptoms or level in adaptive functioning. As hypothesized, the autism group had a lower MMN amplitude than controls. Smaller MMN amplitudes were specifically associated with lower adaptive functioning in the autistic subjects but not in controls while no apparent relationships were observed with autistic-like social interaction and communication problems, atypical language, rigidity, stereotypy or sensory sensitivity symptoms. Our findings indicate that a blunted response to changes in sensory input may underlie or contribute to the generalized difficulties with adapting to daily life circumstances seen in children and adolescents with autism. LAY SUMMARY: Children and adolescents on the autism spectrum have a high prevalence of impaired adaptive functioning. Neuroimaging studies have reported that children and adolescents with autism display attenuated brain activity when discriminating sensory input. However, it is unknown whether this attenuation is related to autistic symptoms and/or adaptive functioning. The present study used electroencephalogram (EEG) to show that attenuated brain response in discrimination of novel compared to repetitive sounds in children and adolescents with autism is related to their impaired adaptive functioning. En ligne : http://dx.doi.org/10.1002/aur.2738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483
in Autism Research > 15-8 (August 2022) . - p.1469-1481[article] Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning [Texte imprimé et/ou numérique] / Jonathan LASSEN, Auteur ; Bob ORANJE, Auteur ; Martin VESTERGAARD, Auteur ; Malene FOLDAGER, Auteur ; Troels W. KJAER, Auteur ; Sidse ARNFRED, Auteur ; Bodil AGGERNAES, Auteur . - p.1469-1481.
Langues : Anglais (eng)
in Autism Research > 15-8 (August 2022) . - p.1469-1481
Mots-clés : Acoustic Stimulation/methods Adolescent Autism Spectrum Disorder/complications Autistic Disorder Brain Child Electroencephalography/methods Humans Asd Eeg adaptive behavior autism mismatch negativity Index. décimale : PER Périodiques Résumé : Children and adolescents on the autism spectrum display sensory disturbances, rigid and repetitive behavior, social communication problems and a high prevalence of impaired adaptive functioning. Autism is associated with slowed behavioral and neural habituation to repeated sensory input and decreased responses to sensory deviations. Mismatch negativity (MMN) reflects a pre-attentive difference in the neural response to sensory deviations relative to regularities and studies overall suggest that children and adolescents with autism tend to have smaller MMN. However, it remains unclear whether reduced MMN in autism is coupled to severity of specific autistic symptoms or more generally to lower level of adaptive functioning. To address these questions, the present study used electroencephalography (EEG) to assess whether auditory MMN in 59 children and adolescents with autism aged 7-14years compared to 59 typically developing children and adolescents were related to specific autistic symptoms or level in adaptive functioning. As hypothesized, the autism group had a lower MMN amplitude than controls. Smaller MMN amplitudes were specifically associated with lower adaptive functioning in the autistic subjects but not in controls while no apparent relationships were observed with autistic-like social interaction and communication problems, atypical language, rigidity, stereotypy or sensory sensitivity symptoms. Our findings indicate that a blunted response to changes in sensory input may underlie or contribute to the generalized difficulties with adapting to daily life circumstances seen in children and adolescents with autism. LAY SUMMARY: Children and adolescents on the autism spectrum have a high prevalence of impaired adaptive functioning. Neuroimaging studies have reported that children and adolescents with autism display attenuated brain activity when discriminating sensory input. However, it is unknown whether this attenuation is related to autistic symptoms and/or adaptive functioning. The present study used electroencephalogram (EEG) to show that attenuated brain response in discrimination of novel compared to repetitive sounds in children and adolescents with autism is related to their impaired adaptive functioning. En ligne : http://dx.doi.org/10.1002/aur.2738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study / L. F. HALLIDAY in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)
![]()
[article]
Titre : Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study Type de document : Texte imprimé et/ou numérique Auteurs : L. F. HALLIDAY, Auteur ; Johanna G. BARRY, Auteur ; M. J. HARDIMAN, Auteur ; Dorothy V. M. BISHOP, Auteur Article en page(s) : p.21 Langues : Anglais (eng) Mots-clés : Dyslexia Event-related desynchronization Event-related spectral perturbation Frequency discrimination Inter-trial coherence Ldn Late discriminative negativity Mmn Mismatch negativity Phase locking Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. METHODS: In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with developmental dyslexia and 20 age-matched controls, divided into younger (6-11 years, n = 10) and older (11-14 years, n = 10) age bands. We focused on early (mismatch negativity; MMN) and late (late discriminative negativity; LDN) conventional mismatch responses and associated measures derived from time-frequency analysis (inter-trial coherence and event-related spectral perturbation). Responses were elicited using an auditory oddball task, whereby a stream of 1000-Hz standards was interspersed with rare large (1,200 Hz) and small (1,030 Hz) frequency deviants. RESULTS: Conventional analyses revealed no significant differences between groups in the size of the MMN to either large or small frequency deviants. However, the younger age band of children with dyslexia showed an enhanced inter-trial coherence in the theta frequency band over the time window corresponding to the MMN to small deviants. By contrast, these same children showed a reduced-amplitude LDN for the small deviants relative to their age-matched controls, whilst the older children with dyslexia showed a shorter and less intense period of event-related desynchronization over this time window. CONCLUSIONS: Initial detection and discrimination of auditory frequency change appears normal or even enhanced in children with dyslexia. Rather, deficits in late-stage auditory processing appear to be a feature of this population. En ligne : http://dx.doi.org/10.1186/1866-1955-6-21 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.21[article] Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study [Texte imprimé et/ou numérique] / L. F. HALLIDAY, Auteur ; Johanna G. BARRY, Auteur ; M. J. HARDIMAN, Auteur ; Dorothy V. M. BISHOP, Auteur . - p.21.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.21
