Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders / M. FIORENTINO in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 49p. Titre : Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : M. FIORENTINO, Auteur ; A. SAPONE, Auteur ; S. SENGER, Auteur ; S. S. CAMHI, Auteur ; S. M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; D. L. KELLY, Auteur ; N. CASCELLA, Auteur ; A. FASANO, Auteur Article en page(s) : 49p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders [Texte imprimé et/ou numérique] / M. FIORENTINO, Auteur ; A. SAPONE, Auteur ; S. SENGER, Auteur ; S. S. CAMHI, Auteur ; S. M. KADZIELSKI, Auteur ; Timothy M. BUIE, Auteur ; D. L. KELLY, Auteur ; N. CASCELLA, Auteur ; A. FASANO, Auteur . - 49p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 49p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/genetics/immunology/metabolism/pathology  Biopsy  Blood-Brain Barrier/immunology/metabolism/pathology  Case-Control Studies  Cerebellum/immunology/metabolism/pathology  Cerebral Cortex/immunology/metabolism/pathology  Child  Child, Preschool  Claudin-3/genetics/immunology  Claudin-5/genetics/immunology  Claudins/genetics/immunology  DNA-Binding Proteins/genetics/immunology  Duodenum/immunology/metabolism/pathology  Female  Gene Expression  Humans  Interleukin-1beta/genetics/immunology  Interleukin-8/genetics/immunology  MARVEL Domain Containing 2 Protein/genetics/immunology  Male  Matrix Metalloproteinase 9/genetics/immunology  Middle Aged  Permeability  Schizophrenia/genetics/immunology/metabolism/pathology  Tight Junctions/immunology/metabolism/pathology  Autism spectrum disorders  Blood-brain barrier  Duodenal biopsies  Gut permeability  Gut-brain axis  Neuroinflammation  Postmortem brain  Schizophrenia Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders. Our goal was to investigate whether an altered BBB and gut permeability is part of the pathophysiology of ASD. METHODS: Postmortem cerebral cortex and cerebellum tissues from ASD, schizophrenia (SCZ), and healthy subjects (HC) and duodenal biopsies from ASD and HC were analyzed for gene and protein expression profiles. Tight junctions and other key molecules associated with the neurovascular unit integrity and function and neuroinflammation were investigated. RESULTS: Claudin (CLDN)-5 and -12 were increased in the ASD cortex and cerebellum. CLDN-3, tricellulin, and MMP-9 were higher in the ASD cortex. IL-8, tPA, and IBA-1 were downregulated in SCZ cortex; IL-1b was increased in the SCZ cerebellum. Differences between SCZ and ASD were observed for most of the genes analyzed in both brain areas. CLDN-5 protein was increased in ASD cortex and cerebellum, while CLDN-12 appeared reduced in both ASD and SCZ cortexes. In the intestine, 75% of the ASD samples analyzed had reduced expression of barrier-forming TJ components (CLDN-1, OCLN, TRIC), whereas 66% had increased pore-forming CLDNs (CLDN-2, -10, -15) compared to controls. CONCLUSIONS: In the ASD brain, there is an altered expression of genes associated with BBB integrity coupled with increased neuroinflammation and possibly impaired gut barrier integrity. While these findings seem to be specific for ASD, the possibility of more distinct SCZ subgroups should be explored with additional studies. En ligne : http://dx.doi.org/10.1186/s13229-016-0110-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder / K. G. MARGOLIS in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362 Titre : Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. G. MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; A. E. SILBERMAN, Auteur ; J. F. FELDMAN, Auteur ; K. F. MURRAY, Auteur ; M. MCSWIGGAN-HARDIN, Auteur ; J. LEVY, Auteur ; M. L. BAUMAN, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; A. H. WHITAKER, Auteur ; Harland S. WINTER, Auteur Article en page(s) : p.349-362 Langues : Anglais (eng) Mots-clés : Autism  Behavior  Comorbidities  Gi  Gastrointestinal  Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / K. G. MARGOLIS, Auteur ; Timothy M. BUIE, Auteur ; J. Blake TURNER, Auteur ; A. E. SILBERMAN, Auteur ; J. F. FELDMAN, Auteur ; K. F. MURRAY, Auteur ; M. MCSWIGGAN-HARDIN, Auteur ; J. LEVY, Auteur ; M. L. BAUMAN, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; A. H. WHITAKER, Auteur ; Harland S. WINTER, Auteur . - p.349-362. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.349-362 Mots-clés : Autism  Behavior  Comorbidities  Gi  Gastrointestinal  Screen Index. décimale : PER Périodiques Résumé : Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in both clinical practice and research. En ligne : http://dx.doi.org/10.1007/s10803-018-3767-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Gastrointestinal issues encountered in autism / Timothy M. BUIE

Public ISBD contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Titre : Gastrointestinal issues encountered in autism Type de document : Texte imprimé et/ou numérique Auteurs : Timothy M. BUIE, Auteur Année de publication : 2006 Importance : p.103-117 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791 contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Gastrointestinal issues encountered in autism [Texte imprimé et/ou numérique] / Timothy M. BUIE, Auteur . - 2006 . - p.103-117. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791

Exemplaires

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Gastrointestinal Problems in Individuals with Autism Spectrum Disorders / Timothy M. BUIE

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Gastrointestinal Problems in Individuals with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Timothy M. BUIE, Auteur Année de publication : 2011 Importance : p.420-430 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Gastrointestinal Problems in Individuals with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Timothy M. BUIE, Auteur . - 2011 . - p.420-430. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

Exemplaires

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aucun exemplaire

Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation / Rafail I. KUSHAK in Autism, 15-3 (May 2011)  

Public ISBD [article]  inAutism > 15-3 (May 2011) . - p.285-294 Titre : Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation Type de document : Texte imprimé et/ou numérique Auteurs : Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur Année de publication : 2011 Article en page(s) : p.285-294 Langues : Anglais (eng) Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130 [article] Intestinal disaccharidase activity in patients with autism. Effect of age, gender, and intestinal inflammation [Texte imprimé et/ou numérique] / Rafail I. KUSHAK, Auteur ; Gregory Y. LAUWERS, Auteur ; Harland S. WINTER, Auteur ; Timothy M. BUIE, Auteur . - 2011 . - p.285-294. Langues : Anglais (eng) in Autism > 15-3 (May 2011) . - p.285-294 Mots-clés : autism  disaccharidases  inflammation  intestine Index. décimale : PER Périodiques Résumé : Intestinal disaccharidase activities were measured in 199 individuals with autism to determine the frequency of enzyme deficiency. All patients had duodenal biopsies that were evaluated morphologically and assayed for lactase, sucrase, and maltase activity. Frequency of lactase deficiency was 58% in autistic children ≤ 5 years old and 65% in older patients. As would be expected, patients with autism at age 5 > years demonstrated significant decline in lactase activity (24%, p = .02) in comparison with ≤ 5 years old autistic patients. Boys ≤ 5 years old with autism had 1.7 fold lower lactase activity than girls with autism (p = .02). Only 6% of autistic patients had intestinal inflammation. Lactase deficiency not associated with intestinal inflammation or injury is common in autistic children and may contribute to abdominal discomfort, pain and observed aberrant behavior. Most autistic children with lactose intolerance are not identified by clinical history. En ligne : http://dx.doi.org/10.1177/1362361310369142 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=130

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