Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 40-9 (September 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Titre : Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study Type de document : Texte imprimé et/ou numérique Auteurs : Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur Année de publication : 2010 Article en page(s) : p.1080-1093 Langues : Anglais (eng) Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Comorbid Psychiatric Disorders Associated with Asperger Syndrome/High-functioning Autism: A Community- and Clinic-based Study [Texte imprimé et/ou numérique] / Marja-Leena MATTILA, Auteur ; Sanna KUUSIKKO, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Leena JOSKITT, Auteur ; Tuula HURTIG, Auteur ; Helena HAAPSAMO, Auteur ; David L. PAULS, Auteur ; Irma MOILANEN, Auteur ; Hanna EBELING, Auteur ; Katja JUSSILA, Auteur ; Risto BLOIGU, Auteur . - 2010 . - p.1080-1093. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1080-1093 Mots-clés : Comorbidity CGAS Asperger-syndrome Autism Pervasive-developmental-disorders Autism-spectrum-disorders Index. décimale : PER Périodiques Résumé : The present study identifies the prevalence and types of comorbid psychiatric disorders associated with Asperger syndrome (AS)/high-functioning autism (HFA) in a combined community- and clinic-based sample of fifty 9- to 16-year-old subjects using the Schedule for Affective Disorders and Schizophrenia for School-Age Children, Present and Lifetime Version. The level of functioning was estimated using the Children’s Global Assessment Scale. The results support common (prevalence 74%) and often multiple comorbid psychiatric disorders in AS/HFA; behavioral disorders were shown in 44%, anxiety disorders in 42% and tic disorders in 26%. Oppositional defiant disorder, major depressive disorder and anxiety disorders as comorbid conditions indicated significantly lower levels of functioning. To target interventions, routine evaluation of psychiatric comorbidity in subjects with AS/HFA is emphasized. En ligne : http://dx.doi.org/10.1007/s10803-010-0958-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder / Katja JUSSILA in Research in Autism Spectrum Disorders, 9 (January 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 9 (January 2015) . - p.38-44 Titre : Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Katja JUSSILA, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Marja-Leena MATTILA, Auteur ; Soile LOUKUSA, Auteur ; Rachel POLLOCK-WURMAN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Tuula HURTIG, Auteur Année de publication : 2015 Article en page(s) : p.38-44 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Social reciprocity  Social Responsiveness Scale  Cross-cultural differences  Screening Index. décimale : PER Périodiques Résumé : Abstract When importing screening questionnaires of ASD, it has been found that parental interpretation/reporting of autistic traits may be culturally influenced. In the current study, our aim was preliminary evaluation of the Finnish parent rated SRS in order to determine whether the measure would show promise as an aid in screening. The study sample consisted of high-functioning school aged male ASD outpatients of Oulu University Hospital (n = 44, age 11.4 ± 2.3) and age-matched controls (n = 44, age 11.8 ± 2.4 years). Internal consistency as well as convergent and discriminative validity was in line with previous research. However, the results indicated that the cut-off published in the SRS manual might be too high to be used in Finland. Our results emphasize the importance of determining the normative range and clinical cut-offs in various cultures when importing diagnostic screening questionnaires in order to avoid getting high percentages of false negatives in the screening phase, and thus risk leaving many children without adequate diagnostic evaluation and rehabilitation. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Cross-cultural differences in the Parent Rated Social Responsiveness Scale (SRS)? Evaluation of the Finnish version among high-functioning school aged males with and without autism spectrum disorder [Texte imprimé et/ou numérique] / Katja JUSSILA, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Marja-Leena MATTILA, Auteur ; Soile LOUKUSA, Auteur ; Rachel POLLOCK-WURMAN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Tuula HURTIG, Auteur . - 2015 . - p.38-44. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.38-44 Mots-clés : Autism spectrum disorder  Social reciprocity  Social Responsiveness Scale  Cross-cultural differences  Screening Index. décimale : PER Périodiques Résumé : Abstract When importing screening questionnaires of ASD, it has been found that parental interpretation/reporting of autistic traits may be culturally influenced. In the current study, our aim was preliminary evaluation of the Finnish parent rated SRS in order to determine whether the measure would show promise as an aid in screening. The study sample consisted of high-functioning school aged male ASD outpatients of Oulu University Hospital (n = 44, age 11.4 ± 2.3) and age-matched controls (n = 44, age 11.8 ± 2.4 years). Internal consistency as well as convergent and discriminative validity was in line with previous research. However, the results indicated that the cut-off published in the SRS manual might be too high to be used in Finland. Our results emphasize the importance of determining the normative range and clinical cut-offs in various cultures when importing diagnostic screening questionnaires in order to avoid getting high percentages of false negatives in the screening phase, and thus risk leaving many children without adequate diagnostic evaluation and rehabilitation. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder / Ville RAATIKAINEN in Autism Research, 13-2 (February 2020)  