Mots-clés : Dyslexia Event-related desynchronization Event-related spectral perturbation Frequency discrimination Inter-trial coherence Ldn Late discriminative negativity Mmn Mismatch negativity Phase locking Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. METHODS: In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with developmental dyslexia and 20 age-matched controls, divided into younger (6-11 years, n = 10) and older (11-14 years, n = 10) age bands. We focused on early (mismatch negativity; MMN) and late (late discriminative negativity; LDN) conventional mismatch responses and associated measures derived from time-frequency analysis (inter-trial coherence and event-related spectral perturbation). Responses were elicited using an auditory oddball task, whereby a stream of 1000-Hz standards was interspersed with rare large (1,200 Hz) and small (1,030 Hz) frequency deviants. RESULTS: Conventional analyses revealed no significant differences between groups in the size of the MMN to either large or small frequency deviants. However, the younger age band of children with dyslexia showed an enhanced inter-trial coherence in the theta frequency band over the time window corresponding to the MMN to small deviants. By contrast, these same children showed a reduced-amplitude LDN for the small deviants relative to their age-matched controls, whilst the older children with dyslexia showed a shorter and less intense period of event-related desynchronization over this time window. CONCLUSIONS: Initial detection and discrimination of auditory frequency change appears normal or even enhanced in children with dyslexia. Rather, deficits in late-stage auditory processing appear to be a feature of this population. En ligne : http://dx.doi.org/10.1186/1866-1955-6-21 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 Automatic cortical representation of auditory pitch changes in Rett syndrome / J. J. FOXE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
![]()
[article]
Titre : Automatic cortical representation of auditory pitch changes in Rett syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. J. FOXE, Auteur ; K. M. BURKE, Auteur ; G. N. ANDRADE, Auteur ; A. DJUKIC, Auteur ; H. P. FREY, Auteur ; S. MOLHOLM, Auteur Article en page(s) : p.34 Langues : Anglais (eng) Mots-clés : Aep Auditory evoked potential Eeg Erp Event-related potential Females High-density electrical mapping Mecp2 Mmn Mismatch negativity Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones. METHODS: Fourteen girls with genetically confirmed Rett syndrome and 22 age-matched neurotypical controls participated (ages 3.9-21.1 years). High-density electrophysiological recordings from 64 scalp electrodes were made while participants passively listened to a regularly occurring stream of 503-Hz auditory tone pips that was occasionally (15 % of presentations) interrupted by a higher-pitched deviant tone of 996 Hz. The MMN was derived by subtracting the AEP to these deviants from the AEP produced to the standard. RESULTS: Despite clearly anomalous morphology and latency of the AEP to simple pure-tone inputs in Rett syndrome, the MMN response was evident in both neurotypicals and Rett patients. However, we found that the pitch-evoked MMN was both delayed and protracted in duration in Rett, pointing to slowing of auditory responsiveness. CONCLUSIONS: The presence of the MMN in Rett patients suggests preserved abilities to process pitch changes in auditory sensory memory. This work represents a beginning step in an effort to comprehensively map the extent of auditory cortical functioning in Rett syndrome. These easily obtained objective brain measures of auditory processing have promise as biomarkers against which future therapeutic efforts can be assayed. En ligne : http://dx.doi.org/10.1186/s11689-016-9166-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.34[article] Automatic cortical representation of auditory pitch changes in Rett syndrome [Texte imprimé et/ou numérique] / J. J. FOXE, Auteur ; K. M. BURKE, Auteur ; G. N. ANDRADE, Auteur ; A. DJUKIC, Auteur ; H. P. FREY, Auteur ; S. MOLHOLM, Auteur . - p.34.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.34
Mots-clés : Aep Auditory evoked potential Eeg Erp Event-related potential Females High-density electrical mapping Mecp2 Mmn Mismatch negativity Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones. METHODS: Fourteen girls with genetically confirmed Rett syndrome and 22 age-matched neurotypical controls participated (ages 3.9-21.1 years). High-density electrophysiological recordings from 64 scalp electrodes were made while participants passively listened to a regularly occurring stream of 503-Hz auditory tone pips that was occasionally (15 % of presentations) interrupted by a higher-pitched deviant tone of 996 Hz. The MMN was derived by subtracting the AEP to these deviants from the AEP produced to the standard. RESULTS: Despite clearly anomalous morphology and latency of the AEP to simple pure-tone inputs in Rett syndrome, the MMN response was evident in both neurotypicals and Rett patients. However, we found that the pitch-evoked MMN was both delayed and protracted in duration in Rett, pointing to slowing of auditory responsiveness. CONCLUSIONS: The presence of the MMN in Rett patients suggests preserved abilities to process pitch changes in auditory sensory memory. This work represents a beginning step in an effort to comprehensively map the extent of auditory cortical functioning in Rett syndrome. These easily obtained objective brain measures of auditory processing have promise as biomarkers against which future therapeutic efforts can be assayed. En ligne : http://dx.doi.org/10.1186/s11689-016-9166-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 Individuals With Autism Have No Detectable Deficit in Neural Markers of Prediction Error When Presented With Auditory Rhythms of Varied Temporal Complexity / Emily J. KNIGHT in Autism Research, 13-12 (December 2020)
![]()
PermalinkPsychophysiological Correlates of Developmental Changes in Healthy and Autistic Boys / Benjamin WEISMÜLLER in Journal of Autism and Developmental Disorders, 45-7 (July 2015)
![]()
PermalinkUniversality of categorical perception deficit in developmental dyslexia: an investigation of Mandarin Chinese tones / Yajing ZHANG in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)
![]()
Permalink