Brief Report: Animacy and Word Order in Individuals with Autism Spectrum Disorders / Johanna K. LAKE in Journal of Autism and Developmental Disorders, 40-9 (September 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1161-1164 Titre : Brief Report: Animacy and Word Order in Individuals with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Shannon CARDY, Auteur ; Karin R. HUMPHREYS, Auteur Année de publication : 2010 Article en page(s) : p.1161-1164 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorder Word-order Animacy Language-production Conceptual-salience Index. décimale : PER Périodiques Résumé : Individuals with autism or autism spectrum disorders (ASDs) are known to have difficulties discriminating animacy and are less likely to attend to animate stimuli, which may underlie the social deficits of autism. For individuals without ASD, animacy also affects word order choices: speakers choose syntactic structures (active vs. passive) that place animate entities as the grammatical subject, as a result of their conceptual salience. This study tested whether highly verbal adults with ASD would show sensitivity to animacy in a picture description task. Results showed that individuals with ASD were as sensitive to animacy as controls, and overwhelmingly placed animate entities as the grammatical subject. One stimulus proved an exception, where only individuals with ASD placed an inanimate entity (a clock) in subject position in preference to an animate one (a boy), which coincides with previous observations that individuals with autism find clocks highly salient. This study provides converging evidence of the role of conceptual salience in word order choices, and furthermore shows animate entities to be highly salient for individuals with ASD, at least as it pertains to these word order choices. En ligne : http://dx.doi.org/10.1007/s10803-010-0972-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] Brief Report: Animacy and Word Order in Individuals with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Shannon CARDY, Auteur ; Karin R. HUMPHREYS, Auteur . - 2010 . - p.1161-1164. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-9 (September 2010) . - p.1161-1164 Mots-clés : Autism-spectrum-disorder Word-order Animacy Language-production Conceptual-salience Index. décimale : PER Périodiques Résumé : Individuals with autism or autism spectrum disorders (ASDs) are known to have difficulties discriminating animacy and are less likely to attend to animate stimuli, which may underlie the social deficits of autism. For individuals without ASD, animacy also affects word order choices: speakers choose syntactic structures (active vs. passive) that place animate entities as the grammatical subject, as a result of their conceptual salience. This study tested whether highly verbal adults with ASD would show sensitivity to animacy in a picture description task. Results showed that individuals with ASD were as sensitive to animacy as controls, and overwhelmingly placed animate entities as the grammatical subject. One stimulus proved an exception, where only individuals with ASD placed an inanimate entity (a clock) in subject position in preference to an animate one (a boy), which coincides with previous observations that individuals with autism find clocks highly salient. This study provides converging evidence of the role of conceptual salience in word order choices, and furthermore shows animate entities to be highly salient for individuals with ASD, at least as it pertains to these word order choices. En ligne : http://dx.doi.org/10.1007/s10803-010-0972-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder / Johanna K. LAKE in Journal of Autism and Developmental Disorders, 47-5 (May 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1391-1402 Titre : Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Danica DENTON, Auteur ; Yona LUNSKY, Auteur ; Amy M. SHUI, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Evdokia ANAGNOSTOU, Auteur Article en page(s) : p.1391-1402 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Atypical antipsychotic medication  Children Index. décimale : PER Périodiques Résumé : This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2–11 (n?=?4749) and those 12–17 (n?=?401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-017-3058-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Medical Conditions and Demographic, Service and Clinical Factors Associated with Atypical Antipsychotic Medication Use Among Children with An Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Danica DENTON, Auteur ; Yona LUNSKY, Auteur ; Amy M. SHUI, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; Evdokia ANAGNOSTOU, Auteur . - p.1391-1402. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-5 (May 2017) . - p.1391-1402 Mots-clés : Autism spectrum disorder  Atypical antipsychotic medication  Children Index. décimale : PER Périodiques Résumé : This study aimed to describe rates of antipsychotic medication use and the association between their use and demographics, clinical variables, and the use of behavioral/education services among children with ASD. For children with ASD ages 2–11 (n?