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Résultat de la recherche
2 recherche sur le mot-clé 'cytoarchitecture'




Autism is associated with in vivo changes in gray matter neurite architecture / Zachary P. CHRISTENSEN in Autism Research, 17-11 (November 2024)
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Titre : Autism is associated with in vivo changes in gray matter neurite architecture Type de document : Texte imprimé et/ou numérique Auteurs : Zachary P. CHRISTENSEN, Auteur ; Edward G. FREEDMAN, Auteur ; John J. FOXE, Auteur Article en page(s) : p.2261-2277 Langues : Anglais (eng) Mots-clés : autism cerebellum children and adolescents cytoarchitecture DWI gray matter neurodevelopment Index. décimale : PER Périodiques Résumé : Abstract Postmortem investigations in autism have identified anomalies in neural cytoarchitecture across limbic, cerebellar, and neocortical networks. These anomalies include narrow cell mini-columns and variable neuron density. However, difficulty obtaining sufficient post-mortem samples has often prevented investigations from converging on reproducible measures. Recent advances in processing magnetic resonance diffusion weighted images (DWI) make in vivo characterization of neuronal cytoarchitecture a potential alternative to post-mortem studies. Using extensive DWI data from the Adolescent Brain Cognitive Developmentsm (ABCD?) study 142 individuals with an autism diagnosis were compared with 8971 controls using a restriction spectrum imaging (RSI) framework that characterized total neurite density (TND), its component restricted normalized directional diffusion (RND), and restricted normalized isotropic diffusion (RNI). A significant decrease in TND was observed in autism in the right cerebellar cortex (??=??0.005, SE =0.0015, p?=?0.0267), with significant decreases in RNI and significant increases in RND found diffusely throughout posterior and anterior aspects of the brain, respectively. Furthermore, these regions remained significant in post-hoc analysis when the autism sample was compared against a subset of 1404 individuals with other psychiatric conditions (pulled from the original 8971). These findings highlight the importance of characterizing neuron cytoarchitecture in autism and the significance of their incorporation as physiological covariates in future studies. En ligne : https://doi.org/10.1002/aur.3239 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542
in Autism Research > 17-11 (November 2024) . - p.2261-2277[article] Autism is associated with in vivo changes in gray matter neurite architecture [Texte imprimé et/ou numérique] / Zachary P. CHRISTENSEN, Auteur ; Edward G. FREEDMAN, Auteur ; John J. FOXE, Auteur . - p.2261-2277.
Langues : Anglais (eng)
in Autism Research > 17-11 (November 2024) . - p.2261-2277
Mots-clés : autism cerebellum children and adolescents cytoarchitecture DWI gray matter neurodevelopment Index. décimale : PER Périodiques Résumé : Abstract Postmortem investigations in autism have identified anomalies in neural cytoarchitecture across limbic, cerebellar, and neocortical networks. These anomalies include narrow cell mini-columns and variable neuron density. However, difficulty obtaining sufficient post-mortem samples has often prevented investigations from converging on reproducible measures. Recent advances in processing magnetic resonance diffusion weighted images (DWI) make in vivo characterization of neuronal cytoarchitecture a potential alternative to post-mortem studies. Using extensive DWI data from the Adolescent Brain Cognitive Developmentsm (ABCD?) study 142 individuals with an autism diagnosis were compared with 8971 controls using a restriction spectrum imaging (RSI) framework that characterized total neurite density (TND), its component restricted normalized directional diffusion (RND), and restricted normalized isotropic diffusion (RNI). A significant decrease in TND was observed in autism in the right cerebellar cortex (??=??0.005, SE =0.0015, p?=?0.0267), with significant decreases in RNI and significant increases in RND found diffusely throughout posterior and anterior aspects of the brain, respectively. Furthermore, these regions remained significant in post-hoc analysis when the autism sample was compared against a subset of 1404 individuals with other psychiatric conditions (pulled from the original 8971). These findings highlight the importance of characterizing neuron cytoarchitecture in autism and the significance of their incorporation as physiological covariates in future studies. En ligne : https://doi.org/10.1002/aur.3239 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 Neuron density is decreased in the prefrontal cortex in Williams syndrome / Caroline HORTON LEW in Autism Research, 10-1 (January 2017)
