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Atypical Topographical Organization of Global Form and Motion Processing in 5-Month-Old Infants at Risk for Autism / Pär NYSTRÖM in Journal of Autism and Developmental Disorders, 51-1 (January 2021)
[article]
Titre : Atypical Topographical Organization of Global Form and Motion Processing in 5-Month-Old Infants at Risk for Autism Type de document : Texte imprimé et/ou numérique Auteurs : Pär NYSTRÖM, Auteur ; Emily JONES, Auteur ; Fahimeh DARKI, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur Article en page(s) : p.364-370 Langues : Anglais (eng) Mots-clés : Autism Developmental disorders Eeg Global coherence Infants Motion Index. décimale : PER Périodiques Résumé : Research indicates that individuals with autism spectrum disorder (ASD) are superior at local processing while the integration of local features to global percepts is reduced. Here, we compared infants at familiar risk for ASD to typically developing infants in terms of global coherence processing at 5 months of age, using steady state visually evoked potentials (SSVEP). We found a different topographical organization for global form and motion processing in infants at risk (n?=?50) than in controls (n?=?23). In contrast, activation patterns for local visual change were strikingly similar between groups. Although preliminary, the results represent the first neurophysiological evidence supporting the view that basic atypicalities in perception may play a role in the developmental pathways leading to ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04523-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.364-370[article] Atypical Topographical Organization of Global Form and Motion Processing in 5-Month-Old Infants at Risk for Autism [Texte imprimé et/ou numérique] / Pär NYSTRÖM, Auteur ; Emily JONES, Auteur ; Fahimeh DARKI, Auteur ; Sven BÖLTE, Auteur ; Terje FALCK-YTTER, Auteur . - p.364-370.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.364-370
Mots-clés : Autism Developmental disorders Eeg Global coherence Infants Motion Index. décimale : PER Périodiques Résumé : Research indicates that individuals with autism spectrum disorder (ASD) are superior at local processing while the integration of local features to global percepts is reduced. Here, we compared infants at familiar risk for ASD to typically developing infants in terms of global coherence processing at 5 months of age, using steady state visually evoked potentials (SSVEP). We found a different topographical organization for global form and motion processing in infants at risk (n?=?50) than in controls (n?=?23). In contrast, activation patterns for local visual change were strikingly similar between groups. Although preliminary, the results represent the first neurophysiological evidence supporting the view that basic atypicalities in perception may play a role in the developmental pathways leading to ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04523-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging / Seraphina K. SOLDERS in Autism Research, 10-10 (October 2017)
[article]
Titre : White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging Type de document : Texte imprimé et/ou numérique Auteurs : Seraphina K. SOLDERS, Auteur ; Ruth A. CARPER, Auteur ; Ralph-Axel MULLER, Auteur Article en page(s) : p.1606-1620 Langues : Anglais (eng) Mots-clés : diffusion autism motion MRI white matter artifact Index. décimale : PER Périodiques Résumé : Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. We included 57 ASD and 50 TD participants, comparing three subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM). Groups were compared on diffusivity measures using Tract-Based Spatial Statistics (TBSS) and probabilistic tractography. Two methods for estimating diffusivity were compared: dti-fit and restore. TBSS: In set FS, FA was reduced in the ASD compared to the TD group throughout the right hemisphere. This effect was less extensive in set QC and absent in set QM. However, effect sizes remained stable or increased with better quality-control in some regions. Tractography: In set QM, MD was significantly higher in ASD overall and RD was higher in bilateral ILF. Effects were more robust in QM than in FS or QC sets. Effect sizes in several tracts increased with stringent quality matching. Restore improved tensor estimates, with some increases in effect sizes, but did not fully compensate for reduced quality. Findings suggest that some previously reported DTI findings for ASD may have been confounded by motion. However, effects in the tightly matched subset indicate that tract-specific anomalies probably do exist in ASD. Our results highlight the need for careful quality-control and motion-matching. Autism Res 2017, 10: 1606–1620. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-10 (October 2017) . - p.1606-1620[article] White matter compromise in autism? Differentiating motion confounds from true differences in diffusion tensor imaging [Texte imprimé et/ou numérique] / Seraphina K. SOLDERS, Auteur ; Ruth A. CARPER, Auteur ; Ralph-Axel MULLER, Auteur . - p.1606-1620.
Langues : Anglais (eng)
in Autism Research > 10-10 (October 2017) . - p.1606-1620
Mots-clés : diffusion autism motion MRI white matter artifact Index. décimale : PER Périodiques Résumé : Common findings from diffusion tensor imaging (DTI) in autism spectrum disorder (ASD) include reduced fractional anisotropy (FA), and increased mean and radial diffusivity (MD, RD) of white matter tracts. However, findings may be confounded by head motion. We examined how group-level motion matching affects DTI comparisons between ASD and typically developing (TD) groups. We included 57 ASD and 50 TD participants, comparing three subsets at increasing levels of motion-matching stringency: full sample (FS); quality-controlled (QC); and quantitatively-matched (QM). Groups were compared on diffusivity measures using Tract-Based Spatial Statistics (TBSS) and probabilistic tractography. Two methods for estimating diffusivity were compared: dti-fit and restore. TBSS: In set FS, FA was reduced in the ASD compared to the TD group throughout the right hemisphere. This effect was less extensive in set QC and absent in set QM. However, effect sizes remained stable or increased with better quality-control in some regions. Tractography: In set QM, MD was significantly higher in ASD overall and RD was higher in bilateral ILF. Effects were more robust in QM than in FS or QC sets. Effect sizes in several tracts increased with stringent quality matching. Restore improved tensor estimates, with some increases in effect sizes, but did not fully compensate for reduced quality. Findings suggest that some previously reported DTI findings for ASD may have been confounded by motion. However, effects in the tightly matched subset indicate that tract-specific anomalies probably do exist in ASD. Our results highlight the need for careful quality-control and motion-matching. Autism Res 2017, 10: 1606–1620. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study / J. LEI in Autism Research, 12-10 (October 2019)
[article]
Titre : Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; D. G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur Article en page(s) : p.1472-1483 Langues : Anglais (eng) Mots-clés : anisotropy autism spectrum disorder diffusion tensor imaging female motion sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408
in Autism Research > 12-10 (October 2019) . - p.1472-1483[article] Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality-Controlled Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / J. LEI, Auteur ; E. LECARIE, Auteur ; J. JURAYJ, Auteur ; S. BOLAND, Auteur ; D. G. SUKHODOLSKY, Auteur ; Pamela VENTOLA, Auteur ; Kevin A. PELPHREY, Auteur ; R. J. JOU, Auteur . - p.1472-1483.
