4 recherche sur le mot-clé 'vasopressin'

Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes / Tanya L. PROCYSHYN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.750-756 Titre : Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes Type de document : texte imprimé Auteurs : Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur Article en page(s) : p.750-756 Langues : Anglais (eng) Mots-clés : attention  autism quotient  autism spectrum  avpr1a  microsatellite analysis  rs1  rs3  vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes [texte imprimé] / Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur . - p.750-756. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.750-756 Mots-clés : attention  autism quotient  autism spectrum  avpr1a  microsatellite analysis  rs1  rs3  vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees / Alexander WEISS in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1843-1853 Titre : Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees Type de document : texte imprimé Auteurs : Alexander WEISS, Auteur ; Vanessa A.D. WILSON, Auteur ; William D. HOPKINS, Auteur Article en page(s) : p.1843-1853 Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Genotype  Pan troglodytes/genetics  Receptors, Vasopressin/genetics  Social Behavior  Avpr1a  autism  development  mother  primate  vasopressin Index. décimale : PER Périodiques Résumé : Previous studies found associations between autism-related phenotypes and both rearing and V1A arginine vasopressin receptor (AVPR1A) genotypes. We tested whether these exposures as well as their interaction were associated with autism-related phenotypes in 121 laboratory-housed chimpanzees. We used expert-derived weights to obtain autism scores from ratings on the 43-item Chimpanzee Personality Questionnaire; higher scores indicated more autistic-like traits. The first model included fixed effects for sex, age, and rearing, and a random effect that addressed the relatedness of subjects. The second model was the same except that it also included the rearing × AVPR1A genotype interaction as a fixed effect. Both models indicated that the phenotype was moderately heritable and that chimpanzees reared by their mothers had lower scores on the scale. The effect of genotype in both models indicated that chimpanzees with an indel deletion had higher scores on the scale, although the credible interval included zero. Moreover, the rearing × genotype interaction in the second model indicated that chimpanzees who possessed the non-deletion genotype and who were reared by their mother were at even greater risk. The credible interval for this effect did not include zero, but fit statistics indicated that the model without the interaction was marginally better, and the interaction was in the opposite direction than we expected based on previous work. These findings highlight the importance of rearing effects in the typical social development of our closet-living nonhuman relative. LAY SUMMARY: We tested whether, in chimpanzees, scores on a scale comprising traits that resembled aspects of autism were related to a gene associated with autism in prior research and/or early rearing. Human-reared chimpanzees had higher scores (indicating more autistic-like traits). Chimpanzees that possessed the gene also had higher scores, but we could not exclude the possibility that there was no effect of genotype. These findings suggest that we can measure autism-like characteristics in chimpanzees, and so study it in this species. En ligne : http://dx.doi.org/10.1002/aur.2550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Early social rearing, the V1A arginine vasopressin receptor genotype, and autistic traits in chimpanzees [texte imprimé] / Alexander WEISS, Auteur ; Vanessa A.D. WILSON, Auteur ; William D. HOPKINS, Auteur . - p.1843-1853. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1843-1853 Mots-clés : Animals  Autism Spectrum Disorder/genetics  Autistic Disorder/genetics  Genotype  Pan troglodytes/genetics  Receptors, Vasopressin/genetics  Social Behavior  Avpr1a  autism  development  mother  primate  vasopressin Index. décimale : PER Périodiques Résumé : Previous studies found associations between autism-related phenotypes and both rearing and V1A arginine vasopressin receptor (AVPR1A) genotypes. We tested whether these exposures as well as their interaction were associated with autism-related phenotypes in 121 laboratory-housed chimpanzees. We used expert-derived weights to obtain autism scores from ratings on the 43-item Chimpanzee Personality Questionnaire; higher scores indicated more autistic-like traits. The first model included fixed effects for sex, age, and rearing, and a random effect that addressed the relatedness of subjects. The second model was the same except that it also included the rearing × AVPR1A genotype interaction as a fixed effect. Both models indicated that the phenotype was moderately heritable and that chimpanzees reared by their mothers had lower scores on the scale. The effect of genotype in both models indicated that chimpanzees with an indel deletion had higher scores on the scale, although the credible interval included zero. Moreover, the rearing × genotype interaction in the second model indicated that chimpanzees who possessed the non-deletion genotype and who were reared by their mother were at even greater risk. The credible interval for this effect did not include zero, but fit statistics indicated that the model without the interaction was marginally better, and the interaction was in the opposite direction than we expected based on previous work. These findings highlight the importance of rearing effects in the typical social development of our closet-living nonhuman relative. LAY SUMMARY: We tested whether, in chimpanzees, scores on a scale comprising traits that resembled aspects of autism were related to a gene associated with autism in prior research and/or early rearing. Human-reared chimpanzees had higher scores (indicating more autistic-like traits). Chimpanzees that possessed the gene also had higher scores, but we could not exclude the possibility that there was no effect of genotype. These findings suggest that we can measure autism-like characteristics in chimpanzees, and so study it in this species. En ligne : http://dx.doi.org/10.1002/aur.2550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms / Meghan MILLER in Autism Research, 6-2 (April 2013)  