Public ISBD [article]  inAutism Research > 13-2 (February 2020) . - p.244-258 Titre : Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur Article en page(s) : p.244-258 Langues : Anglais (eng) Mots-clés : Asd  Mreg  dynamic lag analysis  human brain  lag pattern  resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 [article] Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder [Texte imprimé et/ou numérique] / Ville RAATIKAINEN, Auteur ; Vesa KORHONEN, Auteur ; Viola BORCHARDT, Auteur ; Niko HUOTARI, Auteur ; Heta HELAKARI, Auteur ; Janne KANANEN, Auteur ; Lauri RAITAMAA, Auteur ; Leena JOSKITT, Auteur ; Soile LOUKUSA, Auteur ; Tuula HURTIG, Auteur ; Hanna EBELING, Auteur ; Lucina Q. UDDIN, Auteur ; Vesa KIVINIEMI, Auteur ; Finnish Epilepsy ASSOCIATION, Auteur ; Instrumentariumin TIEDESAATIO, Auteur ; Jane ja Aatos Erkon SAATIO, Auteur . - p.244-258. Langues : Anglais (eng) in Autism Research > 13-2 (February 2020) . - p.244-258 Mots-clés : Asd  Mreg  dynamic lag analysis  human brain  lag pattern  resting state fMRI Index. décimale : PER Périodiques Résumé : This study investigated whole-brain dynamic lag pattern variations between neurotypical (NT) individuals and individuals with autism spectrum disorder (ASD) by applying a novel technique called dynamic lag analysis (DLA). The use of 3D magnetic resonance encephalography data with repetition time = 100 msec enables highly accurate analysis of the spread of activity between brain networks. Sixteen resting-state networks (RSNs) with the highest spatial correlation between NT individuals (n = 20) and individuals with ASD (n = 20) were analyzed. The dynamic lag pattern variation between each RSN pair was investigated using DLA, which measures time lag variation between each RSN pair combination and statistically defines how these lag patterns are altered between ASD and NT groups. DLA analyses indicated that 10.8% of the 120 RSN pairs had statistically significant (P-value <0.003) dynamic lag pattern differences that survived correction with surrogate data thresholding. Alterations in lag patterns were concentrated in salience, executive, visual, and default-mode networks, supporting earlier findings of impaired brain connectivity in these regions in ASD. 92.3% and 84.6% of the significant RSN pairs revealed shorter mean and median temporal lags in ASD versus NT, respectively. Taken together, these results suggest that altered lag patterns indicating atypical spread of activity between large-scale functional brain networks may contribute to the ASD phenotype. Autism Res 2020, 13: 244-258. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Autism spectrum disorder (ASD) is characterized by atypical neurodevelopment. Using an ultra-fast neuroimaging procedure, we investigated communication across brain regions in adults with ASD compared with neurotypical (NT) individuals. We found that ASD individuals had altered information flow patterns across brain regions. Atypical patterns were concentrated in salience, executive, visual, and default-mode network areas of the brain that have previously been implicated in the pathophysiology of the disorder. En ligne : http://dx.doi.org/10.1002/aur.2218 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420

Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism / Tuula HURTIG in Autism, 13-6 (November 2009)  

