Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders / Maria FIORENTINO in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 49p. Titre : Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders Type de document : texte imprimé Auteurs : Maria FIORENTINO, Auteur ; Anna SAPONE, Auteur ; Stefania SENGER, Auteur ; Stephanie S. CAMHI, Auteur ; Sarah M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; Deanna L. KELLY, Auteur ; Nicola CASCELLA, Auteur ; Alessio FASANO, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders [texte imprimé] / Maria FIORENTINO, Auteur ; Anna SAPONE, Auteur ; Stefania SENGER, Auteur ; Stephanie S. CAMHI, Auteur ; Sarah M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; Deanna L. KELLY, Auteur ; Nicola CASCELLA, Auteur ; Alessio FASANO, Auteur . - 49p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 49p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children / Calliope HOLINGUE in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1142-1155 Titre : Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children Type de document : texte imprimé Auteurs : Calliope HOLINGUE, Auteur ; Luther G. KALB, Auteur ; Rashelle J. MUSCI, Auteur ; Colleen LUKENS, Auteur ; Li-Ching LEE, Auteur ; Jamie KACZANIUK, Auteur ; Michelle LANDRUM, Auteur ; Timothy M. BUIE, Auteur ; M. Daniele FALLIN, Auteur Article en page(s) : p.1142-1155 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Constipation/diagnosis/epidemiology  Gastrointestinal Diseases/diagnosis/epidemiology  Humans  Prevalence  Psychometrics  autism  co-morbid conditions  questionnaire Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are one of the prevalent co-occurring issues in autism spectrum disorder (ASD), though the range of symptom frequency estimates varies dramatically across studies, which can limit the further research of GI issues in ASD as well as potential treatment strategies. The wide range of prevalence estimates is partly due to the lack of standardized, validated measures of GI symptoms among people with ASD. The goal of this study was to (1) develop a measure, which included non-verbal and mealtime behaviors, to assess for GI symptoms and (2) evaluate its psychometric characteristics. This was accomplished by drawing on two existing tools, Autism Treatment Network Gastrointestinal Inventory and the Brief Autism Mealtime Behavior Inventory, and deriving new items, to create the "ASD Gastrointestinal and Related Behaviors Inventory" (ASD-GIRBI). The ASD-GIRBI was piloted in an online registry of families with a child with ASD. A psychometric analysis was carried out in a sample of 334 children aged 6-17 years with ASD, resulting in a 36-item tool. The Cronbach's alpha for the overall scale was 0.88. Exploratory factor analysis identified a seven-factor model (1. Bowel movement pain; 2. Aggressive or disruptive during mealtimes; 3. Particular with foods; 4. Abdominal pain and upset stomach; 5. Refusing food; 6. Constipation and encopresis; 7. Motor or other behaviors). Following validation in an independent sample with clinical evaluation of GI symptoms, this tool will be helpful for both research and clinical purposes. En ligne : http://dx.doi.org/10.1002/aur.2707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Characteristics of the autism spectrum disorder gastrointestinal and related behaviors inventory in children [texte imprimé] / Calliope HOLINGUE, Auteur ; Luther G. KALB, Auteur ; Rashelle J. MUSCI, Auteur ; Colleen LUKENS, Auteur ; Li-Ching LEE, Auteur ; Jamie KACZANIUK, Auteur ; Michelle LANDRUM, Auteur ; Timothy M. BUIE, Auteur ; M. Daniele FALLIN, Auteur . - p.1142-1155. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1142-1155 Mots-clés : Autism Spectrum Disorder/complications/diagnosis/epidemiology  Child  Constipation/diagnosis/epidemiology  Gastrointestinal Diseases/diagnosis/epidemiology  Humans  Prevalence  Psychometrics  autism  co-morbid conditions  questionnaire Index. décimale : PER Périodiques Résumé : Gastrointestinal (GI) symptoms are one of the prevalent co-occurring issues in autism spectrum disorder (ASD), though the range of symptom frequency estimates varies dramatically across studies, which can limit the further research of GI issues in ASD as well as potential treatment strategies. The wide range of prevalence estimates is partly due to the lack of standardized, validated measures of GI symptoms among people with ASD. The goal of this study was to (1) develop a measure, which included non-verbal and mealtime behaviors, to assess for GI symptoms and (2) evaluate its psychometric characteristics. This was accomplished by drawing on two existing tools, Autism Treatment Network Gastrointestinal Inventory and the Brief Autism Mealtime Behavior Inventory, and deriving new items, to create the "ASD Gastrointestinal and Related Behaviors Inventory" (ASD-GIRBI). The ASD-GIRBI was piloted in an online registry of families with a child with ASD. A psychometric analysis was carried out in a sample of 334 children aged 6-17 years with ASD, resulting in a 36-item tool. The Cronbach's alpha for the overall scale was 0.88. Exploratory factor analysis identified a seven-factor model (1. Bowel movement pain; 2. Aggressive or disruptive during mealtimes; 3. Particular with foods; 4. Abdominal pain and upset stomach; 5. Refusing food; 6. Constipation and encopresis; 7. Motor or other behaviors). Following validation in an independent sample with clinical evaluation of GI symptoms, this tool will be helpful for both research and clinical purposes. En ligne : http://dx.doi.org/10.1002/aur.2707 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder / Kara Gross MARGOLIS in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362 Titre : Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Kara Gross MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; Anna E. SILBERMAN, Auteur ; Judith F. FELDMAN, Auteur ; Katherine F. MURRAY, Auteur ; Maureen MCSWIGGAN-HARDIN, Auteur ; Joseph LEVY, Auteur ; Margaret L. BAUMAN, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Agnes H. WHITAKER, Auteur ; Harland S. WINTER, Auteur Article en page(s) : p.349-362 Langues : Anglais (eng) Mots-clés : Autism  Behavior  Comorbidities  Gi  Gastrointestinal  Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder [texte imprimé] / Kara Gross MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; Anna E. SILBERMAN, Auteur ; Judith F. FELDMAN, Auteur ; Katherine F. MURRAY, Auteur ; Maureen MCSWIGGAN-HARDIN, Auteur ; Joseph LEVY, Auteur ; Margaret L. BAUMAN, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Agnes H. WHITAKER, Auteur ; Harland S. WINTER, Auteur . - p.349-362. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362 Mots-clés : Autism  Behavior  Comorbidities  Gi  Gastrointestinal  Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Gastrointestinal issues encountered in autism / Timothy M. BUIE

Public ISBD contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Titre : Gastrointestinal issues encountered in autism Type de document : texte imprimé Auteurs : Timothy M. BUIE, Auteur Année de publication : 2006 Importance : p.103-117 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791 contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Gastrointestinal issues encountered in autism [texte imprimé] / Timothy M. BUIE, Auteur . - 2006 . - p.103-117. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791

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Gastrointestinal Problems in Individuals with Autism Spectrum Disorders / Timothy M. BUIE

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Gastrointestinal Problems in Individuals with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Timothy M. BUIE, Auteur Année de publication : 2011 Importance : p.420-430 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Gastrointestinal Problems in Individuals with Autism Spectrum Disorders [texte imprimé] / Timothy M. BUIE, Auteur . - 2011 . - p.420-430. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

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Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation / Rafail I. KUSHAK in Autism, 15-3 (May 2011)  

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