3 recherche sur le mot-clé 'Masc'

Movie for the Assessment of Social Cognition (MASC): Spanish Validation / G. LAHERA in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1886-1896 Titre : Movie for the Assessment of Social Cognition (MASC): Spanish Validation Type de document : Texte imprimé et/ou numérique Auteurs : G. LAHERA, Auteur ; L. BOADA, Auteur ; E. POUSA, Auteur ; I. MIRAPEIX, Auteur ; G. MORON-NOZALEDA, Auteur ; L. MARINAS, Auteur ; L. GISBERT, Auteur ; M. PAMIAS, Auteur ; Mara PARELLADA, Auteur Article en page(s) : p.1886-1896 Langues : Anglais (eng) Mots-clés : Social cognition  Theory of mind  Autism  Asperger syndrome  MASC Index. décimale : PER Périodiques Résumé : We present the Spanish validation of the “Movie for the Assessment of Social Cognition” instrument (MASC-SP). We recruited 22 adolescents and young adults with Asperger syndrome and 26 participants with typical development. The MASC-SP and three other social cognition instruments (Ekman Pictures of Facial Affect test, Reading the Mind in the Eyes Test, and Happé’s Strange Stories) were administered to both groups. Individuals with Asperger syndrome had significantly lower scores in all measures of social cognition. The MASC-SP showed strong correlations with all three measures and relative independence of general cognitive functions. Internal consistency was optimal (0.86) and the test–retest was good. The MASC-SP is an ecologically valid and useful tool for assessing social cognition in the Spanish population. En ligne : http://dx.doi.org/10.1007/s10803-014-2061-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Movie for the Assessment of Social Cognition (MASC): Spanish Validation [Texte imprimé et/ou numérique] / G. LAHERA, Auteur ; L. BOADA, Auteur ; E. POUSA, Auteur ; I. MIRAPEIX, Auteur ; G. MORON-NOZALEDA, Auteur ; L. MARINAS, Auteur ; L. GISBERT, Auteur ; M. PAMIAS, Auteur ; Mara PARELLADA, Auteur . - p.1886-1896. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.1886-1896 Mots-clés : Social cognition  Theory of mind  Autism  Asperger syndrome  MASC Index. décimale : PER Périodiques Résumé : We present the Spanish validation of the “Movie for the Assessment of Social Cognition” instrument (MASC-SP). We recruited 22 adolescents and young adults with Asperger syndrome and 26 participants with typical development. The MASC-SP and three other social cognition instruments (Ekman Pictures of Facial Affect test, Reading the Mind in the Eyes Test, and Happé’s Strange Stories) were administered to both groups. Individuals with Asperger syndrome had significantly lower scores in all measures of social cognition. The MASC-SP showed strong correlations with all three measures and relative independence of general cognitive functions. Internal consistency was optimal (0.86) and the test–retest was good. The MASC-SP is an ecologically valid and useful tool for assessing social cognition in the Spanish population. En ligne : http://dx.doi.org/10.1007/s10803-014-2061-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