Langues : Anglais (eng)
in Autism Research > 12-10 (October 2019) . - p.1472-1483
Mots-clés : anisotropy autism spectrum disorder diffusion tensor imaging female motion sex characteristics Index. décimale : PER Périodiques Résumé : Previous studies using diffusion tensor imaging (DTI) to investigate white matter (WM) structural connectivity have suggested widespread, although inconsistent WM alterations in autism spectrum disorder (ASD), such as greater reductions in fractional anisotropy (FA). However, findings may lack generalizability because: (a) most have focused solely on the ASD male brain phenotype, and not sex-differences in WM integrity; (b) many lack stringent and transparent data quality control such as controlling for head motion in analysis. This study addressed both issues by using Tract-Based Spatial Statistics (TBSS) to separately compare WM differences in 81 ASD (56 male, 25 female; 4-21 years old) and 39 typically developing (TD; 23 males, 16 females; 5-18 years old) children and young people, carefully group-matched on sex, age, cognitive abilities, and head motion. ASD males and females were also matched on autism symptom severity. Two independent-raters completed a multistep scan quality assurance to remove images that were significantly distorted by motion artifacts before analysis. ASD females exhibited significant widespread reductions in FA compared to TD females, suggesting altered WM integrity. In contrast, no significant localized or widespread WM differences were found between ASD and TD males. This study highlights the importance of data quality control in DTI, and outlines important sex-differences in WM alterations in ASD females. Future studies can explore the extent to which neural structural differences might underlie sex-differences in ASD behavioral phenotype, and guide clinical interventions to be tailored toward the unique needs of ASD females and males. Autism Res 2019, 12: 1472-1483. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Previous Diffusion Tensor Imaging (DTI) studies have found atypical brain structural connectivity in males with autism, although findings are inconclusive in females with autism. To investigate potential sex-differences, we studied males and females with and without autism who showed a similar level of head movement during their brain scan. We found that females with autism had widespread atypical neural connectivity than females without autism, although not in males, highlighting sex-differences. En ligne : http://dx.doi.org/10.1002/aur.2180 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 Difficulties predicting time-to-arrival in individuals with autism spectrum disorders / Elizabeth SHEPPARD in Research in Autism Spectrum Disorders, 28 (August 2016)
[article]
Titre : Difficulties predicting time-to-arrival in individuals with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth SHEPPARD, Auteur ; Editha VAN LOON, Auteur ; Geoffrey UNDERWOOD, Auteur ; Danielle ROPAR, Auteur Article en page(s) : p.17-23 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Driving Motion Prediction impairment Time-to-arrival Index. décimale : PER Périodiques Résumé : AbstractBackground Previous research suggests people with ASD may have various difficulties in processing and interacting with motion in the environment. We investigated whether individuals with ASD have difficulty judging the location of moving objects in a driving context using a time-to-arrival task. Methods Participants with and without ASD viewed scenes that simulated self-motion towards a junction, while another car approached on a side road. Scenes terminated prior to either car reaching the junction and participants were required to decide which car would reach the junction first. Results Participants with ASD made fewer correct responses although this was only true when self-motion was on a straight road. Conclusions This difficulty in judging the location of moving objects could contribute to difficulties people with ASD experience in learning to drive. En ligne : http://www.sciencedirect.com/science/article/pii/S1750946716300538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291
in Research in Autism Spectrum Disorders > 28 (August 2016) . - p.17-23[article] Difficulties predicting time-to-arrival in individuals with autism spectrum disorders [Texte imprimé et/ou numérique] / Elizabeth SHEPPARD, Auteur ; Editha VAN LOON, Auteur ; Geoffrey UNDERWOOD, Auteur ; Danielle ROPAR, Auteur . - p.17-23.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 28 (August 2016) . - p.17-23
Mots-clés : Autism spectrum disorders Driving Motion Prediction impairment Time-to-arrival Index. décimale : PER Périodiques Résumé : AbstractBackground Previous research suggests people with ASD may have various difficulties in processing and interacting with motion in the environment. We investigated whether individuals with ASD have difficulty judging the location of moving objects in a driving context using a time-to-arrival task. Methods Participants with and without ASD viewed scenes that simulated self-motion towards a junction, while another car approached on a side road. Scenes terminated prior to either car reaching the junction and participants were required to decide which car would reach the junction first. Results Participants with ASD made fewer correct responses although this was only true when self-motion was on a straight road. Conclusions This difficulty in judging the location of moving objects could contribute to difficulties people with ASD experience in learning to drive. En ligne : http://www.sciencedirect.com/science/article/pii/S1750946716300538 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291