=?4749) and those 12–17 (n?=?401), 5.4 and 17.7% were prescribed at least one atypical antipsychotic medication respectively. In the multivariable model of young children, older age, use of multiple psychotropic medications, prior ASD diagnosis, non-white Hispanic race/ethnicity, and oppositional defiant problems were associated with antipsychotic use. Among older children, only older age was associated with antipsychotic use. In at least one age group, antipsychotic medication use was also related to behaviour, family and occupational therapy, public insurance, site region, externalizing problems, body mass index, and sleep and gastrointestinal problems. En ligne : http://dx.doi.org/10.1007/s10803-017-3058-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Parent Perspectives on Psychotropic Medication Use and Interactions With Prescribing Health Care Providers Among Adolescents and Adults With an Autism Spectrum Disorder / Johanna K. LAKE in Focus on Autism and Other Developmental Disabilities, 30-3 (September 2015)  

Public ISBD [article]  inFocus on Autism and Other Developmental Disabilities > 30-3 (September 2015) . - p.165-173 Titre : Parent Perspectives on Psychotropic Medication Use and Interactions With Prescribing Health Care Providers Among Adolescents and Adults With an Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Alexander MILOVANOV, Auteur ; Amanda SAWYER, Auteur ; Yona LUNSKY, Auteur Article en page(s) : p.165-173 Langues : Anglais (eng) Mots-clés : adults  adolescents  autism spectrum disorder  support systems  parents  medication  health care providers Index. décimale : PER Périodiques Résumé : Adolescents and young adults with an autism spectrum disorder (ASD) are often prescribed psychotropic medications to treat mental health and behavioral issues, and parents of these individuals play a crucial role in overseeing this care. Despite this, little is known about parents’ experiences managing and monitoring their child’s medication treatment, or their experience interacting with prescribing health care providers. To learn more about parents’ perspectives on psychotropic medication use in their adolescent or young adult with ASD, a focus group was conducted with seven mothers whose adolescent or adult child with ASD was prescribed one or more psychotropic medications. Results are summarized according to emergent themes including parent perception of child experience with medication, side effects, medication efficacy, medication monitoring, expertise issues, and service issues. Parents also provided medication recommendations, including a desire for health care providers with greater expertise in ASD, information on medication, and tools for medication monitoring. En ligne : http://dx.doi.org/10.1177/1088357614559215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=266 [article] Parent Perspectives on Psychotropic Medication Use and Interactions With Prescribing Health Care Providers Among Adolescents and Adults With an Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Alexander MILOVANOV, Auteur ; Amanda SAWYER, Auteur ; Yona LUNSKY, Auteur . - p.165-173. Langues : Anglais (eng) in Focus on Autism and Other Developmental Disabilities > 30-3 (September 2015) . - p.165-173 Mots-clés : adults  adolescents  autism spectrum disorder  support systems  parents  medication  health care providers Index. décimale : PER Périodiques Résumé : Adolescents and young adults with an autism spectrum disorder (ASD) are often prescribed psychotropic medications to treat mental health and behavioral issues, and parents of these individuals play a crucial role in overseeing this care. Despite this, little is known about parents’ experiences managing and monitoring their child’s medication treatment, or their experience interacting with prescribing health care providers. To learn more about parents’ perspectives on psychotropic medication use in their adolescent or young adult with ASD, a focus group was conducted with seven mothers whose adolescent or adult child with ASD was prescribed one or more psychotropic medications. Results are summarized according to emergent themes including parent perception of child experience with medication, side effects, medication efficacy, medication monitoring, expertise issues, and service issues. Parents also provided medication recommendations, including a desire for health care providers with greater expertise in ASD, information on medication, and tools for medication monitoring. En ligne : http://dx.doi.org/10.1177/1088357614559215 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=266