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Titre : Neuron density is decreased in the prefrontal cortex in Williams syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Caroline HORTON LEW, Auteur ; Chelsea BROWN, Auteur ; Ursula BELLUGI, Auteur ; Katerina SEMENDEFERI, Auteur Article en page(s) : p.99-112 Langues : Anglais (eng) Mots-clés : frontal pole design-based stereology cytoarchitecture Williams syndrome prefrontal cortex neuron density Index. décimale : PER Périodiques Résumé : Williams Syndrome (WS) is a rare neurodevelopmental disorder associated with a hemideletion in chromosome 7, which manifests a distinct behavioral phenotype characterized by a hyperaffiliative social drive, in striking contrast to the social avoidance behaviors that are common in Autism Spectrum Disorder (ASD). MRI studies have observed structural and functional abnormalities in WS cortex, including the prefrontal cortex (PFC), a region implicated in social cognition. This study utilizes the Bellugi Williams Syndrome Brain Collection, a unique resource that comprises the largest WS postmortem brain collection in existence, and is the first to quantitatively examine WS PFC cytoarchitecture. We measured neuron density in layers II/III and V/VI of five cortical areas: PFC areas BA 10 and BA 11, primary motor BA 4, primary somatosensory BA 3, and visual area BA 18 in six matched pairs of WS and typically developing (TD) controls. Neuron density in PFC was lower in WS relative to TD, with layers V/VI demonstrating the largest decrease in density, reaching statistical significance in BA 10. In contrast, BA 3 and BA 18 demonstrated a higher density in WS compared to TD, although this difference was not statistically significant. Neuron density in BA 4 was similar in WS and TD. While other cortical areas were altered in WS, prefrontal areas appeared to be most affected. Neuron density is also altered in the PFC of individuals with ASD. Together these findings suggest that the PFC is targeted in neurodevelopmental disorders associated with sociobehavioral alterations. En ligne : http://dx.doi.org/10.1002/aur.1677 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-1 (January 2017) . - p.99-112[article] Neuron density is decreased in the prefrontal cortex in Williams syndrome [Texte imprimé et/ou numérique] / Caroline HORTON LEW, Auteur ; Chelsea BROWN, Auteur ; Ursula BELLUGI, Auteur ; Katerina SEMENDEFERI, Auteur . - p.99-112.
Langues : Anglais (eng)
in Autism Research > 10-1 (January 2017) . - p.99-112
Mots-clés : frontal pole design-based stereology cytoarchitecture Williams syndrome prefrontal cortex neuron density Index. décimale : PER Périodiques Résumé : Williams Syndrome (WS) is a rare neurodevelopmental disorder associated with a hemideletion in chromosome 7, which manifests a distinct behavioral phenotype characterized by a hyperaffiliative social drive, in striking contrast to the social avoidance behaviors that are common in Autism Spectrum Disorder (ASD). MRI studies have observed structural and functional abnormalities in WS cortex, including the prefrontal cortex (PFC), a region implicated in social cognition. This study utilizes the Bellugi Williams Syndrome Brain Collection, a unique resource that comprises the largest WS postmortem brain collection in existence, and is the first to quantitatively examine WS PFC cytoarchitecture. We measured neuron density in layers II/III and V/VI of five cortical areas: PFC areas BA 10 and BA 11, primary motor BA 4, primary somatosensory BA 3, and visual area BA 18 in six matched pairs of WS and typically developing (TD) controls. Neuron density in PFC was lower in WS relative to TD, with layers V/VI demonstrating the largest decrease in density, reaching statistical significance in BA 10. In contrast, BA 3 and BA 18 demonstrated a higher density in WS compared to TD, although this difference was not statistically significant. Neuron density in BA 4 was similar in WS and TD. While other cortical areas were altered in WS, prefrontal areas appeared to be most affected. Neuron density is also altered in the PFC of individuals with ASD. Together these findings suggest that the PFC is targeted in neurodevelopmental disorders associated with sociobehavioral alterations. En ligne : http://dx.doi.org/10.1002/aur.1677 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303