Public ISBD [article]  inAutism > 13-6 (November 2009) . - p.583-598 Titre : Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism Type de document : Texte imprimé et/ou numérique Auteurs : Tuula HURTIG, Auteur ; Sanna KUUSIKKO, Auteur ; Katja JUSSILA, Auteur ; Marja-Leena MATTILA, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Helena HAAPSAMO, Auteur ; Leena JOSKITT, Auteur Année de publication : 2009 Article en page(s) : p.583-598 Langues : Anglais (eng) Mots-clés : adolescents anxiety Asperger-syndrome depression high-functioning-autism multi-informant-reports psychiatric-symptoms Index. décimale : PER Périodiques Résumé : The aim of the study was to examine psychiatric symptoms in high-functioning adolescents with autism spectrum disorders reported by multiple informants. Forty-three 11- to 17-year-old adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) and 217 typically developed adolescents completed the Youth Self-Report (YSR), while their parents completed the Child Behavior Checklist (CBCL). Teachers of adolescents with AS/HFA completed the Teacher Report Form (TRF). The informants reported significantly more psychiatric symptoms, especially withdrawn, anxious/depressed, social and attention problems, in adolescents with AS/HFA than in controls. In contrast to findings in the general population, the psychiatric problems of adolescents with AS/HFA are well acknowledged by multiple informants, including self-reports. However, anxiety and depressive symptoms were more commonly reported by adolescents with AS/HFA and their teachers than their parents, indicating that some emotional distress may be hidden from their parents. En ligne : http://dx.doi.org/10.1177/1362361309335719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=924 [article] Multi-informant reports of psychiatric symptoms among high-functioning adolescents with Asperger syndrome or autism [Texte imprimé et/ou numérique] / Tuula HURTIG, Auteur ; Sanna KUUSIKKO, Auteur ; Katja JUSSILA, Auteur ; Marja-Leena MATTILA, Auteur ; Hanna EBELING, Auteur ; Irma MOILANEN, Auteur ; David L. PAULS, Auteur ; Helena HAAPSAMO, Auteur ; Leena JOSKITT, Auteur . - 2009 . - p.583-598. Langues : Anglais (eng) in Autism > 13-6 (November 2009) . - p.583-598 Mots-clés : adolescents anxiety Asperger-syndrome depression high-functioning-autism multi-informant-reports psychiatric-symptoms Index. décimale : PER Périodiques Résumé : The aim of the study was to examine psychiatric symptoms in high-functioning adolescents with autism spectrum disorders reported by multiple informants. Forty-three 11- to 17-year-old adolescents with Asperger syndrome (AS) or high-functioning autism (HFA) and 217 typically developed adolescents completed the Youth Self-Report (YSR), while their parents completed the Child Behavior Checklist (CBCL). Teachers of adolescents with AS/HFA completed the Teacher Report Form (TRF). The informants reported significantly more psychiatric symptoms, especially withdrawn, anxious/depressed, social and attention problems, in adolescents with AS/HFA than in controls. In contrast to findings in the general population, the psychiatric problems of adolescents with AS/HFA are well acknowledged by multiple informants, including self-reports. However, anxiety and depressive symptoms were more commonly reported by adolescents with AS/HFA and their teachers than their parents, indicating that some emotional distress may be hidden from their parents. En ligne : http://dx.doi.org/10.1177/1362361309335719 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=924

Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening / Marja-Leena MATTILA in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2162-2180 Titre : Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening Type de document : Texte imprimé et/ou numérique Auteurs : Marja-Leena MATTILA, Auteur ; Katja JUSSILA, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Risto BLOIGU, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur ; Irma MOILANEN, Auteur Année de publication : 2012 Article en page(s) : p.2162-2180 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Asperger’s syndrome  Autism  Autism Spectrum Screening Questionnaire  ASSQ  Validation Index. décimale : PER Périodiques Résumé : We assessed the validity and determined cut-off scores for the Finnish Autism Spectrum Screening Questionnaire (ASSQ). A population sample of 8-year-old children (n = 4,408) was rated via the ASSQ by parents and/or teachers, and a subgroup of 104 children was examined via structured interview, semi-structured observation, IQ measurement, school observation, and medical records. Autism spectrum disorders (ASDs) were diagnosed following DSM-IV-TR criteria. A search for hospital-registered ASDs was performed. For Finnish higher-functioning primary school-aged, 7- to 12-year-olds, the optimal cut-off score was 30 in clinical settings and 28 in total population screening using summed ASSQ scores of parents’ and teachers’ ratings. Determining appropriate cut-off scores in ASD screening in different languages and in different cultures is of utmost importance. En ligne : http://dx.doi.org/10.1007/s10803-012-1464-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Validation of the Finnish Autism Spectrum Screening Questionnaire (ASSQ) for Clinical Settings and Total Population Screening [Texte imprimé et/ou numérique] / Marja-Leena MATTILA, Auteur ; Katja JUSSILA, Auteur ; SIRKKA-LIISA LINNA, Auteur ; Marko KIELINEN, Auteur ; Risto BLOIGU, Auteur ; Sanna KUUSIKKO-GAUFFIN, Auteur ; Leena JOSKITT, Auteur ; Hanna EBELING, Auteur ; Tuula HURTIG, Auteur ; Irma MOILANEN, Auteur . - 2012 . - p.2162-2180. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2162-2180 Mots-clés : Autism spectrum disorder  Asperger’s syndrome  Autism  Autism Spectrum Screening Questionnaire  ASSQ  Validation Index. décimale : PER Périodiques Résumé : We assessed the validity and determined cut-off scores for the Finnish Autism Spectrum Screening Questionnaire (ASSQ). A population sample of 8-year-old children (n = 4,408) was rated via the ASSQ by parents and/or teachers, and a subgroup of 104 children was examined via structured interview, semi-structured observation, IQ measurement, school observation, and medical records. Autism spectrum disorders (ASDs) were diagnosed following DSM-IV-TR criteria. A search for hospital-registered ASDs was performed. For Finnish higher-functioning primary school-aged, 7- to 12-year-olds, the optimal cut-off score was 30 in clinical settings and 28 in total population screening using summed ASSQ scores of parents’ and teachers’ ratings. Determining appropriate cut-off scores in ASD screening in different languages and in different cultures is of utmost importance. En ligne : http://dx.doi.org/10.1007/s10803-012-1464-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

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