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Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder / Gerrit I. VAN SCHALKWYK in Journal of Autism and Developmental Disorders, 45-9 (September 2015)
[article]
Titre : Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur Article en page(s) : p.3061-3066 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Developmental disorder Aggression Irritability Nicotine Nicotine patch Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066[article] Reduction of Aggressive Episodes After Repeated Transdermal Nicotine Administration in a Hospitalized Adolescent with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Gerrit I. VAN SCHALKWYK, Auteur ; Alan S. LEWIS, Auteur ; Zheala QAYYUM, Auteur ; Kourtney KOSLOSKY, Auteur ; Marina R. PICCIOTTO, Auteur ; Fred R. VOLKMAR, Auteur . - p.3061-3066.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3061-3066
Mots-clés : Autism spectrum disorder Developmental disorder Aggression Irritability Nicotine Nicotine patch Nicotinic acetylcholine receptor Index. décimale : PER Périodiques Résumé : Aggression remains a major cause of morbidity in patients with autism spectrum disorder (ASD). Current pharmacotherapy for aggression is not always effective and is often associated with morbidity. Nicotinic acetylcholinergic neurotransmission may play a prominent role in ASD pathophysiology based on human and animal studies, and preclinical studies show nicotine administration can reduce aggression-related behaviors. Transdermal nicotine has been used to treat agitation in neuropsychiatric conditions with cholinergic dysfunction. Here we report the use of transdermal nicotine as an adjunctive medication to treat aggression in a hospitalized adolescent with ASD. Nicotine patch was recurrently well tolerated, and reduced the need for emergency medication and restraint. These findings suggest further study of transdermal nicotine for aggression comorbid with ASD is warranted. En ligne : http://dx.doi.org/10.1007/s10803-015-2471-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / A. S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)
[article]
Titre : An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur Article en page(s) : p.2748-2757 Langues : Anglais (eng) Mots-clés : Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367
in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757[article] An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / A. S. LEWIS, Auteur ; Gerrit I. VAN SCHALKWYK, Auteur ; M. O. LOPEZ, Auteur ; Fred R. VOLKMAR, Auteur ; M. R. PICCIOTTO, Auteur ; D. G. SUKHODOLSKY, Auteur . - p.2748-2757.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-8 (August 2018) . - p.2748-2757
Mots-clés : Adult Aggression Autism spectrum disorder Irritability Nicotine Nicotinic acetylcholine receptor Sleep Index. décimale : PER Périodiques Résumé : Nicotinic acetylcholine receptors (nAChRs), particularly the alpha7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or placebo, each for 1 week. All participants tolerated nicotine treatment well. Five subjects contributed data to the primary outcome, Aberrant Behavior Checklist-Irritability (ABC-I) subscale change from baseline, which was improved by nicotine compared to placebo. Sleep ratings were also improved by nicotine and correlated with ABC-I improvement. These findings support further investigation of nAChR agonists for aggression and sleep in ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3536-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model / Hafiz M. MAHMOOD in Autism Research, 13-8 (August 2020)
[article]
Titre : The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model Type de document : Texte imprimé et/ou numérique Auteurs : Hafiz M. MAHMOOD, Auteur ; Hesham M. ALDHALAAN, Auteur ; Tahani K. ALSHAMMARI, Auteur ; Mashael A. ALQASEM, Auteur ; Musaad A. ALSHAMMARI, Auteur ; Norah A. ALBEKAIRI, Auteur ; Shakir D. ALSHARARI, Auteur Article en page(s) : p.1311-1334 Langues : Anglais (eng) Mots-clés : BTBR T?+?tf/J autism nicotine nicotinic receptor Index. décimale : PER Périodiques Résumé : Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T?+?tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T?+?tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three-chamber social interaction, self-grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2?weeks in BTBR T?+?tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T?+?tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T?+?tf/J mice. Overall, the findings indicate that the pharmacological modulation of nicotinic receptors is involved in modulating core behavioral phenotypes in the BTBR T?+?tf/J mouse model. LAY SUMMARY: The involvement of brain nicotinic neurotransmission system plays a crucial role in regulating autism-related behavioral features. In addition, the brain of the autistic-like mouse model has a low acetylcholine level. Here, we report that nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy. Autism Res 2020, 13: 1311-1334. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Autism Research > 13-8 (August 2020) . - p.1311-1334[article] The Role of Nicotinic Receptors in the Attenuation of Autism-Related Behaviors in a Murine BTBR T + tf/J Autistic Model [Texte imprimé et/ou numérique] / Hafiz M. MAHMOOD, Auteur ; Hesham M. ALDHALAAN, Auteur ; Tahani K. ALSHAMMARI, Auteur ; Mashael A. ALQASEM, Auteur ; Musaad A. ALSHAMMARI, Auteur ; Norah A. ALBEKAIRI, Auteur ; Shakir D. ALSHARARI, Auteur . - p.1311-1334.
Langues : Anglais (eng)
in Autism Research > 13-8 (August 2020) . - p.1311-1334
Mots-clés : BTBR T?+?tf/J autism nicotine nicotinic receptor Index. décimale : PER Périodiques Résumé : Nicotinic receptors are distributed throughout the central and peripheral nervous system. Postmortem studies have reported that some nicotinic receptor subtypes are altered in the brains of autistic people. Recent studies have demonstrated the importance of nicotinic acetylcholine receptors (nAChRs) in the autistic behavior of BTBR T?+?tf/J mouse model of autism. This study was undertaken to examine the behavioral effects of targeted nAChRs using pharmacological ligands, including nicotine and mecamylamine in BTBR T?+?tf/J and C57BL/6J mice in a panel of behavioral tests relating to autism. These behavioral tests included the three-chamber social interaction, self-grooming, marble burying, locomotor activity, and rotarod test. We examined the effect of various oral doses of nicotine (50, 100, and 400 mcg/mL; po) over a period of 2?weeks in BTBR T?+?tf/J mouse model. The results indicated that the chronic administration of nicotine modulated sociability and repetitive behavior in BTBR T?+?tf/J mice while no effects observed in C57BL/6J mice. Furthermore, the nonselective nAChR antagonist, mecamylamine, reversed nicotine effects on sociability and increased repetitive behaviors in BTBR T?+?tf/J mice. Overall, the findings indicate that the pharmacological modulation of nicotinic receptors is involved in modulating core behavioral phenotypes in the BTBR T?+?tf/J mouse model. LAY SUMMARY: The involvement of brain nicotinic neurotransmission system plays a crucial role in regulating autism-related behavioral features. In addition, the brain of the autistic-like mouse model has a low acetylcholine level. Here, we report that nicotine, at certain doses, improved sociability and reduced repetitive behaviors in a mouse model of autism, implicating the potential therapeutic values of a pharmacological intervention targeting nicotinic receptors for autism therapy. Autism Res 2020, 13: 1311-1334. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2342 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430