Synapse Proteomes and Disease: The MASC Paradigm / Àlex BAYES  

Public ISBD in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Titre : Synapse Proteomes and Disease: The MASC Paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Àlex BAYES, Auteur ; Seth G. N. GRANT, Auteur Année de publication : 2016 Importance : p.85-99 Langues : Anglais (eng) Mots-clés : Autism  Cognition  Intellectual disability  Learning  MAGUK  MASC  Proteomics  Schizophrenia  Synapse  Synaptopathy Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The synapse is composed of ?2000 proteins, and mutations and genetic variants in these proteins result in a large number of disorders, collectively known as synaptopathies. A major subset of synapse proteins assemble with membrane-associated guanylate kinase (MAGUK) proteins into multiprotein complexes known as MAGUK-associated signaling complexes (MASCs). In total, 145 MASC genes have been related to 197 nervous system conditions. Cognitive behavioral disorders are prominent among these disorders, especially intellectual disability, autism, and schizophrenia. An extensive body of literature in mice has also demonstrated that mutations in MAGUK proteins result in cognitive impairments. Here we provide a detailed analysis of the genetic basis of MASC diseases. These comprehensive studies of synapse complexes and their roles in disease are a general paradigm linking proteomics, genetics, and molecular machines to brain disease. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00006-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Synapse Proteomes and Disease: The MASC Paradigm [Texte imprimé et/ou numérique] / Àlex BAYES, Auteur ; Seth G. N. GRANT, Auteur . - 2016 . - p.85-99. Langues : Anglais (eng) Mots-clés : Autism  Cognition  Intellectual disability  Learning  MAGUK  MASC  Proteomics  Schizophrenia  Synapse  Synaptopathy Index. décimale : SCI-D SCI-D - Neurosciences Résumé : The synapse is composed of ?2000 proteins, and mutations and genetic variants in these proteins result in a large number of disorders, collectively known as synaptopathies. A major subset of synapse proteins assemble with membrane-associated guanylate kinase (MAGUK) proteins into multiprotein complexes known as MAGUK-associated signaling complexes (MASCs). In total, 145 MASC genes have been related to 197 nervous system conditions. Cognitive behavioral disorders are prominent among these disorders, especially intellectual disability, autism, and schizophrenia. An extensive body of literature in mice has also demonstrated that mutations in MAGUK proteins result in cognitive impairments. Here we provide a detailed analysis of the genetic basis of MASC diseases. These comprehensive studies of synapse complexes and their roles in disease are a general paradigm linking proteomics, genetics, and molecular machines to brain disease. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00006-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301

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Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different? / L. BOADA in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.3046-3059 Titre : Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different? Type de document : Texte imprimé et/ou numérique Auteurs : L. BOADA, Auteur ; G. LAHERA, Auteur ; Laura PINA-CAMACHO, Auteur ; J. MERCHAN-NARANJO, Auteur ; Covadonga M. DIAZ-CANEJA, Auteur ; J. M. BELLON, Auteur ; J. M. RUIZ-VARGAS, Auteur ; Mara PARELLADA, Auteur Article en page(s) : p.3046-3059 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Masc  Psychosis  Schizophrenia  Social cognition  Theory of mind Index. décimale : PER Périodiques Résumé : Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Only performance on the Movie for the Assessment of Social Cognition (MASC) test was independent of age and intelligence. Proportionately, individuals in the control group made significantly more overmentalization errors than both patients group did and made fewer undermentalization errors than patients with SSD did. AUC analyses showed that the MASC was the instrument that best discriminated between the clinical and control groups. Multivariate analysis showed negative symptom severity as a potential mediator of the association between social cognition deficit and poor global functioning. En ligne : http://dx.doi.org/10.1007/s10803-020-04408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Social Cognition in Autism and Schizophrenia Spectrum Disorders: The Same but Different? [Texte imprimé et/ou numérique] / L. BOADA, Auteur ; G. LAHERA, Auteur ; Laura PINA-CAMACHO, Auteur ; J. MERCHAN-NARANJO, Auteur ; Covadonga M. DIAZ-CANEJA, Auteur ; J. M. BELLON, Auteur ; J. M. RUIZ-VARGAS, Auteur ; Mara PARELLADA, Auteur . - p.3046-3059. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.3046-3059 Mots-clés : Autism spectrum disorders  Masc  Psychosis  Schizophrenia  Social cognition  Theory of mind Index. décimale : PER Périodiques Résumé : Social cognition impairment is a core shared phenotype in both schizophrenia spectrum disorders (SSD) and autism spectrum disorders (ASD). This study compares social cognition performance through four different instruments in a sample of 147 individuals with ASD or SSD and in healthy controls. We found that both clinical groups perform similarly to each other and worse than healthy controls in all social cognition tasks. Only performance on the Movie for the Assessment of Social Cognition (MASC) test was independent of age and intelligence. Proportionately, individuals in the control group made significantly more overmentalization errors than both patients group did and made fewer undermentalization errors than patients with SSD did. AUC analyses showed that the MASC was the instrument that best discriminated between the clinical and control groups. Multivariate analysis showed negative symptom severity as a potential mediator of the association between social cognition deficit and poor global functioning. En ligne : http://dx.doi.org/10.1007/s10803-020-04408-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428