Onset of maternal psychiatric disorders after the birth of a child with autism spectrum disorder: A retrospective cohort study / Jenny FAIRTHORNE in Autism, 20-1 (January 2016)  

Public ISBD [article]  inAutism > 20-1 (January 2016) . - p.37-44 Titre : Onset of maternal psychiatric disorders after the birth of a child with autism spectrum disorder: A retrospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Jenny FAIRTHORNE, Auteur ; Peter JACOBY, Auteur ; Jenny BOURKE, Auteur ; Nick DE KLERK, Auteur ; Helen LEONARD, Auteur Article en page(s) : p.37-44 Langues : Anglais (eng) Mots-clés : autism  care-giver  health  intellectual disability  linked data  mental population  psychiatric study Index. décimale : PER Périodiques Résumé : Background: Mothers of a child with autism spectrum disorder have more psychiatric disorders after the birth of their child. This might be because they have more psychiatric disorders before the birth, or the increase could be related to the burden of caring for their child.Aims: We aimed to calculate the incidence of a psychiatric diagnosis in women with no psychiatric history after the birth of their eldest child with autism spectrum disorder compared to women with no child with autism spectrum disorder or intellectual disability and no psychiatric history.Methods: By linking datasets from Western Australian population-based registries, we calculated the incidence of a psychiatric disorder in mothers of children with autism spectrum disorder and compared to mothers of children with no autism spectrum disorder or intellectual disability. Negative binomial regression using STATA 13 was used for all analyses.Results: Apart from alcohol and substance abuse, mothers of children with autism spectrum disorder had higher incidences of all categories of psychiatric disorders than other mothers.Conclusion and implications: The increase of psychiatric disorders in mothers of children with autism spectrum disorder and no psychiatric history compared to similar mothers with no child with autism spectrum disorder or intellectual disability might be due to a pre-existing genetic disposition coupled with an environmental trigger provided by the challenges of raising their children with autism spectrum disorder. In addition, the increased burden borne by the mothers of children with autism spectrum disorder might result in a higher incidence of psychiatric disorders in mothers who are not genetically disposed. En ligne : http://dx.doi.org/10.1177/1362361314566048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Onset of maternal psychiatric disorders after the birth of a child with autism spectrum disorder: A retrospective cohort study [Texte imprimé et/ou numérique] / Jenny FAIRTHORNE, Auteur ; Peter JACOBY, Auteur ; Jenny BOURKE, Auteur ; Nick DE KLERK, Auteur ; Helen LEONARD, Auteur . - p.37-44. Langues : Anglais (eng) in Autism > 20-1 (January 2016) . - p.37-44 Mots-clés : autism  care-giver  health  intellectual disability  linked data  mental population  psychiatric study Index. décimale : PER Périodiques Résumé : Background: Mothers of a child with autism spectrum disorder have more psychiatric disorders after the birth of their child. This might be because they have more psychiatric disorders before the birth, or the increase could be related to the burden of caring for their child.Aims: We aimed to calculate the incidence of a psychiatric diagnosis in women with no psychiatric history after the birth of their eldest child with autism spectrum disorder compared to women with no child with autism spectrum disorder or intellectual disability and no psychiatric history.Methods: By linking datasets from Western Australian population-based registries, we calculated the incidence of a psychiatric disorder in mothers of children with autism spectrum disorder and compared to mothers of children with no autism spectrum disorder or intellectual disability. Negative binomial regression using STATA 13 was used for all analyses.Results: Apart from alcohol and substance abuse, mothers of children with autism spectrum disorder had higher incidences of all categories of psychiatric disorders than other mothers.Conclusion and implications: The increase of psychiatric disorders in mothers of children with autism spectrum disorder and no psychiatric history compared to similar mothers with no child with autism spectrum disorder or intellectual disability might be due to a pre-existing genetic disposition coupled with an environmental trigger provided by the challenges of raising their children with autism spectrum disorder. In addition, the increased burden borne by the mothers of children with autism spectrum disorder might result in a higher incidence of psychiatric disorders in mothers who are not genetically disposed. En ligne : http://dx.doi.org/10.1177/1362361314566048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome population / Deidra YOUNG in Research in Autism Spectrum Disorders, 5-1 (January-March 2011)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.442-449 Titre : The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome population Type de document : Texte imprimé et/ou numérique Auteurs : Deidra YOUNG, Auteur ; Helen LEONARD, Auteur ; Carol BOWER, Auteur ; Ami BEBBINGTON, Auteur ; Nick DE KLERK, Auteur ; Lakshmi NAGARAJAN, Auteur Année de publication : 2011 Article en page(s) : p.442-449 Langues : Anglais (eng) Mots-clés : Rett-syndrome Health-status Health-service-use Trajectory Longitudinal MECP2-mutation Multilevel-regression Index. décimale : PER Périodiques Résumé : This study aimed to investigate the trajectories over time of health status and health service use in Rett syndrome by mutation type. Data were obtained from questionnaires administered over 6 years to 256 participants from the Australian Rett Syndrome Database. Health status (episodes of illness and medication load) and health service use (general practitioner and specialist visits and hospital stays) were summarized into composite scores with principal component analysis. Linear and mixed regression models examined effects of mutation type and other variables on these scores over time. For some mutations (such as p.R255X and p.R168X) health status was poorer at a younger age and improved over time, while for p.R133C it was better at a younger age and deteriorated with time. For those with p.R133C health service use was lowest at a younger age and highest at 25 years. With other mutations, such as p.R255X, p.R270X, p.R294X, C terminal and p.R306C, health service use was higher at a younger age, but dropped off considerably by 25 years of age. Health service use generally declined in parallel with deterioration in health status, although this pattern differed by mutation type, demonstrating important variability in the course of Rett syndrome. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111 [article] The relationship between MECP2 mutation type and health status and service use trajectories over time in a Rett syndrome population [Texte imprimé et/ou numérique] / Deidra YOUNG, Auteur ; Helen LEONARD, Auteur ; Carol BOWER, Auteur ; Ami BEBBINGTON, Auteur ; Nick DE KLERK, Auteur ; Lakshmi NAGARAJAN, Auteur . - 2011 . - p.442-449. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 5-1 (January-March 2011) . - p.442-449 Mots-clés : Rett-syndrome Health-status Health-service-use Trajectory Longitudinal MECP2-mutation Multilevel-regression Index. décimale : PER Périodiques Résumé : This study aimed to investigate the trajectories over time of health status and health service use in Rett syndrome by mutation type. Data were obtained from questionnaires administered over 6 years to 256 participants from the Australian Rett Syndrome Database. Health status (episodes of illness and medication load) and health service use (general practitioner and specialist visits and hospital stays) were summarized into composite scores with principal component analysis. Linear and mixed regression models examined effects of mutation type and other variables on these scores over time. For some mutations (such as p.R255X and p.R168X) health status was poorer at a younger age and improved over time, while for p.R133C it was better at a younger age and deteriorated with time. For those with p.R133C health service use was lowest at a younger age and highest at 25 years. With other mutations, such as p.R255X, p.R270X, p.R294X, C terminal and p.R306C, health service use was higher at a younger age, but dropped off considerably by 25 years of age. Health service use generally declined in parallel with deterioration in health status, although this pattern differed by mutation type, demonstrating important variability in the course of Rett syndrome. En ligne : http://dx.doi.org/10.1016/j.rasd.2010.06.007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=111

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