Defining Positive Outcomes in More and Less Cognitively Able Autistic Adults / James B. MCCAULEY in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1548-1560 Titre : Defining Positive Outcomes in More and Less Cognitively Able Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : James B. MCCAULEY, Auteur ; Andrew PICKLES, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur Article en page(s) : p.1548-1560 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Identifying positive outcomes for a wide range of intellectual abilities in autism spectrum disorder (ASD) remains a challenge. Several past studies of autistic adults have used outcome definitions that do not reflect the experiences of less cognitively able adults. The aim of the current study was to (1) define three domains of outcomes: autonomy, social relationships, and purpose, and (2) examine how these outcomes relate to concurrent aspects of adult functioning. Using data from a longitudinal sample of 126 adults (85% diagnosed with ASD at some point), mean age 26, who first entered the study in early childhood, we generated distinct outcomes for less (daily living skills above an 8-year-old level, having regular activities outside the home, and social contacts outside the family) and more cognitively able adults (living independently, having paid employment, and at least one true friend). Verbal IQ, assessed in adulthood, was a significant predictor of more outcomes achieved for individuals within more and less cognitively able groups. For less cognitively able adults, having ever received a formal ASD diagnosis (in contrast to current Autism Diagnostic Observation Schedule [ADOS] CSS scores) was associated with lower odds of positive outcomes. For more cognitively able adults, living skills and happiness measures were positively associated with number of outcomes met; higher ADOS CSS, internalizing and externalizing symptoms, being racially diverse, and having caregiver education below college graduation were all negatively associated with the number of positive outcomes. Tailoring outcomes to ability levels may lead to better identification of goals and service needs. Lay Summary This article describes the outcomes of autistic adults who are more and less cognitively able. For less cognitively able individuals, an earlier autism diagnosis was negatively related to outcomes. Several factors that were associated with positive outcomes for more cognitively able individuals, including daily living skills, fewer mental health problems, family demographics, and subjective measures of happiness. Our study identifies several important factors for families, individuals, and service providers to consider and discuss when planning the transition to adulthood. Autism Res 2020, 13: 1548–1560. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Defining Positive Outcomes in More and Less Cognitively Able Autistic Adults [Texte imprimé et/ou numérique] / James B. MCCAULEY, Auteur ; Andrew PICKLES, Auteur ; Marisela HUERTA, Auteur ; Catherine LORD, Auteur . - p.1548-1560. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1548-1560 Index. décimale : PER Périodiques Résumé : Abstract Identifying positive outcomes for a wide range of intellectual abilities in autism spectrum disorder (ASD) remains a challenge. Several past studies of autistic adults have used outcome definitions that do not reflect the experiences of less cognitively able adults. The aim of the current study was to (1) define three domains of outcomes: autonomy, social relationships, and purpose, and (2) examine how these outcomes relate to concurrent aspects of adult functioning. Using data from a longitudinal sample of 126 adults (85% diagnosed with ASD at some point), mean age 26, who first entered the study in early childhood, we generated distinct outcomes for less (daily living skills above an 8-year-old level, having regular activities outside the home, and social contacts outside the family) and more cognitively able adults (living independently, having paid employment, and at least one true friend). Verbal IQ, assessed in adulthood, was a significant predictor of more outcomes achieved for individuals within more and less cognitively able groups. For less cognitively able adults, having ever received a formal ASD diagnosis (in contrast to current Autism Diagnostic Observation Schedule [ADOS] CSS scores) was associated with lower odds of positive outcomes. For more cognitively able adults, living skills and happiness measures were positively associated with number of outcomes met; higher ADOS CSS, internalizing and externalizing symptoms, being racially diverse, and having caregiver education below college graduation were all negatively associated with the number of positive outcomes. Tailoring outcomes to ability levels may lead to better identification of goals and service needs. Lay Summary This article describes the outcomes of autistic adults who are more and less cognitively able. For less cognitively able individuals, an earlier autism diagnosis was negatively related to outcomes. Several factors that were associated with positive outcomes for more cognitively able individuals, including daily living skills, fewer mental health problems, family demographics, and subjective measures of happiness. Our study identifies several important factors for families, individuals, and service providers to consider and discuss when planning the transition to adulthood. Autism Res 2020, 13: 1548–1560. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2359 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Development of the Observation Schedule for Children with Autism-Anxiety, Behaviour and Parenting (OSCA-ABP): A New Measure of Child and Parenting Behavior for Use with Young Autistic Children / Melanie PALMER in Journal of Autism and Developmental Disorders, 51-1 (January 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.1-14 Titre : Development of the Observation Schedule for Children with Autism-Anxiety, Behaviour and Parenting (OSCA-ABP): A New Measure of Child and Parenting Behavior for Use with Young Autistic Children Type de document : Texte imprimé et/ou numérique Auteurs : Melanie PALMER, Auteur ; Juan PARIS PEREZ, Auteur ; Joanne TARVER, Auteur ; Thomas CAWTHORNE, Auteur ; Margot FRAYNE, Auteur ; Sophie WEBB, Auteur ; Elena BAKER, Auteur ; Isabel YORKE, Auteur ; Dale F. HAY, Auteur ; Vicky SLONIMS, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Stephen SCOTT, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.1-14 Langues : Anglais (eng) Mots-clés : Autism  Child emotional and behavioral problems  Measurement  Observation  Parenting Index. décimale : PER Périodiques Résumé : Co-occurring emotional and behavioral problems (EBPs) frequently exist in young autistic children. There is evidence based on parental report that parenting interventions reduce child EBPs. More objective measures of child EBPs should supplement parent reported outcomes in trials. We describe the development of a new measure of child and parenting behavior, the Observation Schedule for Children with Autism-Anxiety, Behaviour and Parenting (OSCA-ABP). Participants were 83 parents/carers and their 4-8-year-old autistic children. The measure demonstrated good variance and potential sensitivity to change. Child and parenting behavior were reliably coded among verbal and minimally verbal children. Associations between reports from other informants and observed behavior showed the measure had sufficient convergent validity. The measure has promise to contribute to research and clinical practice in autism mental health beyond objective measurement in trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04506-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Development of the Observation Schedule for Children with Autism-Anxiety, Behaviour and Parenting (OSCA-ABP): A New Measure of Child and Parenting Behavior for Use with Young Autistic Children [Texte imprimé et/ou numérique] / Melanie PALMER, Auteur ; Juan PARIS PEREZ, Auteur ; Joanne TARVER, Auteur ; Thomas CAWTHORNE, Auteur ; Margot FRAYNE, Auteur ; Sophie WEBB, Auteur ; Elena BAKER, Auteur ; Isabel YORKE, Auteur ; Dale F. HAY, Auteur ; Vicky SLONIMS, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur ; Stephen SCOTT, Auteur ; Tony CHARMAN, Auteur . - p.1-14. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-1 (January 2021) . - p.1-14 Mots-clés : Autism  Child emotional and behavioral problems  Measurement  Observation  Parenting Index. décimale : PER Périodiques Résumé : Co-occurring emotional and behavioral problems (EBPs) frequently exist in young autistic children. There is evidence based on parental report that parenting interventions reduce child EBPs. More objective measures of child EBPs should supplement parent reported outcomes in trials. We describe the development of a new measure of child and parenting behavior, the Observation Schedule for Children with Autism-Anxiety, Behaviour and Parenting (OSCA-ABP). Participants were 83 parents/carers and their 4-8-year-old autistic children. The measure demonstrated good variance and potential sensitivity to change. Child and parenting behavior were reliably coded among verbal and minimally verbal children. Associations between reports from other informants and observed behavior showed the measure had sufficient convergent validity. The measure has promise to contribute to research and clinical practice in autism mental health beyond objective measurement in trials. En ligne : http://dx.doi.org/10.1007/s10803-020-04506-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders / Matthew J. HOLLOCKS in Journal of Autism and Developmental Disorders, 46-10 (October 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-10 (October 2016) . - p.3295-3307 Titre : Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Matthew J. HOLLOCKS, Auteur ; Andrew PICKLES, Auteur ; Patricia HOWLIN, Auteur ; Emily SIMONOFF, Auteur Article en page(s) : p.3295-3307 Langues : Anglais (eng) Mots-clés : Attention  Comorbidity  Cortisol  Emotion  Stress Index. décimale : PER Périodiques Résumé : Young people with autism spectrum disorder (ASD) have a high prevalence (~40 %) of anxiety disorders compared to their non-ASD peers. It is unclear whether cognitive and biological processes associated with anxiety in ASD are analogous to anxiety in typically developing (TD) populations. In this study 55 boys with ASD (34 with a co-occurring anxiety disorder, 21 without) and 28 male controls, aged 10–16 years and with a full-scale IQ ? 70, completed a series of clinical, cognitive (attention bias/interpretation bias) and biological measures (salivary cortisol/HR response to social stress) associated with anxiety in TD populations. Structural equation modelling was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2878-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293 [article] Dual Cognitive and Biological Correlates of Anxiety in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Matthew J. HOLLOCKS, Auteur ; Andrew PICKLES, Auteur ; Patricia HOWLIN, Auteur ; Emily SIMONOFF, Auteur . - p.3295-3307. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-10 (October 2016) . - p.3295-3307 Mots-clés : Attention  Comorbidity  Cortisol  Emotion  Stress Index. décimale : PER Périodiques Résumé : Young people with autism spectrum disorder (ASD) have a high prevalence (~40 %) of anxiety disorders compared to their non-ASD peers. It is unclear whether cognitive and biological processes associated with anxiety in ASD are analogous to anxiety in typically developing (TD) populations. In this study 55 boys with ASD (34 with a co-occurring anxiety disorder, 21 without) and 28 male controls, aged 10–16 years and with a full-scale IQ ? 70, completed a series of clinical, cognitive (attention bias/interpretation bias) and biological measures (salivary cortisol/HR response to social stress) associated with anxiety in TD populations. Structural equation modelling was used to reveal that that both attentional biases and physiological responsiveness were significant, but unrelated, predictors of anxiety in ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2878-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=293

Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample / Jeremy R. PARR in Journal of Autism and Developmental Disorders, 41-3 (March 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.332-340 Titre : Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur ; Gillian BAIRD, Auteur ; Michael RUTTER, Auteur ; Andrew PICKLES, Auteur ; Eric FOMBONNE, Auteur ; Anthony J. BAILEY, Auteur ; INTERNATIONAL MOLECULAR GENETIC STUDY OF AUTISM CONSORTIUM (IMGSAC), Auteur Année de publication : 2011 Article en page(s) : p.332-340 Langues : Anglais (eng) Mots-clés : ASD  Regression  Genetics  Language  Development  Concordance Index. décimale : PER Périodiques Résumé : The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. En ligne : http://dx.doi.org/10.1007/s10803-010-1055-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118 [article] Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample [Texte imprimé et/ou numérique] / Jeremy R. PARR, Auteur ; Ann LE COUTEUR, Auteur ; Gillian BAIRD, Auteur ; Michael RUTTER, Auteur ; Andrew PICKLES, Auteur ; Eric FOMBONNE, Auteur ; Anthony J. BAILEY, Auteur ; INTERNATIONAL MOLECULAR GENETIC STUDY OF AUTISM CONSORTIUM (IMGSAC), Auteur . - 2011 . - p.332-340. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-3 (March 2011) . - p.332-340 Mots-clés : ASD  Regression  Genetics  Language  Development  Concordance Index. décimale : PER Périodiques Résumé : The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself. En ligne : http://dx.doi.org/10.1007/s10803-010-1055-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=118

Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder / Rachael BEDFORD in Autism Research, 9-9 (September 2016)  

Public ISBD [article]  inAutism Research > 9-9 (September 2016) . - p.993-1001 Titre : Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachael BEDFORD, Auteur ; Andrew PICKLES, Auteur ; Catherine LORD, Auteur Article en page(s) : p.993-1001 Langues : Anglais (eng) Mots-clés : walking  language development  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background: Motor milestones such as the onset of walking are important developmental markers, not only for later motor skills but also for more widespread social-cognitive development. The aim of the current study was to test whether gross motor abilities, specifically the onset of walking, predicted the subsequent rate of language development in a large cohort of children with autism spectrum disorder (ASD). Methods: We ran growth curve models for expressive and receptive language measured at 2, 3, 5 and 9 years in 209 autistic children. Measures of gross motor, visual reception and autism symptoms were collected at the 2 year visit. In Model 1, walking onset was included as a predictor of the slope of language development. Model 2 included a measure of non-verbal IQ and autism symptom severity as covariates. The final model, Model 3, additionally covaried for gross motor ability. Results: In the first model, parent-reported age of walking onset significantly predicted the subsequent rate of language development although the relationship became non-significant when gross motor skill, non-verbal ability and autism severity scores were included (Models 2 & 3). Gross motor score, however, did remain a significant predictor of both expressive and receptive language development. Conclusions: Taken together, the model results provide some evidence that early motor abilities in young children with ASD can have longitudinal cross-domain influences, potentially contributing, in part, to the linguistic difficulties that characterise ASD. En ligne : http://dx.doi.org/10.1002/aur.1587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Early gross motor skills predict the subsequent development of language in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Rachael BEDFORD, Auteur ; Andrew PICKLES, Auteur ; Catherine LORD, Auteur . - p.993-1001. Langues : Anglais (eng) in Autism Research > 9-9 (September 2016) . - p.993-1001 Mots-clés : walking  language development  autism spectrum disorder Index. décimale : PER Périodiques Résumé : Background: Motor milestones such as the onset of walking are important developmental markers, not only for later motor skills but also for more widespread social-cognitive development. The aim of the current study was to test whether gross motor abilities, specifically the onset of walking, predicted the subsequent rate of language development in a large cohort of children with autism spectrum disorder (ASD). Methods: We ran growth curve models for expressive and receptive language measured at 2, 3, 5 and 9 years in 209 autistic children. Measures of gross motor, visual reception and autism symptoms were collected at the 2 year visit. In Model 1, walking onset was included as a predictor of the slope of language development. Model 2 included a measure of non-verbal IQ and autism symptom severity as covariates. The final model, Model 3, additionally covaried for gross motor ability. Results: In the first model, parent-reported age of walking onset significantly predicted the subsequent rate of language development although the relationship became non-significant when gross motor skill, non-verbal ability and autism severity scores were included (Models 2 & 3). Gross motor score, however, did remain a significant predictor of both expressive and receptive language development. Conclusions: Taken together, the model results provide some evidence that early motor abilities in young children with ASD can have longitudinal cross-domain influences, potentially contributing, in part, to the linguistic difficulties that characterise ASD. En ligne : http://dx.doi.org/10.1002/aur.1587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Editorial Perspective: The paradox of precision health in early development - building large samples to yield individual-level measures / Pasco FEARON ; Andrew PICKLES ; Emily J.H. JONES in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

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Evaluation of an adapted virtual training for master trainers of the WHO Caregiver Skills Training Program during the COVID-19 pandemic / Afiqah YUSUF ; Hannah PICKARD ; Pamela DIXON ; Andy SHIH ; Stephanie Shire ; Andrew PICKLES ; Mayada ELSABBAGH in Autism, 28-2 (February 2024)  

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Everyday Memory’ Impairments in Autism Spectrum Disorders / Catherine R. G. JONES in Journal of Autism and Developmental Disorders, 41-4 (April 2011)  

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Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 54-12 (December 2013)  

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Evidence for sex differences in fetal programming of physiological stress reactivity in infancy / Florin TIBU in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

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Factors associated with mental health symptoms among UK autistic children and young people and their parents during the COVID-19 pandemic / Melanie PALMER in Autism, 27-7 (October 2023)  

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Generalisation of Social Communication Skills by Autistic Children During Play-Based Assessments Across Home, School and an Unfamiliar Research Setting / Tony CHARMAN ; Kathy LEADBITTER ; Ceri ELLIS ; Lauren TAYLOR ; Heather MOORE ; Carol TAYLOR ; Kirsty JAMES ; Matea BALABANOVSKA ; Sophie LANGHORNE ; Catherine ALDRED ; Vicky SLONIMS ; Vicki GRAHAME ; Patricia HOWLIN ; Helen MCCONACHIE ; Jeremy PARR ; Richard EMSLEY ; Ann LE COUTEUR ; Jonathan GREEN ; Andrew PICKLES ; Pact- G. Trial Group AND THE in Journal of Autism and Developmental Disorders, 55-7 (July 2025)  

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Gut Permeability in Autism Spectrum Disorders / Neil R. DALTON in Autism Research, 7-3 (June 2014)  

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Heterogeneity and plasticity in the development of language: a 17-year follow-up of children referred early for possible autism / Andrew PICKLES in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

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How do autistic people fare in adult life and can we predict it from childhood? / Rachel KENT ; Tony CHARMAN ; Gillian BAIRD ; Andrew PICKLES ; Emily SIMONOFF in Autism Research, 16-2 (February 2023)  

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