Polypharmacy profiles and predictors among adults with autism spectrum disorders / Johanna K. LAKE in Research in Autism Spectrum Disorders, 6-3 (July-September 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1142-1149 Titre : Polypharmacy profiles and predictors among adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Johanna K. LAKE, Auteur ; Robert BALOGH, Auteur ; Yona LUNSKY, Auteur Année de publication : 2012 Article en page(s) : p.1142-1149 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Medication  Polypharmacy  Psychotropic medication Index. décimale : PER Périodiques Résumé : Pharmacological interventions are frequently used to treat commonly associated mental health and behavioural issues in individuals with autism spectrum disorders (ASD). Despite high rates of psychotropic drug use documented in children with ASD, very few studies have examined medication profiles, side effects, and rates of polypharmacy in adolescents and adults with ASD. To address this, we examined medication profiles and predictors of polypharmacy among 142 adults with ASD who had experienced a psychiatric crisis. Of the 142 adults sampled, 91 (64.1%) were prescribed at least 1 psychotropic medication and 41 (28.9%) were taking 3 or more psychotropic medications. Variables associated with and predictive of polypharmacy included history of aggression, residence, and psychiatric support. Adults with ASD are a highly medicated population and polypharmacy is a significant concern in this vulnerable group of individuals. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154 [article] Polypharmacy profiles and predictors among adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Johanna K. LAKE, Auteur ; Robert BALOGH, Auteur ; Yona LUNSKY, Auteur . - 2012 . - p.1142-1149. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-3 (July-September 2012) . - p.1142-1149 Mots-clés : Autism spectrum disorder  Medication  Polypharmacy  Psychotropic medication Index. décimale : PER Périodiques Résumé : Pharmacological interventions are frequently used to treat commonly associated mental health and behavioural issues in individuals with autism spectrum disorders (ASD). Despite high rates of psychotropic drug use documented in children with ASD, very few studies have examined medication profiles, side effects, and rates of polypharmacy in adolescents and adults with ASD. To address this, we examined medication profiles and predictors of polypharmacy among 142 adults with ASD who had experienced a psychiatric crisis. Of the 142 adults sampled, 91 (64.1%) were prescribed at least 1 psychotropic medication and 41 (28.9%) were taking 3 or more psychotropic medications. Variables associated with and predictive of polypharmacy included history of aggression, residence, and psychiatric support. Adults with ASD are a highly medicated population and polypharmacy is a significant concern in this vulnerable group of individuals. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.03.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=154

Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review / Amanda SAWYER in Research in Autism Spectrum Disorders, 8-7 (July 2014)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813 Titre : Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur Article en page(s) : p.803-813 Langues : Anglais (eng) Mots-clés : Autism  Adults  Challenging behaviours  Psychopharmacology  Intellectual disability Index. décimale : PER Périodiques Résumé : AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Psychopharmacological treatment of challenging behaviours in adults with autism and intellectual disabilities: A systematic review [Texte imprimé et/ou numérique] / Amanda SAWYER, Auteur ; Johanna K. LAKE, Auteur ; Yona LUNSKY, Auteur ; Shi-Kai LIU, Auteur ; Pushpal DESARKAR, Auteur . - p.803-813. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.803-813 Mots-clés : Autism  Adults  Challenging behaviours  Psychopharmacology  Intellectual disability Index. décimale : PER Périodiques Résumé : AbstractIntroduction Autism is a neurodevelopmental disorder with a high co-occurrence with intellectual disability. Adults with Autism and intellectual disability have a high incidence of challenging behaviour, defined as repetitive self injurious or aggressive behaviour. We underwent a systemic review of the evidence for treating challenging behaviours in adults with Autism and intellectual disability. Methods A literature search was conducted using three large databases to extract studies on the treatment of challenging behaviour among adults with Autism and intellectual disability. Papers, which met this criterion, were reviewed and analysed to assess study evidence and quality. Results Seven articles were selected which included five agents: fluvoxamine, sertraline, clomipramine, risperidone, and ziprasidone. Randomized control studies of fluvoxamine and risperidone, provided efficacy for the treatment of challenging behaviour in adults with Autism and intellectual disability. Open label trials of sertraline, clomipramine and ziprasidone were also effective in treating challenging behaviours for this population. Discussion Risperidone and fluvoxamine provided the best evidence for treating challenging behaviour, and risperidone was the only medication with multiple trials showing its efficacy. Further studies are required to demonstrate the efficacy of psychopharmacology in treating challenging behaviours among adults with Autism and intellectual disability. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.021 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

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