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The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study / E. S. JAMNADASS in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)
[article]
Titre : The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study Type de document : Texte imprimé et/ou numérique Auteurs : E. S. JAMNADASS, Auteur ; J. A. KEELAN, Auteur ; L. P. HOLLIER, Auteur ; M. HICKEY, Auteur ; M. T. MAYBERY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.17 Langues : Anglais (eng) Mots-clés : Androgens Autism-Spectrum Quotient Autistic-like traits Cord blood Estrogens Perinatal Sex steroids Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal androgen exposure has been hypothesized to be linked to autism spectrum disorder (ASD). While previous studies have found a link between testosterone levels in amniotic fluid and autistic-like traits, a similar relationship has not been found for testosterone in umbilical cord blood. However, it may be the net biological activity of multiple androgens and estrogens that influences postnatal effects of prenatal sex steroids. Accordingly, composite levels of androgens (A) and estrogens (E) were investigated, along with their ratio, in relation to autistic-like traits in young adulthood. METHODS: Sex steroid data in umbilical cord blood were available from 860 individuals at delivery. Samples were analyzed for androgens (testosterone, androstenedione, and dehydroepiandrosterone) and estrogens (estrone, estradiol, estriol, and estetrol). Levels of bioavailable testosterone, estradiol, and estrone were measured and used to calculate A and E composites and the A to E ratio. Participants were approached in early adulthood to complete the autism-spectrum quotient (AQ) as a self-report measure of autistic-like traits, with 183 males (M = 20.10 years, SD = 0.65 years) and 189 females (M =19.92 years, SD = 0.68 years) providing data. RESULTS: Males exhibited significantly higher androgen composites and A to E composite ratios than females. Males also scored significantly higher on the details/patterns subscale of the AQ. Subsequent categorical and continuous analyses, which accounted for covariates, revealed no substantial relationships between the A/E composites or the A to E ratio and the AQ total or subscale scores. CONCLUSIONS: The current study found no link between the A/E composites or the A to E ratio in cord blood and autistic-like traits in the population as measured by the AQ. These outcomes do not exclude the possibility that these sex steroid variables may predict other neurodevelopmental traits in early development. En ligne : http://dx.doi.org/10.1186/s11689-015-9114-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.17[article] The perinatal androgen to estrogen ratio and autistic-like traits in the general population: a longitudinal pregnancy cohort study [Texte imprimé et/ou numérique] / E. S. JAMNADASS, Auteur ; J. A. KEELAN, Auteur ; L. P. HOLLIER, Auteur ; M. HICKEY, Auteur ; M. T. MAYBERY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.17.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.17
Mots-clés : Androgens Autism-Spectrum Quotient Autistic-like traits Cord blood Estrogens Perinatal Sex steroids Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal androgen exposure has been hypothesized to be linked to autism spectrum disorder (ASD). While previous studies have found a link between testosterone levels in amniotic fluid and autistic-like traits, a similar relationship has not been found for testosterone in umbilical cord blood. However, it may be the net biological activity of multiple androgens and estrogens that influences postnatal effects of prenatal sex steroids. Accordingly, composite levels of androgens (A) and estrogens (E) were investigated, along with their ratio, in relation to autistic-like traits in young adulthood. METHODS: Sex steroid data in umbilical cord blood were available from 860 individuals at delivery. Samples were analyzed for androgens (testosterone, androstenedione, and dehydroepiandrosterone) and estrogens (estrone, estradiol, estriol, and estetrol). Levels of bioavailable testosterone, estradiol, and estrone were measured and used to calculate A and E composites and the A to E ratio. Participants were approached in early adulthood to complete the autism-spectrum quotient (AQ) as a self-report measure of autistic-like traits, with 183 males (M = 20.10 years, SD = 0.65 years) and 189 females (M =19.92 years, SD = 0.68 years) providing data. RESULTS: Males exhibited significantly higher androgen composites and A to E composite ratios than females. Males also scored significantly higher on the details/patterns subscale of the AQ. Subsequent categorical and continuous analyses, which accounted for covariates, revealed no substantial relationships between the A/E composites or the A to E ratio and the AQ total or subscale scores. CONCLUSIONS: The current study found no link between the A/E composites or the A to E ratio in cord blood and autistic-like traits in the population as measured by the AQ. These outcomes do not exclude the possibility that these sex steroid variables may predict other neurodevelopmental traits in early development. En ligne : http://dx.doi.org/10.1186/s11689-015-9114-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=347 The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper / Christopher GILLBERG in Autism Research, 10-6 (June 2017)
[article]
Titre : The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper Type de document : Texte imprimé et/ou numérique Auteurs : Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur Article en page(s) : p.1022-1044 Langues : Anglais (eng) Mots-clés : autism cholesterol cortisol estrogens steroid hormones testosterone vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309
in Autism Research > 10-6 (June 2017) . - p.1022-1044[article] The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper [Texte imprimé et/ou numérique] / Christopher GILLBERG, Auteur ; Elisabeth FERNELL, Auteur ; Eva KOCOVSKA, Auteur ; Helen MINNIS, Auteur ; Thomas BOURGERON, Auteur ; Lucy THOMPSON, Auteur ; Clare S. ALLELY, Auteur . - p.1022-1044.
Langues : Anglais (eng)
in Autism Research > 10-6 (June 2017) . - p.1022-1044
Mots-clés : autism cholesterol cortisol estrogens steroid hormones testosterone vitamin D Index. décimale : PER Périodiques Résumé : Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the “autisms” [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as “steroid metabolism” and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. En ligne : http://dx.doi.org/10.1002/aur.1777 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309