Public ISBD [article]  inAutism Research > 6-2 (April 2013) . - p.91-102 Titre : Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms Type de document : texte imprimé Auteurs : Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur Année de publication : 2013 Article en page(s) : p.91-102 Langues : Anglais (eng) Mots-clés : neuropeptides  oxytocin  vasopressin  autism  sex differences  repetitive behaviors  anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199 [article] Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms [texte imprimé] / Meghan MILLER, Auteur ; Karen L. BALES, Auteur ; Sandra L. TAYLOR, Auteur ; Jong YOON, Auteur ; Caroline M. HOSTETLER, Auteur ; Cameron S. CARTER, Auteur ; Marjorie SOLOMON, Auteur . - 2013 . - p.91-102. Langues : Anglais (eng) in Autism Research > 6-2 (April 2013) . - p.91-102 Mots-clés : neuropeptides  oxytocin  vasopressin  autism  sex differences  repetitive behaviors  anxiety Index. décimale : PER Périodiques Résumé : There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high-functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. En ligne : http://dx.doi.org/10.1002/aur.1270 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199

Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives / Shubham DWIVEDI in Research in Autism, 133 (May 2026)  

Public ISBD [article]  inResearch in Autism > 133 (May 2026) . - p.202900 Titre : Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives Type de document : texte imprimé Auteurs : Shubham DWIVEDI, Auteur ; Monica TSCHANG, Auteur ; Amirthavarshini SUBBURAMAN, Auteur ; Sara VARGHESE, Auteur ; Swathi V. REDDY, Auteur ; Shalini SHUKLA, Auteur ; Shikha PANDEY, Auteur ; Priya GUPTA, Auteur ; Priyanka SHARMA, Auteur ; Dharmendra Prasad KEWAT, Auteur ; Deepak KUMAR, Auteur ; Dhruv PATEL, Auteur ; Reshu AGRAWAL, Auteur ; Ramu SINGH, Auteur ; Anglina KISKU, Auteur ; Sri Harshini GOLI, Auteur ; Kunjbihari SULAKHIYA, Auteur ; Suneel KUMAR, Auteur Article en page(s) : p.202900 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Vasopressin  Glutamate  GABA  Brain-derived neurotrophic factor  Genetics  Environmental factors Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by differences in social interaction, communication, and behavior. The etiology of ASD is multifaceted, with genetic, environmental, and epigenetic variables playing important roles. This complex interplay of factors has driven extensive research into the underlying molecular and neurological processes of ASD. As a result of these investigations, researchers have developed a more comprehensive understanding of the disorder’s underlying mechanisms, which has led to the identification of new therapeutic targets. This review discusses new targets, including synaptic plasticity regulators and immune system modulators. Despite significant advancements, several obstacles remain in ASD research, including variability in symptomatology, biomarker unavailability, and the need for individualized therapeutic strategies. The search for effective treatments is further complicated by the lack of robust clinical trials and ethical issues surrounding interventions. Here we discuss challenges in ASD management and propose innovative approaches to overcome them in future ASD research. Applying advanced technology and interdisciplinary expertise to the understanding of the interplay of biological and environmental factors that contribute to ASD will aid in the development of personalized therapies and overall improvement in the quality of life for individuals with ASD. En ligne : https://doi.org/10.1016/j.reia.2026.202900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Novel targets for autism spectrum disorder: Recent developments, challenges, and future perspectives [texte imprimé] / Shubham DWIVEDI, Auteur ; Monica TSCHANG, Auteur ; Amirthavarshini SUBBURAMAN, Auteur ; Sara VARGHESE, Auteur ; Swathi V. REDDY, Auteur ; Shalini SHUKLA, Auteur ; Shikha PANDEY, Auteur ; Priya GUPTA, Auteur ; Priyanka SHARMA, Auteur ; Dharmendra Prasad KEWAT, Auteur ; Deepak KUMAR, Auteur ; Dhruv PATEL, Auteur ; Reshu AGRAWAL, Auteur ; Ramu SINGH, Auteur ; Anglina KISKU, Auteur ; Sri Harshini GOLI, Auteur ; Kunjbihari SULAKHIYA, Auteur ; Suneel KUMAR, Auteur . - p.202900. Langues : Anglais (eng) in Research in Autism > 133 (May 2026) . - p.202900 Mots-clés : Autism spectrum disorder  Vasopressin  Glutamate  GABA  Brain-derived neurotrophic factor  Genetics  Environmental factors Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition marked by differences in social interaction, communication, and behavior. The etiology of ASD is multifaceted, with genetic, environmental, and epigenetic variables playing important roles. This complex interplay of factors has driven extensive research into the underlying molecular and neurological processes of ASD. As a result of these investigations, researchers have developed a more comprehensive understanding of the disorder’s underlying mechanisms, which has led to the identification of new therapeutic targets. This review discusses new targets, including synaptic plasticity regulators and immune system modulators. Despite significant advancements, several obstacles remain in ASD research, including variability in symptomatology, biomarker unavailability, and the need for individualized therapeutic strategies. The search for effective treatments is further complicated by the lack of robust clinical trials and ethical issues surrounding interventions. Here we discuss challenges in ASD management and propose innovative approaches to overcome them in future ASD research. Applying advanced technology and interdisciplinary expertise to the understanding of the interplay of biological and environmental factors that contribute to ASD will aid in the development of personalized therapies and overall improvement in the quality of life for individuals with ASD. En ligne : https://doi.org/10.1016/j.reia.2026.202900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585